Genetic Disorders of Adrenocortical Function View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018

AUTHORS

Fady Hannah-Shmouni , Constantine A. Stratakis

ABSTRACT

The first detailed description of the human adrenal glands was by Eustachius (1520–1574); their presence was confirmed by Piccolomini (1562–1605) and Casserius (1552–1616) (Vrezas et al. 2000). Their function, however, was largely unknown until the late nineteenth century. In the last 30 years, our growing understanding of adrenocortical development and function has led to the discovery of numerous genetic disorders that affect the adrenal glands. Developmental pathways have also been linked to the formation of adrenocortical tumors (ACTs), which represent a heterogeneous group of lesions of the adrenal cortex. ACTs have been found to be due to or associated with somatic or germline mutations in key molecular pathways, including the cyclic AMP (cAMP) and Wnt signaling pathways. In this chapter, we review the various genetic causes of adrenocortical disorders and focus on congenital causes of adrenal insufficiency associated with hypoplasia of the adrenal glands, genetic causes of autoimmunity that affect the adrenal glands, and genetic causes of benign and malignant ACT. More... »

PAGES

727-763

References to SciGraph publications

  • 2012-07. Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome in NATURE GENETICS
  • 2013-02. Tumor Protein p53 (TP53) Testing and Li-Fraumeni Syndrome in MOLECULAR DIAGNOSIS & THERAPY
  • 1997-09. New p57KIP2 mutations in Beckwith-Wiedemann syndrome in HUMAN GENETICS
  • 2014-06. Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors in NATURE GENETICS
  • 1994-12. An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita in NATURE
  • 1998-09. Hyperplastic and tumorous lesions of the adrenals in an unselected autopsy series in ENDOCRINE PATHOLOGY
  • 2012-06. Prognostic and predictive value of TP53mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy: results from the BIG 02-98 phase III trial in BREAST CANCER RESEARCH
  • 2000-09. Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex in NATURE GENETICS
  • 2016-05. A genetic and molecular update on adrenocortical causes of Cushing syndrome in NATURE REVIEWS ENDOCRINOLOGY
  • 2012-10. Assembly of allosteric macromolecular switches: lessons from PKA in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2001-07. Adrenocortical carcinomas: surgical trends and results of a 253-patient series from the French Association of Endocrine Surgeons study group in WORLD JOURNAL OF SURGERY
  • 2016-04. Carney triad can be (rarely) associated with germline succinate dehydrogenase defects in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2007-11. Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias in NATURE REVIEWS ENDOCRINOLOGY
  • 1994-12. Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism in NATURE
  • 2013-04. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension in NATURE GENETICS
  • 1992-01. A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension in NATURE
  • 1999-06. A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans in NATURE GENETICS
  • 1997-07. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene in NATURE GENETICS
  • 2005-02. Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2 in NATURE GENETICS
  • 2004-12. Triple-A syndrome with prominent ophthalmic features and a novel mutation in the AAASgene: a case report in BMC OPHTHALMOLOGY
  • 2010-01. Beckwith–Wiedemann syndrome in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2013-09. Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism in NATURE GENETICS
  • 2004-02. Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators in ONCOGENE
  • Book

    TITLE

    Principles of Endocrinology and Hormone Action

    ISBN

    978-3-319-44674-5
    978-3-319-44675-2

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-44675-2_29

    DOI

    http://dx.doi.org/10.1007/978-3-319-44675-2_29

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100655311


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hannah-Shmouni", 
            "givenName": "Fady", 
            "id": "sg:person.01315132137.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315132137.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stratakis", 
            "givenName": "Constantine A.", 
            "id": "sg:person.011151216517.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011151216517.08"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1161/hypertensionaha.113.01733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000316244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.113.01733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000316244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.113.01733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000316244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-1004(1999)13:1<69::aid-humu8>3.0.co;2-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000633589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.2006.tb00561.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000796273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/9629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000913953", 
              "https://doi.org/10.1038/9629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/9629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000913953", 
              "https://doi.org/10.1038/9629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000134753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001959749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2265.2000.01144.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002104132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.00030.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002225644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2265.2011.04220.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003100084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje.0.1440029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003160614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje.0.1440029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003160614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje.0.1440029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003160614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003568915", 
              "https://doi.org/10.1038/ng.2550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrendo.2016.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003679662", 
              "https://doi.org/10.1038/nrendo.2016.24"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0797-303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004103506", 
              "https://doi.org/10.1038/ng0797-303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/erc-14-0254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004309336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005050878", 
              "https://doi.org/10.1038/ng1501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005050878", 
              "https://doi.org/10.1038/ng1501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e31821ec4ce", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005284464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e31821ec4ce", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005284464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e328333bf00", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005722703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e328333bf00", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005722703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e328333bf00", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005722703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tem.2006.10.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006764893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncpendmet0648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007479215", 
              "https://doi.org/10.1038/ncpendmet0648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-1847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008946764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1304603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008978713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jmor.1051260408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010473411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/355262a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010671658", 
              "https://doi.org/10.1038/355262a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/jpem-2013-0369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011127590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2016-1700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011486330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/joim.12162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011779054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr3179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012055898", 
              "https://doi.org/10.1186/bcr3179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.beem.2008.10.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012101148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2265.2009.03689.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012205529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2009.106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013049070", 
              "https://doi.org/10.1038/ejhg.2009.106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2009.106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013049070", 
              "https://doi.org/10.1038/ejhg.2009.106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1215245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013566359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.30729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014594528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.30729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014594528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fendo.2015.00113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014913853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fendo.2015.00113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014913853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje-16-0262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015727619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2265.2000.01122.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015758824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.10917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015820687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.beem.2008.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016237988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci116853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016468627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e318285f6a2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016630153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e318285f6a2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016630153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje-15-0205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017148390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.37.11.831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017352275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.2005.036061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017666915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mus.23770", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017703167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2265.2006.02709.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019477355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-001-0047-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019675765", 
              "https://doi.org/10.1007/s00268-001-0047-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-001-0047-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019675765", 
              "https://doi.org/10.1007/s00268-001-0047-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje-11-0679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021624109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00282-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022046231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40291-013-0020-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022921391", 
              "https://doi.org/10.1007/s40291-013-0020-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000070226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022995818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tem.2005.10.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023501444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004390050573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023574549", 
              "https://doi.org/10.1007/s004390050573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004390050573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023574549", 
              "https://doi.org/10.1007/s004390050573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-3476(70)80472-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023627532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje-14-1113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023722572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc1309730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024612927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.27.7.465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025598696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2007.08.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026553446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026843638", 
              "https://doi.org/10.1038/ng.2695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1310359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026986035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.7.2718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027160139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/372635a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027354836", 
              "https://doi.org/10.1038/372635a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc0706182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027709600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mce.2011.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029707919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.1320550419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030081828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.1320550419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030081828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030087812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030682778", 
              "https://doi.org/10.1038/ng.2275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.161479898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030767494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/med.0b013e3282fe7416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031658867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/med.0b013e3282fe7416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031658867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lpm.2012.09.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032777379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/372672a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032815378", 
              "https://doi.org/10.1038/372672a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e31825d538b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033261015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e31825d538b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033261015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034260511", 
              "https://doi.org/10.1038/79238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034260511", 
              "https://doi.org/10.1038/79238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.092775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034408635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199112123252403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034803167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034900688", 
              "https://doi.org/10.1038/ng.2956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1249480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035118083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035463962", 
              "https://doi.org/10.1038/nrm3432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/jpem.2006.19.11.1299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036932596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2415-4-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037176723", 
              "https://doi.org/10.1186/1471-2415-4-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mce.2013.10.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038359276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000134765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038577163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mce.2006.12.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039078452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-0004.2005.00482.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039111025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-0004.2005.00482.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039111025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02739963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040738659", 
              "https://doi.org/10.1007/bf02739963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02739963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040738659", 
              "https://doi.org/10.1007/bf02739963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.beem.2006.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042010993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.10235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044590457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044710813", 
              "https://doi.org/10.1038/sj.onc.1207277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044710813", 
              "https://doi.org/10.1038/sj.onc.1207277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-3476(67)80179-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044922010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2265.2004.02048.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045978457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2011-1565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045993048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2015.142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046340851", 
              "https://doi.org/10.1038/ejhg.2015.142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000342504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046360105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/humu.21178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046632556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/humu.21178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046632556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/humu.20495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047721109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-1497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048468645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-3476(99)70302-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049194107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-3476(99)70302-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049194107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.28346", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049958814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm197706302962609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050003114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci25091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051969443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.34271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052655277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/302575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058610144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1198785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062462997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.276.5311.404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062556407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/er.2013-1053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064286057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2002-021362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064286368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2002-021845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064286557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2002-030014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064286661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2003-030502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064286881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2004-0016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064287625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2004-2377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064288217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2005-2708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064288997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2006-0188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064289104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2006-0603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064289217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2008-0594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064290643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2009-0516", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064291318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2009-2631", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064291902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2010-1704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064292369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2011-1659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064292967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2011-1982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064293030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2011-3000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064293255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2012-1230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064293439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2012-2374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064293705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2013-4237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064294870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2013-4280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064294881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2014-4167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064295592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.83.9.3214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064300402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jcem-24-10-947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064305620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jcem.86.11.8062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064324026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jcem.86.9.7903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064324785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jcem.87.6.8521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064325252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/edm-14-0074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067716547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/edm-14-0074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067716547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/edm-14-0074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067716547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-131-8-199910190-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073703639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076569044", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077003893", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080741171", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081246957", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082894735", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018", 
        "datePublishedReg": "2018-01-01", 
        "description": "The first detailed description of the human adrenal glands was by Eustachius (1520\u20131574); their presence was confirmed by Piccolomini (1562\u20131605) and Casserius (1552\u20131616) (Vrezas et al. 2000). Their function, however, was largely unknown until the late nineteenth century. In the last 30 years, our growing understanding of adrenocortical development and function has led to the discovery of numerous genetic disorders that affect the adrenal glands. Developmental pathways have also been linked to the formation of adrenocortical tumors (ACTs), which represent a heterogeneous group of lesions of the adrenal cortex. ACTs have been found to be due to or associated with somatic or germline mutations in key molecular pathways, including the cyclic AMP (cAMP) and Wnt signaling pathways. In this chapter, we review the various genetic causes of adrenocortical disorders and focus on congenital causes of adrenal insufficiency associated with hypoplasia of the adrenal glands, genetic causes of autoimmunity that affect the adrenal glands, and genetic causes of benign and malignant ACT.", 
        "editor": [
          {
            "familyName": "Belfiore", 
            "givenName": "Antonino", 
            "type": "Person"
          }, 
          {
            "familyName": "LeRoith", 
            "givenName": "Derek", 
            "type": "Person"
          }
        ], 
        "genre": "chapter", 
        "id": "sg:pub.10.1007/978-3-319-44675-2_29", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": {
          "isbn": [
            "978-3-319-44674-5", 
            "978-3-319-44675-2"
          ], 
          "name": "Principles of Endocrinology and Hormone Action", 
          "type": "Book"
        }, 
        "name": "Genetic Disorders of Adrenocortical Function", 
        "pagination": "727-763", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/978-3-319-44675-2_29"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d447773c8b6158ab7b24f6dddb0def40968f141c1ec30f4e4e309d489084e9e1"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1100655311"
            ]
          }
        ], 
        "publisher": {
          "location": "Cham", 
          "name": "Springer International Publishing", 
          "type": "Organisation"
        }, 
        "sameAs": [
          "https://doi.org/10.1007/978-3-319-44675-2_29", 
          "https://app.dimensions.ai/details/publication/pub.1100655311"
        ], 
        "sdDataset": "chapters", 
        "sdDatePublished": "2019-04-15T15:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000603.jsonl", 
        "type": "Chapter", 
        "url": "http://link.springer.com/10.1007/978-3-319-44675-2_29"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-44675-2_29'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-44675-2_29'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-44675-2_29'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-44675-2_29'


     

    This table displays all metadata directly associated to this object as RDF triples.

    501 TRIPLES      23 PREDICATES      162 URIs      20 LITERALS      8 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/978-3-319-44675-2_29 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N7946799976fc414e9fa1d13e713e739d
    4 schema:citation sg:pub.10.1007/bf02739963
    5 sg:pub.10.1007/s00268-001-0047-y
    6 sg:pub.10.1007/s004390050573
    7 sg:pub.10.1007/s40291-013-0020-0
    8 sg:pub.10.1038/355262a0
    9 sg:pub.10.1038/372635a0
    10 sg:pub.10.1038/372672a0
    11 sg:pub.10.1038/79238
    12 sg:pub.10.1038/9629
    13 sg:pub.10.1038/ejhg.2009.106
    14 sg:pub.10.1038/ejhg.2015.142
    15 sg:pub.10.1038/ncpendmet0648
    16 sg:pub.10.1038/ng.2275
    17 sg:pub.10.1038/ng.2550
    18 sg:pub.10.1038/ng.2695
    19 sg:pub.10.1038/ng.2956
    20 sg:pub.10.1038/ng0797-303
    21 sg:pub.10.1038/ng1501
    22 sg:pub.10.1038/nrendo.2016.24
    23 sg:pub.10.1038/nrm3432
    24 sg:pub.10.1038/sj.onc.1207277
    25 sg:pub.10.1186/1471-2415-4-7
    26 sg:pub.10.1186/bcr3179
    27 https://app.dimensions.ai/details/publication/pub.1076569044
    28 https://app.dimensions.ai/details/publication/pub.1077003893
    29 https://app.dimensions.ai/details/publication/pub.1080741171
    30 https://app.dimensions.ai/details/publication/pub.1081246957
    31 https://app.dimensions.ai/details/publication/pub.1082894735
    32 https://doi.org/10.1002/(sici)1098-1004(1999)13:1<69::aid-humu8>3.0.co;2-6
    33 https://doi.org/10.1002/ajmg.10235
    34 https://doi.org/10.1002/ajmg.1320550419
    35 https://doi.org/10.1002/ajmg.a.10917
    36 https://doi.org/10.1002/ajmg.a.30729
    37 https://doi.org/10.1002/ajmg.a.34271
    38 https://doi.org/10.1002/ana.101
    39 https://doi.org/10.1002/cncr.28346
    40 https://doi.org/10.1002/humu.20495
    41 https://doi.org/10.1002/humu.21178
    42 https://doi.org/10.1002/jmor.1051260408
    43 https://doi.org/10.1002/mus.23770
    44 https://doi.org/10.1016/j.ajhg.2007.08.005
    45 https://doi.org/10.1016/j.beem.2006.09.002
    46 https://doi.org/10.1016/j.beem.2008.10.008
    47 https://doi.org/10.1016/j.beem.2008.10.011
    48 https://doi.org/10.1016/j.lpm.2012.09.011
    49 https://doi.org/10.1016/j.mce.2006.12.035
    50 https://doi.org/10.1016/j.mce.2011.09.009
    51 https://doi.org/10.1016/j.mce.2013.10.028
    52 https://doi.org/10.1016/j.tem.2005.10.004
    53 https://doi.org/10.1016/j.tem.2006.10.001
    54 https://doi.org/10.1016/s0022-3476(67)80179-3
    55 https://doi.org/10.1016/s0022-3476(70)80472-3
    56 https://doi.org/10.1016/s0022-3476(99)70302-1
    57 https://doi.org/10.1016/s0092-8674(01)00282-3
    58 https://doi.org/10.1046/j.1365-2265.2000.01122.x
    59 https://doi.org/10.1046/j.1365-2265.2000.01144.x
    60 https://doi.org/10.1056/nejm197706302962609
    61 https://doi.org/10.1056/nejm199112123252403
    62 https://doi.org/10.1056/nejmc0706182
    63 https://doi.org/10.1056/nejmc1309730
    64 https://doi.org/10.1056/nejmoa1215245
    65 https://doi.org/10.1056/nejmoa1304603
    66 https://doi.org/10.1056/nejmoa1310359
    67 https://doi.org/10.1073/pnas.161479898
    68 https://doi.org/10.1073/pnas.91.7.2718
    69 https://doi.org/10.1086/302575
    70 https://doi.org/10.1097/cco.0b013e328333bf00
    71 https://doi.org/10.1097/med.0b013e3282fe7416
    72 https://doi.org/10.1097/pas.0b013e31821ec4ce
    73 https://doi.org/10.1097/pas.0b013e31825d538b
    74 https://doi.org/10.1097/pas.0b013e318285f6a2
    75 https://doi.org/10.1111/j.1365-2265.2004.02048.x
    76 https://doi.org/10.1111/j.1365-2265.2006.02709.x
    77 https://doi.org/10.1111/j.1365-2265.2009.03689.x
    78 https://doi.org/10.1111/j.1365-2265.2011.04220.x
    79 https://doi.org/10.1111/j.1399-0004.2005.00482.x
    80 https://doi.org/10.1111/j.1750-3639.2006.tb00561.x
    81 https://doi.org/10.1111/joim.12162
    82 https://doi.org/10.1126/science.1198785
    83 https://doi.org/10.1126/science.1249480
    84 https://doi.org/10.1126/science.276.5311.404
    85 https://doi.org/10.1136/jmg.2005.036061
    86 https://doi.org/10.1136/jmg.27.7.465
    87 https://doi.org/10.1136/jmg.37.11.831
    88 https://doi.org/10.1152/physrev.00030.2010
    89 https://doi.org/10.1158/0008-5472.can-04-1847
    90 https://doi.org/10.1158/1078-0432.ccr-10-1497
    91 https://doi.org/10.1159/000070226
    92 https://doi.org/10.1159/000134753
    93 https://doi.org/10.1159/000134765
    94 https://doi.org/10.1159/000342504
    95 https://doi.org/10.1161/hypertensionaha.113.01733
    96 https://doi.org/10.1172/jci116853
    97 https://doi.org/10.1172/jci25091
    98 https://doi.org/10.1210/er.2013-1053
    99 https://doi.org/10.1210/jc.2002-021362
    100 https://doi.org/10.1210/jc.2002-021845
    101 https://doi.org/10.1210/jc.2002-030014
    102 https://doi.org/10.1210/jc.2003-030502
    103 https://doi.org/10.1210/jc.2004-0016
    104 https://doi.org/10.1210/jc.2004-2377
    105 https://doi.org/10.1210/jc.2005-2708
    106 https://doi.org/10.1210/jc.2006-0188
    107 https://doi.org/10.1210/jc.2006-0603
    108 https://doi.org/10.1210/jc.2008-0594
    109 https://doi.org/10.1210/jc.2009-0516
    110 https://doi.org/10.1210/jc.2009-2631
    111 https://doi.org/10.1210/jc.2010-1704
    112 https://doi.org/10.1210/jc.2011-1565
    113 https://doi.org/10.1210/jc.2011-1659
    114 https://doi.org/10.1210/jc.2011-1982
    115 https://doi.org/10.1210/jc.2011-3000
    116 https://doi.org/10.1210/jc.2012-1230
    117 https://doi.org/10.1210/jc.2012-2374
    118 https://doi.org/10.1210/jc.2013-4237
    119 https://doi.org/10.1210/jc.2013-4280
    120 https://doi.org/10.1210/jc.2014-4167
    121 https://doi.org/10.1210/jc.2016-1700
    122 https://doi.org/10.1210/jc.83.9.3214
    123 https://doi.org/10.1210/jcem-24-10-947
    124 https://doi.org/10.1210/jcem.86.11.8062
    125 https://doi.org/10.1210/jcem.86.9.7903
    126 https://doi.org/10.1210/jcem.87.6.8521
    127 https://doi.org/10.1242/dev.092775
    128 https://doi.org/10.1515/jpem-2013-0369
    129 https://doi.org/10.1515/jpem.2006.19.11.1299
    130 https://doi.org/10.1530/edm-14-0074
    131 https://doi.org/10.1530/eje-11-0679
    132 https://doi.org/10.1530/eje-14-1113
    133 https://doi.org/10.1530/eje-15-0205
    134 https://doi.org/10.1530/eje-16-0262
    135 https://doi.org/10.1530/eje.0.1440029
    136 https://doi.org/10.1530/erc-14-0254
    137 https://doi.org/10.3389/fendo.2015.00113
    138 https://doi.org/10.7326/0003-4819-131-8-199910190-00006
    139 schema:datePublished 2018
    140 schema:datePublishedReg 2018-01-01
    141 schema:description The first detailed description of the human adrenal glands was by Eustachius (1520–1574); their presence was confirmed by Piccolomini (1562–1605) and Casserius (1552–1616) (Vrezas et al. 2000). Their function, however, was largely unknown until the late nineteenth century. In the last 30 years, our growing understanding of adrenocortical development and function has led to the discovery of numerous genetic disorders that affect the adrenal glands. Developmental pathways have also been linked to the formation of adrenocortical tumors (ACTs), which represent a heterogeneous group of lesions of the adrenal cortex. ACTs have been found to be due to or associated with somatic or germline mutations in key molecular pathways, including the cyclic AMP (cAMP) and Wnt signaling pathways. In this chapter, we review the various genetic causes of adrenocortical disorders and focus on congenital causes of adrenal insufficiency associated with hypoplasia of the adrenal glands, genetic causes of autoimmunity that affect the adrenal glands, and genetic causes of benign and malignant ACT.
    142 schema:editor N58a14bb69f494db983a83e231b16c3b8
    143 schema:genre chapter
    144 schema:inLanguage en
    145 schema:isAccessibleForFree false
    146 schema:isPartOf N5af7a1995f564d43a79902567d00878b
    147 schema:name Genetic Disorders of Adrenocortical Function
    148 schema:pagination 727-763
    149 schema:productId N4e81ee3984b3473a8f42e1d95fd4719f
    150 N75d634701cf5428196254a6d880b0cd0
    151 Nbb039b69e25b4772a0fa763ad5435ff0
    152 schema:publisher N8099c0443c964231b794f742532e3e33
    153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100655311
    154 https://doi.org/10.1007/978-3-319-44675-2_29
    155 schema:sdDatePublished 2019-04-15T15:04
    156 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    157 schema:sdPublisher N3887e7d9a787496cb70c4be5fa83b32b
    158 schema:url http://link.springer.com/10.1007/978-3-319-44675-2_29
    159 sgo:license sg:explorer/license/
    160 sgo:sdDataset chapters
    161 rdf:type schema:Chapter
    162 N1b001efb9fe841358be83b941a140d59 schema:name National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
    163 rdf:type schema:Organization
    164 N1e57dfefa8634579848b490d9c3e8e0b rdf:first sg:person.011151216517.08
    165 rdf:rest rdf:nil
    166 N27ef7a7fc6cb45be997d294d6cef0726 schema:familyName LeRoith
    167 schema:givenName Derek
    168 rdf:type schema:Person
    169 N3887e7d9a787496cb70c4be5fa83b32b schema:name Springer Nature - SN SciGraph project
    170 rdf:type schema:Organization
    171 N4e81ee3984b3473a8f42e1d95fd4719f schema:name readcube_id
    172 schema:value d447773c8b6158ab7b24f6dddb0def40968f141c1ec30f4e4e309d489084e9e1
    173 rdf:type schema:PropertyValue
    174 N58a14bb69f494db983a83e231b16c3b8 rdf:first N774952f41f4e47fe875884c5c75e1e87
    175 rdf:rest N9f0fa2482860435c8885f7a3ed2c20b0
    176 N5af7a1995f564d43a79902567d00878b schema:isbn 978-3-319-44674-5
    177 978-3-319-44675-2
    178 schema:name Principles of Endocrinology and Hormone Action
    179 rdf:type schema:Book
    180 N75d634701cf5428196254a6d880b0cd0 schema:name dimensions_id
    181 schema:value pub.1100655311
    182 rdf:type schema:PropertyValue
    183 N774952f41f4e47fe875884c5c75e1e87 schema:familyName Belfiore
    184 schema:givenName Antonino
    185 rdf:type schema:Person
    186 N7946799976fc414e9fa1d13e713e739d rdf:first sg:person.01315132137.22
    187 rdf:rest N1e57dfefa8634579848b490d9c3e8e0b
    188 N8099c0443c964231b794f742532e3e33 schema:location Cham
    189 schema:name Springer International Publishing
    190 rdf:type schema:Organisation
    191 N9f0fa2482860435c8885f7a3ed2c20b0 rdf:first N27ef7a7fc6cb45be997d294d6cef0726
    192 rdf:rest rdf:nil
    193 Nb8f486b3b3f54f40ba3408f30ea3e733 schema:name National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
    194 rdf:type schema:Organization
    195 Nbb039b69e25b4772a0fa763ad5435ff0 schema:name doi
    196 schema:value 10.1007/978-3-319-44675-2_29
    197 rdf:type schema:PropertyValue
    198 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    199 schema:name Biological Sciences
    200 rdf:type schema:DefinedTerm
    201 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    202 schema:name Genetics
    203 rdf:type schema:DefinedTerm
    204 sg:person.011151216517.08 schema:affiliation N1b001efb9fe841358be83b941a140d59
    205 schema:familyName Stratakis
    206 schema:givenName Constantine A.
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011151216517.08
    208 rdf:type schema:Person
    209 sg:person.01315132137.22 schema:affiliation Nb8f486b3b3f54f40ba3408f30ea3e733
    210 schema:familyName Hannah-Shmouni
    211 schema:givenName Fady
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315132137.22
    213 rdf:type schema:Person
    214 sg:pub.10.1007/bf02739963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040738659
    215 https://doi.org/10.1007/bf02739963
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1007/s00268-001-0047-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1019675765
    218 https://doi.org/10.1007/s00268-001-0047-y
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1007/s004390050573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023574549
    221 https://doi.org/10.1007/s004390050573
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1007/s40291-013-0020-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022921391
    224 https://doi.org/10.1007/s40291-013-0020-0
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/355262a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010671658
    227 https://doi.org/10.1038/355262a0
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/372635a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027354836
    230 https://doi.org/10.1038/372635a0
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/372672a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032815378
    233 https://doi.org/10.1038/372672a0
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/79238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034260511
    236 https://doi.org/10.1038/79238
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/9629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000913953
    239 https://doi.org/10.1038/9629
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/ejhg.2009.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013049070
    242 https://doi.org/10.1038/ejhg.2009.106
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/ejhg.2015.142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046340851
    245 https://doi.org/10.1038/ejhg.2015.142
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/ncpendmet0648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007479215
    248 https://doi.org/10.1038/ncpendmet0648
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/ng.2275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030682778
    251 https://doi.org/10.1038/ng.2275
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/ng.2550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003568915
    254 https://doi.org/10.1038/ng.2550
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/ng.2695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026843638
    257 https://doi.org/10.1038/ng.2695
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/ng.2956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034900688
    260 https://doi.org/10.1038/ng.2956
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/ng0797-303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004103506
    263 https://doi.org/10.1038/ng0797-303
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/ng1501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005050878
    266 https://doi.org/10.1038/ng1501
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nrendo.2016.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003679662
    269 https://doi.org/10.1038/nrendo.2016.24
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nrm3432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035463962
    272 https://doi.org/10.1038/nrm3432
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/sj.onc.1207277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044710813
    275 https://doi.org/10.1038/sj.onc.1207277
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1186/1471-2415-4-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037176723
    278 https://doi.org/10.1186/1471-2415-4-7
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1186/bcr3179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012055898
    281 https://doi.org/10.1186/bcr3179
    282 rdf:type schema:CreativeWork
    283 https://app.dimensions.ai/details/publication/pub.1076569044 schema:CreativeWork
    284 https://app.dimensions.ai/details/publication/pub.1077003893 schema:CreativeWork
    285 https://app.dimensions.ai/details/publication/pub.1080741171 schema:CreativeWork
    286 https://app.dimensions.ai/details/publication/pub.1081246957 schema:CreativeWork
    287 https://app.dimensions.ai/details/publication/pub.1082894735 schema:CreativeWork
    288 https://doi.org/10.1002/(sici)1098-1004(1999)13:1<69::aid-humu8>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000633589
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1002/ajmg.10235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044590457
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1002/ajmg.1320550419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030081828
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1002/ajmg.a.10917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015820687
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1002/ajmg.a.30729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014594528
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1002/ajmg.a.34271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052655277
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1002/ana.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030087812
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1002/cncr.28346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049958814
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1002/humu.20495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047721109
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1002/humu.21178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046632556
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1002/jmor.1051260408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010473411
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1002/mus.23770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017703167
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/j.ajhg.2007.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026553446
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.beem.2006.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042010993
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.beem.2008.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016237988
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/j.beem.2008.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012101148
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/j.lpm.2012.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032777379
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/j.mce.2006.12.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039078452
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/j.mce.2011.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029707919
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/j.mce.2013.10.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038359276
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1016/j.tem.2005.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023501444
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1016/j.tem.2006.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006764893
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/s0022-3476(67)80179-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044922010
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1016/s0022-3476(70)80472-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023627532
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1016/s0022-3476(99)70302-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049194107
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1016/s0092-8674(01)00282-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022046231
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1046/j.1365-2265.2000.01122.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015758824
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1046/j.1365-2265.2000.01144.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002104132
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1056/nejm197706302962609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050003114
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1056/nejm199112123252403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034803167
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1056/nejmc0706182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027709600
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1056/nejmc1309730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024612927
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1056/nejmoa1215245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013566359
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1056/nejmoa1304603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008978713
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1056/nejmoa1310359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026986035
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1073/pnas.161479898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030767494
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1073/pnas.91.7.2718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027160139
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1086/302575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058610144
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1097/cco.0b013e328333bf00 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005722703
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1097/med.0b013e3282fe7416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031658867
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1097/pas.0b013e31821ec4ce schema:sameAs https://app.dimensions.ai/details/publication/pub.1005284464
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1097/pas.0b013e31825d538b schema:sameAs https://app.dimensions.ai/details/publication/pub.1033261015
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1097/pas.0b013e318285f6a2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016630153
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1111/j.1365-2265.2004.02048.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045978457
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1111/j.1365-2265.2006.02709.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019477355
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1111/j.1365-2265.2009.03689.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012205529
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1111/j.1365-2265.2011.04220.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003100084
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1111/j.1399-0004.2005.00482.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039111025
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1111/j.1750-3639.2006.tb00561.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000796273
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1111/joim.12162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011779054
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1126/science.1198785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062462997
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1126/science.1249480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035118083
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1126/science.276.5311.404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556407
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1136/jmg.2005.036061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017666915
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1136/jmg.27.7.465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025598696
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1136/jmg.37.11.831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017352275
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1152/physrev.00030.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002225644
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1158/0008-5472.can-04-1847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008946764
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1158/1078-0432.ccr-10-1497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048468645
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1159/000070226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022995818
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1159/000134753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001959749
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1159/000134765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038577163
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1159/000342504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046360105
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1161/hypertensionaha.113.01733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000316244
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1172/jci116853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016468627
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1172/jci25091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051969443
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1210/er.2013-1053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286057
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1210/jc.2002-021362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286368
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1210/jc.2002-021845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286557
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1210/jc.2002-030014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286661
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1210/jc.2003-030502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286881
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1210/jc.2004-0016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064287625
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1210/jc.2004-2377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288217
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1210/jc.2005-2708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288997
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1210/jc.2006-0188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064289104
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1210/jc.2006-0603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064289217
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1210/jc.2008-0594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064290643
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1210/jc.2009-0516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064291318
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1210/jc.2009-2631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064291902
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1210/jc.2010-1704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292369
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1210/jc.2011-1565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045993048
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1210/jc.2011-1659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292967
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1210/jc.2011-1982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293030
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1210/jc.2011-3000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293255
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1210/jc.2012-1230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293439
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1210/jc.2012-2374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293705
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1210/jc.2013-4237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064294870
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1210/jc.2013-4280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064294881
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1210/jc.2014-4167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064295592
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1210/jc.2016-1700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011486330
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1210/jc.83.9.3214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064300402
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1210/jcem-24-10-947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064305620
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1210/jcem.86.11.8062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064324026
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1210/jcem.86.9.7903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064324785
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1210/jcem.87.6.8521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064325252
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1242/dev.092775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034408635
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1515/jpem-2013-0369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011127590
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1515/jpem.2006.19.11.1299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036932596
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1530/edm-14-0074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067716547
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1530/eje-11-0679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021624109
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1530/eje-14-1113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023722572
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1530/eje-15-0205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017148390
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1530/eje-16-0262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015727619
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1530/eje.0.1440029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003160614
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1530/erc-14-0254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004309336
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.3389/fendo.2015.00113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014913853
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.7326/0003-4819-131-8-199910190-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073703639
    501 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...