Molecular Cytology Applications on Gynecological Cytology View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018-07-25

AUTHORS

Francesca Carozzi , Giovanni Negri , Cristina Sani

ABSTRACT

In the last years, several new molecular techniques were introduced into cytology laboratories. The principal aim of molecular cytology tests applied to gynecology specimens is to improve the diagnostic accuracy of the Pap or HPV test and to personalize the management of women with cervical abnormalities. The use of biomarkers in cervical cytology has some potential advantages compared with histology. The cytological sampling can be easily obtained noninvasively during routine testing, while histological sampling requires colposcopy. The introduction of liquid-based samples in gynecological cytology (LBC) has strongly facilitated the development and the application of molecular techniques. LBC allows the use of biomarkers and molecular tests on the residual cellularity, adding valuable molecular informations to cell morphology potentially combining in one sample diagnosis and research. Most of these techniques are based on the detection of HPV or surrogate markers of the viral oncogenic activity. Their current and future applications will be critically analyzed. More... »

PAGES

127-149

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-74942-6_8

DOI

http://dx.doi.org/10.1007/978-3-319-74942-6_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105812143


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