Clinical Evaluation and Management of Chronic Lymphocytic Leukemia View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018-11-16

AUTHORS

Nitin Jain , Susan O’Brien

ABSTRACT

Chronic lymphocytic leukemia (CLL) is the most leukemia in the United States and is characterized by clonal expansion of CD5-positive B cells. The diagnosis of CLL requires the presence of greater than or equal to 5 × 109/L clonal B-lymphocytes in the peripheral blood. Most patients with CLL do not need treatment at the time of diagnosis. Common indications for treatment include worsening lymphadenopathy, organomegaly, or development of cytopenias. Chemoimmunotherapy has been the standard treatment for patients with CLL. In the last few years, several novel targeted therapy agents have been developed targeting CLL cells. With the introduction of these agents such as ibrutinib, idelalisib, and venetoclax, the role of chemotherapy for patients with CLL has declined. More... »

PAGES

401-409

Book

TITLE

Concise Guide to Hematology

ISBN

978-3-319-97872-7
978-3-319-97873-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-97873-4_33

DOI

http://dx.doi.org/10.1007/978-3-319-97873-4_33

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1109957956


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