Phytocomplexity: The Key to Rational Chemoprevention View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Sushma R. Gundala , M. Hope Robinson , Ritu Aneja

ABSTRACT

Current chemotherapies have been derived from and inspired by the varied natural repository of phytochemicals and have been the linchpin of cancer treatment for years. However, isolation of individual active ingredients has proven to be expensive while offering narrow therapeutic windows and associated toxicities. In contrast, whole foods are endowed with an intricate natural balance among their constituent phytochemicals and have proven to impart optimal health benefits, leading to an enhanced interest in dietary interventions to treat as well as prevent cancer. Several dietary agents including fruits, vegetables, and spices have been investigated for their therapeutic and preventive efficacies. However, their incorporation in therapeutic regimens has been unsuccessful due to inadequate research emphasis on phytocomplexity, the intricate and dynamic interactions among pharmacologically active plant chemicals, and their inactive counterparts within their natural milieu, which affect the absorption, distribution, metabolism, and excretion of the constituent phytochemicals, conferring bioactivity on the plant-derived foods. This chapter illustrates the need to acknowledge the role of phytocomplexity and the possibility of synergistic activity in the current approach pertaining to dietary agents. More... »

PAGES

39-87

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  • Book

    TITLE

    Critical Dietary Factors in Cancer Chemoprevention

    ISBN

    978-3-319-21460-3
    978-3-319-21461-0

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-21461-0_4

    DOI

    http://dx.doi.org/10.1007/978-3-319-21461-0_4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001838662


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