The Ketone Body Beta-Hydroxybutyrate in Starvation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2019-03-07

AUTHORS

P. Rojas-Morales , J. Pedraza-Chaverri

ABSTRACT

The ketone body β-hydroxybutyrate (BHB) is a central molecule that plays pivotal roles in whole-body energy metabolism by fueling most tissues in conditions of nutrient deprivation, but its function is not limited to a metabolic intermediate during nutritional challenge. Emerging studies have positioned BHB as a signaling metabolite regulating a broad range of processes – from inflammation to longevity – through cellular receptors, epigenetic modifications, and by yet unknown mechanisms. In addition, several pieces of evidence point out that BHB might function as a signal controlling energy metabolism in the particular scenario of negative energy balance. This chapter provides an overview of how BHB, apart from helping to solve energy crisis by directly fueling oxidative metabolism, has the potential ability to reduce energy expenditure and promote autophagy, thus contributing to fine-tune systemic energy balance in the face of food limitation. More... »

PAGES

1139-1152

Book

TITLE

Handbook of Famine, Starvation, and Nutrient Deprivation

ISBN

978-3-319-55386-3
978-3-319-55387-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-55387-0_51

DOI

http://dx.doi.org/10.1007/978-3-319-55387-0_51

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112587081


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