Understanding and Modeling the Complexity of the Immune System View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Véronique Thomas-Vaslin

ABSTRACT

The immune system is a complex biological micro-ecosystem, adaptive, highly diversified, self-organized and cognitive network of cells, and molecular entities with degeneracy properties. The adaptive immune system has evolved into a complex system of billions of highly diversified lymphocytes all interacting as a connective dynamic multi-scale organized and distributed system, in order to collectively insure body identity and integrity. This complex system insures species preservation of symbiotic and polygenomic organisms. The immune system is characterized by complexity at many different levels; network organization during the development, through fluid cell populations with inter- and intra-cell signalling, an extraordinary lymphocyte somatic receptor diversity, lymphocyte clonotype selection and competition at cell level, migration and interaction inside the immunological tissues and fluid dissemination through the organism, homeostatic regulation, while rapid adaptation to a changing environment. Lymphocytes are the key actors of the immune system of vertebrates, in the middle of a multi-scale biological organization “from molecule to organism,” and at the confluence with other different biological systems and the environment. The perception of antigens induces a network of immuno-receptors that could be viewed as an internal representation of antigens. Fluctuations, variability, and diversity are key factor for the immune system to adapt perturbations and aging and to be or not resilient. Theoretical approaches of this complex system and multi-scale dynamic modeling are a challenge in the domain of complex systems. Theoretical, mathematics, and computer models developed to improve our understanding of the multi-scale complexity of the immune system should be developed. More... »

PAGES

261-270

Book

TITLE

First Complex Systems Digital Campus World E-Conference 2015

ISBN

978-3-319-45900-4
978-3-319-45901-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-45901-1_29

DOI

http://dx.doi.org/10.1007/978-3-319-45901-1_29

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002373974


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM, UMRS959, CNRS, FRE3632, Immunology-Immunopathology-Immunotherapy (I3) Paris France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas-Vaslin", 
        "givenName": "V\u00e9ronique", 
        "id": "sg:person.0663343212.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663343212.52"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2017", 
    "datePublishedReg": "2017-01-01", 
    "description": "The immune system is a complex biological micro-ecosystem, adaptive, highly diversified, self-organized and cognitive network of cells, and molecular entities with degeneracy properties. The adaptive immune system has evolved into a complex system of billions of highly diversified lymphocytes all interacting as a connective dynamic multi-scale organized and distributed system, in order to collectively insure body identity and integrity. This complex system insures species preservation of symbiotic and polygenomic organisms. The immune system is characterized by complexity at many different levels; network organization during the development, through fluid cell populations with inter- and intra-cell signalling, an extraordinary lymphocyte somatic receptor diversity, lymphocyte clonotype selection and competition at cell level, migration and interaction inside the immunological tissues and fluid dissemination through the organism, homeostatic regulation, while rapid adaptation to a changing environment. Lymphocytes are the key actors of the immune system of vertebrates, in the middle of a multi-scale biological organization \u201cfrom molecule to organism,\u201d and at the confluence with other different biological systems and the environment. The perception of antigens induces a network of immuno-receptors that could be viewed as an internal representation of antigens. Fluctuations, variability, and diversity are key factor for the immune system to adapt perturbations and aging and to be or not resilient. Theoretical approaches of this complex system and multi-scale dynamic modeling are a challenge in the domain of complex systems. Theoretical, mathematics, and computer models developed to improve our understanding of the multi-scale complexity of the immune system should be developed.", 
    "editor": [
      {
        "familyName": "Bourgine", 
        "givenName": "Paul", 
        "type": "Person"
      }, 
      {
        "familyName": "Collet", 
        "givenName": "Pierre", 
        "type": "Person"
      }, 
      {
        "familyName": "Parrend", 
        "givenName": "Pierre", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-319-45901-1_29", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-319-45900-4", 
        "978-3-319-45901-1"
      ], 
      "name": "First Complex Systems Digital Campus World E-Conference 2015", 
      "type": "Book"
    }, 
    "name": "Understanding and Modeling the Complexity of the Immune System", 
    "pagination": "261-270", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-319-45901-1_29"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0b4dbe2fa36e0c48d73f9a24b1279b416d2638ee8a2b1e6f572a672af456d78c"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002373974"
        ]
      }
    ], 
    "publisher": {
      "location": "Cham", 
      "name": "Springer International Publishing", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-319-45901-1_29", 
      "https://app.dimensions.ai/details/publication/pub.1002373974"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T23:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000004.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-3-319-45901-1_29"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-45901-1_29'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-45901-1_29'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-45901-1_29'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-45901-1_29'


 

This table displays all metadata directly associated to this object as RDF triples.

74 TRIPLES      22 PREDICATES      27 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-319-45901-1_29 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N970fac5eec3c44a493a8dd3dbd33d785
4 schema:datePublished 2017
5 schema:datePublishedReg 2017-01-01
6 schema:description The immune system is a complex biological micro-ecosystem, adaptive, highly diversified, self-organized and cognitive network of cells, and molecular entities with degeneracy properties. The adaptive immune system has evolved into a complex system of billions of highly diversified lymphocytes all interacting as a connective dynamic multi-scale organized and distributed system, in order to collectively insure body identity and integrity. This complex system insures species preservation of symbiotic and polygenomic organisms. The immune system is characterized by complexity at many different levels; network organization during the development, through fluid cell populations with inter- and intra-cell signalling, an extraordinary lymphocyte somatic receptor diversity, lymphocyte clonotype selection and competition at cell level, migration and interaction inside the immunological tissues and fluid dissemination through the organism, homeostatic regulation, while rapid adaptation to a changing environment. Lymphocytes are the key actors of the immune system of vertebrates, in the middle of a multi-scale biological organization “from molecule to organism,” and at the confluence with other different biological systems and the environment. The perception of antigens induces a network of immuno-receptors that could be viewed as an internal representation of antigens. Fluctuations, variability, and diversity are key factor for the immune system to adapt perturbations and aging and to be or not resilient. Theoretical approaches of this complex system and multi-scale dynamic modeling are a challenge in the domain of complex systems. Theoretical, mathematics, and computer models developed to improve our understanding of the multi-scale complexity of the immune system should be developed.
7 schema:editor N02d90d9adc39400eb63123795cdf93f3
8 schema:genre chapter
9 schema:inLanguage en
10 schema:isAccessibleForFree false
11 schema:isPartOf N650c0c4d7686460f9ab88b141f592c5a
12 schema:name Understanding and Modeling the Complexity of the Immune System
13 schema:pagination 261-270
14 schema:productId N740895eb73ff49d2900c0a3de5fa1be8
15 N9df97a4caac1498e869ea9b3ccf3117a
16 Nb05324a3ad7e460a97690b2cf0c550d1
17 schema:publisher N48f41153e59e449f8663bca659e50082
18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002373974
19 https://doi.org/10.1007/978-3-319-45901-1_29
20 schema:sdDatePublished 2019-04-15T23:36
21 schema:sdLicense https://scigraph.springernature.com/explorer/license/
22 schema:sdPublisher Neb083728c63d4e2ea7917e007cfa98e2
23 schema:url http://link.springer.com/10.1007/978-3-319-45901-1_29
24 sgo:license sg:explorer/license/
25 sgo:sdDataset chapters
26 rdf:type schema:Chapter
27 N02d90d9adc39400eb63123795cdf93f3 rdf:first Nbd02d14851594b15b14740587da9e49e
28 rdf:rest N70a3bd5c6da242b3be46a9e418219585
29 N11645afb431343fb96fbd09c6dc37df8 schema:familyName Collet
30 schema:givenName Pierre
31 rdf:type schema:Person
32 N48f41153e59e449f8663bca659e50082 schema:location Cham
33 schema:name Springer International Publishing
34 rdf:type schema:Organisation
35 N57174448d73d402a984463fafbd7d1c5 schema:familyName Parrend
36 schema:givenName Pierre
37 rdf:type schema:Person
38 N650c0c4d7686460f9ab88b141f592c5a schema:isbn 978-3-319-45900-4
39 978-3-319-45901-1
40 schema:name First Complex Systems Digital Campus World E-Conference 2015
41 rdf:type schema:Book
42 N70a3bd5c6da242b3be46a9e418219585 rdf:first N11645afb431343fb96fbd09c6dc37df8
43 rdf:rest N985fbaa61ecc4cbabf09071ffff4f058
44 N740895eb73ff49d2900c0a3de5fa1be8 schema:name dimensions_id
45 schema:value pub.1002373974
46 rdf:type schema:PropertyValue
47 N970fac5eec3c44a493a8dd3dbd33d785 rdf:first sg:person.0663343212.52
48 rdf:rest rdf:nil
49 N985fbaa61ecc4cbabf09071ffff4f058 rdf:first N57174448d73d402a984463fafbd7d1c5
50 rdf:rest rdf:nil
51 N9df97a4caac1498e869ea9b3ccf3117a schema:name doi
52 schema:value 10.1007/978-3-319-45901-1_29
53 rdf:type schema:PropertyValue
54 Nb05324a3ad7e460a97690b2cf0c550d1 schema:name readcube_id
55 schema:value 0b4dbe2fa36e0c48d73f9a24b1279b416d2638ee8a2b1e6f572a672af456d78c
56 rdf:type schema:PropertyValue
57 Nbd02d14851594b15b14740587da9e49e schema:familyName Bourgine
58 schema:givenName Paul
59 rdf:type schema:Person
60 Neb083728c63d4e2ea7917e007cfa98e2 schema:name Springer Nature - SN SciGraph project
61 rdf:type schema:Organization
62 Nf3f6b9098ed443f6b6278032bb541124 schema:name Sorbonne Universités, UPMC Univ Paris 06, INSERM, UMRS959, CNRS, FRE3632, Immunology-Immunopathology-Immunotherapy (I3) Paris France
63 rdf:type schema:Organization
64 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
65 schema:name Medical and Health Sciences
66 rdf:type schema:DefinedTerm
67 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
68 schema:name Immunology
69 rdf:type schema:DefinedTerm
70 sg:person.0663343212.52 schema:affiliation Nf3f6b9098ed443f6b6278032bb541124
71 schema:familyName Thomas-Vaslin
72 schema:givenName Véronique
73 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663343212.52
74 rdf:type schema:Person
 




Preview window. Press ESC to close (or click here)


...