Pediatric Radiotherapy: Surgical Considerations, Sequelae, and Future Directions View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Ryan P. Lee , John T. Lucas , Christopher L. Tinkle , Thomas E. Merchant , Frederick A. Boop

ABSTRACT

Radiation therapy is a critical component in the treatment of children with central nervous system tumors. As the use of this modality continues to increase in complexity and sophistication, it is imperative for the neurosurgeon to understand the additional challenges that the use of radiotherapy may pose in both surgical and nonsurgical management. Operating after radiation to the surgical site may increase infection rate, decrease probability of wound healing, increase rate of intraoperative complications, distort typical anatomy, and alter operative approach. Radiation therapy can also result in many long-term sequelae, including radiation necrosis, vasculopathy, neurocognitive deficits, and secondary malignancies, many of which may require additional workup and surgical intervention. Such risks must be understood by all members of the team when developing management strategies in these patients, and a multidisciplinary approach is vital. This chapter discusses these topics and also reviews future directions for radiation therapy, including technologic advances, image guidance, and large-scale informatics efforts. Also promising is the role of next-generation sequencing in better understanding nuances in tumor biology and thus radiation sensitivity. Advanced sequencing efforts may also help predict susceptibility to sequelae of radiotherapy in individual patients. More... »

PAGES

1-14

Book

TITLE

Textbook of Pediatric Neurosurgery

ISBN

978-3-319-31512-6
978-3-319-31512-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-31512-6_152-1

DOI

http://dx.doi.org/10.1007/978-3-319-31512-6_152-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090776506


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