21 Ancient DNA View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

Winfried Henke , Ian Tattersall , Susanne Hummel

ABSTRACT

Ancient DNA research, defined as the retrieval and analysis of DNA sequences from various degraded biological source materials, has promoted many biological and medical research fields during the last two decades. In particular, historical anthropology and paleoanthropology stand to benefit from direct access to back-dating genetic data, as has already been shown through applications ranging from individual identification, reconstruction of kinship and marriage patterns to human phylogeny. The DNA-based prerequisites and basic methodological strategies for access to the various types of information are explained, as well as the characteristics of ancient DNA that limit the different approaches. Major restrictions arise from the degradation of ancient DNA down to fragment sizes of at the most only a few hundred base pairs. This fact links ancient DNA analysis almost exclusively to the PCR technique that enables us to deduce genetic information from degraded nucleic acids. Futhermore, ancient DNA extracts regularly consist of only a few intact target sequences, which may additionally reveal sequence deviations due to the degradation process. Both these factors make the analysis vulnerable to the generation of nonauthentic results. These pitfalls of ancient DNA analysis are explained and discussed in detail with reference to the most recent relevant literature. Wherever possible and available, suggestions for strategies to overcome commonly experienced obstacles in ancient DNA analysis are highlighted and evaluated. More... »

PAGES

643-671

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  • Book

    TITLE

    Handbook of Paleoanthropology

    ISBN

    978-3-540-32474-4
    978-3-540-33761-4

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-540-33761-4_21

    DOI

    http://dx.doi.org/10.1007/978-3-540-33761-4_21

    DIMENSIONS

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