The Astrocytic Na+, K+-ATPase: Stimulation by Increased Extracellular K+, β-Adrenergic Activation, Ouabain-Mediated Signaling, and Interaction with the Transporter NKCC1 View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Leif Hertz , Dan Song , Liang Peng

ABSTRACT

The astrocytic Na+,K+-ATPase is important because increasing evidence indicates that increased extracellular K+ in brain following neuronal excitation initially is accumulated into astrocytes. This is due to higher Na+,K+-ATPase activity in astrocytes than in neurons and because the extracellular K+-sensitive site of the astrocytic Na+,K+-ATPase, in contrast to that of the neuronal enzyme, has low enough affinity for K+ to be further activated by increased K+ concentrations. However, K+ must eventually be re-accumulated into neurons in order to prevent neuronal K+ depletion. Accumulated astrocytic K+ is released through Kir4.1 channels, but a presently unsolved problem is how renewed astrocytic uptake is prevented. Experiments in well-differentiated cultured astrocytes providing a solution of this problem are discussed. At the same time subunit composition of the astrocytic Na+,K+-ATPase and its influence on the enzyme’s kinetic parameters is reviewed together with stimulation of the enzyme by noradrenaline and its functional importance. So are details of Na+,K+-ATPase signaling in response to submicromolar concentrations of ouabain and/or low mM K+ concentrations without which the catalytic activity of the astrocytic enzyme is abolished. Two pathophysiological conditions are discussed, cerebral ischemia/reperfusion and hepatic encephalopathy. In the former ouabain signaling dependence on extracellular Ca2+ is crucial and provides therapeutic possibilities. In the latter the ability of NH4 + to mimic K+ in both catalytic and signaling effects of the Na+,K+-ATPase is essential. In both conditions it is important that operation of the Na+, K+, Cl− and water cotransporter NKCC1 is dependent upon ion gradients created by the Na+,K+-ATPase. More... »

PAGES

195-221

References to SciGraph publications

  • 1982-04. Stimulus-induced changes in extracellular Na+ and Cl− concentration in relation to changes in the size of the extracellular space in EXPERIMENTAL BRAIN RESEARCH
  • 2013-03. Requirement of Glycogenolysis for Uptake of Increased Extracellular K+ in Astrocytes: Potential Implications for K+ Homeostasis and Glycogen Usage in Brain in NEUROCHEMICAL RESEARCH
  • 2012-11. Extracellular K+ and Astrocyte Signaling via Connexin and Pannexin Channels in NEUROCHEMICAL RESEARCH
  • 2014-04. Basic Mechanism Leading to Stimulation of Glycogenolysis by Isoproterenol, EGF, Elevated Extracellular K+ Concentrations, or GABA in NEUROCHEMICAL RESEARCH
  • 2015-02. Why are Astrocytes Important? in NEUROCHEMICAL RESEARCH
  • 2016. Glucose, Lactate, β-Hydroxybutyrate, Acetate, GABA, and Succinate as Substrates for Synthesis of Glutamate and GABA in the Glutamine–Glutamate/GABA Cycle in THE GLUTAMATE/GABA-GLUTAMINE CYCLE
  • 2015-12. Role of the Astrocytic Na+, K+-ATPase in K+ Homeostasis in Brain: K+ Uptake, Signaling Pathways and Substrate Utilization in NEUROCHEMICAL RESEARCH
  • 2012-11. Glial K+ Clearance and Cell Swelling: Key Roles for Cotransporters and Pumps in NEUROCHEMICAL RESEARCH
  • 2015-02. Ammonia, Like K+, Stimulates the Na+, K+, 2 Cl− Cotransporter NKCC1 and the Na+,K+-ATPase and Interacts with Endogenous Ouabain in Astrocytes in NEUROCHEMICAL RESEARCH
  • 2004-08. The Identification of the Sodium Pump in BIOSCIENCE REPORTS
  • 2008-10. Computer simulations of neuron-glia interactions mediated by ion flux in JOURNAL OF COMPUTATIONAL NEUROSCIENCE
  • 2001-10. The Functional Role of β Subunits in Oligomeric P-Type ATPases in JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
  • 2013-04. Cell-Specific mRNA Alterations in Na+, K+-ATPase α and β Isoforms and FXYD in Mice Treated Chronically with Carbamazepine, an Anti-Bipolar Drug in NEUROCHEMICAL RESEARCH
  • 1988-07. Brain ion homeostasis in cerebral ischemia in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2013-12. Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering in NATURE MEDICINE
  • Book

    TITLE

    Regulation of Membrane Na+-K+ ATPase

    ISBN

    978-3-319-24748-9
    978-3-319-24750-2

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-24750-2_12

    DOI

    http://dx.doi.org/10.1007/978-3-319-24750-2_12

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013024543


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Laboratory of Brain Metabolic Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hertz", 
            "givenName": "Leif", 
            "id": "sg:person.01055536710.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055536710.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Laboratory of Brain Metabolic Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Song", 
            "givenName": "Dan", 
            "id": "sg:person.01205436051.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205436051.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Laboratory of Brain Metabolic Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peng", 
            "givenName": "Liang", 
            "id": "sg:person.01027240611.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027240611.51"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1074/jbc.m112.370734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000538330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.275.3.1976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000548701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-012-0938-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001544717", 
              "https://doi.org/10.1007/s11064-012-0938-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-014-1352-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002323841", 
              "https://doi.org/10.1007/s11064-014-1352-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m002951200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002592688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m804016200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003083540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2012.248336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003168393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2012.248336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003168393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fncom.2013.00114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003641668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jhep.2013.10.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003901320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jhep.2013.10.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003901320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mrm.10187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005657124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3305-11.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005806125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-3002(57)90343-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005969205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-3002(57)90343-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005969205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuint.2007.05.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006186009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.108.119974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006769734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.108.119974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006769734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.108.119974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006769734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(85)90930-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007430137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0169-328x(94)90264-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007664237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0169-328x(94)90264-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007664237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jhep.2010.06.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007716361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(72)90399-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007809409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(72)90399-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007809409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1469-7793.2000.00427.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007966692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpregu.00782.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007997979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/873590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008213052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(75)90943-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008928980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(75)90943-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008928980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abbi.1994.1136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009010811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2010.194738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010033430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0098469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011001134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(95)01042-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011516346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10827-008-0083-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011517642", 
              "https://doi.org/10.1007/s10827-008-0083-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10827-008-0083-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011517642", 
              "https://doi.org/10.1007/s10827-008-0083-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/ane.0b013e3181cdb06b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012186064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/ane.0b013e3181cdb06b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012186064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2007.04878.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013799140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2009.181826", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013816936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10540-005-2740-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016344770", 
              "https://doi.org/10.1007/s10540-005-2740-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10540-005-2740-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016344770", 
              "https://doi.org/10.1007/s10540-005-2740-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1010623724749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017390691", 
              "https://doi.org/10.1023/a:1010623724749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0301-0082(00)00067-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018189315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(74)90353-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019286539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(74)90353-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019286539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-012-0731-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020245046", 
              "https://doi.org/10.1007/s11064-012-0731-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.23469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020380711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-014-1403-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020529738", 
              "https://doi.org/10.1007/s11064-014-1403-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/01.ane.0000228859.95126.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022939359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/01.ane.0000228859.95126.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022939359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bja/aes134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023453885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.1972.sp009771", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023472190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2011.226316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024664041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00238100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027491550", 
              "https://doi.org/10.1007/bf00238100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00238100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027491550", 
              "https://doi.org/10.1007/bf00238100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.22297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028224568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.22297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028224568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.76.9.4661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028643678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.27282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028669594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuint.2010.04.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029123110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.110.2.201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029412032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.23499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030012770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2736(89)90044-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030052065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2736(89)90044-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030052065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.247767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031200939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1717-08.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032209909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fendo.2013.00165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032690098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.22629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032816638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2009.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033145651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-0186(99)00117-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033155160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4178-07.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035235220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneumeth.2010.10.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035480814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-0186(80)90038-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036748040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-0186(80)90038-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036748040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2010.06995.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036975099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2010.06995.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036975099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2002334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037691403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.440020104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039055136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj0850093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039154297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj0850093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039154297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2010.04.079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039486720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-014-1244-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039590011", 
              "https://doi.org/10.1007/s11064-014-1244-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.22299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040315538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/ane.0b013e3181d278f7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040381988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/ane.0b013e3181d278f7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040381988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/ane.0b013e3181d278f7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040381988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2007.04.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041443854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1139/y92-271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042340662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fendo.2013.00176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042738606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2012.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042774772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043632558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-012-0759-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044346525", 
              "https://doi.org/10.1007/s11064-012-0759-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-013-0986-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044516006", 
              "https://doi.org/10.1007/s11064-013-0986-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.16.7394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045573224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2011.05.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045862756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-0186(95)00081-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046053567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0306-4522(01)00247-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046938900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047005795", 
              "https://doi.org/10.1038/nm.3400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-4886(82)90231-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048963643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1472-8206.2008.00620.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049097845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-201x.2002.00984.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049373230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-014-1505-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049987953", 
              "https://doi.org/10.1007/s11064-014-1505-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fendo.2013.00102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050670348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-3623(79)90087-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050889365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-3623(79)90087-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050889365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuint.2013.09.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051103983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0908-08.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053517717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdf330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053606972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1740925x10000013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054941799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1740925x10000013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054941799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1570159x12666140828222115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069195958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1570159x12666140828222723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069195959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/1694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070913978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/jn.2000.83.3.1443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074603580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/jn.00240.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074977557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076517366", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.11-02-00381.1991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077647001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078485628", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078941502", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-319-45096-4_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079359544", 
              "https://doi.org/10.1007/978-3-319-45096-4_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03160362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079637563", 
              "https://doi.org/10.1007/bf03160362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.08-06-01922.1988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079716429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.jbchem.a130256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080295124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.1972.52.3.563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080437432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/jn.1980.44.4.617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082350247"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016", 
        "datePublishedReg": "2016-01-01", 
        "description": "The astrocytic Na+,K+-ATPase is important because increasing evidence indicates that increased extracellular K+ in brain following neuronal excitation initially is accumulated into astrocytes. This is due to higher Na+,K+-ATPase activity in astrocytes than in neurons and because the extracellular K+-sensitive site of the astrocytic Na+,K+-ATPase, in contrast to that of the neuronal enzyme, has low enough affinity for K+ to be further activated by increased K+ concentrations. However, K+ must eventually be re-accumulated into neurons in order to prevent neuronal K+ depletion. Accumulated astrocytic K+ is released through Kir4.1 channels, but a presently unsolved problem is how renewed astrocytic uptake is prevented. Experiments in well-differentiated cultured astrocytes providing a solution of this problem are discussed. At the same time subunit composition of the astrocytic Na+,K+-ATPase and its influence on the enzyme\u2019s kinetic parameters is reviewed together with stimulation of the enzyme by noradrenaline and its functional importance. So are details of Na+,K+-ATPase signaling in response to submicromolar concentrations of ouabain and/or low mM K+ concentrations without which the catalytic activity of the astrocytic enzyme is abolished. Two pathophysiological conditions are discussed, cerebral ischemia/reperfusion and hepatic encephalopathy. In the former ouabain signaling dependence on extracellular Ca2+ is crucial and provides therapeutic possibilities. In the latter the ability of NH4 + to mimic K+ in both catalytic and signaling effects of the Na+,K+-ATPase is essential. In both conditions it is important that operation of the Na+, K+, Cl\u2212 and water cotransporter NKCC1 is dependent upon ion gradients created by the Na+,K+-ATPase.", 
        "editor": [
          {
            "familyName": "Chakraborti", 
            "givenName": "Sajal", 
            "type": "Person"
          }, 
          {
            "familyName": "Dhalla", 
            "givenName": "Naranjan S", 
            "type": "Person"
          }
        ], 
        "genre": "chapter", 
        "id": "sg:pub.10.1007/978-3-319-24750-2_12", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": {
          "isbn": [
            "978-3-319-24748-9", 
            "978-3-319-24750-2"
          ], 
          "name": "Regulation of Membrane Na+-K+ ATPase", 
          "type": "Book"
        }, 
        "name": "The Astrocytic Na+, K+-ATPase: Stimulation by Increased Extracellular K+, \u03b2-Adrenergic Activation, Ouabain-Mediated Signaling, and Interaction with the Transporter NKCC1", 
        "pagination": "195-221", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/978-3-319-24750-2_12"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3e0c4bc4eed7b156eb65a3e3c9c4d2ad7ce69030b2c44bc98b36b47e89c36967"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1013024543"
            ]
          }
        ], 
        "publisher": {
          "location": "Cham", 
          "name": "Springer International Publishing", 
          "type": "Organisation"
        }, 
        "sameAs": [
          "https://doi.org/10.1007/978-3-319-24750-2_12", 
          "https://app.dimensions.ai/details/publication/pub.1013024543"
        ], 
        "sdDataset": "chapters", 
        "sdDatePublished": "2019-04-15T21:06", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000285.jsonl", 
        "type": "Chapter", 
        "url": "http://link.springer.com/10.1007/978-3-319-24750-2_12"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-24750-2_12'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-24750-2_12'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-24750-2_12'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-24750-2_12'


     

    This table displays all metadata directly associated to this object as RDF triples.

    408 TRIPLES      23 PREDICATES      130 URIs      20 LITERALS      8 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/978-3-319-24750-2_12 schema:about anzsrc-for:11
    2 anzsrc-for:1109
    3 schema:author N70629e53338848dbb5bd53a34f4a30c4
    4 schema:citation sg:pub.10.1007/978-3-319-45096-4_2
    5 sg:pub.10.1007/bf00238100
    6 sg:pub.10.1007/bf03160362
    7 sg:pub.10.1007/s10540-005-2740-9
    8 sg:pub.10.1007/s10827-008-0083-9
    9 sg:pub.10.1007/s11064-012-0731-3
    10 sg:pub.10.1007/s11064-012-0759-4
    11 sg:pub.10.1007/s11064-012-0938-3
    12 sg:pub.10.1007/s11064-013-0986-3
    13 sg:pub.10.1007/s11064-014-1244-z
    14 sg:pub.10.1007/s11064-014-1352-9
    15 sg:pub.10.1007/s11064-014-1403-2
    16 sg:pub.10.1007/s11064-014-1505-x
    17 sg:pub.10.1023/a:1010623724749
    18 sg:pub.10.1038/nm.3400
    19 https://app.dimensions.ai/details/publication/pub.1076517366
    20 https://app.dimensions.ai/details/publication/pub.1078485628
    21 https://app.dimensions.ai/details/publication/pub.1078941502
    22 https://doi.org/10.1002/glia.20817
    23 https://doi.org/10.1002/glia.22299
    24 https://doi.org/10.1002/glia.22629
    25 https://doi.org/10.1002/glia.440020104
    26 https://doi.org/10.1002/hep.27282
    27 https://doi.org/10.1002/jnr.22297
    28 https://doi.org/10.1002/jnr.23469
    29 https://doi.org/10.1002/jnr.23499
    30 https://doi.org/10.1002/mrm.10187
    31 https://doi.org/10.1006/abbi.1994.1136
    32 https://doi.org/10.1016/0005-2736(89)90044-8
    33 https://doi.org/10.1016/0006-2952(74)90353-0
    34 https://doi.org/10.1016/0006-3002(57)90343-8
    35 https://doi.org/10.1016/0006-8993(72)90399-x
    36 https://doi.org/10.1016/0006-8993(75)90943-9
    37 https://doi.org/10.1016/0006-8993(85)90930-8
    38 https://doi.org/10.1016/0006-8993(95)01042-0
    39 https://doi.org/10.1016/0014-4886(82)90231-x
    40 https://doi.org/10.1016/0169-328x(94)90264-x
    41 https://doi.org/10.1016/0197-0186(80)90038-8
    42 https://doi.org/10.1016/0197-0186(95)00081-x
    43 https://doi.org/10.1016/0306-3623(79)90087-9
    44 https://doi.org/10.1016/j.brainres.2010.04.079
    45 https://doi.org/10.1016/j.jhep.2010.06.041
    46 https://doi.org/10.1016/j.jhep.2013.10.012
    47 https://doi.org/10.1016/j.jneumeth.2010.10.004
    48 https://doi.org/10.1016/j.nbd.2012.12.007
    49 https://doi.org/10.1016/j.neuint.2007.05.008
    50 https://doi.org/10.1016/j.neuint.2010.04.014
    51 https://doi.org/10.1016/j.neuint.2013.09.005
    52 https://doi.org/10.1016/j.neuron.2009.03.003
    53 https://doi.org/10.1016/j.neuroscience.2007.04.001
    54 https://doi.org/10.1016/j.neuroscience.2011.05.006
    55 https://doi.org/10.1016/s0197-0186(99)00117-5
    56 https://doi.org/10.1016/s0301-0082(00)00067-8
    57 https://doi.org/10.1016/s0306-4522(01)00247-0
    58 https://doi.org/10.1017/s1740925x10000013
    59 https://doi.org/10.1042/bj0850093
    60 https://doi.org/10.1046/j.1365-201x.2002.00984.x
    61 https://doi.org/10.1073/pnas.76.9.4661
    62 https://doi.org/10.1073/pnas.89.16.7394
    63 https://doi.org/10.1074/jbc.275.3.1976
    64 https://doi.org/10.1074/jbc.m002951200
    65 https://doi.org/10.1074/jbc.m111.247767
    66 https://doi.org/10.1074/jbc.m112.370734
    67 https://doi.org/10.1074/jbc.m804016200
    68 https://doi.org/10.1085/jgp.110.2.201
    69 https://doi.org/10.1093/bja/aes134
    70 https://doi.org/10.1093/emboj/cdf330
    71 https://doi.org/10.1093/oxfordjournals.jbchem.a130256
    72 https://doi.org/10.1111/j.1469-7793.2000.00427.x
    73 https://doi.org/10.1111/j.1471-4159.2007.04878.x
    74 https://doi.org/10.1111/j.1471-4159.2010.06995.x
    75 https://doi.org/10.1111/j.1472-8206.2008.00620.x
    76 https://doi.org/10.1113/jphysiol.1972.sp009771
    77 https://doi.org/10.1113/jphysiol.2009.181826
    78 https://doi.org/10.1113/jphysiol.2010.194738
    79 https://doi.org/10.1113/jphysiol.2011.226316
    80 https://doi.org/10.1113/jphysiol.2012.248336
    81 https://doi.org/10.1126/scisignal.2002334
    82 https://doi.org/10.1139/y92-271
    83 https://doi.org/10.1152/ajpregu.00782.2005
    84 https://doi.org/10.1152/jn.00240.2001
    85 https://doi.org/10.1152/jn.1980.44.4.617
    86 https://doi.org/10.1152/jn.2000.83.3.1443
    87 https://doi.org/10.1152/physrev.1972.52.3.563
    88 https://doi.org/10.1155/2014/873590
    89 https://doi.org/10.1161/hypertensionaha.108.119974
    90 https://doi.org/10.1213/01.ane.0000228859.95126.69
    91 https://doi.org/10.1213/ane.0b013e3181cdb06b
    92 https://doi.org/10.1213/ane.0b013e3181d278f7
    93 https://doi.org/10.1371/journal.pone.0098469
    94 https://doi.org/10.1523/jneurosci.08-06-01922.1988
    95 https://doi.org/10.1523/jneurosci.0908-08.2008
    96 https://doi.org/10.1523/jneurosci.11-02-00381.1991
    97 https://doi.org/10.1523/jneurosci.1717-08.2008
    98 https://doi.org/10.1523/jneurosci.3305-11.2011
    99 https://doi.org/10.1523/jneurosci.4178-07.2008
    100 https://doi.org/10.2174/1570159x12666140828222115
    101 https://doi.org/10.2174/1570159x12666140828222723
    102 https://doi.org/10.2741/1694
    103 https://doi.org/10.3389/fendo.2013.00102
    104 https://doi.org/10.3389/fendo.2013.00165
    105 https://doi.org/10.3389/fendo.2013.00176
    106 https://doi.org/10.3389/fncom.2013.00114
    107 schema:datePublished 2016
    108 schema:datePublishedReg 2016-01-01
    109 schema:description The astrocytic Na+,K+-ATPase is important because increasing evidence indicates that increased extracellular K+ in brain following neuronal excitation initially is accumulated into astrocytes. This is due to higher Na+,K+-ATPase activity in astrocytes than in neurons and because the extracellular K+-sensitive site of the astrocytic Na+,K+-ATPase, in contrast to that of the neuronal enzyme, has low enough affinity for K+ to be further activated by increased K+ concentrations. However, K+ must eventually be re-accumulated into neurons in order to prevent neuronal K+ depletion. Accumulated astrocytic K+ is released through Kir4.1 channels, but a presently unsolved problem is how renewed astrocytic uptake is prevented. Experiments in well-differentiated cultured astrocytes providing a solution of this problem are discussed. At the same time subunit composition of the astrocytic Na+,K+-ATPase and its influence on the enzyme’s kinetic parameters is reviewed together with stimulation of the enzyme by noradrenaline and its functional importance. So are details of Na+,K+-ATPase signaling in response to submicromolar concentrations of ouabain and/or low mM K+ concentrations without which the catalytic activity of the astrocytic enzyme is abolished. Two pathophysiological conditions are discussed, cerebral ischemia/reperfusion and hepatic encephalopathy. In the former ouabain signaling dependence on extracellular Ca2+ is crucial and provides therapeutic possibilities. In the latter the ability of NH4 + to mimic K+ in both catalytic and signaling effects of the Na+,K+-ATPase is essential. In both conditions it is important that operation of the Na+, K+, Cl− and water cotransporter NKCC1 is dependent upon ion gradients created by the Na+,K+-ATPase.
    110 schema:editor N87d0d0b91f8a453e897c7bcf9c64a19c
    111 schema:genre chapter
    112 schema:inLanguage en
    113 schema:isAccessibleForFree false
    114 schema:isPartOf N0edc124b14a545b083a0e12831d9bd05
    115 schema:name The Astrocytic Na+, K+-ATPase: Stimulation by Increased Extracellular K+, β-Adrenergic Activation, Ouabain-Mediated Signaling, and Interaction with the Transporter NKCC1
    116 schema:pagination 195-221
    117 schema:productId N7b194d426f484e6b8594f177c19a2996
    118 N95b4b470398b4267973fcb7441a6933c
    119 Nf025a881d12746e1ab715cfecbb996e0
    120 schema:publisher Nb837f8da0e624291810d0f666a2caba9
    121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013024543
    122 https://doi.org/10.1007/978-3-319-24750-2_12
    123 schema:sdDatePublished 2019-04-15T21:06
    124 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    125 schema:sdPublisher Neb48d514aef14733aeb389eec2b86011
    126 schema:url http://link.springer.com/10.1007/978-3-319-24750-2_12
    127 sgo:license sg:explorer/license/
    128 sgo:sdDataset chapters
    129 rdf:type schema:Chapter
    130 N05e8934a4e1341129a2d30f943e43653 rdf:first N11eed013705449f7bb1081c5176e9e5a
    131 rdf:rest rdf:nil
    132 N0edc124b14a545b083a0e12831d9bd05 schema:isbn 978-3-319-24748-9
    133 978-3-319-24750-2
    134 schema:name Regulation of Membrane Na+-K+ ATPase
    135 rdf:type schema:Book
    136 N11eed013705449f7bb1081c5176e9e5a schema:familyName Dhalla
    137 schema:givenName Naranjan S
    138 rdf:type schema:Person
    139 N18799555e76049be87ac9c2d265126fb schema:name Laboratory of Brain Metabolic Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University
    140 rdf:type schema:Organization
    141 N3b365927a6d84b539890dd219b7a267e schema:name Laboratory of Brain Metabolic Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University
    142 rdf:type schema:Organization
    143 N431aa5d28a6f4bddb447c3d657e15ffe schema:familyName Chakraborti
    144 schema:givenName Sajal
    145 rdf:type schema:Person
    146 N46adff20fd7242e28323a31a5f772e63 schema:name Laboratory of Brain Metabolic Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University
    147 rdf:type schema:Organization
    148 N53336bc2c957452a91574a1c6b418b5a rdf:first sg:person.01205436051.58
    149 rdf:rest Ncb8b48f9dc3c4cef88aca65fe38dd698
    150 N70629e53338848dbb5bd53a34f4a30c4 rdf:first sg:person.01055536710.81
    151 rdf:rest N53336bc2c957452a91574a1c6b418b5a
    152 N7b194d426f484e6b8594f177c19a2996 schema:name readcube_id
    153 schema:value 3e0c4bc4eed7b156eb65a3e3c9c4d2ad7ce69030b2c44bc98b36b47e89c36967
    154 rdf:type schema:PropertyValue
    155 N87d0d0b91f8a453e897c7bcf9c64a19c rdf:first N431aa5d28a6f4bddb447c3d657e15ffe
    156 rdf:rest N05e8934a4e1341129a2d30f943e43653
    157 N95b4b470398b4267973fcb7441a6933c schema:name doi
    158 schema:value 10.1007/978-3-319-24750-2_12
    159 rdf:type schema:PropertyValue
    160 Nb837f8da0e624291810d0f666a2caba9 schema:location Cham
    161 schema:name Springer International Publishing
    162 rdf:type schema:Organisation
    163 Ncb8b48f9dc3c4cef88aca65fe38dd698 rdf:first sg:person.01027240611.51
    164 rdf:rest rdf:nil
    165 Neb48d514aef14733aeb389eec2b86011 schema:name Springer Nature - SN SciGraph project
    166 rdf:type schema:Organization
    167 Nf025a881d12746e1ab715cfecbb996e0 schema:name dimensions_id
    168 schema:value pub.1013024543
    169 rdf:type schema:PropertyValue
    170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Medical and Health Sciences
    172 rdf:type schema:DefinedTerm
    173 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Neurosciences
    175 rdf:type schema:DefinedTerm
    176 sg:person.01027240611.51 schema:affiliation N3b365927a6d84b539890dd219b7a267e
    177 schema:familyName Peng
    178 schema:givenName Liang
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027240611.51
    180 rdf:type schema:Person
    181 sg:person.01055536710.81 schema:affiliation N18799555e76049be87ac9c2d265126fb
    182 schema:familyName Hertz
    183 schema:givenName Leif
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055536710.81
    185 rdf:type schema:Person
    186 sg:person.01205436051.58 schema:affiliation N46adff20fd7242e28323a31a5f772e63
    187 schema:familyName Song
    188 schema:givenName Dan
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205436051.58
    190 rdf:type schema:Person
    191 sg:pub.10.1007/978-3-319-45096-4_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079359544
    192 https://doi.org/10.1007/978-3-319-45096-4_2
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1007/bf00238100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027491550
    195 https://doi.org/10.1007/bf00238100
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1007/bf03160362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079637563
    198 https://doi.org/10.1007/bf03160362
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1007/s10540-005-2740-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016344770
    201 https://doi.org/10.1007/s10540-005-2740-9
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1007/s10827-008-0083-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011517642
    204 https://doi.org/10.1007/s10827-008-0083-9
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1007/s11064-012-0731-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020245046
    207 https://doi.org/10.1007/s11064-012-0731-3
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1007/s11064-012-0759-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044346525
    210 https://doi.org/10.1007/s11064-012-0759-4
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/s11064-012-0938-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001544717
    213 https://doi.org/10.1007/s11064-012-0938-3
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/s11064-013-0986-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044516006
    216 https://doi.org/10.1007/s11064-013-0986-3
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/s11064-014-1244-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1039590011
    219 https://doi.org/10.1007/s11064-014-1244-z
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s11064-014-1352-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002323841
    222 https://doi.org/10.1007/s11064-014-1352-9
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s11064-014-1403-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020529738
    225 https://doi.org/10.1007/s11064-014-1403-2
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s11064-014-1505-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049987953
    228 https://doi.org/10.1007/s11064-014-1505-x
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1023/a:1010623724749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017390691
    231 https://doi.org/10.1023/a:1010623724749
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nm.3400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047005795
    234 https://doi.org/10.1038/nm.3400
    235 rdf:type schema:CreativeWork
    236 https://app.dimensions.ai/details/publication/pub.1076517366 schema:CreativeWork
    237 https://app.dimensions.ai/details/publication/pub.1078485628 schema:CreativeWork
    238 https://app.dimensions.ai/details/publication/pub.1078941502 schema:CreativeWork
    239 https://doi.org/10.1002/glia.20817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043632558
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1002/glia.22299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040315538
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1002/glia.22629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032816638
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1002/glia.440020104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039055136
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1002/hep.27282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028669594
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1002/jnr.22297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028224568
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1002/jnr.23469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020380711
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1002/jnr.23499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030012770
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1002/mrm.10187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005657124
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1006/abbi.1994.1136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009010811
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/0005-2736(89)90044-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030052065
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/0006-2952(74)90353-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019286539
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/0006-3002(57)90343-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005969205
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/0006-8993(72)90399-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007809409
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/0006-8993(75)90943-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008928980
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/0006-8993(85)90930-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007430137
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/0006-8993(95)01042-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011516346
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/0014-4886(82)90231-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048963643
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/0169-328x(94)90264-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007664237
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/0197-0186(80)90038-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036748040
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/0197-0186(95)00081-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046053567
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/0306-3623(79)90087-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050889365
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.brainres.2010.04.079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039486720
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.jhep.2010.06.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007716361
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.jhep.2013.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003901320
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.jneumeth.2010.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035480814
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.nbd.2012.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042774772
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.neuint.2007.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006186009
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.neuint.2010.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029123110
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.neuint.2013.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051103983
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.neuron.2009.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033145651
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.neuroscience.2007.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041443854
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.neuroscience.2011.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045862756
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s0197-0186(99)00117-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033155160
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/s0301-0082(00)00067-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018189315
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/s0306-4522(01)00247-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046938900
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1017/s1740925x10000013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054941799
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1042/bj0850093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039154297
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1046/j.1365-201x.2002.00984.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049373230
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1073/pnas.76.9.4661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028643678
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1073/pnas.89.16.7394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045573224
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1074/jbc.275.3.1976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000548701
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1074/jbc.m002951200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002592688
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1074/jbc.m111.247767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031200939
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1074/jbc.m112.370734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000538330
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1074/jbc.m804016200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003083540
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1085/jgp.110.2.201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029412032
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1093/bja/aes134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023453885
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1093/emboj/cdf330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053606972
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1093/oxfordjournals.jbchem.a130256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080295124
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1111/j.1469-7793.2000.00427.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007966692
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1111/j.1471-4159.2007.04878.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013799140
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1111/j.1471-4159.2010.06995.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036975099
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1111/j.1472-8206.2008.00620.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049097845
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1113/jphysiol.1972.sp009771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023472190
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1113/jphysiol.2009.181826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013816936
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1113/jphysiol.2010.194738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010033430
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1113/jphysiol.2011.226316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024664041
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1113/jphysiol.2012.248336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003168393
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1126/scisignal.2002334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037691403
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1139/y92-271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042340662
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1152/ajpregu.00782.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007997979
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1152/jn.00240.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074977557
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1152/jn.1980.44.4.617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082350247
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1152/jn.2000.83.3.1443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074603580
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1152/physrev.1972.52.3.563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080437432
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1155/2014/873590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008213052
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1161/hypertensionaha.108.119974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006769734
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1213/01.ane.0000228859.95126.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022939359
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1213/ane.0b013e3181cdb06b schema:sameAs https://app.dimensions.ai/details/publication/pub.1012186064
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1213/ane.0b013e3181d278f7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040381988
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1371/journal.pone.0098469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011001134
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1523/jneurosci.08-06-01922.1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079716429
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1523/jneurosci.0908-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053517717
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1523/jneurosci.11-02-00381.1991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077647001
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1523/jneurosci.1717-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032209909
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1523/jneurosci.3305-11.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005806125
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1523/jneurosci.4178-07.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035235220
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.2174/1570159x12666140828222115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069195958
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.2174/1570159x12666140828222723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069195959
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.2741/1694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070913978
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.3389/fendo.2013.00102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050670348
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.3389/fendo.2013.00165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032690098
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.3389/fendo.2013.00176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042738606
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.3389/fncom.2013.00114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003641668
    408 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...