Cushing Syndrome in Childhood View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018

AUTHORS

Maya Lodish , Margaret F. Keil , Constantine A. Stratakis

ABSTRACT

Cushing syndrome is a multisystem disorder resulting from the body’s prolonged exposure to excess glucocorticoids. It is characterized by truncal obesity, growth deceleration, striae, muscle weakness, and hypertension. Most commonly, Cushing syndrome in childhood results from the exogenous administration of glucocorticoids. In this chapter, we present the causes and discuss the treatment of endogenous Cushing syndrome. The most common cause of endogenous Cushing syndrome in children is adrenocorticotropin overproduction from a pituitary adenoma, known as Cushing disease, accounts for approximately 75% of all cases of Cushing syndrome in children older than 7 years. Cushing syndrome may also be due to adrenal hypersecretion of cortisol secondary to carcinoma, adenoma, or hyperplasia, especially in younger children. Finally, the most infrequent form of Cushing syndrome is due to ectopic secretion of adrenocorticotropin and/or corticotropin releasing factor. Genetic causes of Cushing syndrome are increasingly identified, including somatic and germline mutations. Early identification and treatment of Cushing syndrome is imperative for successful treatment and optimization of growth and cardiovascular health. More... »

PAGES

335-353

Book

TITLE

Pediatric Endocrinology

ISBN

978-3-319-73781-2
978-3-319-73782-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-73782-9_15

DOI

http://dx.doi.org/10.1007/978-3-319-73782-9_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103211487


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