Genome Diversity and Dynamics in Candida albicans View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017-02-04

AUTHORS

Christophe d’Enfert , Marie-Elisabeth Bougnoux , Adeline Feri , Mélanie Legrand , Raphaël Loll-Krippleber , Timea Marton , Corinne Maufrais , Jeanne Ropars , Natacha Sertour , Emilie Sitterlé

ABSTRACT

The fungal pathogen Candida albicans shows significant diversity at the genetic and phenotypic levels. In this Chapter, we review our current knowledge of the C. albicans diploid genome and its variability, the genetic structure of the C. albicans population and the mechanisms that are involved in C. albicans genome dynamics, with a focus on the parasexual cycle and loss-of-heterozygosity events. We further explore the impact of genetic diversity and genome dynamics on C. albicans phenotypic diversity. Finally, we discuss how our current knowledge of C. albicans genetic diversity could be leveraged in the future in order to get insights in the mechanisms underlying important biological attributes that are subject to variations across C. albicans isolates. More... »

PAGES

205-232

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-50409-4_11

DOI

http://dx.doi.org/10.1007/978-3-319-50409-4_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083531954


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