Basic Principles of rTMS in Aphasia Treatment After Stroke View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Wolf-Dieter Heiss , Alexander Thiel

ABSTRACT

Aphasia, the most disabling functional defect after ischemic stroke, affects more than a third of all stroke victims. It improves during the first 4 weeks in one-third of patients and during the first 6 months in approximately half of them. Early and intensive speech and language therapy (SLT) is the only effective treatment to date but usually is limited in duration and intensity. Therefore, improved and additional treatment strategies are required to improve recovery of language functions. Poststroke aphasia results from the lesion of cortical areas involved in the motor production of speech (Broca’s aphasia) or in the semantic aspects of language comprehension (Wernicke’s aphasia). Such lesions induce an important reorganization of speech/language-specific brain networks due to an imbalance between cortical facilitation and inhibition. In fact, functional recovery is associated with changes in the excitability of the damaged neural structures and their connections. Two main mechanisms are involved in poststroke recovery: the recruitment of perilesional regions of the left hemisphere in case of small lesions and the acquisition of language processing ability in homotopic areas of the nondominant right hemisphere when left hemispheric language abilities are severely impaired. The purpose of NIBS application in the neurorehabilitation of aphasic patients is to act on specific networks involved in the pathophysiology of language processing and to promote adaptative cortical reorganization after stroke. The rehabilitation of poststroke aphasia refers to two different strategies: the recruitment of perilesional cortical regions in the dominant (left) hemisphere on one hand and the development of language ability in the nondominant (right) hemisphere on the other hand using either rTMS or tDCS. The compensatory potential of the nondominant hemisphere is probably limited, and the recovery from poststroke aphasia seems to be more effective in patients who recover left hemisphere networks and left IFG function. Therefore, the majority of NIBS trials in poststroke aphasia aimed to reinforce the activity of brain regions in the left hemisphere. This goal can be achieved by using an excitatory NIBS protocol (either high frequency rTMS, intermittent TBS (iTBS) or anodal tDCS) to reactivate the lesioned area or an inhibitory NIBS protocol (either low-frequency rTMS or cathodal tDCS) to reduce activities in the contralesional homologous area. Most conventional rTMS studies employed an inhibitory paradigm (low-frequency stimulation) for the stimulation of the contralesional right IFG (pars triangularis, BA 45) aiming to reduce right hemisphere hyperactivity and transcallosal inhibition exerted on the left Broca’s area. In our controlled proof-of-principle study, 30 patients with subacute poststroke aphasia were randomized to a 10-day protocol of 20 min inhibitory 1 Hz rTMS over the right triangular part of the posterior inferior frontal gyrus (pIFG) or sham stimulation followed by 45 min of speech and language therapy (SLT). Activity in language networks was measured with O-15-water positron emission tomography during verb generation before and after treatment. Language performance was assessed using the Aachen Aphasia Test battery (AAT). The results of this study indicate that inhibitory 1Hz rTMS over the right pIFG in combination with SLT improves recovery from poststroke aphasia and favors recruitment of left hemisphere language networks. More... »

PAGES

73-85

Book

TITLE

Therapeutic rTMS in Neurology

ISBN

978-3-319-25719-8
978-3-319-25721-1

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-25721-1_6

DOI

http://dx.doi.org/10.1007/978-3-319-25721-1_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006291813


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Max Planck Institute for Neurological Research"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heiss", 
        "givenName": "Wolf-Dieter", 
        "id": "sg:person.014142346732.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014142346732.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University", 
          "id": "https://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Department of Neurology and Neurosurgery, McGill University"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thiel", 
        "givenName": "Alexander", 
        "id": "sg:person.01072654045.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072654045.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00415-010-5868-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001607073", 
          "https://doi.org/10.1007/s00415-010-5868-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000174487.81126.ef", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005355664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000174487.81126.ef", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005355664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000323217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007282915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11065-011-9181-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008225689", 
          "https://doi.org/10.1007/s11065-011-9181-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008545423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008545423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000338773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009146060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/ern.12.76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009854821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-0082(01)00027-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010413223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnhum.2013.00888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010828637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011430707", 
          "https://doi.org/10.1038/nn868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011430707", 
          "https://doi.org/10.1038/nn868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.109.576785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012791877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.109.576785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012791877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1545968314521009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013308414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1545968314521009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013308414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(03)00321-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014611582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1977.tb10649.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016554520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1531-8249(199904)45:4<430::aid-ana3>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017097631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000047571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018308984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.24.12.1784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020808826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/123.12.2512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024980552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.44.1.127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025521561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000118376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026215527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bandl.2011.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027309893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.66.2.155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027805608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainresbull.2013.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028438004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awl090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029120744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02687038.2011.616925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029136073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1044/jslhr.4101.172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030232456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.apmr.2011.04.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030465975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/ern.12.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031727077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.21393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032943753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-200012000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032987070", 
          "https://doi.org/10.1097/00004647-200012000-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-200012000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032987070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bandl.2011.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034306194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.111.000574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035345567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.111.000574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035345567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(03)00485-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036256247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(03)00485-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036256247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000355499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036464842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.30.11.2331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042635747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-198012000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045215062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-198012000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045215062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11910-009-0067-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048913885", 
          "https://doi.org/10.1007/s11910-009-0067-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11910-009-0067-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048913885", 
          "https://doi.org/10.1007/s11910-009-0067-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410380416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051443574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/016164102101200320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051888830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.56.6.665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052692642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bandl.2011.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052814483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000221815.64093.8c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053468773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000221815.64093.8c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053468773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/16501960310010115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058409551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000238468.84401.d4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000238468.84401.d4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000238468.84401.d4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1310/tsr1505-427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064988876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1310/tsr2003-250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064989165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077423031", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077854249", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/rnn-2010-0559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078202065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/nre-2011-0640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078374282"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016", 
    "datePublishedReg": "2016-01-01", 
    "description": "Aphasia, the most disabling functional defect after ischemic stroke, affects more than a third of all stroke victims. It improves during the first 4 weeks in one-third of patients and during the first 6 months in approximately half of them. Early and intensive speech and language therapy (SLT) is the only effective treatment to date but usually is limited in duration and intensity. Therefore, improved and additional treatment strategies are required to improve recovery of language functions. Poststroke aphasia results from the lesion of cortical areas involved in the motor production of speech (Broca\u2019s aphasia) or in the semantic aspects of language comprehension (Wernicke\u2019s aphasia). Such lesions induce an important reorganization of speech/language-specific brain networks due to an imbalance between cortical facilitation and inhibition. In fact, functional recovery is associated with changes in the excitability of the damaged neural structures and their connections. Two main mechanisms are involved in poststroke recovery: the recruitment of perilesional regions of the left hemisphere in case of small lesions and the acquisition of language processing ability in homotopic areas of the nondominant right hemisphere when left hemispheric language abilities are severely impaired. The purpose of NIBS application in the neurorehabilitation of aphasic patients is to act on specific networks involved in the pathophysiology of language processing and to promote adaptative cortical reorganization after stroke. The rehabilitation of poststroke aphasia refers to two different strategies: the recruitment of perilesional cortical regions in the dominant (left) hemisphere on one hand and the development of language ability in the nondominant (right) hemisphere on the other hand using either rTMS or tDCS. The compensatory potential of the nondominant hemisphere is probably limited, and the recovery from poststroke aphasia seems to be more effective in patients who recover left hemisphere networks and left IFG function. Therefore, the majority of NIBS trials in poststroke aphasia aimed to reinforce the activity of brain regions in the left hemisphere. This goal can be achieved by using an excitatory NIBS protocol (either high frequency rTMS, intermittent TBS (iTBS) or anodal tDCS) to reactivate the lesioned area or an inhibitory NIBS protocol (either low-frequency rTMS or cathodal tDCS) to reduce activities in the contralesional homologous area. Most conventional rTMS studies employed an inhibitory paradigm (low-frequency stimulation) for the stimulation of the contralesional right IFG (pars triangularis, BA 45) aiming to reduce right hemisphere hyperactivity and transcallosal inhibition exerted on the left Broca\u2019s area. In our controlled proof-of-principle study, 30 patients with subacute poststroke aphasia were randomized to a 10-day protocol of 20 min inhibitory 1 Hz rTMS over the right triangular part of the posterior inferior frontal gyrus (pIFG) or sham stimulation followed by 45 min of speech and language therapy (SLT). Activity in language networks was measured with O-15-water positron emission tomography during verb generation before and after treatment. Language performance was assessed using the Aachen Aphasia Test battery (AAT). The results of this study indicate that inhibitory 1Hz rTMS over the right pIFG in combination with SLT improves recovery from poststroke aphasia and favors recruitment of left hemisphere language networks.", 
    "editor": [
      {
        "familyName": "Platz", 
        "givenName": "Thomas", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-319-25721-1_6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-319-25719-8", 
        "978-3-319-25721-1"
      ], 
      "name": "Therapeutic rTMS in Neurology", 
      "type": "Book"
    }, 
    "name": "Basic Principles of rTMS in Aphasia Treatment After Stroke", 
    "pagination": "73-85", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-319-25721-1_6"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1df84807fb02e6e78740e4354eef12bf4a84be8c44ae75a4dc3aef99cac56924"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006291813"
        ]
      }
    ], 
    "publisher": {
      "location": "Cham", 
      "name": "Springer International Publishing", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-319-25721-1_6", 
      "https://app.dimensions.ai/details/publication/pub.1006291813"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T20:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000247.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-3-319-25721-1_6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-25721-1_6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-25721-1_6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-25721-1_6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-25721-1_6'


 

This table displays all metadata directly associated to this object as RDF triples.

230 TRIPLES      23 PREDICATES      78 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-319-25721-1_6 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N34488598ef264c58906504c962df5f62
4 schema:citation sg:pub.10.1007/s00415-010-5868-x
5 sg:pub.10.1007/s11065-011-9181-y
6 sg:pub.10.1007/s11910-009-0067-9
7 sg:pub.10.1038/nn868
8 sg:pub.10.1097/00004647-200012000-00001
9 https://app.dimensions.ai/details/publication/pub.1077423031
10 https://app.dimensions.ai/details/publication/pub.1077854249
11 https://doi.org/10.1002/1531-8249(199904)45:4<430::aid-ana3>3.0.co;2-p
12 https://doi.org/10.1002/ana.21393
13 https://doi.org/10.1002/ana.410380416
14 https://doi.org/10.1016/j.apmr.2011.04.026
15 https://doi.org/10.1016/j.bandl.2011.02.005
16 https://doi.org/10.1016/j.bandl.2011.05.002
17 https://doi.org/10.1016/j.bandl.2011.07.005
18 https://doi.org/10.1016/j.brainresbull.2013.07.005
19 https://doi.org/10.1016/s0301-0082(01)00027-2
20 https://doi.org/10.1016/s1474-4422(03)00321-1
21 https://doi.org/10.1016/s1474-4422(03)00485-x
22 https://doi.org/10.1038/sj.jcbfm.9600350
23 https://doi.org/10.1044/jslhr.4101.172
24 https://doi.org/10.1080/02687038.2011.616925
25 https://doi.org/10.1080/16501960310010115
26 https://doi.org/10.1093/brain/123.12.2512
27 https://doi.org/10.1093/brain/awl090
28 https://doi.org/10.1097/00004647-200012000-00001
29 https://doi.org/10.1097/00004728-198012000-00001
30 https://doi.org/10.1111/j.1471-4159.1977.tb10649.x
31 https://doi.org/10.1136/jnnp.56.6.665
32 https://doi.org/10.1136/jnnp.66.2.155
33 https://doi.org/10.1159/000047571
34 https://doi.org/10.1159/000118376
35 https://doi.org/10.1159/000323217
36 https://doi.org/10.1159/000338773
37 https://doi.org/10.1159/000355499
38 https://doi.org/10.1161/01.res.44.1.127
39 https://doi.org/10.1161/01.str.0000174487.81126.ef
40 https://doi.org/10.1161/01.str.0000221815.64093.8c
41 https://doi.org/10.1161/01.str.24.12.1784
42 https://doi.org/10.1161/01.str.30.11.2331
43 https://doi.org/10.1161/strokeaha.109.576785
44 https://doi.org/10.1161/strokeaha.111.000574
45 https://doi.org/10.1177/1545968314521009
46 https://doi.org/10.1179/016164102101200320
47 https://doi.org/10.1212/01.wnl.0000238468.84401.d4
48 https://doi.org/10.1310/tsr1505-427
49 https://doi.org/10.1310/tsr2003-250
50 https://doi.org/10.1586/ern.12.76
51 https://doi.org/10.1586/ern.12.78
52 https://doi.org/10.3233/nre-2011-0640
53 https://doi.org/10.3233/rnn-2010-0559
54 https://doi.org/10.3389/fnhum.2013.00888
55 schema:datePublished 2016
56 schema:datePublishedReg 2016-01-01
57 schema:description Aphasia, the most disabling functional defect after ischemic stroke, affects more than a third of all stroke victims. It improves during the first 4 weeks in one-third of patients and during the first 6 months in approximately half of them. Early and intensive speech and language therapy (SLT) is the only effective treatment to date but usually is limited in duration and intensity. Therefore, improved and additional treatment strategies are required to improve recovery of language functions. Poststroke aphasia results from the lesion of cortical areas involved in the motor production of speech (Broca’s aphasia) or in the semantic aspects of language comprehension (Wernicke’s aphasia). Such lesions induce an important reorganization of speech/language-specific brain networks due to an imbalance between cortical facilitation and inhibition. In fact, functional recovery is associated with changes in the excitability of the damaged neural structures and their connections. Two main mechanisms are involved in poststroke recovery: the recruitment of perilesional regions of the left hemisphere in case of small lesions and the acquisition of language processing ability in homotopic areas of the nondominant right hemisphere when left hemispheric language abilities are severely impaired. The purpose of NIBS application in the neurorehabilitation of aphasic patients is to act on specific networks involved in the pathophysiology of language processing and to promote adaptative cortical reorganization after stroke. The rehabilitation of poststroke aphasia refers to two different strategies: the recruitment of perilesional cortical regions in the dominant (left) hemisphere on one hand and the development of language ability in the nondominant (right) hemisphere on the other hand using either rTMS or tDCS. The compensatory potential of the nondominant hemisphere is probably limited, and the recovery from poststroke aphasia seems to be more effective in patients who recover left hemisphere networks and left IFG function. Therefore, the majority of NIBS trials in poststroke aphasia aimed to reinforce the activity of brain regions in the left hemisphere. This goal can be achieved by using an excitatory NIBS protocol (either high frequency rTMS, intermittent TBS (iTBS) or anodal tDCS) to reactivate the lesioned area or an inhibitory NIBS protocol (either low-frequency rTMS or cathodal tDCS) to reduce activities in the contralesional homologous area. Most conventional rTMS studies employed an inhibitory paradigm (low-frequency stimulation) for the stimulation of the contralesional right IFG (pars triangularis, BA 45) aiming to reduce right hemisphere hyperactivity and transcallosal inhibition exerted on the left Broca’s area. In our controlled proof-of-principle study, 30 patients with subacute poststroke aphasia were randomized to a 10-day protocol of 20 min inhibitory 1 Hz rTMS over the right triangular part of the posterior inferior frontal gyrus (pIFG) or sham stimulation followed by 45 min of speech and language therapy (SLT). Activity in language networks was measured with O-15-water positron emission tomography during verb generation before and after treatment. Language performance was assessed using the Aachen Aphasia Test battery (AAT). The results of this study indicate that inhibitory 1Hz rTMS over the right pIFG in combination with SLT improves recovery from poststroke aphasia and favors recruitment of left hemisphere language networks.
58 schema:editor N083ac2e92032480d95e6e23552192a78
59 schema:genre chapter
60 schema:inLanguage en
61 schema:isAccessibleForFree false
62 schema:isPartOf Nb4c20bde86344f17b8dde0723c431edd
63 schema:name Basic Principles of rTMS in Aphasia Treatment After Stroke
64 schema:pagination 73-85
65 schema:productId N2545c303328746d09a4c545ef90112aa
66 N29d8a02170a142d58910701f2dd258b4
67 Nf7e150c4f5c24f9489011af67cd38aea
68 schema:publisher Nd3abf68aad0c4e5bbbb0ddd328de3bb5
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006291813
70 https://doi.org/10.1007/978-3-319-25721-1_6
71 schema:sdDatePublished 2019-04-15T20:59
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N1ca4eba0d7bf45b6bdf2a85373ca7aa8
74 schema:url http://link.springer.com/10.1007/978-3-319-25721-1_6
75 sgo:license sg:explorer/license/
76 sgo:sdDataset chapters
77 rdf:type schema:Chapter
78 N083ac2e92032480d95e6e23552192a78 rdf:first Nf7e11739516c4d1b9c09e3cadbad185a
79 rdf:rest rdf:nil
80 N11486a62571a44febabec336a82f7349 rdf:first sg:person.01072654045.62
81 rdf:rest rdf:nil
82 N1ca4eba0d7bf45b6bdf2a85373ca7aa8 schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N2545c303328746d09a4c545ef90112aa schema:name readcube_id
85 schema:value 1df84807fb02e6e78740e4354eef12bf4a84be8c44ae75a4dc3aef99cac56924
86 rdf:type schema:PropertyValue
87 N29d8a02170a142d58910701f2dd258b4 schema:name dimensions_id
88 schema:value pub.1006291813
89 rdf:type schema:PropertyValue
90 N34488598ef264c58906504c962df5f62 rdf:first sg:person.014142346732.64
91 rdf:rest N11486a62571a44febabec336a82f7349
92 N3d93d46ffaf24378914db980dd6949fb schema:name Max Planck Institute for Neurological Research
93 rdf:type schema:Organization
94 Nb4c20bde86344f17b8dde0723c431edd schema:isbn 978-3-319-25719-8
95 978-3-319-25721-1
96 schema:name Therapeutic rTMS in Neurology
97 rdf:type schema:Book
98 Nd3abf68aad0c4e5bbbb0ddd328de3bb5 schema:location Cham
99 schema:name Springer International Publishing
100 rdf:type schema:Organisation
101 Nf7e11739516c4d1b9c09e3cadbad185a schema:familyName Platz
102 schema:givenName Thomas
103 rdf:type schema:Person
104 Nf7e150c4f5c24f9489011af67cd38aea schema:name doi
105 schema:value 10.1007/978-3-319-25721-1_6
106 rdf:type schema:PropertyValue
107 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
108 schema:name Medical and Health Sciences
109 rdf:type schema:DefinedTerm
110 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
111 schema:name Clinical Sciences
112 rdf:type schema:DefinedTerm
113 sg:person.01072654045.62 schema:affiliation https://www.grid.ac/institutes/grid.14709.3b
114 schema:familyName Thiel
115 schema:givenName Alexander
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072654045.62
117 rdf:type schema:Person
118 sg:person.014142346732.64 schema:affiliation N3d93d46ffaf24378914db980dd6949fb
119 schema:familyName Heiss
120 schema:givenName Wolf-Dieter
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014142346732.64
122 rdf:type schema:Person
123 sg:pub.10.1007/s00415-010-5868-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001607073
124 https://doi.org/10.1007/s00415-010-5868-x
125 rdf:type schema:CreativeWork
126 sg:pub.10.1007/s11065-011-9181-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225689
127 https://doi.org/10.1007/s11065-011-9181-y
128 rdf:type schema:CreativeWork
129 sg:pub.10.1007/s11910-009-0067-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048913885
130 https://doi.org/10.1007/s11910-009-0067-9
131 rdf:type schema:CreativeWork
132 sg:pub.10.1038/nn868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011430707
133 https://doi.org/10.1038/nn868
134 rdf:type schema:CreativeWork
135 sg:pub.10.1097/00004647-200012000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032987070
136 https://doi.org/10.1097/00004647-200012000-00001
137 rdf:type schema:CreativeWork
138 https://app.dimensions.ai/details/publication/pub.1077423031 schema:CreativeWork
139 https://app.dimensions.ai/details/publication/pub.1077854249 schema:CreativeWork
140 https://doi.org/10.1002/1531-8249(199904)45:4<430::aid-ana3>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1017097631
141 rdf:type schema:CreativeWork
142 https://doi.org/10.1002/ana.21393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032943753
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1002/ana.410380416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051443574
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1016/j.apmr.2011.04.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030465975
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1016/j.bandl.2011.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034306194
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/j.bandl.2011.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027309893
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/j.bandl.2011.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052814483
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1016/j.brainresbull.2013.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028438004
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/s0301-0082(01)00027-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010413223
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/s1474-4422(03)00321-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014611582
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/s1474-4422(03)00485-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036256247
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1038/sj.jcbfm.9600350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008545423
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1044/jslhr.4101.172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030232456
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1080/02687038.2011.616925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029136073
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1080/16501960310010115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058409551
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1093/brain/123.12.2512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024980552
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1093/brain/awl090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029120744
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1097/00004647-200012000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032987070
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1097/00004728-198012000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045215062
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1111/j.1471-4159.1977.tb10649.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016554520
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1136/jnnp.56.6.665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052692642
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1136/jnnp.66.2.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027805608
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1159/000047571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018308984
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1159/000118376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026215527
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1159/000323217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007282915
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1159/000338773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009146060
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1159/000355499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036464842
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1161/01.res.44.1.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025521561
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1161/01.str.0000174487.81126.ef schema:sameAs https://app.dimensions.ai/details/publication/pub.1005355664
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1161/01.str.0000221815.64093.8c schema:sameAs https://app.dimensions.ai/details/publication/pub.1053468773
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1161/01.str.24.12.1784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020808826
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1161/01.str.30.11.2331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042635747
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1161/strokeaha.109.576785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012791877
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1161/strokeaha.111.000574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035345567
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1177/1545968314521009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013308414
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1179/016164102101200320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051888830
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1212/01.wnl.0000238468.84401.d4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064348553
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1310/tsr1505-427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064988876
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1310/tsr2003-250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064989165
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1586/ern.12.76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009854821
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1586/ern.12.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031727077
221 rdf:type schema:CreativeWork
222 https://doi.org/10.3233/nre-2011-0640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078374282
223 rdf:type schema:CreativeWork
224 https://doi.org/10.3233/rnn-2010-0559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078202065
225 rdf:type schema:CreativeWork
226 https://doi.org/10.3389/fnhum.2013.00888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010828637
227 rdf:type schema:CreativeWork
228 https://www.grid.ac/institutes/grid.14709.3b schema:alternateName McGill University
229 schema:name Department of Neurology and Neurosurgery, McGill University
230 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...