Host Defense Peptides and Their Advancements in Translational Staphylococcus aureus Research View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Sarah C. Mansour , Robert E.W. Hancock , Michael Otto

ABSTRACT

Staphylococcus aureus is responsible for a multitude of infections ranging from skin and soft tissue infections to more severe invasive diseases. In response to S. aureus, host defense peptides (HDPs) are produced as nature’s own sentinel effector molecules. HDPs are small, often cationic, molecules that possess numerous biological activities, such as antimicrobial activity, cellular recruitment, anti-inflammatory properties, and wound healing, all of which play a role in controlling S. aureus infections. In hopes of capitalizing on the powerful anti-infective functions of HDPs, there has been a considerable amount of interest in deriving HDP-based therapeutics. Here, we highlight current advancements in HDP research, constraints to commercial development, and solutions for safer and more feasible HDP-based therapies against S. aureus. More... »

PAGES

301-321

References to SciGraph publications

Book

TITLE

Host Defense Peptides and Their Potential as Therapeutic Agents

ISBN

978-3-319-32947-5
978-3-319-32949-9

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-32949-9_12

DOI

http://dx.doi.org/10.1007/978-3-319-32949-9_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021313834


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