GC-Rich DNA Fragments and Oxidized Cell-Free DNA Have Different Effects on NF-kB and NRF2 Signaling in MSC View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Vasilina A. Sergeeva , Svetlana V. Kostyuk , Elizaveta S. Ershova , Elena M. Malinovskaya , Tatiana D. Smirnova , Larisa V. Kameneva , Natalia N. Veiko

ABSTRACT

It has been established that cell-free DNA circulating in the bloodstream affects cells. The characteristics of cfDNA depend on the physiological state of the organism. As we showed previously, diseases can cause either GC-enrichment of the cell-free DNA pool or its oxidation. Thus, in cases of cerebral atherosclerosis, heart attack and rheumatic arthritis the cell-free DNA pool is GC-enriched and, in the case of cancer, both GC-enriched and oxidized. Herein we investigated the time-dependent effect of oxidized and GC-rich cell-free DNA on NF-kB and NRF2 signaling pathways in human mesenchymal stem cells and showed that they affect cells in different ways. Oxidized DNA drastically increases expression of NRF2 in a short period of time, but the effect does not last long. GC-rich DNA causes a prolonged increase in mRNA levels of NF-kB and NRF2 which lasts 48 and 24 h, respectively. More... »

PAGES

109-112

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-42044-8_21

DOI

http://dx.doi.org/10.1007/978-3-319-42044-8_21

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048727576

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27753029


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