Genetics of Benign Adrenocortical Tumors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Fady Hannah-Shmouni , Constantine A. Stratakis

ABSTRACT

Benign adrenocortical tumors (ACT) represent a heterogeneous group of lesions. Cortisol-producing lesions are due mostly to defects of the cyclic AMP (cAMP) signaling pathway, whereas the majority of aldosterone-producing lesions are the result of mutations in KCNJ5. Bilateral adrenal hyperplasias were recently linked to ARMC5 defects; the ARMC5 protein has an unknown function. Finally, benign ACTs are found in the context of a number of other conditions from multiple endocrine neoplasia type 1 (MEN-1) to Carney triad and others. In this chapter, we review all newly identified genetic associations and diseases associated with ACTs. More... »

PAGES

31-53

Book

TITLE

Management of Adrenal Masses in Children and Adults

ISBN

978-3-319-44134-4
978-3-319-44136-8

From Grant

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-44136-8_3

DOI

http://dx.doi.org/10.1007/978-3-319-44136-8_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013058197


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