Physiopathology and Fate of End-Stage CHF in the Era of MCS View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017-07-15

AUTHORS

Vito Piazza , A. Montalto , C. Amarelli , A. Loforte , Francesco Musumeci

ABSTRACT

Heart failure is a clinical syndrome with different etiologies and quite variable presentation. The acute onset can be due to exacerbation of signs and symptoms of known HF (acute decompensated heart failure) or to the sudden appearance of HF in a patient with previous normal cardiac function (new-onset or de novo HF), as it happens after myocardial infarction or myocarditis. In chronic HF symptoms of ventricular dysfunction occur in a time span of weeks or months, generally caused by long-lasting ischemic heart disease, dilated cardiomyopathies, and hypertensive and valvular disease. With the advent of echocardiography, HF has been classified into two major subclasses: (1) heart failure with reduced ejection fraction (HFrEF), also called systolic heart failure, and (2) heart failure with preserved ejection fraction (HFpEF), also known as diastolic heart failure. The prevalence of heart failure increases rapidly with age. The Framingham Heart Study showed a prevalence of 8/1000 and up to 66/100 in 50–59 and 80–89 aged men, respectively [1]. In women, the prevalence of cardiac insufficiency was 8/1000 for the age group of 50–59 years and 7/1000 for age between 80 and 89 years. The incidence has similar trends, doubling for each subsequent decade of life. There are several reasons for this increase: the aging of the population, the improved efficacy of treatment of acute coronary syndromes with prolonged life span expectancy, and the significant increase of diabetes and obesity. As consequence the hospitalizations are progressively raising, due not only to the occurrence of worsening symptoms but also to comorbidities such as renal failure, electrolyte abnormalities, and multiorgan dysfunction. Risk factors for heart failure are age, sex, hypertension, diabetes, obesity, coronary artery disease, insulin resistance, genetic factors, and use of cardiotoxic drugs. In the SOLVD registry, 70% of patients suffering from heart failure had coronary heart disease and 7% hypertensive disease [2]. More... »

PAGES

13-23

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-43383-7_2

DOI

http://dx.doi.org/10.1007/978-3-319-43383-7_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090680142


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