The Helicobacter pylori Type IV Secretion System Encoded by the cag Pathogenicity Island: Architecture, Function, and Signaling View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Steffen Backert , Rainer Haas , Markus Gerhard , Michael Naumann

ABSTRACT

Various gram-negative pathogens express type IV secretion systems (T4SSs) which translocate bacterial virulence factors into host target cells to hijack cellular processes for their own benefit and causing disease. The pathology of Helicobacter pylori, the causative agent of chronic gastritis, peptic ulcer disease, and gastric cancer in humans, strongly depends on a T4SS encoded by the cag pathogenicity island (cagPAI). This T4SS represents a pilus-like structure and a membrane-spanning complex. T4SS assembly is achieved by various protein–protein interactions and several pilus-associated components (CagL, CagI, CagY, and CagA) that allow docking to the host cell integrin member α5β1 followed by delivery of its major effector protein, CagA, across the host cell membrane. In addition, recent studies have shown that H. pylori exploits human CEACAM receptors via the adhesin HopQ, encoded outside of the cagPAI, for bacterial adherence and translocation of CagA. Here, we review the composition and assembly of the H. pylori T4SS and its fundamental role in the infection process. We discuss major CagA-dependent and CagA-independent signaling events by the T4SS in vitro and in animal models in vivo, which include the induction of cytoskeletal rearrangements, membrane dynamics, disturbance of cell polarity as well as transcriptional responses involved in inflammation, cell proliferation, and anti-apoptosis. The contribution of these signaling cascades to H. pylori colonization, and pathogenesis is reviewed. More... »

PAGES

187-220

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-75241-9_8

DOI

http://dx.doi.org/10.1007/978-3-319-75241-9_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101523479

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29536360


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225 Max von Pettenkofer-Institute for Hygiene and Medical Microbiology, Ludwig-Maximilians-University, Munich, Germany
226 rdf:type schema:Organization
227 grid-institutes:grid.5330.5 schema:alternateName Division of Microbiology, Department of Biology, Friedrich Alexander University Erlangen-Nuremberg, Staudtstr. 5, 91058, Erlangen, Germany
228 schema:name Division of Microbiology, Department of Biology, Friedrich Alexander University Erlangen-Nuremberg, Staudtstr. 5, 91058, Erlangen, Germany
229 rdf:type schema:Organization
230 grid-institutes:grid.5807.a schema:alternateName Institute of Experimental Internal Medicine, Otto von Guericke University, 39120, Magdeburg, Germany
231 schema:name Institute of Experimental Internal Medicine, Otto von Guericke University, 39120, Magdeburg, Germany
232 rdf:type schema:Organization
 




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