PET and SPECT View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Clemens Decristoforo , Uwe Haberkorn , Roland Haubner , Walter Mier , Sibylle I. Ziegler

ABSTRACT

PET and SPECT Tracers for Molecular Imaging Molecular imaging combines noninvasive imaging methods with tools of molecular and cellular biology. Traditional imaging approaches in nuclear medicine were solely based on the detection of anatomical and structural features. Complementary to these conventional methods, advances in biology made it possible to visualize cellular and biochemical processes. Until the event of PET imaging, the spectrum of nuclides used for tracers was largely restricted to iodine isotopes and 99 m-technetium. Today several PET nuclides have largely extended the range of different tracers. Today a broad range of SPECT and PET tracers are available to visualize differentiated uptake in diseased organs/tissues in contrast to healthy tissue. The most commonly targeted cellular differences include transport, enzyme activity, receptor expression, metabolism, and hypoxia. This article provides a comprehensive description of a selection of the most commonly used tracers with respect to their mode of action, structure, molecular target, and clinical application. Radiotracer During the last decade, radiolabeled peptides have become an important class of radiopharmaceuticals in nuclear medicine. This chapter will give an overview of the different steps involved in the development of such tracer. This starts with a brief summary of techniques used for lead structure finding, followed by a discussion of strategies for tracer optimization and labeling approaches. The second part of this chapter will focus on the in vitro and in vivo evaluation of radiolabeled peptides. Whereas the first part is more of a review of different techniques and strategies, which should give nonspecialists an insight in the chemical development process, the second part is more of a practical guideline which should help with planning appropriate protocols for the evaluation of peptide-based radiotracer. More... »

PAGES

361-402

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  • Book

    TITLE

    Small Animal Imaging

    ISBN

    978-3-319-42200-8
    978-3-319-42202-2

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-42202-2_15

    DOI

    http://dx.doi.org/10.1007/978-3-319-42202-2_15

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085564507


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