Proliferation Markers in Breast Cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Frederique Penault-Llorca , Nina Radosevic-Robin

ABSTRACT

Breast cancer proliferation can be measured by several approaches (mitotic count, S-phase fraction assessment, evaluation of cell cycle-related protein expression, molecular tests). It is used to predict outcome, by discriminating luminal A from luminal B breast cancer, and consequently to guide the choice of chemotherapy in hormone receptor-positive, HER2-negative breast cancer. Proliferation reflects tumor aggressiveness and gives valuable information for the identification of patients at risk of early relapses and thus potentially candidates for chemotherapy. Dynamic evaluation of proliferation allows identification of the patients resistant to neoadjuvant endocrine treatment and, at a lesser degree, to neoadjuvant chemotherapy. Evaluation of proliferation does not bring any added value to the management of HER2-positive, triple negative or metastatic breast cancer. More... »

PAGES

81-98

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  • Book

    TITLE

    Molecular Pathology of Breast Cancer

    ISBN

    978-3-319-41759-2
    978-3-319-41761-5

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-41761-5_7

    DOI

    http://dx.doi.org/10.1007/978-3-319-41761-5_7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1087289661


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