Inflammasomes in the Kidney View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018-09-05

AUTHORS

Holly L. Hutton , Maliha A. Alikhan , A. Richard Kitching

ABSTRACT

Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases. In addition to leukocyte-derived inflammasomes, renal tissue cells express functional inflammasome components. Furthermore, a range of endogenous substances that directly activate inflammasomes also mediate kidney injury. Many of the functional studies have focussed on the NLRP3 inflammasome, and there is also evidence for the involvement of other inflammasomes in some conditions. While, at least in some disease, the mechanistic details of the involvement of the inflammasome remain to be elucidated, therapies focussed on inflammasomes and their products have potential in treating kidney disease in the future. More... »

PAGES

177-210

References to SciGraph publications

Book

TITLE

Inflammasomes: Clinical and Therapeutic Implications

ISBN

978-3-319-89389-1
978-3-319-89390-7

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-89390-7_8

DOI

http://dx.doi.org/10.1007/978-3-319-89390-7_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106613516

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30536172


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