Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018

AUTHORS

Magnus T. Dillon , Kevin J. Harrington

ABSTRACT

ATR inhibitors are a new class of anti-cancer compounds reaching early phase clinical trials. They are predicted to have anti-cancer activity as monotherapy, and in combination with DNA damaging chemotherapies and ionizing radiation. We outline the clinical trials in progress using the current clinical candidates VX-970 (M6620) and AZD6738, discuss potential biomarkers for this class of drug and consider future avenues for development of ATR inhibitors. More... »

PAGES

99-127

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  • Book

    TITLE

    Targeting the DNA Damage Response for Anti-Cancer Therapy

    ISBN

    978-3-319-75834-3
    978-3-319-75836-7

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-75836-7_5

    DOI

    http://dx.doi.org/10.1007/978-3-319-75836-7_5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104249159


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