The Biology of Head and Neck Cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Kevin J. Harrington

ABSTRACT

Cancer is a genetic disease that arises when the information in cellular DNA is corrupted, leading to abnormal patterns of gene expression. As a result, the effects of normal genes that control normal cellular functions, such as growth, survival and invasion/motility, are enhanced and those of genes that act to suppress these effects are repressed. The main mechanism of genetic alteration is through the accumulation of mutations, but it is increasingly clear that non-mutational (epigenetic) changes that affect patterns of gene transcription play a key role in the process. In addition to effects that occur in cancer cells, there is a growing understanding of the influence of changes in the so-called tumour microenvironment (TME) on the biological behaviour of cancers. More... »

PAGES

51-66

References to SciGraph publications

  • 2005-01. Biological significance of c-erbB family oncogenes in head and neck cancer in CANCER AND METASTASIS REVIEWS
  • 2013-09. ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression in ONCOGENE
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  • 2012-04. A phase II study of cell cycle inhibitor UCN-01 in patients with metastatic melanoma: a California Cancer Consortium trial in INVESTIGATIONAL NEW DRUGS
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  • 2015-10. Bridging the gap between in vitro and in vivo: Dose and schedule predictions for the ATR inhibitor AZD6738 in SCIENTIFIC REPORTS
  • 2013-09. Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2006-03. Gefitinib (ZD1839, Iressa™) as palliative treatment in recurrent or metastatic head and neck cancer in BRITISH JOURNAL OF CANCER
  • 2011-07. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR in NATURE CHEMICAL BIOLOGY
  • 2012-07. Targeting radiation-resistant hypoxic tumour cells through ATR inhibition in BRITISH JOURNAL OF CANCER
  • Book

    TITLE

    Critical Issues in Head and Neck Oncology

    ISBN

    978-3-319-42907-6
    978-3-319-42909-0

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-42909-0_3

    DOI

    http://dx.doi.org/10.1007/978-3-319-42909-0_3

    DIMENSIONS

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