Stem Cell Roles and Applications in Genetic Neurodegenerative Diseases View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018-11-08

AUTHORS

John Ku , Ahmed El-Hashash

ABSTRACT

Neurodegeneration is an umbrella term for the progressive loss of function or structure of neurons. A wide range of neurodegenerative diseases, including Alzheimer’s, amyotrophic lateral sclerosis, Parkinson’s and Huntington’s diseases, occur because of neurodegenerative processes. There are currently no cures for both the neurological disorders/diseases Alzheimer’s and Parkinson’s that are marked by a selective loss of neurons. Current drug treatments for these types of diseases do not address the underlying pathology and can only relieve patient’s symptoms. Therefore, there is an urgent need to develop novel therapeutic approaches that can delay the onset or slow the progression of these diseases. Stem cells are potential and promising therapeutic options since they can be expanded easily and survive transplantation effectively. Stem cells can facilitate neovascularization and neurogenesis processes by producing multiple growth factors, cytokines, and other factors that have anti-apoptotic, anti-inflammatory, or anti-oxidative effects. Furthermore, the cell replacement therapeutic approaches are promising for common neurological diseases such as Alzheimer’s and Parkinson’s. More... »

PAGES

129-147

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  • Book

    TITLE

    Stem Cells for Cancer and Genetic Disease Treatment

    ISBN

    978-3-319-98064-5
    978-3-319-98065-2

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-98065-2_9

    DOI

    http://dx.doi.org/10.1007/978-3-319-98065-2_9

    DIMENSIONS

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