The Role of the Mycobiota in the Gut-Liver Axis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018-11-10

AUTHORS

Maria Camila Alvarez-Silva , Thorsten Brach , Asker Daniel Brejnrod , Manimozhiyan Arumugam

ABSTRACT

The human mycobiota, consisting of all the fungi living in and on our body, is an understudied and underestimated part of the human microbiota. Fungal colonization is a well-established cause of human health problems, but for methodological reasons the mycobiota has not been studied as intensely as other constituents of the human microbiota. In this chapter, we highlight the importance of human gut mycobiota and host-fungal homeostasis. We lay out currently proposed mechanisms through which disturbance of host-fungal homeostasis can lead to fungal-related diseases in general as well as liver diseases in particular. We also address the methodological challenges of investigating the fungal component of the human microbiota. While new sequencing technologies have improved our understanding of the human microbiota, investigating and characterizing fungi requires more attention. We draw parallels to the better-established sequencing-based characterization of prokaryotes in the human microbiota, and examine the perspectives for advancing the field of studying fungal communities. More... »

PAGES

133-145

Book

TITLE

The Human Gut-Liver-Axis in Health and Disease

ISBN

978-3-319-98889-4
978-3-319-98890-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-98890-0_9

DOI

http://dx.doi.org/10.1007/978-3-319-98890-0_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1109841215


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