Novel Treatments in Development for Melanoma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Chantale Bernatchez , Zachary A. Cooper , Jennifer A. Wargo , Patrick Hwu , Gregory Lizée

ABSTRACT

The past several years can be considered a renaissance era in the treatment of metastatic melanoma. Following a 30-year stretch in which oncologists barely put a dent in a very grim overall survival (OS) rate for these patients, things have rapidly changed course with the recent approval of three new melanoma drugs by the FDA. Both oncogene-targeted therapy and immune checkpoint blockade approaches have shown remarkable efficacy in a subset of melanoma patients and have clearly been game-changers in terms of clinical impact. However, most patients still succumb to their disease, and thus, there remains an urgent need to improve upon current therapies. Fortunately, innovations in molecular medicine have led to many silent gains that have greatly increased our understanding of the nature of cancer biology as well as the complex interactions between tumors and the immune system. They have also allowed for the first time a detailed understanding of an individual patient's cancer at the genomic and proteomic level. This information is now starting to be employed at all stages of cancer treatment, including diagnosis, choice of drug therapy, treatment monitoring, and analysis of resistance mechanisms upon recurrence. This new era of personalized medicine will foreseeably lead to paradigm shifts in immunotherapeutic treatment approaches such as individualized cancer vaccines and adoptive transfer of genetically modified T cells. Advances in xenograft technology will also allow for the testing of drug combinations using in vivo models, a truly necessary development as the number of new drugs needing to be tested is predicted to skyrocket in the coming years. This chapter will provide an overview of recent technological developments in cancer research, and how they are expected to impact future diagnosis, monitoring, and development of novel treatments for metastatic melanoma. More... »

PAGES

371-416

References to SciGraph publications

  • 2013-09. Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2013-12. Mining the mutanome: developing highly personalized Immunotherapies based on mutational analysis of tumors in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2004-03. The Tübingen approach: identification, selection, and validation of tumor-associated HLA peptides for cancer therapy in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2004-10. Toll-like receptor control of the adaptive immune responses in NATURE IMMUNOLOGY
  • 2007-09. Taking dendritic cells into medicine in NATURE
  • 2002-06. Mutations of the BRAF gene in human cancer in NATURE
  • 2002-11. Natural selection of tumor variants in the generation of “tumor escape” phenotypes in NATURE IMMUNOLOGY
  • 2008-08. Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis in NATURE
  • 2012-12. Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2012-12. Adoptive cell therapy with autologous tumor infiltrating lymphocytes and low-dose Interleukin-2 in metastatic melanoma patients in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2014-12. Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2007-11. Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2012-10. CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2011-10. A human memory T cell subset with stem cell–like properties in NATURE MEDICINE
  • 2014-12. Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma in MOLECULAR CANCER
  • 2015-01. High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma in NATURE MEDICINE
  • 2013-12. HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2013-04. Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion in NATURE MEDICINE
  • 2013-12. Overview of Various Techniques/Platforms With Critical Evaluation of Each in CURRENT TREATMENT OPTIONS IN ONCOLOGY
  • 2014-01. Targeted therapy for melanoma: rational combinatorial approaches in ONCOGENE
  • 2012-04. The blockade of immune checkpoints in cancer immunotherapy in NATURE REVIEWS CANCER
  • 2013-12. A melanocyte lineage program confers resistance to MAP kinase pathway inhibition in NATURE
  • 2011-12. Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2004-11. Cognate CD4+ T cell licensing of dendritic cells in CD8+ T cell immunity in NATURE IMMUNOLOGY
  • 1998-03. Dendritic cells and the control of immunity in NATURE
  • 2004-09. Cancer immunotherapy: moving beyond current vaccines in NATURE MEDICINE
  • 2012-08. Cross-presentation by dendritic cells in NATURE REVIEWS IMMUNOLOGY
  • 2014-12. Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8+ T cells in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2014-12. Hypermutation in human cancer genomes: footprints and mechanisms in NATURE REVIEWS CANCER
  • 1993. Dendritic Cells: Antigen Presentation, Accessory Function and Clinical Relevance in DENDRITIC CELLS IN FUNDAMENTAL AND CLINICAL IMMUNOLOGY
  • 2014-07. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond in NATURE REVIEWS CANCER
  • 2013-05. Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy in GENE THERAPY
  • 2014-11. Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing in NATURE
  • 2012-08. Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival in NATURE MEDICINE
  • 2013-06. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells in NATURE MEDICINE
  • 2012-02. Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting in NATURE
  • 2012-05. Adoptive T-cell therapy for malignant melanoma patients with TILs obtained by ultrasound-guided needle biopsy in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2009-07. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells in NATURE MEDICINE
  • 2013-06. Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3 in CELL DEATH & DISEASE
  • 2013-07. Activation, dysfunction and retention of T cells in vaccine sites after injection of incomplete Freund’s adjuvant, with or without peptide in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2011-03. Tumor immunosurveillance in human cancers in CANCER AND METASTASIS REVIEWS
  • 2012-04. Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma in NATURE BIOTECHNOLOGY
  • 2012-04. Adoptive immunotherapy for cancer: harnessing the T cell response in NATURE REVIEWS IMMUNOLOGY
  • 2009-12. Treatment of Metastatic Melanoma with Autologous Melan-A/Mart-1-Specific Cytotoxic T Lymphocyte Clones in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2013-07. Mutational heterogeneity in cancer and the search for new cancer-associated genes in NATURE
  • 2014-12. Targeting RAS–ERK signalling in cancer: promises and challenges in NATURE REVIEWS DRUG DISCOVERY
  • 2014-11. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-22539-5_16

    DOI

    http://dx.doi.org/10.1007/978-3-319-22539-5_16

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010713832

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26601872


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adoptive Transfer", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cancer Vaccines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Melanoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Targeted Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Precision Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "University of Texas MD Anderson Cancer Center"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bernatchez", 
            "givenName": "Chantale", 
            "id": "sg:person.01360742715.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360742715.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "University of Texas MD Anderson Cancer Center"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cooper", 
            "givenName": "Zachary A.", 
            "id": "sg:person.01354045521.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354045521.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "University of Texas MD Anderson Cancer Center"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wargo", 
            "givenName": "Jennifer A.", 
            "id": "sg:person.0637157757.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637157757.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "University of Texas MD Anderson Cancer Center"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hwu", 
            "givenName": "Patrick", 
            "id": "sg:person.0702415721.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702415721.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "University of Texas MD Anderson Cancer Center"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liz\u00e9e", 
            "givenName": "Gregory", 
            "id": "sg:person.0770536703.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770536703.41"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00262-013-1435-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000376172", 
              "https://doi.org/10.1007/s00262-013-1435-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.prp.2014.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000467737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000560597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1300538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000910911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000934935", 
              "https://doi.org/10.1038/nature14001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-0-12-397927-8.00002-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001008510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.183.3.1185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001748098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198812223192527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001852342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001965372", 
              "https://doi.org/10.1038/nm1100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001965372", 
              "https://doi.org/10.1038/nm1100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-06-0613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002404348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/gt.2012.75", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002592674", 
              "https://doi.org/10.1038/gt.2012.75"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/14760584.2013.836911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002621002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-2837", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002624813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/08830189709116851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002814666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0802655105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002944349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.03.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003056135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1076514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003163159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3005930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003723338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)60868-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003772891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-2930-9_1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004094870", 
              "https://doi.org/10.1007/978-1-4615-2930-9_1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-2930-9_1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004094870", 
              "https://doi.org/10.1007/978-1-4615-2930-9_1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2012.333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004163178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.advms.2014.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004171075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004855456", 
              "https://doi.org/10.1038/nm.3161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-12-476218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005730102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.11.1669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006040605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006344417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2013-03-490565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006707229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa050092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007050226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa050092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007050226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ppo.0000000000000035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007419351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ppo.0000000000000035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007419351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ppo.0000000000000035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007419351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008050192", 
              "https://doi.org/10.1038/nm.3105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-1187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008070533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.iy.11.040193.001241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008113050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-10-388298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008456233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cas.12050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009184340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pharmthera.2014.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009239921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phrs.2014.10.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009674484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3008226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009684137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-0118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009803606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009869790", 
              "https://doi.org/10.1038/nm.2883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009964429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-10-169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010098796", 
              "https://doi.org/10.1186/1479-5876-10-169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1203486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010153811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-011-1182-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010605365", 
              "https://doi.org/10.1007/s00262-011-1182-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010934159", 
              "https://doi.org/10.1038/nm.2446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2051-1426-2-25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010964520", 
              "https://doi.org/10.1186/2051-1426-2-25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2051-1426-2-25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010964520", 
              "https://doi.org/10.1186/2051-1426-2-25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2051-1426-1-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011304979", 
              "https://doi.org/10.1186/2051-1426-1-11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-14-2277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011393544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.1982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011471951", 
              "https://doi.org/10.1038/nm.1982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.1982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011471951", 
              "https://doi.org/10.1038/nm.1982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(14)70072-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011546878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2015.00046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011649760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-10-69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012425461", 
              "https://doi.org/10.1186/1479-5876-10-69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012432963", 
              "https://doi.org/10.1038/nrd4281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1407222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012474298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc1302338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012716185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-13-0170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012734694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e31826e8f5f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012791581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e31826e8f5f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012791581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1251102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012791716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1002011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012824919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013056074", 
              "https://doi.org/10.1038/nri3191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0041074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013849912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.289488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014258215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e318177092b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014389895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e318177092b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014389895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.201343718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015157702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btn128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015632695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-0041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015769986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-13-194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016145024", 
              "https://doi.org/10.1186/1476-4598-13-194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2302/kjm.45.100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016895785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humimm.2009.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017091974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017863023", 
              "https://doi.org/10.1038/nature13988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.28304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018762775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/cancers6042296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018895459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11864-013-0259-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020011252", 
              "https://doi.org/10.1007/s11864-013-0259-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.201344094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020147979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1406498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020435459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-2731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020566898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.hoc.2014.03.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020860669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-2208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021155883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1001775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021184917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1129003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021480946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021761707", 
              "https://doi.org/10.1038/nature12213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-0433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022656387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-003-0480-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022672404", 
              "https://doi.org/10.1007/s00262-003-0480-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40425-014-0036-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022863025", 
              "https://doi.org/10.1186/s40425-014-0036-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40425-014-0036-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022863025", 
              "https://doi.org/10.1186/s40425-014-0036-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-2612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023145197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.242600099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023269633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023536940", 
              "https://doi.org/10.1038/nature00766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023536940", 
              "https://doi.org/10.1038/nature00766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cellbio.24.110707.175347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023721842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-2824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023819621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/146532402760271091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023890673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/146532402760271091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023890673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/14760584.2014.957684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023990016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2005.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024333851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2567.2010.03300.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024414693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.06.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024635810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024763403", 
              "https://doi.org/10.1038/nature06175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-1297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024856654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/pcmr.12218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024861976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(14)61403-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024995107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-2479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025100725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-1490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025390799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2012.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025454353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-1626", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025613580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-9-131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025835104", 
              "https://doi.org/10.1186/1479-5876-9-131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-0388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025949321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-1183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026427580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.142417699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027015074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-12-400044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027124393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3760", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027198182", 
              "https://doi.org/10.1038/nrc3760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.00.240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027315638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.174.2.710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027349643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-1621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027583933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3006504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027702744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2010.31", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027787087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-1177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027855772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0025055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028670765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-0259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028903581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028970029", 
              "https://doi.org/10.1038/nm.3773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-13-0181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028973069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-1934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029183601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.seminoncol.2012.02.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029352765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3002842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029390413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-2846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029418890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2012.10.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029768374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-0735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030249717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2014.10.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031009404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2014.10.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031009404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-2085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031149900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031409434", 
              "https://doi.org/10.1038/ni1129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031409434", 
              "https://doi.org/10.1038/ni1129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci66236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031526347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-03-211714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031594949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-2776(08)60875-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031723720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1202830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031788101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2005.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032257842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-0103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032449439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200205000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032639048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200205000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032639048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-3231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032743970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/89.21.1595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033132508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-1551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033297283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-14-0257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033447415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033654577", 
              "https://doi.org/10.1038/nature10755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-2061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033954839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-0712", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034607636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034861855", 
              "https://doi.org/10.1038/nature07091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2013.34", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035667951", 
              "https://doi.org/10.1038/onc.2013.34"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2013.34", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035667951", 
              "https://doi.org/10.1038/onc.2013.34"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2013.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035922671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2007-05-089375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036085921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-13-0227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036123010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036241928", 
              "https://doi.org/10.1038/nature12688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1210093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036427533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-1759(87)80018-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036662409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-1630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037051738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-0142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037146674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-0143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037521958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200401000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038123200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200401000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038123200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2013.192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038550518", 
              "https://doi.org/10.1038/cddis.2013.192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdu211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038607733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-06-0614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038608923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039273126", 
              "https://doi.org/10.1038/nbt.2157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-med-092012-112807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039285396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2010.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039784712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1008501107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040292685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2012.05.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040937685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-011-9270-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041474080", 
              "https://doi.org/10.1007/s10555-011-9270-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-3083.2008.02202.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041544228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200107000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041687681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-200107000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041687681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1103782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041864150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-1632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042327287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0436605100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042588552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-2776(08)60785-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042797371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1200690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042896583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199008303230904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042955950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1422916112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043020583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcyt.2014.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043349938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcyt.2014.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043349938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-14-0146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043471301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci69619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044155985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-12-1003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044631773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.178.1.361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044654817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1102-999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044871830", 
              "https://doi.org/10.1038/ni1102-999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1102-999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044871830", 
              "https://doi.org/10.1038/ni1102-999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-13-0006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044932559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-13-0215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044941438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-14-0452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044999627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-012-1245-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045079342", 
              "https://doi.org/10.1007/s00262-012-1245-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-11-88", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045094221", 
              "https://doi.org/10.1186/1479-5876-11-88"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.11045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045116159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.1892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045126626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-007-0343-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045388944", 
              "https://doi.org/10.1007/s00262-007-0343-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-007-0343-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045388944", 
              "https://doi.org/10.1007/s00262-007-0343-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045627677", 
              "https://doi.org/10.1038/nrc3816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-2708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046384238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1200694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047413837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047528347", 
              "https://doi.org/10.1038/nri3254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e31824e801f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047743705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e31824e801f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047743705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2013.53.0105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047895673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047946992", 
              "https://doi.org/10.1038/nrc3239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048341608", 
              "https://doi.org/10.1038/32588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048341608", 
              "https://doi.org/10.1038/32588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2009.144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048433096", 
              "https://doi.org/10.1038/jid.2009.144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-05-431718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048531275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20051848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048709192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.0809535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048990798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/onci.20226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049018600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-2339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049144681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-0380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049457896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0800251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050025318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-med-112311-083918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050132066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-05-354449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050941278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2014.59.6023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051350115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.189.5.757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051929047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1003466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052212829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1755-148x.2011.00950.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052447580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-013-1446-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052682909", 
              "https://doi.org/10.1007/s00262-013-1446-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052724075", 
              "https://doi.org/10.1038/ni1112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052724075", 
              "https://doi.org/10.1038/ni1112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2012.46.6441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052897696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e31823284c3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052951411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e31823284c3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052951411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2010.272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053678344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2010.272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053678344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac050760y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054997116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac050760y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054997116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/2162402x.2015.1014246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058420451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/10430340260355374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.2007.0171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059272997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.2013.217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059273933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1546328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062490335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3489291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062616710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3003578", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062687386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1615/critrevimmunol.v23.i12.50", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068131815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/onci.18851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072306307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/onci.24743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072306438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/onci.26615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072306553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074352724", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075286381", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.172.10.6057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076835117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.179.8.5033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077493683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/107327481302000406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078792788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/107327481302000406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078792788"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016", 
        "datePublishedReg": "2016-01-01", 
        "description": "The past several years can be considered a renaissance era in the treatment of metastatic melanoma. Following a 30-year stretch in which oncologists barely put a dent in a very grim overall survival (OS) rate for these patients, things have rapidly changed course with the recent approval of three new melanoma drugs by the FDA. Both oncogene-targeted therapy and immune checkpoint blockade approaches have shown remarkable efficacy in a subset of melanoma patients and have clearly been game-changers in terms of clinical impact. However, most patients still succumb to their disease, and thus, there remains an urgent need to improve upon current therapies. Fortunately, innovations in molecular medicine have led to many silent gains that have greatly increased our understanding of the nature of cancer biology as well as the complex interactions between tumors and the immune system. They have also allowed for the first time a detailed understanding of an individual patient's cancer at the genomic and proteomic level. This information is now starting to be employed at all stages of cancer treatment, including diagnosis, choice of drug therapy, treatment monitoring, and analysis of resistance mechanisms upon recurrence. This new era of personalized medicine will foreseeably lead to paradigm shifts in immunotherapeutic treatment approaches such as individualized cancer vaccines and adoptive transfer of genetically modified T cells. Advances in xenograft technology will also allow for the testing of drug combinations using in vivo models, a truly necessary development as the number of new drugs needing to be tested is predicted to skyrocket in the coming years. This chapter will provide an overview of recent technological developments in cancer research, and how they are expected to impact future diagnosis, monitoring, and development of novel treatments for metastatic melanoma. ", 
        "editor": [
          {
            "familyName": "Kaufman", 
            "givenName": "Howard L.", 
            "type": "Person"
          }, 
          {
            "familyName": "Mehnert", 
            "givenName": "Janice M.", 
            "type": "Person"
          }
        ], 
        "genre": "chapter", 
        "id": "sg:pub.10.1007/978-3-319-22539-5_16", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2438826", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": {
          "isbn": [
            "978-3-319-22538-8", 
            "978-3-319-22539-5"
          ], 
          "name": "Melanoma", 
          "type": "Book"
        }, 
        "name": "Novel Treatments in Development for Melanoma", 
        "pagination": "371-416", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/978-3-319-22539-5_16"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "330ab2ac49a61225d02b8d9b21efa6fe9bd4415f8215352397e96d5f5ac07fc3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1010713832"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26601872"
            ]
          }
        ], 
        "publisher": {
          "location": "Cham", 
          "name": "Springer International Publishing", 
          "type": "Organisation"
        }, 
        "sameAs": [
          "https://doi.org/10.1007/978-3-319-22539-5_16", 
          "https://app.dimensions.ai/details/publication/pub.1010713832"
        ], 
        "sdDataset": "chapters", 
        "sdDatePublished": "2019-04-15T12:54", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000469.jsonl", 
        "type": "Chapter", 
        "url": "http://link.springer.com/10.1007/978-3-319-22539-5_16"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-22539-5_16'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-22539-5_16'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-22539-5_16'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-22539-5_16'


     

    This table displays all metadata directly associated to this object as RDF triples.

    865 TRIPLES      23 PREDICATES      264 URIs      29 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/978-3-319-22539-5_16 schema:about N1fda455de13a461fbdaadc8c76a13c76
    2 N40c5d290160242a2b571bed5057864eb
    3 N692fd4c7c0034d6fb03ccf37637392e2
    4 N7557fc1e903c4223ab5142bf5298b2ba
    5 N7d0ea489eaf8467b8fa61a388745dba8
    6 Na23b16971f6346a7b4dc8e4378b55624
    7 Ne822d324c8ba447e9e1926d8c3044990
    8 Neef744fab50a42b7abaf9065853b6e05
    9 anzsrc-for:11
    10 anzsrc-for:1112
    11 schema:author Na3e6a2d50b8d4d94bf65c153c2f27289
    12 schema:citation sg:pub.10.1007/978-1-4615-2930-9_1
    13 sg:pub.10.1007/s00262-003-0480-x
    14 sg:pub.10.1007/s00262-007-0343-y
    15 sg:pub.10.1007/s00262-011-1182-4
    16 sg:pub.10.1007/s00262-012-1245-1
    17 sg:pub.10.1007/s00262-013-1435-5
    18 sg:pub.10.1007/s00262-013-1446-2
    19 sg:pub.10.1007/s10555-011-9270-7
    20 sg:pub.10.1007/s11864-013-0259-z
    21 sg:pub.10.1038/32588
    22 sg:pub.10.1038/cddis.2013.192
    23 sg:pub.10.1038/gt.2012.75
    24 sg:pub.10.1038/jid.2009.144
    25 sg:pub.10.1038/nature00766
    26 sg:pub.10.1038/nature06175
    27 sg:pub.10.1038/nature07091
    28 sg:pub.10.1038/nature10755
    29 sg:pub.10.1038/nature12213
    30 sg:pub.10.1038/nature12688
    31 sg:pub.10.1038/nature13988
    32 sg:pub.10.1038/nature14001
    33 sg:pub.10.1038/nbt.2157
    34 sg:pub.10.1038/ni1102-999
    35 sg:pub.10.1038/ni1112
    36 sg:pub.10.1038/ni1129
    37 sg:pub.10.1038/nm.1982
    38 sg:pub.10.1038/nm.2446
    39 sg:pub.10.1038/nm.2883
    40 sg:pub.10.1038/nm.3105
    41 sg:pub.10.1038/nm.3161
    42 sg:pub.10.1038/nm.3773
    43 sg:pub.10.1038/nm1100
    44 sg:pub.10.1038/nrc3239
    45 sg:pub.10.1038/nrc3760
    46 sg:pub.10.1038/nrc3816
    47 sg:pub.10.1038/nrd4281
    48 sg:pub.10.1038/nri3191
    49 sg:pub.10.1038/nri3254
    50 sg:pub.10.1038/onc.2013.34
    51 sg:pub.10.1186/1476-4598-13-194
    52 sg:pub.10.1186/1479-5876-10-169
    53 sg:pub.10.1186/1479-5876-10-69
    54 sg:pub.10.1186/1479-5876-11-88
    55 sg:pub.10.1186/1479-5876-9-131
    56 sg:pub.10.1186/2051-1426-1-11
    57 sg:pub.10.1186/2051-1426-2-25
    58 sg:pub.10.1186/s40425-014-0036-y
    59 https://app.dimensions.ai/details/publication/pub.1074352724
    60 https://app.dimensions.ai/details/publication/pub.1075286381
    61 https://doi.org/10.1002/cncr.28304
    62 https://doi.org/10.1002/eji.201343718
    63 https://doi.org/10.1002/eji.201344094
    64 https://doi.org/10.1002/ijc.11045
    65 https://doi.org/10.1016/b978-0-12-397927-8.00002-6
    66 https://doi.org/10.1016/j.advms.2014.12.002
    67 https://doi.org/10.1016/j.biomaterials.2014.10.053
    68 https://doi.org/10.1016/j.canlet.2012.05.011
    69 https://doi.org/10.1016/j.canlet.2012.10.018
    70 https://doi.org/10.1016/j.cell.2010.03.014
    71 https://doi.org/10.1016/j.cell.2012.06.024
    72 https://doi.org/10.1016/j.coi.2005.02.003
    73 https://doi.org/10.1016/j.ejca.2012.11.019
    74 https://doi.org/10.1016/j.gde.2013.11.011
    75 https://doi.org/10.1016/j.hoc.2014.03.001
    76 https://doi.org/10.1016/j.humimm.2009.12.007
    77 https://doi.org/10.1016/j.immuni.2008.08.004
    78 https://doi.org/10.1016/j.it.2005.01.005
    79 https://doi.org/10.1016/j.jcyt.2014.02.004
    80 https://doi.org/10.1016/j.pharmthera.2014.12.003
    81 https://doi.org/10.1016/j.phrs.2014.10.002
    82 https://doi.org/10.1016/j.prp.2014.01.011
    83 https://doi.org/10.1016/s0022-1759(87)80018-2
    84 https://doi.org/10.1016/s0065-2776(08)60785-3
    85 https://doi.org/10.1016/s0065-2776(08)60875-5
    86 https://doi.org/10.1016/s0140-6736(12)60868-x
    87 https://doi.org/10.1016/s0140-6736(14)61403-3
    88 https://doi.org/10.1016/s1470-2045(14)70072-5
    89 https://doi.org/10.1021/ac050760y
    90 https://doi.org/10.1038/emboj.2012.333
    91 https://doi.org/10.1038/mt.2010.24
    92 https://doi.org/10.1038/mt.2010.272
    93 https://doi.org/10.1038/mt.2010.31
    94 https://doi.org/10.1053/j.seminoncol.2012.02.007
    95 https://doi.org/10.1056/nejm198812223192527
    96 https://doi.org/10.1056/nejm199008303230904
    97 https://doi.org/10.1056/nejmc1302338
    98 https://doi.org/10.1056/nejmoa050092
    99 https://doi.org/10.1056/nejmoa0800251
    100 https://doi.org/10.1056/nejmoa1002011
    101 https://doi.org/10.1056/nejmoa1003466
    102 https://doi.org/10.1056/nejmoa1103782
    103 https://doi.org/10.1056/nejmoa1200690
    104 https://doi.org/10.1056/nejmoa1200694
    105 https://doi.org/10.1056/nejmoa1210093
    106 https://doi.org/10.1056/nejmoa1406498
    107 https://doi.org/10.1056/nejmoa1407222
    108 https://doi.org/10.1073/pnas.0436605100
    109 https://doi.org/10.1073/pnas.0802655105
    110 https://doi.org/10.1073/pnas.1008501107
    111 https://doi.org/10.1073/pnas.1422916112
    112 https://doi.org/10.1073/pnas.142417699
    113 https://doi.org/10.1073/pnas.242600099
    114 https://doi.org/10.1074/jbc.m111.289488
    115 https://doi.org/10.1080/146532402760271091
    116 https://doi.org/10.1080/2162402x.2015.1014246
    117 https://doi.org/10.1084/jem.178.1.361
    118 https://doi.org/10.1084/jem.183.3.1185
    119 https://doi.org/10.1084/jem.189.5.757
    120 https://doi.org/10.1084/jem.190.11.1669
    121 https://doi.org/10.1084/jem.20051848
    122 https://doi.org/10.1089/10430340260355374
    123 https://doi.org/10.1089/hum.2007.0171
    124 https://doi.org/10.1089/hum.2013.217
    125 https://doi.org/10.1093/annonc/mdu211
    126 https://doi.org/10.1093/bioinformatics/btn128
    127 https://doi.org/10.1093/jnci/89.21.1595
    128 https://doi.org/10.1097/00002371-200107000-00012
    129 https://doi.org/10.1097/00002371-200205000-00007
    130 https://doi.org/10.1097/00002371-200401000-00004
    131 https://doi.org/10.1097/cji.0b013e318177092b
    132 https://doi.org/10.1097/cji.0b013e31823284c3
    133 https://doi.org/10.1097/cji.0b013e31824e801f
    134 https://doi.org/10.1097/cji.0b013e31826e8f5f
    135 https://doi.org/10.1097/ppo.0000000000000035
    136 https://doi.org/10.1111/cas.12050
    137 https://doi.org/10.1111/j.1365-2567.2010.03300.x
    138 https://doi.org/10.1111/j.1365-3083.2008.02202.x
    139 https://doi.org/10.1111/j.1755-148x.2011.00950.x
    140 https://doi.org/10.1111/pcmr.12218
    141 https://doi.org/10.1126/science.1076514
    142 https://doi.org/10.1126/science.1129003
    143 https://doi.org/10.1126/science.1203486
    144 https://doi.org/10.1126/science.1251102
    145 https://doi.org/10.1126/science.1546328
    146 https://doi.org/10.1126/science.3489291
    147 https://doi.org/10.1126/scitranslmed.3002842
    148 https://doi.org/10.1126/scitranslmed.3003578
    149 https://doi.org/10.1126/scitranslmed.3005930
    150 https://doi.org/10.1126/scitranslmed.3006504
    151 https://doi.org/10.1126/scitranslmed.3008226
    152 https://doi.org/10.1146/annurev-med-092012-112807
    153 https://doi.org/10.1146/annurev-med-112311-083918
    154 https://doi.org/10.1146/annurev.cellbio.24.110707.175347
    155 https://doi.org/10.1146/annurev.iy.11.040193.001241
    156 https://doi.org/10.1158/0008-5472.can-03-3231
    157 https://doi.org/10.1158/0008-5472.can-04-1621
    158 https://doi.org/10.1158/0008-5472.can-09-2824
    159 https://doi.org/10.1158/0008-5472.can-10-0118
    160 https://doi.org/10.1158/0008-5472.can-10-0735
    161 https://doi.org/10.1158/0008-5472.can-11-2837
    162 https://doi.org/10.1158/0008-5472.can-12-1187
    163 https://doi.org/10.1158/0008-5472.can-14-2277
    164 https://doi.org/10.1158/1078-0432.ccr-05-2061
    165 https://doi.org/10.1158/1078-0432.ccr-06-1183
    166 https://doi.org/10.1158/1078-0432.ccr-10-0041
    167 https://doi.org/10.1158/1078-0432.ccr-10-0712
    168 https://doi.org/10.1158/1078-0432.ccr-10-1297
    169 https://doi.org/10.1158/1078-0432.ccr-10-1490
    170 https://doi.org/10.1158/1078-0432.ccr-11-2479
    171 https://doi.org/10.1158/1078-0432.ccr-11-2612
    172 https://doi.org/10.1158/1078-0432.ccr-12-1177
    173 https://doi.org/10.1158/1078-0432.ccr-12-1626
    174 https://doi.org/10.1158/1078-0432.ccr-12-1630
    175 https://doi.org/10.1158/1078-0432.ccr-12-1632
    176 https://doi.org/10.1158/1078-0432.ccr-12-2731
    177 https://doi.org/10.1158/1078-0432.ccr-13-0103
    178 https://doi.org/10.1158/1078-0432.ccr-13-0142
    179 https://doi.org/10.1158/1078-0432.ccr-13-0143
    180 https://doi.org/10.1158/1078-0432.ccr-13-0259
    181 https://doi.org/10.1158/1078-0432.ccr-13-0380
    182 https://doi.org/10.1158/1078-0432.ccr-13-1551
    183 https://doi.org/10.1158/1078-0432.ccr-13-2846
    184 https://doi.org/10.1158/1078-0432.ccr-14-0388
    185 https://doi.org/10.1158/1078-0432.ccr-14-0433
    186 https://doi.org/10.1158/1078-0432.ccr-14-1934
    187 https://doi.org/10.1158/1078-0432.ccr-14-2085
    188 https://doi.org/10.1158/1078-0432.ccr-14-2208
    189 https://doi.org/10.1158/1078-0432.ccr-14-2339
    190 https://doi.org/10.1158/1078-0432.ccr-14-2708
    191 https://doi.org/10.1158/1535-7163.mct-06-0613
    192 https://doi.org/10.1158/1535-7163.mct-06-0614
    193 https://doi.org/10.1158/1535-7163.mct-12-1003
    194 https://doi.org/10.1158/1535-7163.mct-14-0257
    195 https://doi.org/10.1158/1535-7163.mct-14-0452
    196 https://doi.org/10.1158/2159-8290.cd-12-0313
    197 https://doi.org/10.1158/2159-8290.cd-12-0470
    198 https://doi.org/10.1158/2326-6066.cir-13-0006
    199 https://doi.org/10.1158/2326-6066.cir-13-0170
    200 https://doi.org/10.1158/2326-6066.cir-13-0181
    201 https://doi.org/10.1158/2326-6066.cir-13-0215
    202 https://doi.org/10.1158/2326-6066.cir-13-0227
    203 https://doi.org/10.1158/2326-6066.cir-14-0146
    204 https://doi.org/10.1172/jci66236
    205 https://doi.org/10.1172/jci69619
    206 https://doi.org/10.1177/107327481302000406
    207 https://doi.org/10.1182/blood-2007-05-089375
    208 https://doi.org/10.1182/blood-2009-03-211714
    209 https://doi.org/10.1182/blood-2011-05-354449
    210 https://doi.org/10.1182/blood-2011-10-388298
    211 https://doi.org/10.1182/blood-2011-12-400044
    212 https://doi.org/10.1182/blood-2012-05-431718
    213 https://doi.org/10.1182/blood-2012-12-476218
    214 https://doi.org/10.1182/blood-2013-03-490565
    215 https://doi.org/10.1189/jlb.0809535
    216 https://doi.org/10.1200/jco.2005.00.240
    217 https://doi.org/10.1200/jco.2012.46.6441
    218 https://doi.org/10.1200/jco.2013.53.0105
    219 https://doi.org/10.1200/jco.2014.59.6023
    220 https://doi.org/10.1371/journal.pone.0025055
    221 https://doi.org/10.1371/journal.pone.0041074
    222 https://doi.org/10.1586/14760584.2013.836911
    223 https://doi.org/10.1586/14760584.2014.957684
    224 https://doi.org/10.1615/critrevimmunol.v23.i12.50
    225 https://doi.org/10.18632/oncotarget.1892
    226 https://doi.org/10.2302/kjm.45.100
    227 https://doi.org/10.3109/08830189709116851
    228 https://doi.org/10.3389/fimmu.2015.00046
    229 https://doi.org/10.3390/cancers6042296
    230 https://doi.org/10.4049/jimmunol.1001775
    231 https://doi.org/10.4049/jimmunol.1202830
    232 https://doi.org/10.4049/jimmunol.1300538
    233 https://doi.org/10.4049/jimmunol.172.10.6057
    234 https://doi.org/10.4049/jimmunol.174.2.710
    235 https://doi.org/10.4049/jimmunol.179.8.5033
    236 https://doi.org/10.4161/onci.18851
    237 https://doi.org/10.4161/onci.20226
    238 https://doi.org/10.4161/onci.24743
    239 https://doi.org/10.4161/onci.26615
    240 schema:datePublished 2016
    241 schema:datePublishedReg 2016-01-01
    242 schema:description The past several years can be considered a renaissance era in the treatment of metastatic melanoma. Following a 30-year stretch in which oncologists barely put a dent in a very grim overall survival (OS) rate for these patients, things have rapidly changed course with the recent approval of three new melanoma drugs by the FDA. Both oncogene-targeted therapy and immune checkpoint blockade approaches have shown remarkable efficacy in a subset of melanoma patients and have clearly been game-changers in terms of clinical impact. However, most patients still succumb to their disease, and thus, there remains an urgent need to improve upon current therapies. Fortunately, innovations in molecular medicine have led to many silent gains that have greatly increased our understanding of the nature of cancer biology as well as the complex interactions between tumors and the immune system. They have also allowed for the first time a detailed understanding of an individual patient's cancer at the genomic and proteomic level. This information is now starting to be employed at all stages of cancer treatment, including diagnosis, choice of drug therapy, treatment monitoring, and analysis of resistance mechanisms upon recurrence. This new era of personalized medicine will foreseeably lead to paradigm shifts in immunotherapeutic treatment approaches such as individualized cancer vaccines and adoptive transfer of genetically modified T cells. Advances in xenograft technology will also allow for the testing of drug combinations using in vivo models, a truly necessary development as the number of new drugs needing to be tested is predicted to skyrocket in the coming years. This chapter will provide an overview of recent technological developments in cancer research, and how they are expected to impact future diagnosis, monitoring, and development of novel treatments for metastatic melanoma.
    243 schema:editor Nb1b4077600004571abfa330d25fa24f8
    244 schema:genre chapter
    245 schema:inLanguage en
    246 schema:isAccessibleForFree false
    247 schema:isPartOf N74fc4f6c90c64e43bf34befabd3aa601
    248 schema:name Novel Treatments in Development for Melanoma
    249 schema:pagination 371-416
    250 schema:productId N5bbd6b0f39b743cf858200ad8c908947
    251 N681545b6f91c496ab044645cce1cdfa0
    252 Nde89ebe873e74f2f9a7b4babde5b30e1
    253 Nfca34d3ee1d544b3858bd44530fcad12
    254 schema:publisher N7cdbf6d616ff4d5784ed2fa70c2a7d26
    255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010713832
    256 https://doi.org/10.1007/978-3-319-22539-5_16
    257 schema:sdDatePublished 2019-04-15T12:54
    258 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    259 schema:sdPublisher Ne0b0d629b14348dd82f5a1fbbbe768e4
    260 schema:url http://link.springer.com/10.1007/978-3-319-22539-5_16
    261 sgo:license sg:explorer/license/
    262 sgo:sdDataset chapters
    263 rdf:type schema:Chapter
    264 N041c4190077c4c508162e9c3c71d72c1 rdf:first sg:person.0637157757.45
    265 rdf:rest Nce9f2a3b2d6c4ff4a68c3716cd95e6a6
    266 N1fda455de13a461fbdaadc8c76a13c76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    267 schema:name Adoptive Transfer
    268 rdf:type schema:DefinedTerm
    269 N40c5d290160242a2b571bed5057864eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    270 schema:name Molecular Targeted Therapy
    271 rdf:type schema:DefinedTerm
    272 N47feaecc176f415ea687a74f9a8cee93 schema:familyName Mehnert
    273 schema:givenName Janice M.
    274 rdf:type schema:Person
    275 N5bbd6b0f39b743cf858200ad8c908947 schema:name pubmed_id
    276 schema:value 26601872
    277 rdf:type schema:PropertyValue
    278 N5e7c0ae686664c83ac6b307f3b2abb17 rdf:first sg:person.0770536703.41
    279 rdf:rest rdf:nil
    280 N5f46ff12d7de4adbba28f959eafcf76e rdf:first N47feaecc176f415ea687a74f9a8cee93
    281 rdf:rest rdf:nil
    282 N681545b6f91c496ab044645cce1cdfa0 schema:name readcube_id
    283 schema:value 330ab2ac49a61225d02b8d9b21efa6fe9bd4415f8215352397e96d5f5ac07fc3
    284 rdf:type schema:PropertyValue
    285 N692fd4c7c0034d6fb03ccf37637392e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    286 schema:name T-Lymphocytes
    287 rdf:type schema:DefinedTerm
    288 N74fc4f6c90c64e43bf34befabd3aa601 schema:isbn 978-3-319-22538-8
    289 978-3-319-22539-5
    290 schema:name Melanoma
    291 rdf:type schema:Book
    292 N7557fc1e903c4223ab5142bf5298b2ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    293 schema:name Precision Medicine
    294 rdf:type schema:DefinedTerm
    295 N7b4d7fde0db64589b680411478f34257 rdf:first sg:person.01354045521.83
    296 rdf:rest N041c4190077c4c508162e9c3c71d72c1
    297 N7cdbf6d616ff4d5784ed2fa70c2a7d26 schema:location Cham
    298 schema:name Springer International Publishing
    299 rdf:type schema:Organisation
    300 N7d0ea489eaf8467b8fa61a388745dba8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    301 schema:name Melanoma
    302 rdf:type schema:DefinedTerm
    303 Na23b16971f6346a7b4dc8e4378b55624 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    304 schema:name Humans
    305 rdf:type schema:DefinedTerm
    306 Na3e6a2d50b8d4d94bf65c153c2f27289 rdf:first sg:person.01360742715.28
    307 rdf:rest N7b4d7fde0db64589b680411478f34257
    308 Nb1b4077600004571abfa330d25fa24f8 rdf:first Nddf52b504077437fb65b12667e6db754
    309 rdf:rest N5f46ff12d7de4adbba28f959eafcf76e
    310 Nce9f2a3b2d6c4ff4a68c3716cd95e6a6 rdf:first sg:person.0702415721.17
    311 rdf:rest N5e7c0ae686664c83ac6b307f3b2abb17
    312 Nddf52b504077437fb65b12667e6db754 schema:familyName Kaufman
    313 schema:givenName Howard L.
    314 rdf:type schema:Person
    315 Nde89ebe873e74f2f9a7b4babde5b30e1 schema:name dimensions_id
    316 schema:value pub.1010713832
    317 rdf:type schema:PropertyValue
    318 Ne0b0d629b14348dd82f5a1fbbbe768e4 schema:name Springer Nature - SN SciGraph project
    319 rdf:type schema:Organization
    320 Ne822d324c8ba447e9e1926d8c3044990 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    321 schema:name Antineoplastic Combined Chemotherapy Protocols
    322 rdf:type schema:DefinedTerm
    323 Neef744fab50a42b7abaf9065853b6e05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    324 schema:name Cancer Vaccines
    325 rdf:type schema:DefinedTerm
    326 Nfca34d3ee1d544b3858bd44530fcad12 schema:name doi
    327 schema:value 10.1007/978-3-319-22539-5_16
    328 rdf:type schema:PropertyValue
    329 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    330 schema:name Medical and Health Sciences
    331 rdf:type schema:DefinedTerm
    332 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    333 schema:name Oncology and Carcinogenesis
    334 rdf:type schema:DefinedTerm
    335 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1007/978-3-319-22539-5_16
    336 rdf:type schema:MonetaryGrant
    337 sg:person.01354045521.83 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    338 schema:familyName Cooper
    339 schema:givenName Zachary A.
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354045521.83
    341 rdf:type schema:Person
    342 sg:person.01360742715.28 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    343 schema:familyName Bernatchez
    344 schema:givenName Chantale
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360742715.28
    346 rdf:type schema:Person
    347 sg:person.0637157757.45 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    348 schema:familyName Wargo
    349 schema:givenName Jennifer A.
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637157757.45
    351 rdf:type schema:Person
    352 sg:person.0702415721.17 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    353 schema:familyName Hwu
    354 schema:givenName Patrick
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702415721.17
    356 rdf:type schema:Person
    357 sg:person.0770536703.41 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    358 schema:familyName Lizée
    359 schema:givenName Gregory
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770536703.41
    361 rdf:type schema:Person
    362 sg:pub.10.1007/978-1-4615-2930-9_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004094870
    363 https://doi.org/10.1007/978-1-4615-2930-9_1
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1007/s00262-003-0480-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022672404
    366 https://doi.org/10.1007/s00262-003-0480-x
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1007/s00262-007-0343-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1045388944
    369 https://doi.org/10.1007/s00262-007-0343-y
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1007/s00262-011-1182-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010605365
    372 https://doi.org/10.1007/s00262-011-1182-4
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1007/s00262-012-1245-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045079342
    375 https://doi.org/10.1007/s00262-012-1245-1
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1007/s00262-013-1435-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000376172
    378 https://doi.org/10.1007/s00262-013-1435-5
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1007/s00262-013-1446-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052682909
    381 https://doi.org/10.1007/s00262-013-1446-2
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1007/s10555-011-9270-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041474080
    384 https://doi.org/10.1007/s10555-011-9270-7
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1007/s11864-013-0259-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1020011252
    387 https://doi.org/10.1007/s11864-013-0259-z
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/32588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048341608
    390 https://doi.org/10.1038/32588
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/cddis.2013.192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038550518
    393 https://doi.org/10.1038/cddis.2013.192
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/gt.2012.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002592674
    396 https://doi.org/10.1038/gt.2012.75
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/jid.2009.144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048433096
    399 https://doi.org/10.1038/jid.2009.144
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/nature00766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023536940
    402 https://doi.org/10.1038/nature00766
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/nature06175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024763403
    405 https://doi.org/10.1038/nature06175
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/nature07091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034861855
    408 https://doi.org/10.1038/nature07091
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/nature10755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033654577
    411 https://doi.org/10.1038/nature10755
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/nature12213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021761707
    414 https://doi.org/10.1038/nature12213
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1038/nature12688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036241928
    417 https://doi.org/10.1038/nature12688
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1038/nature13988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017863023
    420 https://doi.org/10.1038/nature13988
    421 rdf:type schema:CreativeWork
    422 sg:pub.10.1038/nature14001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000934935
    423 https://doi.org/10.1038/nature14001
    424 rdf:type schema:CreativeWork
    425 sg:pub.10.1038/nbt.2157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039273126
    426 https://doi.org/10.1038/nbt.2157
    427 rdf:type schema:CreativeWork
    428 sg:pub.10.1038/ni1102-999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044871830
    429 https://doi.org/10.1038/ni1102-999
    430 rdf:type schema:CreativeWork
    431 sg:pub.10.1038/ni1112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052724075
    432 https://doi.org/10.1038/ni1112
    433 rdf:type schema:CreativeWork
    434 sg:pub.10.1038/ni1129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031409434
    435 https://doi.org/10.1038/ni1129
    436 rdf:type schema:CreativeWork
    437 sg:pub.10.1038/nm.1982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011471951
    438 https://doi.org/10.1038/nm.1982
    439 rdf:type schema:CreativeWork
    440 sg:pub.10.1038/nm.2446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010934159
    441 https://doi.org/10.1038/nm.2446
    442 rdf:type schema:CreativeWork
    443 sg:pub.10.1038/nm.2883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009869790
    444 https://doi.org/10.1038/nm.2883
    445 rdf:type schema:CreativeWork
    446 sg:pub.10.1038/nm.3105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008050192
    447 https://doi.org/10.1038/nm.3105
    448 rdf:type schema:CreativeWork
    449 sg:pub.10.1038/nm.3161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004855456
    450 https://doi.org/10.1038/nm.3161
    451 rdf:type schema:CreativeWork
    452 sg:pub.10.1038/nm.3773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028970029
    453 https://doi.org/10.1038/nm.3773
    454 rdf:type schema:CreativeWork
    455 sg:pub.10.1038/nm1100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001965372
    456 https://doi.org/10.1038/nm1100
    457 rdf:type schema:CreativeWork
    458 sg:pub.10.1038/nrc3239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047946992
    459 https://doi.org/10.1038/nrc3239
    460 rdf:type schema:CreativeWork
    461 sg:pub.10.1038/nrc3760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027198182
    462 https://doi.org/10.1038/nrc3760
    463 rdf:type schema:CreativeWork
    464 sg:pub.10.1038/nrc3816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045627677
    465 https://doi.org/10.1038/nrc3816
    466 rdf:type schema:CreativeWork
    467 sg:pub.10.1038/nrd4281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012432963
    468 https://doi.org/10.1038/nrd4281
    469 rdf:type schema:CreativeWork
    470 sg:pub.10.1038/nri3191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013056074
    471 https://doi.org/10.1038/nri3191
    472 rdf:type schema:CreativeWork
    473 sg:pub.10.1038/nri3254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047528347
    474 https://doi.org/10.1038/nri3254
    475 rdf:type schema:CreativeWork
    476 sg:pub.10.1038/onc.2013.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035667951
    477 https://doi.org/10.1038/onc.2013.34
    478 rdf:type schema:CreativeWork
    479 sg:pub.10.1186/1476-4598-13-194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016145024
    480 https://doi.org/10.1186/1476-4598-13-194
    481 rdf:type schema:CreativeWork
    482 sg:pub.10.1186/1479-5876-10-169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010098796
    483 https://doi.org/10.1186/1479-5876-10-169
    484 rdf:type schema:CreativeWork
    485 sg:pub.10.1186/1479-5876-10-69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012425461
    486 https://doi.org/10.1186/1479-5876-10-69
    487 rdf:type schema:CreativeWork
    488 sg:pub.10.1186/1479-5876-11-88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045094221
    489 https://doi.org/10.1186/1479-5876-11-88
    490 rdf:type schema:CreativeWork
    491 sg:pub.10.1186/1479-5876-9-131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025835104
    492 https://doi.org/10.1186/1479-5876-9-131
    493 rdf:type schema:CreativeWork
    494 sg:pub.10.1186/2051-1426-1-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011304979
    495 https://doi.org/10.1186/2051-1426-1-11
    496 rdf:type schema:CreativeWork
    497 sg:pub.10.1186/2051-1426-2-25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010964520
    498 https://doi.org/10.1186/2051-1426-2-25
    499 rdf:type schema:CreativeWork
    500 sg:pub.10.1186/s40425-014-0036-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1022863025
    501 https://doi.org/10.1186/s40425-014-0036-y
    502 rdf:type schema:CreativeWork
    503 https://app.dimensions.ai/details/publication/pub.1074352724 schema:CreativeWork
    504 https://app.dimensions.ai/details/publication/pub.1075286381 schema:CreativeWork
    505 https://doi.org/10.1002/cncr.28304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018762775
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1002/eji.201343718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015157702
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1002/eji.201344094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020147979
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1002/ijc.11045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045116159
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1016/b978-0-12-397927-8.00002-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001008510
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1016/j.advms.2014.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004171075
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1016/j.biomaterials.2014.10.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031009404
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1016/j.canlet.2012.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040937685
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1016/j.canlet.2012.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029768374
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1016/j.cell.2010.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003056135
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1016/j.cell.2012.06.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024635810
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1016/j.coi.2005.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032257842
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1016/j.ejca.2012.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025454353
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1016/j.gde.2013.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035922671
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1016/j.hoc.2014.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020860669
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1016/j.humimm.2009.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017091974
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1016/j.immuni.2008.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009964429
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1016/j.it.2005.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024333851
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1016/j.jcyt.2014.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043349938
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1016/j.pharmthera.2014.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009239921
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1016/j.phrs.2014.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009674484
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1016/j.prp.2014.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000467737
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1016/s0022-1759(87)80018-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036662409
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1016/s0065-2776(08)60785-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042797371
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1016/s0065-2776(08)60875-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031723720
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1016/s0140-6736(12)60868-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003772891
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1016/s0140-6736(14)61403-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024995107
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1016/s1470-2045(14)70072-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011546878
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1021/ac050760y schema:sameAs https://app.dimensions.ai/details/publication/pub.1054997116
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1038/emboj.2012.333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004163178
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1038/mt.2010.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039784712
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1038/mt.2010.272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053678344
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1038/mt.2010.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027787087
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1053/j.seminoncol.2012.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029352765
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1056/nejm198812223192527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001852342
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1056/nejm199008303230904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042955950
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1056/nejmc1302338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012716185
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1056/nejmoa050092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007050226
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1056/nejmoa0800251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050025318
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1056/nejmoa1002011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012824919
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1056/nejmoa1003466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052212829
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1056/nejmoa1103782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041864150
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1056/nejmoa1200690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042896583
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1056/nejmoa1200694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047413837
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1056/nejmoa1210093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036427533
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1056/nejmoa1406498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020435459
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1056/nejmoa1407222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012474298
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1073/pnas.0436605100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042588552
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1073/pnas.0802655105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002944349
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1073/pnas.1008501107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040292685
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1073/pnas.1422916112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043020583
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.1073/pnas.142417699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027015074
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.1073/pnas.242600099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023269633
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.1074/jbc.m111.289488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014258215
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.1080/146532402760271091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023890673
    614 rdf:type schema:CreativeWork
    615 https://doi.org/10.1080/2162402x.2015.1014246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058420451
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.1084/jem.178.1.361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044654817
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.1084/jem.183.3.1185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001748098
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.1084/jem.189.5.757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051929047
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.1084/jem.190.11.1669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006040605
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.1084/jem.20051848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048709192
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.1089/10430340260355374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202446
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.1089/hum.2007.0171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272997
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.1089/hum.2013.217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059273933
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.1093/annonc/mdu211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038607733
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.1093/bioinformatics/btn128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015632695
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.1093/jnci/89.21.1595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033132508
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.1097/00002371-200107000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041687681
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.1097/00002371-200205000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032639048
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.1097/00002371-200401000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038123200
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.1097/cji.0b013e318177092b schema:sameAs https://app.dimensions.ai/details/publication/pub.1014389895
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.1097/cji.0b013e31823284c3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052951411
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.1097/cji.0b013e31824e801f schema:sameAs https://app.dimensions.ai/details/publication/pub.1047743705
    650 rdf:type schema:CreativeWork
    651 https://doi.org/10.1097/cji.0b013e31826e8f5f schema:sameAs https://app.dimensions.ai/details/publication/pub.1012791581
    652 rdf:type schema:CreativeWork
    653 https://doi.org/10.1097/ppo.0000000000000035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007419351
    654 rdf:type schema:CreativeWork
    655 https://doi.org/10.1111/cas.12050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009184340
    656 rdf:type schema:CreativeWork
    657 https://doi.org/10.1111/j.1365-2567.2010.03300.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024414693
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.1111/j.1365-3083.2008.02202.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041544228
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.1111/j.1755-148x.2011.00950.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052447580
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.1111/pcmr.12218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024861976
    664 rdf:type schema:CreativeWork
    665 https://doi.org/10.1126/science.1076514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003163159
    666 rdf:type schema:CreativeWork
    667 https://doi.org/10.1126/science.1129003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021480946
    668 rdf:type schema:CreativeWork
    669 https://doi.org/10.1126/science.1203486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010153811
    670 rdf:type schema:CreativeWork
    671 https://doi.org/10.1126/science.1251102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012791716
    672 rdf:type schema:CreativeWork
    673 https://doi.org/10.1126/science.1546328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062490335
    674 rdf:type schema:CreativeWork
    675 https://doi.org/10.1126/science.3489291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062616710
    676 rdf:type schema:CreativeWork
    677 https://doi.org/10.1126/scitranslmed.3002842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029390413
    678 rdf:type schema:CreativeWork
    679 https://doi.org/10.1126/scitranslmed.3003578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062687386
    680 rdf:type schema:CreativeWork
    681 https://doi.org/10.1126/scitranslmed.3005930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003723338
    682 rdf:type schema:CreativeWork
    683 https://doi.org/10.1126/scitranslmed.3006504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027702744
    684 rdf:type schema:CreativeWork
    685 https://doi.org/10.1126/scitranslmed.3008226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009684137
    686 rdf:type schema:CreativeWork
    687 https://doi.org/10.1146/annurev-med-092012-112807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039285396
    688 rdf:type schema:CreativeWork
    689 https://doi.org/10.1146/annurev-med-112311-083918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050132066
    690 rdf:type schema:CreativeWork
    691 https://doi.org/10.1146/annurev.cellbio.24.110707.175347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023721842
    692 rdf:type schema:CreativeWork
    693 https://doi.org/10.1146/annurev.iy.11.040193.001241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008113050
    694 rdf:type schema:CreativeWork
    695 https://doi.org/10.1158/0008-5472.can-03-3231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032743970
    696 rdf:type schema:CreativeWork
    697 https://doi.org/10.1158/0008-5472.can-04-1621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027583933
    698 rdf:type schema:CreativeWork
    699 https://doi.org/10.1158/0008-5472.can-09-2824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023819621
    700 rdf:type schema:CreativeWork
    701 https://doi.org/10.1158/0008-5472.can-10-0118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009803606
    702 rdf:type schema:CreativeWork
    703 https://doi.org/10.1158/0008-5472.can-10-0735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030249717
    704 rdf:type schema:CreativeWork
    705 https://doi.org/10.1158/0008-5472.can-11-2837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002624813
    706 rdf:type schema:CreativeWork
    707 https://doi.org/10.1158/0008-5472.can-12-1187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008070533
    708 rdf:type schema:CreativeWork
    709 https://doi.org/10.1158/0008-5472.can-14-2277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011393544
    710 rdf:type schema:CreativeWork
    711 https://doi.org/10.1158/1078-0432.ccr-05-2061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033954839
    712 rdf:type schema:CreativeWork
    713 https://doi.org/10.1158/1078-0432.ccr-06-1183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026427580
    714 rdf:type schema:CreativeWork
    715 https://doi.org/10.1158/1078-0432.ccr-10-0041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015769986
    716 rdf:type schema:CreativeWork
    717 https://doi.org/10.1158/1078-0432.ccr-10-0712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034607636
    718 rdf:type schema:CreativeWork
    719 https://doi.org/10.1158/1078-0432.ccr-10-1297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024856654
    720 rdf:type schema:CreativeWork
    721 https://doi.org/10.1158/1078-0432.ccr-10-1490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025390799
    722 rdf:type schema:CreativeWork
    723 https://doi.org/10.1158/1078-0432.ccr-11-2479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025100725
    724 rdf:type schema:CreativeWork
    725 https://doi.org/10.1158/1078-0432.ccr-11-2612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023145197
    726 rdf:type schema:CreativeWork
    727 https://doi.org/10.1158/1078-0432.ccr-12-1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027855772
    728 rdf:type schema:CreativeWork
    729 https://doi.org/10.1158/1078-0432.ccr-12-1626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025613580
    730 rdf:type schema:CreativeWork
    731 https://doi.org/10.1158/1078-0432.ccr-12-1630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037051738
    732 rdf:type schema:CreativeWork
    733 https://doi.org/10.1158/1078-0432.ccr-12-1632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042327287
    734 rdf:type schema:CreativeWork
    735 https://doi.org/10.1158/1078-0432.ccr-12-2731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020566898
    736 rdf:type schema:CreativeWork
    737 https://doi.org/10.1158/1078-0432.ccr-13-0103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032449439
    738 rdf:type schema:CreativeWork
    739 https://doi.org/10.1158/1078-0432.ccr-13-0142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037146674
    740 rdf:type schema:CreativeWork
    741 https://doi.org/10.1158/1078-0432.ccr-13-0143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037521958
    742 rdf:type schema:CreativeWork
    743 https://doi.org/10.1158/1078-0432.ccr-13-0259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028903581
    744 rdf:type schema:CreativeWork
    745 https://doi.org/10.1158/1078-0432.ccr-13-0380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049457896
    746 rdf:type schema:CreativeWork
    747 https://doi.org/10.1158/1078-0432.ccr-13-1551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033297283
    748 rdf:type schema:CreativeWork
    749 https://doi.org/10.1158/1078-0432.ccr-13-2846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029418890
    750 rdf:type schema:CreativeWork
    751 https://doi.org/10.1158/1078-0432.ccr-14-0388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025949321
    752 rdf:type schema:CreativeWork
    753 https://doi.org/10.1158/1078-0432.ccr-14-0433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022656387
    754 rdf:type schema:CreativeWork
    755 https://doi.org/10.1158/1078-0432.ccr-14-1934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029183601
    756 rdf:type schema:CreativeWork
    757 https://doi.org/10.1158/1078-0432.ccr-14-2085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031149900
    758 rdf:type schema:CreativeWork
    759 https://doi.org/10.1158/1078-0432.ccr-14-2208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021155883
    760 rdf:type schema:CreativeWork
    761 https://doi.org/10.1158/1078-0432.ccr-14-2339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049144681
    762 rdf:type schema:CreativeWork
    763 https://doi.org/10.1158/1078-0432.ccr-14-2708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046384238
    764 rdf:type schema:CreativeWork
    765 https://doi.org/10.1158/1535-7163.mct-06-0613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002404348
    766 rdf:type schema:CreativeWork
    767 https://doi.org/10.1158/1535-7163.mct-06-0614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038608923
    768 rdf:type schema:CreativeWork
    769 https://doi.org/10.1158/1535-7163.mct-12-1003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044631773
    770 rdf:type schema:CreativeWork
    771 https://doi.org/10.1158/1535-7163.mct-14-0257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033447415
    772 rdf:type schema:CreativeWork
    773 https://doi.org/10.1158/1535-7163.mct-14-0452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044999627
    774 rdf:type schema:CreativeWork
    775 https://doi.org/10.1158/2159-8290.cd-12-0313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006344417
    776 rdf:type schema:CreativeWork
    777 https://doi.org/10.1158/2159-8290.cd-12-0470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000560597
    778 rdf:type schema:CreativeWork
    779 https://doi.org/10.1158/2326-6066.cir-13-0006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044932559
    780 rdf:type schema:CreativeWork
    781 https://doi.org/10.1158/2326-6066.cir-13-0170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012734694
    782 rdf:type schema:CreativeWork
    783 https://doi.org/10.1158/2326-6066.cir-13-0181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028973069
    784 rdf:type schema:CreativeWork
    785 https://doi.org/10.1158/2326-6066.cir-13-0215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044941438
    786 rdf:type schema:CreativeWork
    787 https://doi.org/10.1158/2326-6066.cir-13-0227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036123010
    788 rdf:type schema:CreativeWork
    789 https://doi.org/10.1158/2326-6066.cir-14-0146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043471301
    790 rdf:type schema:CreativeWork
    791 https://doi.org/10.1172/jci66236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031526347
    792 rdf:type schema:CreativeWork
    793 https://doi.org/10.1172/jci69619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044155985
    794 rdf:type schema:CreativeWork
    795 https://doi.org/10.1177/107327481302000406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078792788
    796 rdf:type schema:CreativeWork
    797 https://doi.org/10.1182/blood-2007-05-089375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036085921
    798 rdf:type schema:CreativeWork
    799 https://doi.org/10.1182/blood-2009-03-211714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031594949
    800 rdf:type schema:CreativeWork
    801 https://doi.org/10.1182/blood-2011-05-354449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050941278
    802 rdf:type schema:CreativeWork
    803 https://doi.org/10.1182/blood-2011-10-388298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008456233
    804 rdf:type schema:CreativeWork
    805 https://doi.org/10.1182/blood-2011-12-400044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027124393
    806 rdf:type schema:CreativeWork
    807 https://doi.org/10.1182/blood-2012-05-431718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048531275
    808 rdf:type schema:CreativeWork
    809 https://doi.org/10.1182/blood-2012-12-476218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005730102
    810 rdf:type schema:CreativeWork
    811 https://doi.org/10.1182/blood-2013-03-490565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006707229
    812 rdf:type schema:CreativeWork
    813 https://doi.org/10.1189/jlb.0809535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048990798
    814 rdf:type schema:CreativeWork
    815 https://doi.org/10.1200/jco.2005.00.240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027315638
    816 rdf:type schema:CreativeWork
    817 https://doi.org/10.1200/jco.2012.46.6441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052897696
    818 rdf:type schema:CreativeWork
    819 https://doi.org/10.1200/jco.2013.53.0105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047895673
    820 rdf:type schema:CreativeWork
    821 https://doi.org/10.1200/jco.2014.59.6023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051350115
    822 rdf:type schema:CreativeWork
    823 https://doi.org/10.1371/journal.pone.0025055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028670765
    824 rdf:type schema:CreativeWork
    825 https://doi.org/10.1371/journal.pone.0041074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013849912
    826 rdf:type schema:CreativeWork
    827 https://doi.org/10.1586/14760584.2013.836911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002621002
    828 rdf:type schema:CreativeWork
    829 https://doi.org/10.1586/14760584.2014.957684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023990016
    830 rdf:type schema:CreativeWork
    831 https://doi.org/10.1615/critrevimmunol.v23.i12.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068131815
    832 rdf:type schema:CreativeWork
    833 https://doi.org/10.18632/oncotarget.1892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045126626
    834 rdf:type schema:CreativeWork
    835 https://doi.org/10.2302/kjm.45.100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016895785
    836 rdf:type schema:CreativeWork
    837 https://doi.org/10.3109/08830189709116851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002814666
    838 rdf:type schema:CreativeWork
    839 https://doi.org/10.3389/fimmu.2015.00046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011649760
    840 rdf:type schema:CreativeWork
    841 https://doi.org/10.3390/cancers6042296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018895459
    842 rdf:type schema:CreativeWork
    843 https://doi.org/10.4049/jimmunol.1001775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021184917
    844 rdf:type schema:CreativeWork
    845 https://doi.org/10.4049/jimmunol.1202830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031788101
    846 rdf:type schema:CreativeWork
    847 https://doi.org/10.4049/jimmunol.1300538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000910911
    848 rdf:type schema:CreativeWork
    849 https://doi.org/10.4049/jimmunol.172.10.6057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076835117
    850 rdf:type schema:CreativeWork
    851 https://doi.org/10.4049/jimmunol.174.2.710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027349643
    852 rdf:type schema:CreativeWork
    853 https://doi.org/10.4049/jimmunol.179.8.5033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077493683
    854 rdf:type schema:CreativeWork
    855 https://doi.org/10.4161/onci.18851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072306307
    856 rdf:type schema:CreativeWork
    857 https://doi.org/10.4161/onci.20226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049018600
    858 rdf:type schema:CreativeWork
    859 https://doi.org/10.4161/onci.24743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072306438
    860 rdf:type schema:CreativeWork
    861 https://doi.org/10.4161/onci.26615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072306553
    862 rdf:type schema:CreativeWork
    863 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
    864 schema:name University of Texas MD Anderson Cancer Center
    865 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...