Amniotic Fluid: A Source of Stem Cells for Therapeutic Use and Modeling of Human Genetic Diseases View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Somaieh Kazemnejad , Manijeh Khanmohammadi , Abolfazl Shirazi , Shaghayegh Arasteh , Sayeh Khanjani , Mehdi Aleahmad

ABSTRACT

Nowadays, amniotic fluid (AF) has been introduced as a renewable stem cell source with easy procurement, availability, and without ethical issues associated with embryonic stem cells and adult stem cells like bone marrow. The immunomodulatory properties of amniotic fluid stem cells (AFSCs) along with capacity for long-term culturing, expansion, and cryopreservation make it suitable for potential applications in pharmaceutical screening, disease modeling, and cell-based therapies. Furthermore, there is compelling evidence about safety and functionality of AFSCs in treatment of different diseases in animal models. These features hold promise in clinical treatment of diseases by safe and accessible autologous cells in near future. On the other hand, AFSCs could represent a useful stem cell model for studying the molecular basis of prenatal diagnosed diseases since AFSCs demonstrate some pluripotent properties and are able to differentiate into different lineages. In this chapter, we describe the potential benefits and pitfalls of AFSCs in the regenerative medicine and modeling of human genetic diseases. More... »

PAGES

171-188

Book

TITLE

Perinatal Tissue-Derived Stem Cells

ISBN

978-3-319-46408-4
978-3-319-46410-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-46410-7_8

DOI

http://dx.doi.org/10.1007/978-3-319-46410-7_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038749475


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