Immunopathogenesis of Psoriasis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Paola Di Meglio , Frank O. Nestle

ABSTRACT

Psoriasis is a common, complex, inflammatory skin disease resulting from the interplay of genetic, environmental and immunological factors. In the last four decades, advances in understanding psoriasis etiopathogenesis have resulted from pivotal genetics studies, as well as, the integration of clinical and experimental models of disease. This has resulted in the identification of several psoriasis susceptibility genes as well as cellular and molecular mediators, with some of these findings already translated in novel targeted therapies. Here we review the psoriasis literature, describing the elucidation of key pathogenic mechanisms and their translation into effective drugs. Moreover, we describe how the stratified medicine approaches being developed in psoriasis and the quest for psoriasis biomarkers are poised to predict individual susceptibility to disease, detect the onset of disease at the very earliest stages pre-empting its progression, and to develop and prescribe safe and effective medicines to each patient. More... »

PAGES

373-395

References to SciGraph publications

Book

TITLE

Clinical and Basic Immunodermatology

ISBN

978-3-319-29783-5
978-3-319-29785-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-29785-9_21

DOI

http://dx.doi.org/10.1007/978-3-319-29785-9_21

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085053777


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