Natriuretic Peptides: Physiology for the Clinician View Full Text


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Chapter Info

DATE

2016-10-25

AUTHORS

Siu-Hin Wan , Horng H. Chen

ABSTRACT

Natriuretic peptides (NPs) are a family of hormones that have significant cardiorenal properties. As an important component of blood pressure homeostasis in humans, NPs are potent vasodilatory hormones that mediate diuresis, natriuresis and cardiac remodeling (Levin et al., N Engl J Med 339(5):321–328, 1998). Neurohormonal signaling plays an essential role in cardiovascular disease. Whereas antagonism of the renin-angiotensin-aldosterone pathway, a mediator of pro-vascocontriction, leads to improved outcomes in heart failure, the potentiation of the NPs leads to vasodilation and improved cardiac remodeling. Therefore, NPs have been investigated both as a biomarker for cardiovascular disease as well as a potential treatment agent. More... »

PAGES

161-172

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-42982-3_13

DOI

http://dx.doi.org/10.1007/978-3-319-42982-3_13

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027845563


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