Cerebral Metabolism and Function View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017-08-29

AUTHORS

Lionel Velly , Nicolas Bruder

ABSTRACT

The brain has an extremely active metabolism. The weight of the adult brain is approximately 1400 g representing 2% of body weight and at the same time accounts for 20% of oxygen (3 to 5 ml ∙ 100 g−1 ∙ min−1) and 25% of glucose consumption in a subject at rest (31 μmol ∙ 100 g−1 ∙ min−1). This brain metabolism requires a high cerebral blood flow (CBF) of approximately 750 mL ∙ min−1 or 50 mL ∙ 100 g−1 ∙ min−1 equivalent to 15% of cardiac output at rest. The oxygen supply is in excess of oxygen consumption explaining a low cerebral extraction of oxygen (25–30%), but the brain has very little energy stores. This requires a very accurate and fast adaptation of CBF to cerebral metabolism. Another important anatomic characteristic of the brain is its containment in a rigid structure meaning that a change in volume gives rise to an exponential change in intracranial pressure (ICP) after volume compensation mechanisms are exceeded. Hence, the status of the cerebral circulation and its consequences on brain metabolism are very specific to this organ. More... »

PAGES

285-300

Book

TITLE

Metabolic Disorders and Critically Ill Patients

ISBN

978-3-319-64008-2
978-3-319-64010-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-64010-5_12

DOI

http://dx.doi.org/10.1007/978-3-319-64010-5_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100114439


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