Liquid Biopsy in Esophageal, Gastric, and Pancreatic Cancers View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

E. Giovannetti , D. Massihnia , N. Barraco , A. Listì , L. Incorvaia , M. Castiglia , Antonio Russo

ABSTRACT

Esophageal, gastric and pancreatic cancers represent lethal solid tumors and endoscopic biopsies are the main tool for the histological characterization of these cancer. However, there are many problems for tissue biopsy, together with possible surgical complications, tumor diffusion, and incorrect and/or negative results. Furthermore, in many cases there is no sufficient material from both primary tumors and metastasis for a proper molecular characterization. For these reasons, liquid biopsies represent an attractive minimally invasive methodology for the management of oncological patients. Liquid biopsy includes circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), circulating microRNAs and proteins and extracellular vesicles. Nevertheless, CTCs and ctDNA are the most commonly studied components of liquid biopsy and may acquire an important role also in esophageal, gastric and pancreatic cancers for a better desease management. In this chapter we will discuss how CTCs, exosomes and circulating nucleic acids can be used to obtain prognostic and predictive information and also could be a useful tool for early diagnosis. More... »

PAGES

137-150

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  • Book

    TITLE

    Liquid Biopsy in Cancer Patients

    ISBN

    978-3-319-55659-8
    978-3-319-55661-1

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-55661-1_15

    DOI

    http://dx.doi.org/10.1007/978-3-319-55661-1_15

    DIMENSIONS

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