Polyethylene Glycolation (PEGylation) and the Similar View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018-05-26

AUTHORS

Dong Soo Lee , Yun-Sang Lee

ABSTRACT

To overcome the adverse effect of hydrophobicity of nanomaterials, polyethylene glycolation (PEGylation) is popularly used, which were already in clinical use of peptide or monoclonal antibodies. The same PEGylation is tried to hydrophilize nanomaterials but the results of this PEGylation differs according to the size, shape, terminal residues and others. The bodily response to the nanomaterials depend upon immune recognition of the PEG by IgM or innate immune cells. Mechanism of innate immune response to PEGylated nanomaterials are poorly understood. Zwitterions such as polybetaines were proposed to replace PEGs for hydrophilization. The mechanism is being investigated and not yet clearly known. The method to modify the surface of nanomaterials with PEGs and zwitterions can also influence final bodily response and thus simple and easy method of encapsulation was developed. The effect of diverse modification of nanomaterials with PEGs or zwitterions shall be understood with nanomaterials modified with this encapsulation method. More... »

PAGES

331-345

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-67720-0_18

DOI

http://dx.doi.org/10.1007/978-3-319-67720-0_18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104230919


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, 08826, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Nuclear Medicine, Seoul National University College of Medicine, 03080, Seoul, Republic of Korea", 
            "Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, 08826, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Dong Soo", 
        "id": "sg:person.015617314175.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015617314175.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, 08826, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Nuclear Medicine, Seoul National University College of Medicine, 03080, Seoul, Republic of Korea", 
            "Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, 08826, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Yun-Sang", 
        "id": "sg:person.01152420166.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152420166.90"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2018-05-26", 
    "datePublishedReg": "2018-05-26", 
    "description": "To overcome the adverse effect of hydrophobicity of nanomaterials, polyethylene glycolation (PEGylation) is popularly used, which were already in clinical use of peptide or monoclonal antibodies. The same PEGylation is tried to hydrophilize nanomaterials but the results of this PEGylation differs according to the size, shape, terminal residues and others. The bodily response to the nanomaterials depend upon immune recognition of the PEG by IgM or innate immune cells. Mechanism of innate immune response to PEGylated nanomaterials are poorly understood. Zwitterions such as polybetaines were proposed to replace PEGs for hydrophilization. The mechanism is being investigated and not yet clearly known. The method to modify the surface of nanomaterials with PEGs and zwitterions can also influence final bodily response and thus simple and easy method of encapsulation was developed. The effect of diverse modification of nanomaterials with PEGs or zwitterions shall be understood with nanomaterials modified with this encapsulation method.", 
    "editor": [
      {
        "familyName": "Lee", 
        "givenName": "Dong Soo", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-319-67720-0_18", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-319-67719-4", 
        "978-3-319-67720-0"
      ], 
      "name": "Radionanomedicine", 
      "type": "Book"
    }, 
    "keywords": [
      "polyethylene glycolation", 
      "surface of nanomaterials", 
      "PEGylated nanomaterials", 
      "nanomaterials", 
      "encapsulation method", 
      "innate immune response", 
      "PEGylation", 
      "immune cells", 
      "immune response", 
      "easy method", 
      "immune recognition", 
      "diverse modifications", 
      "clinical use", 
      "PEG", 
      "monoclonal antibodies", 
      "adverse effects", 
      "bodily responses", 
      "hydrophilization", 
      "encapsulation", 
      "response", 
      "IgM", 
      "hydrophobicity", 
      "surface", 
      "polybetaines", 
      "antibodies", 
      "method", 
      "size", 
      "modification", 
      "PEGs", 
      "glycolation", 
      "effect", 
      "cells", 
      "mechanism", 
      "peptides", 
      "shape", 
      "terminal residues", 
      "zwitterion", 
      "use", 
      "Similar", 
      "residues", 
      "results", 
      "recognition"
    ], 
    "name": "Polyethylene Glycolation (PEGylation) and the Similar", 
    "pagination": "331-345", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104230919"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-319-67720-0_18"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-319-67720-0_18", 
      "https://app.dimensions.ai/details/publication/pub.1104230919"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-09-02T16:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/chapter/chapter_72.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-3-319-67720-0_18"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-67720-0_18'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-67720-0_18'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-67720-0_18'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-67720-0_18'


 

This table displays all metadata directly associated to this object as RDF triples.

109 TRIPLES      22 PREDICATES      66 URIs      59 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-319-67720-0_18 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N975aed73526241c58b29e8ab38b16c0b
4 schema:datePublished 2018-05-26
5 schema:datePublishedReg 2018-05-26
6 schema:description To overcome the adverse effect of hydrophobicity of nanomaterials, polyethylene glycolation (PEGylation) is popularly used, which were already in clinical use of peptide or monoclonal antibodies. The same PEGylation is tried to hydrophilize nanomaterials but the results of this PEGylation differs according to the size, shape, terminal residues and others. The bodily response to the nanomaterials depend upon immune recognition of the PEG by IgM or innate immune cells. Mechanism of innate immune response to PEGylated nanomaterials are poorly understood. Zwitterions such as polybetaines were proposed to replace PEGs for hydrophilization. The mechanism is being investigated and not yet clearly known. The method to modify the surface of nanomaterials with PEGs and zwitterions can also influence final bodily response and thus simple and easy method of encapsulation was developed. The effect of diverse modification of nanomaterials with PEGs or zwitterions shall be understood with nanomaterials modified with this encapsulation method.
7 schema:editor N651b748fde99453ea4977fda3ee2e8c0
8 schema:genre chapter
9 schema:isAccessibleForFree false
10 schema:isPartOf N523c6b75a91a47889e3e423a542bbae5
11 schema:keywords IgM
12 PEG
13 PEGs
14 PEGylated nanomaterials
15 PEGylation
16 Similar
17 adverse effects
18 antibodies
19 bodily responses
20 cells
21 clinical use
22 diverse modifications
23 easy method
24 effect
25 encapsulation
26 encapsulation method
27 glycolation
28 hydrophilization
29 hydrophobicity
30 immune cells
31 immune recognition
32 immune response
33 innate immune response
34 mechanism
35 method
36 modification
37 monoclonal antibodies
38 nanomaterials
39 peptides
40 polybetaines
41 polyethylene glycolation
42 recognition
43 residues
44 response
45 results
46 shape
47 size
48 surface
49 surface of nanomaterials
50 terminal residues
51 use
52 zwitterion
53 schema:name Polyethylene Glycolation (PEGylation) and the Similar
54 schema:pagination 331-345
55 schema:productId N67d66cbe257240cd9ab8e044c2a7fda5
56 Na0d15d8538aa4cf4aae32f27c2fe65e6
57 schema:publisher Ne3901b090b994597b6299bfac28cea2d
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104230919
59 https://doi.org/10.1007/978-3-319-67720-0_18
60 schema:sdDatePublished 2022-09-02T16:18
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher Nd26fe434419348d68c91500e9113a436
63 schema:url https://doi.org/10.1007/978-3-319-67720-0_18
64 sgo:license sg:explorer/license/
65 sgo:sdDataset chapters
66 rdf:type schema:Chapter
67 N170df079249840fb88b3ff4867a86e46 schema:familyName Lee
68 schema:givenName Dong Soo
69 rdf:type schema:Person
70 N523c6b75a91a47889e3e423a542bbae5 schema:isbn 978-3-319-67719-4
71 978-3-319-67720-0
72 schema:name Radionanomedicine
73 rdf:type schema:Book
74 N651b748fde99453ea4977fda3ee2e8c0 rdf:first N170df079249840fb88b3ff4867a86e46
75 rdf:rest rdf:nil
76 N67d66cbe257240cd9ab8e044c2a7fda5 schema:name doi
77 schema:value 10.1007/978-3-319-67720-0_18
78 rdf:type schema:PropertyValue
79 N975aed73526241c58b29e8ab38b16c0b rdf:first sg:person.015617314175.88
80 rdf:rest Nbc5906a670e24fc4b28d14b7d422baab
81 Na0d15d8538aa4cf4aae32f27c2fe65e6 schema:name dimensions_id
82 schema:value pub.1104230919
83 rdf:type schema:PropertyValue
84 Nbc5906a670e24fc4b28d14b7d422baab rdf:first sg:person.01152420166.90
85 rdf:rest rdf:nil
86 Nd26fe434419348d68c91500e9113a436 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 Ne3901b090b994597b6299bfac28cea2d schema:name Springer Nature
89 rdf:type schema:Organisation
90 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
91 schema:name Medical and Health Sciences
92 rdf:type schema:DefinedTerm
93 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
94 schema:name Immunology
95 rdf:type schema:DefinedTerm
96 sg:person.01152420166.90 schema:affiliation grid-institutes:grid.31501.36
97 schema:familyName Lee
98 schema:givenName Yun-Sang
99 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152420166.90
100 rdf:type schema:Person
101 sg:person.015617314175.88 schema:affiliation grid-institutes:grid.31501.36
102 schema:familyName Lee
103 schema:givenName Dong Soo
104 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015617314175.88
105 rdf:type schema:Person
106 grid-institutes:grid.31501.36 schema:alternateName Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, 08826, Seoul, Republic of Korea
107 schema:name Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, 08826, Seoul, Republic of Korea
108 Department of Nuclear Medicine, Seoul National University College of Medicine, 03080, Seoul, Republic of Korea
109 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...