Redox Regulation of Vascular Remodeling View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Leonardo Y. Tanaka , Denise de Castro Fernandes , Francisco R. M. Laurindo

ABSTRACT

Vascular remodeling, the structural reorganization of whole-vessel circumference, is the main determinant of lumen caliber due to sustained blood flow changes and in vasculoproliferative diseases. Here we discuss the importance of redox processes as central determinants of vascular remodeling. The strong dependence of shear stress-associated remodeling on endothelial redox signaling indicates primary roles of NO biovailability as remodeling determinant. In addition, superoxide can limit NO bioavailability and counteract expansive remodeling, while hydrogen peroxide favors it. Nox NADPH oxidases appear essential oxidant sources in this context and reportedly mediate flow-induced remodeling. Also, vascular injury and repair is strongly modulated by redox processes, with oxidant generation as a major early response to injury. The neointima, in addition, is under sustained oxidative stress promoted at least partially by Noxes. Also, we provide evidence that superoxide dismutase under-activity supports constrictive remodeling in the injury/repair model. Furthermore, we showed that the peri/epicellular pool of protein disulfide isomerase (PDI) importantly orchestrates cytoskeletal/extracellular matrix organization to support an anti-constrictive remodeling effect during vessel repair. Overall, such redox modulation extrapolates known roles of redox signaling in individual cellular events towards a predictable synchronized responsiveness of whole vessel remodeling to redox-based interventions, with potentially significant therapeutic implications. More... »

PAGES

227-243

References to SciGraph publications

Book

TITLE

Biochemistry of Oxidative Stress

ISBN

978-3-319-45864-9
978-3-319-45865-6

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-45865-6_15

DOI

http://dx.doi.org/10.1007/978-3-319-45865-6_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028611208


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