Anti-angiogenic Targeting in Metastatic Colorectal Cancer Therapy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Thomas Zander , Valentin Goede , Michael Hallek

ABSTRACT

Angiogenesis has been identified as a hallmark of cancer. Thus, anti-angiogenic targeting has been evaluated in cancer. Colorectal cancer is one of the entities where this therapeutic principal has been most successfully introduced into the daily care of patients. Today, several anti-angiogenic drugs are approved in all lines of metastasized colorectal cancer (mCRC). In adjuvant settings, anti-angiogenic treatment did not show any benefit. In summary, still overall the benefit from anti-angiogenic treatment is modest and the identification of specific patient subgroups benefiting from this treatment is missing. Several new drugs are in development to further improve the treatment of patients with mCRC. In addition, large efforts were made to identify predictive biomarker, but so far, none of these has entered the clinical routine. Here we present the current status of anti-angiogenic drugs in mCRC and the new drugs in development for this clinical entity. More... »

PAGES

1-16

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  • Book

    TITLE

    Tumor Angiogenesis

    ISBN

    978-3-319-31215-6
    978-3-319-31215-6

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-31215-6_16-1

    DOI

    http://dx.doi.org/10.1007/978-3-319-31215-6_16-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085139239


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