STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017-09-13

AUTHORS

Jonathan Pacheco , Luis Vaca

ABSTRACT

The basic paradigm of a mechanism for calcium influx triggered after a reduction on calcium store content implies a sensor of calcium concentration on the endoplasmic reticulum (the stores) and a calcium channel immersed on the plasma membrane. These two basic components are STIM and Orai, the most fundamental and minimal molecular constituents of the store-operated calcium entry mechanism. However, even when minimal components can be reduced to these two proteins, the intricate process involved in approximating two cellular membranes (endoplasmic reticulum, ER and plasma membrane, PM) require the participation of several other components, many of which remain unidentified to this date. Here we review several of the proteins identified as constituents of the so-called store-operated calcium influx complex (SOCIC) and discuss their role in modulating this complex phenomenon. More... »

PAGES

189-210

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-57732-6_10

DOI

http://dx.doi.org/10.1007/978-3-319-57732-6_10

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091608209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28900915


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