Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2017-09-13

AUTHORS

Sunitha Bollimuntha , Biswaranjan Pani , Brij B. Singh

ABSTRACT

Calcium (Ca2+) is a ubiquitous second messenger that performs significant physiological task such as neurosecretion, exocytosis, neuronal growth/differentiation, and the development and/or maintenance of neural circuits. An important regulatory aspect of neuronal Ca2+ homeostasis is store-operated Ca2+ entry (SOCE) which, in recent years, has gained much attention for influencing a variety of nerve cell responses. Essentially, activation of SOCE ensues following the activation of the plasma membrane (PM) store-operated Ca2+ channels (SOCC) triggered by the depletion of endoplasmic reticulum (ER) Ca2+ stores. In addition to the TRPC (transient receptor potential canonical) and the Orai family of ion channels, STIM (stromal interacting molecule) proteins have been baptized as key molecular regulators of SOCE. Functional significance of the TRPC channels in neurons has been elaborately studied; however, information on Orai and STIM components of SOCE, although seems imminent, is currently limited. Importantly, perturbations in SOCE have been implicated in a spectrum of neuropathological conditions. Hence, understanding the precise involvement of SOCC in neurodegeneration would presumably unveil avenues for plausible therapeutic interventions. We thus review the role of SOCE-regulated neuronal Ca2+ signaling in selecting neurodegenerative conditions. More... »

PAGES

535-556

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-57732-6_27

DOI

http://dx.doi.org/10.1007/978-3-319-57732-6_27

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091597682

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28900932


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