Serological Markers of Infection in the Infected Total Knee Arthroplasty View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018

AUTHORS

Alexander J. Rondon , Timothy L. Tan , Javad Parvizi

ABSTRACT

Diagnosis of periprosthetic joint infection (PJI) is challenging as no perfect test for it exists. Often a combination of serological, synovial, microbiological, histological, and radiological investigations is performed that are expensive, invasive, and imperfect. Serum biomarkers are dependable diagnostic tools given the low-risk nature and ease of collecting blood that aid in the diagnosis of PJI. However, it must be noted they are not without limitations. This chapter will focus on current serological markers and their efficacy in diagnosing PJI. Routine workup for PJI involves the measurements of serum white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). The combination of ESR and CRP is very effective to “rule out” PJI. Additional biomarkers such as IL-6, IL-4, TNF-alpha, procalcitonin, and siCAM1 have also shown value in the diagnosis of PJI. Scientific investigation continues to work toward a “gold standard” serum test for the diagnosis of PJI. More... »

PAGES

71-78

References to SciGraph publications

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  • Book

    TITLE

    The Infected Total Knee Arthroplasty

    ISBN

    978-3-319-66729-4
    978-3-319-66730-0

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-66730-0_9

    DOI

    http://dx.doi.org/10.1007/978-3-319-66730-0_9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092989616


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