Safety Profile of Current OA Therapies: Evidence from Clinical Trials View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Anthony V. Perruccio , Vinod Chandran

ABSTRACT

The pharmacologic management of osteoarthritis (OA) is primarily targeted at managing symptoms, and there are several classes of agents in current use. Many of these agents, though efficacious, are associated with adverse events. Over time, the complement of adverse events under investigation has broadened, expanding from gastrointestinal (GI) events to also include cardiovascular (CV) and neurological events. Pharmacologic management in OA is challenging, especially in older adults particularly due to comorbidities, different causes of pain, and a high rate of polypharmacy. In addition, while OA is treated as a homogeneous diagnostic category, there is evidence to suggest otherwise. This has implications for the pharmacologic management of OA and design of drug trials. There is significant adverse GI risk associated with nonselective NSAIDs and adverse CV risk associated with both nonselective and selective NSAIDs. While topical NSAIDs appear to have a better safety profile than oral NSAIDS, there can be some risk of GI and CVD adverse events associated with their use. Intra-articular treatment for knee OA is generally associated with risk of mild adverse events of limited duration. However, there is an identified need for studies of longer follow-up with this intervention. With respect to the use of platelet-rich plasma (PRP), it is suggested that the inclusion of leukocytes in the treatment of OA be avoided. Treatment with TNF blockers and IL-1β inhibition is generally well tolerated; majority of adverse events are graded as mild to moderate in severity. Further work with improved study designs is needed. Favorable safety profiles are critical from a clinical perspective. Pragmatic studies that include a wider range of people, including the older age groups with a greater burden of arthritis, are necessary to inform clinical practice. More... »

PAGES

211-234

References to SciGraph publications

  • 2012-07. Evolution of Topical NSAIDs in the Guidelines for Treatment of Osteoarthritis in Elderly Patients in DRUGS & AGING
  • 2012-11. Osteoarthritis: Is viscosupplementation really so unsafe for knee OA? in NATURE REVIEWS RHEUMATOLOGY
  • 2012-12. Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial in BMC MUSCULOSKELETAL DISORDERS
  • 2010-01. Clinical and biochemical characteristics after intra-articular injection for the treatment of osteoarthritis of the knee: prospective randomized study of sodium hyaluronate and corticosteroid in JOURNAL OF ORTHOPAEDIC SCIENCE
  • 2012-12. Control of Arthritis Pain with Anti–Nerve-Growth Factor: Risk and Benefit in CURRENT RHEUMATOLOGY REPORTS
  • 2012-08. Hyaluronic Acid in the Treatment of Knee Osteoarthritis in BIODRUGS
  • 2001-11. Liver Function and Phase I Drug Metabolism in the Elderly in DRUGS & AGING
  • 2012-10. Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee in ARTHRITIS RESEARCH & THERAPY
  • 2008-12. Viscosupplementation for grade II osteoarthritis of the ankle: a prospective study at 18 months’ follow-up in MUSCULOSKELETAL SURGERY
  • 2005-12. Long-term use of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction in the general population in BMC MEDICINE
  • 2011-08. A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee in ARTHRITIS RESEARCH & THERAPY
  • 2012-05. Coming to Terms with Nonsteroidal Anti-Inflammatory Drug Gastropathy in DRUGS
  • 2014-07. The type of platelet-rich plasma may influence the safety of the approach in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2008-12. Cost-effectiveness analysis for joint pain treatment in patients with osteoarthritis treated at the Instituto Mexicano del Seguro Social (IMSS): Comparison of nonsteroidal anti-inflammatory drugs (NSAIDs) vs. cyclooxygenase-2 selective inhibitors in COST EFFECTIVENESS AND RESOURCE ALLOCATION
  • 2000-09. Oral versus Topical NSAIDs in Rheumatic Diseases in DRUGS
  • 2013-12. Cost-Effectiveness Analyses of Osteoarthritis Oral Therapies: a Systematic Review in APPLIED HEALTH ECONOMICS AND HEALTH POLICY
  • 2011-07. Topical Therapies for Osteoarthritis in DRUGS
  • 2011-01. Safety and Efficacy of Topical Diclofenac Sodium Gel for Knee Osteoarthritis in Elderly and Younger Patients in DRUGS & AGING
  • 2012-10. Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2002-04. Acetaminophen toxicity: suicidal vs accidental in CRITICAL CARE
  • 2011-12. Musculoskeletal comorbidities in cardiovascular disease, diabetes and respiratory disease: the impact on activity limitations; a representative population-based study in BMC PUBLIC HEALTH
  • 2008-04. Hospitalizations for Upper and Lower GI Events Associated With Traditional NSAIDs and Acetaminophen Among the Elderly in Quebec, Canada in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2012-03. Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2012-04. Hyaluronic Acid for the Treatment of Osteoarthritis in all Joints Except the Knee in BIODRUGS
  • 2012-04. Non-Steroidal Anti-Inflammatory Drugs and Gastroprotection with Proton Pump Inhibitors in CLINICAL DRUG INVESTIGATION
  • 2008-12. Comorbidity, limitations in activities and pain in patients with osteoarthritis of the hip or knee in BMC MUSCULOSKELETAL DISORDERS
  • 2014. Capsaicin for Osteoarthritis Pain in CAPSAICIN AS A THERAPEUTIC MOLECULE
  • Book

    TITLE

    Osteoarthritis

    ISBN

    978-3-319-19559-9
    978-3-319-19560-5

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-19560-5_11

    DOI

    http://dx.doi.org/10.1007/978-3-319-19560-5_11

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022268652


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