Biophysical and Molecular Features of Thermosensitive TRP Channels Involved in Sensory Transduction View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Gonzalo Ferreira , Natalia Raddatz , Yenisleidy Lorenzo , Carlos González , Ramón Latorre

ABSTRACT

Temperature is one of the physical variables that cells and biological organisms constantly monitor to achieve homeostasis and maintain chemical reactions at a suitable speed for the living environment to which they are adapted. In order to monitor and maintain temperature on a constant basis, thermosensitive molecules were selected during evolution. One of the most remarkable sets of molecules acting as sensors is constituted by thermosensitive transient receptor potential channels (thermoTRP channels). TRP channels are a superfamily of non-selective tetrameric cation channels closely related to the classic superfamily of voltage-gated channels, having a set of distinctive sequence elements in common, while acting as polymodal receptors. This latter ability is what makes them suitable for integrating many kinds of signals in different cells, ranging from chemical to physical stimulation (i.e.: temperature-, mechano- and chemo-sensitivity). These channels act as allosteric proteins modifying sensitivity to one stimulus in the presence of another, and thus allowing the integration of many different signaling processes that are critical for sensing the extracellular and intracellular environment and for maintaining homeostasis. This ability has made them vital for life support. Several subfamilies of TRP channels have been described. From these subfamilies, some types of channels have been distinguished as being temperature-sensitive, such as TRPV1–4, TRPM 2–5/8, TRPA1 and TRPC5. In this chapter, thermosensitivity will be defined. Then, we will describe the thermosensitive molecules identified so far, focusing our analysis on ion channels, particularly on thermosensitive TRP channels involved in sensory transduction. Their gating and permeation properties and gating modifiers shall be at the center of the discussion so as to place them in the context of ion channels and life evolution. More... »

PAGES

1-39

References to SciGraph publications

  • 2007. Insights into TRPM4 Function, Regulation and Physiological Role in TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNELS
  • 1969-10. Abnormal Electroretinogram from a Drosophila Mutant in NATURE
  • 1997-10. The capsaicin receptor: a heat-activated ion channel in the pain pathway in NATURE
  • 2011-02. Characterization of calmodulin binding domains in TRPV2 and TRPV5 C-tails in AMINO ACIDS
  • 2007-03. Direct activation of the ion channel TRPA1 by Ca2+ in NATURE NEUROSCIENCE
  • 1994-01. Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore in NATURE
  • 2009-12. Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels in MOLECULAR PAIN
  • 2007-03. TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli in NATURE CHEMICAL BIOLOGY
  • 2002-07. TRPV3 is a calcium-permeable temperature-sensitive cation channel in NATURE
  • 1999-04. A capsaicin-receptor homologue with a high threshold for noxious heat in NATURE
  • 2002-03. Identification of a cold receptor reveals a general role for TRP channels in thermosensation in NATURE
  • 2009-12. Ion channels involved in cold detection in mammals: TRP and non-TRP mechanisms in BIOPHYSICAL REVIEWS
  • 2006-05. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels in NATURE NEUROSCIENCE
  • 2013-06. Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1 in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2013-12. TRPV1 structures in distinct conformations reveal activation mechanisms in NATURE
  • 2004-06. Gene regulation by riboswitches in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2001-05. LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability in NATURE
  • 2013-12. Species differences and molecular determinant of TRPA1 cold sensitivity in NATURE COMMUNICATIONS
  • 2007. Canonical Transient Receptor Potential 5 in TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNELS
  • 2013-12. Structure of the TRPV1 ion channel determined by electron cryo-microscopy in NATURE
  • 2014-08. G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2009-12. Pore dilation occurs in TRPA1 but not in TRPM8 channels in MOLECULAR PAIN
  • 2010-12-24. The Non-selective Monovalent Cationic Channels TRPM4 and TRPM5 in TRANSIENT RECEPTOR POTENTIAL CHANNELS
  • 2007. TRPM2 in TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNELS
  • 2008-09. Pore region of TRPV3 ion channel is specifically required for heat activation in NATURE NEUROSCIENCE
  • 2006-04. High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol in NATURE NEUROSCIENCE
  • 2001-05. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology in NATURE
  • 2000-10. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity in NATURE CELL BIOLOGY
  • 2004-08. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels in NATURE
  • 2003-06. Ion channels: Opposite thermosensor in fruitfly and mouse in NATURE
  • 2002-06. Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family in NATURE GENETICS
  • 2005-10. Homo- and heteromeric assembly of TRP channel subunits in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2003-12. TRP channels as cellular sensors in NATURE
  • 2007-07. The menthol receptor TRPM8 is the principal detector of environmental cold in NATURE
  • 2009-10. TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2002-07. TRPV3 is a temperature-sensitive vanilloid receptor-like protein in NATURE
  • 2012-11. The transient receptor potential channel TRPA1: from gene to pathophysiology in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2004-01. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 in NATURE
  • 2000-09. Identification of the gene causing mucolipidosis type IV in NATURE GENETICS
  • 2004-04. Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2008-05. Fire in the hole: pore dilation of the capsaicin receptor TRPV1 in NATURE NEUROSCIENCE
  • 1984-03. A comparison between total body thermosensitivity and local thermosensitivity in mammals and birds in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2008-03. A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic in NATURE NEUROSCIENCE
  • 2002-06. Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia in NATURE GENETICS
  • 2001-06. The trp ion channel family in NATURE REVIEWS NEUROSCIENCE
  • 2001. Temperature-dependent sex determination and gonadal differentiation in reptiles in GENES AND MECHANISMS IN VERTEBRATE SEX DETERMINATION
  • 2011-09. The transient receptor potential family of ion channels in GENOME BIOLOGY
  • 2003-07. A TRPV family ion channel required for hearing in Drosophila in NATURE
  • 2014-02. A network perspective on unraveling the role of TRP channels in biology and disease in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2010-12-24. Structural Biology of TRP Channels in TRANSIENT RECEPTOR POTENTIAL CHANNELS
  • 2002-06. Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1 in NATURE NEUROSCIENCE
  • 2014-12. Evolutionary origins of sensation in metazoans: functional evidence for a new sensory organ in sponges in BMC EVOLUTIONARY BIOLOGY
  • 2010-06. Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain in NATURE NEUROSCIENCE
  • 2008-12. Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells in NATURE CELL BIOLOGY
  • 2005-12. Heat activation of TRPM5 underlies thermal sensitivity of sweet taste in NATURE
  • 2006-11. Nitric oxide activates TRP channels by cysteine S-nitrosylation in NATURE CHEMICAL BIOLOGY
  • 2010-04-15. Molecular basis of infrared detection by snakes in NATURE
  • 2003-02. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells in NATURE GENETICS
  • 2012-01. Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila in NATURE
  • 2011. Thermo-TRP Channels: Biophysics of Polymodal Receptors in TRANSIENT RECEPTOR POTENTIAL CHANNELS
  • 2005-05. PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain in NATURE NEUROSCIENCE
  • 2005-10. ThermoTRP channels and cold sensing: what are they really up to? in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2010-12-24. TRP Channels in Parasites in TRANSIENT RECEPTOR POTENTIAL CHANNELS
  • Book

    TITLE

    TRP Channels in Sensory Transduction

    ISBN

    978-3-319-18704-4
    978-3-319-18705-1

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-18705-1_1

    DOI

    http://dx.doi.org/10.1007/978-3-319-18705-1_1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042000199


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of the Republic", 
              "id": "https://www.grid.ac/institutes/grid.11630.35", 
              "name": [
                "Departamento de Biof\u00edsica, Facultad de Medicina, Universidad de La Rep\u00fablica"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferreira", 
            "givenName": "Gonzalo", 
            "id": "sg:person.01142577753.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142577753.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Facultad de Ciencias, Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valparaiso"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raddatz", 
            "givenName": "Natalia", 
            "id": "sg:person.01064740766.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064740766.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Facultad de Ciencias, Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valparaiso"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lorenzo", 
            "givenName": "Yenisleidy", 
            "id": "sg:person.016655564201.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016655564201.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Facultad de Ciencias, Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valparaiso"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gonz\u00e1lez", 
            "givenName": "Carlos", 
            "id": "sg:person.01324545661.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324545661.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Facultad de Ciencias, Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valparaiso"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Latorre", 
            "givenName": "Ram\u00f3n", 
            "id": "sg:person.0703447630.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703447630.48"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1074/jbc.m112.341859", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000386570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3632-04.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000513766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2580-10.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000695908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1744-8069-5-62", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000880172", 
              "https://doi.org/10.1186/1744-8069-5-62"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(60)86871-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001041121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001066920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)80564-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001338216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2010.191999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001435943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms3501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001583254", 
              "https://doi.org/10.1038/ncomms3501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m402966200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001727625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002291889", 
              "https://doi.org/10.1038/nature08943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002291889", 
              "https://doi.org/10.1038/nature08943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m300945200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002508022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002522697", 
              "https://doi.org/10.1038/nature04248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002522697", 
              "https://doi.org/10.1038/nature04248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002522697", 
              "https://doi.org/10.1038/nature04248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4451-04.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002673187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2007.05.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002812795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m607849200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002873906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.201010498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002940492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.270256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003012502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1114124108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003107649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.20028752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003502394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.192526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003704583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00351.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003821757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2004.081059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003963913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.141036198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004129775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.neuro.29.051605.112958", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004133517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00670-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004300715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1000357107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004944890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.21.9652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005090185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2002.016352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005129773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35079100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005359703", 
              "https://doi.org/10.1038/35079100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35079100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005359703", 
              "https://doi.org/10.1038/35079100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2007.02.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005365990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/39807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005468710", 
              "https://doi.org/10.1038/39807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/39807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005468710", 
              "https://doi.org/10.1038/39807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1115387108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005569380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0966-842x(97)01080-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005876391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m510422200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006216894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006281558", 
              "https://doi.org/10.1038/nature00894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006281558", 
              "https://doi.org/10.1038/nature00894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00143-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006605513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/367179a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007191771", 
              "https://doi.org/10.1038/367179a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn0602-852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007761325", 
              "https://doi.org/10.1038/nn0602-852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn0602-852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007761325", 
              "https://doi.org/10.1038/nn0602-852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m504745200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007863668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4778-08.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008206364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200111004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008266374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-009-0703-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008603661", 
              "https://doi.org/10.1007/s00424-009-0703-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-009-0703-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008603661", 
              "https://doi.org/10.1007/s00424-009-0703-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-009-0703-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008603661", 
              "https://doi.org/10.1007/s00424-009-0703-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2007.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008861173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009014356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009014356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009114829", 
              "https://doi.org/10.1038/nature02196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009114829", 
              "https://doi.org/10.1038/nature02196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.145466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009231656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1469-7793.2001.t01-1-00697.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009446179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m600807200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009492519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.312645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009646141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2007.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009696714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.200810109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009905950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00719-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010221844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.100129497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010566669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2005.097998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010735471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2005.097998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010735471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m303251200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010963625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0026218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010977471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m006184200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011173603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.bjp.0705467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011657597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m404164200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011726365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.272823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013257881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.052548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013279978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013396858", 
              "https://doi.org/10.1038/ncb1801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m707205200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013941501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3189-10.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014415472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014675898", 
              "https://doi.org/10.1038/nature00882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014675898", 
              "https://doi.org/10.1038/nature00882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.physiol.68.040204.101406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014971350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.physiol.68.040204.101406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014971350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1696-08.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015366988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2574-05.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015427564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015824551", 
              "https://doi.org/10.1038/nn1843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2740-08.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015952106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m406260200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016387999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2006.10.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016610693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017065104", 
              "https://doi.org/10.1038/nn1451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017065104", 
              "https://doi.org/10.1038/nn1451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2006.03.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017268716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m204828200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017698402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m607756200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017974650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(03)00431-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018517565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(03)00431-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018517565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(03)00431-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018517565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9297(07)62941-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018772203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000097263.10220.0c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018965511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000097263.10220.0c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018965511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2005.04.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019323662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2005.04.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019323662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(95)01038-g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020268832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.02.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020428657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20101256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021156351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20101256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021156351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20101256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021156351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.20028605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021385339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021696391", 
              "https://doi.org/10.1038/nn1665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0896-6273(92)90085-r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021732029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semcdb.2006.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021782388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0031448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021846931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.200409236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021917311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.20028740", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022104573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-013-1292-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022323552", 
              "https://doi.org/10.1007/s00424-013-1292-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bpj.2009.11.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022338073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bpj.2009.11.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022338073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-3-218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022480513", 
              "https://doi.org/10.1186/gb-2011-12-3-218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-94-007-0265-3_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022535430", 
              "https://doi.org/10.1007/978-94-007-0265-3_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-94-007-0265-3_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022535430", 
              "https://doi.org/10.1007/978-94-007-0265-3_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2013.11.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022658462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2013.11.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022658462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(04)00150-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022676499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5080-05.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022808300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m500596200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023176442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1645-04.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023184705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35077544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024001280", 
              "https://doi.org/10.1038/35077544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35077544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024001280", 
              "https://doi.org/10.1038/35077544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/19.11.2483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024002152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.200308906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024188771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0934-04.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024662825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025006672", 
              "https://doi.org/10.1038/nature01733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025006672", 
              "https://doi.org/10.1038/nature01733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1105196108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025179525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m706535200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025887588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0237-05.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025949320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-540-34891-7_6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025998826", 
              "https://doi.org/10.1007/978-3-540-34891-7_6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026327319", 
              "https://doi.org/10.1038/ng901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026327319", 
              "https://doi.org/10.1038/ng901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.102596199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026445650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-0348-7781-7_7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026477366", 
              "https://doi.org/10.1007/978-3-0348-7781-7_7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2008/602870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026679844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamcr.2009.04.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026827332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20060166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026872459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20060166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026872459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00637-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027077586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7601083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027094175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7601083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027094175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2008.04.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027176861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2008.04.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027176861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1744-8069-5-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027378111", 
              "https://doi.org/10.1186/1744-8069-5-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.201210810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027514784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2007.144287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027762954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2008.161257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028466419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-005-1437-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028470114", 
              "https://doi.org/10.1007/s00424-005-1437-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-005-1437-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028470114", 
              "https://doi.org/10.1007/s00424-005-1437-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2010.200717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028576080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2004.070839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028654832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12551-009-0020-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028710147", 
              "https://doi.org/10.1007/s12551-009-0020-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12551-009-0020-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028710147", 
              "https://doi.org/10.1007/s12551-009-0020-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/9.17.2471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029421993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.bjp.0705924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029463845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029741434", 
              "https://doi.org/10.1038/35036318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029741434", 
              "https://doi.org/10.1038/35036318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-012-1204-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030127469", 
              "https://doi.org/10.1007/s00424-012-1204-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.26.15435", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030264553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-4388(03)00101-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030409285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-4388(03)00101-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030409285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m501686200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030568900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.106153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030853318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)81135-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030883899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00489.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030958428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2012.242842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031005706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031246864", 
              "https://doi.org/10.1038/nn.2169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4903-13.2014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031337274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2011.02.051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031363619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.bjp.0706040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031733825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2008.165738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031755200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.physiol.68.040204.100431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032055653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.physiol.68.040204.100431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032055653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-005-1467-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032292347", 
              "https://doi.org/10.1007/s00424-005-1467-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-005-1467-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032292347", 
              "https://doi.org/10.1007/s00424-005-1467-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m210810200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032933590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-94-007-0265-3_1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032934438", 
              "https://doi.org/10.1007/978-94-007-0265-3_1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-94-007-0265-3_1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032934438", 
              "https://doi.org/10.1007/978-94-007-0265-3_1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1337252100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033351968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0504-08.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033730493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m302590200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033892944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0010580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033896693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.75.103004.142819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033906151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2004.08.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033974839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2009.06702.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034031929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2009.06702.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034031929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/224285a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034038812", 
              "https://doi.org/10.1038/224285a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2007.04.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034088876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(98)01279-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034177061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02732", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034791748", 
              "https://doi.org/10.1038/nature02732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02732", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034791748", 
              "https://doi.org/10.1038/nature02732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.201311024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034901972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2004.065391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034948262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m607591200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034996447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.223941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034997233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-010-0712-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035075241", 
              "https://doi.org/10.1007/s00726-010-0712-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-010-0712-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035075241", 
              "https://doi.org/10.1007/s00726-010-0712-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(02)00448-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035078099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035284521", 
              "https://doi.org/10.1038/nature05910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-94-007-0265-3_26", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035671967", 
              "https://doi.org/10.1007/978-94-007-0265-3_26"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1384-09.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035863227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-6147(00)01832-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036477605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036537818", 
              "https://doi.org/10.1038/nchembio821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036688363", 
              "https://doi.org/10.1038/nature12823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0808487106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037274847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037386936", 
              "https://doi.org/10.1038/nature02282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037386936", 
              "https://doi.org/10.1038/nature02282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physiolgenomics.00322.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037397883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037681936", 
              "https://doi.org/10.1038/ng1076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037681936", 
              "https://doi.org/10.1038/ng1076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2012.12.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037970485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0896-6273(92)90086-s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037980025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn2056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038530879", 
              "https://doi.org/10.1038/nn2056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m208277200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038594305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038705790", 
              "https://doi.org/10.1038/nn.2552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038705790", 
              "https://doi.org/10.1038/nn.2552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1532-0456(01)00267-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038854589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.200810153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038946905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m607227200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039788534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn0508-528", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039994048", 
              "https://doi.org/10.1038/nn0508-528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.11.6155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040203850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2324-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040708801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1084370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041129516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041144702", 
              "https://doi.org/10.1038/nrm1403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041144702", 
              "https://doi.org/10.1038/nrm1403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041144702", 
              "https://doi.org/10.1038/nrm1403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m702577200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041242812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.111.2.313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041282282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m305127200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041383315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2108-10.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041581270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2006.123059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041605996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00158-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041856635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0143-4160(03)00044-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041985220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0143-4160(03)00044-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041985220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pain.2005.07.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042075466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pain.2005.07.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042075466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pain.2005.07.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042075466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-013-1392-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042205277", 
              "https://doi.org/10.1007/s00424-013-1392-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042434383", 
              "https://doi.org/10.1038/nature10715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042852549", 
              "https://doi.org/10.1038/nature12822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m002391200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043125566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(03)74719-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043296479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2010.03.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043415713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0896-6273(89)90069-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044047291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044215674", 
              "https://doi.org/10.1038/nature719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044215674", 
              "https://doi.org/10.1038/nature719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m200062200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044404936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00652-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044720269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2005.088377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044843517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2005.088377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044843517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m306705200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044879521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0406773101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045618855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0059593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045627130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1956-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045634452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045735975", 
              "https://doi.org/10.1038/ng889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045735975", 
              "https://doi.org/10.1038/ng889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00581552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045833579", 
              "https://doi.org/10.1007/bf00581552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00581552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045833579", 
              "https://doi.org/10.1007/bf00581552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35079092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046105258", 
              "https://doi.org/10.1038/35079092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35079092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046105258", 
              "https://doi.org/10.1038/35079092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-540-34891-7_16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046448435", 
              "https://doi.org/10.1007/978-3-540-34891-7_16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bpj.2013.03.055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046524129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m207882200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046729788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.273581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046787029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/18906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046797649", 
              "https://doi.org/10.1038/18906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/18906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046797649", 
              "https://doi.org/10.1038/18906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-003-1221-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046798381", 
              "https://doi.org/10.1007/s00424-003-1221-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2004.04.080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046841714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-540-34891-7_14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047141107", 
              "https://doi.org/10.1007/978-3-540-34891-7_14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0703420104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047364115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-012-1158-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047693657", 
              "https://doi.org/10.1007/s00424-012-1158-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/423822a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047717110", 
              "https://doi.org/10.1038/423822a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/423822a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047717110", 
              "https://doi.org/10.1038/423822a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/pr.55.4.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048347718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2958.1998.01049.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048360114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200506210-00023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048941847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200506210-00023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048941847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200506210-00023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048941847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2148-14-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049065341", 
              "https://doi.org/10.1186/1471-2148-14-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2148-14-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049065341", 
              "https://doi.org/10.1186/1471-2148-14-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049348245", 
              "https://doi.org/10.1038/nchembio862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3752-06.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049432785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(00)02212-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049494555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.05.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049768025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.05.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049768025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0890-04.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050192797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050313039", 
              "https://doi.org/10.1038/79095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050313039", 
              "https://doi.org/10.1038/79095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1062473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050449731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b801481g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051041679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0048437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051218193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0143-4160(03)00057-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051463292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0143-4160(03)00057-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051463292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0202-04.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051623289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3110041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3110041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.107.040899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052896891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2006.06.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052897568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2006.06.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052897568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0079-6123(08)62027-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052954486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-94-007-0265-3_20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053024369", 
              "https://doi.org/10.1007/978-94-007-0265-3_20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-94-007-0265-3_20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053024369", 
              "https://doi.org/10.1007/978-94-007-0265-3_20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.362194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053423952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m508210200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053452541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2009.06901.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053637455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2009.06901.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053637455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053745509", 
              "https://doi.org/10.1038/nn1692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053745509", 
              "https://doi.org/10.1038/nn1692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1058519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062444425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1073140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062446663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1083646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062448038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1098845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062449700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1108609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062451506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.287.5461.2229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062568865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/stke.2722005re3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062692561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.173.3.1120-1124.1991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062720130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138920111793937952", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069177773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physiolgenomics.2001.4.3.165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074751852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.23-04-01340.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075241252"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015", 
        "datePublishedReg": "2015-01-01", 
        "description": "Temperature is one of the physical variables that cells and biological organisms constantly monitor to achieve homeostasis and maintain chemical reactions at a suitable speed for the living environment to which they are adapted. In order to monitor and maintain temperature on a constant basis, thermosensitive molecules were selected during evolution. One of the most remarkable sets of molecules acting as sensors is constituted by thermosensitive transient receptor potential channels (thermoTRP channels). TRP channels are a superfamily of non-selective tetrameric cation channels closely related to the classic superfamily of voltage-gated channels, having a set of distinctive sequence elements in common, while acting as polymodal receptors. This latter ability is what makes them suitable for integrating many kinds of signals in different cells, ranging from chemical to physical stimulation (i.e.: temperature-, mechano- and chemo-sensitivity). These channels act as allosteric proteins modifying sensitivity to one stimulus in the presence of another, and thus allowing the integration of many different signaling processes that are critical for sensing the extracellular and intracellular environment and for maintaining homeostasis. This ability has made them vital for life support. Several subfamilies of TRP channels have been described. From these subfamilies, some types of channels have been distinguished as being temperature-sensitive, such as TRPV1\u20134, TRPM 2\u20135/8, TRPA1 and TRPC5. In this chapter, thermosensitivity will be defined. Then, we will describe the thermosensitive molecules identified so far, focusing our analysis on ion channels, particularly on thermosensitive TRP channels involved in sensory transduction. Their gating and permeation properties and gating modifiers shall be at the center of the discussion so as to place them in the context of ion channels and life evolution.", 
        "editor": [
          {
            "familyName": "Madrid", 
            "givenName": "Rodolfo", 
            "type": "Person"
          }, 
          {
            "familyName": "Bacigalupo", 
            "givenName": "Juan", 
            "type": "Person"
          }
        ], 
        "genre": "chapter", 
        "id": "sg:pub.10.1007/978-3-319-18705-1_1", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": {
          "isbn": [
            "978-3-319-18704-4", 
            "978-3-319-18705-1"
          ], 
          "name": "TRP Channels in Sensory Transduction", 
          "type": "Book"
        }, 
        "name": "Biophysical and Molecular Features of Thermosensitive TRP Channels Involved in Sensory Transduction", 
        "pagination": "1-39", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/978-3-319-18705-1_1"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c811b1a28dca28a327b1c3649a78febbd397680f2e8a86efde73c271a4cf2938"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1042000199"
            ]
          }
        ], 
        "publisher": {
          "location": "Cham", 
          "name": "Springer International Publishing", 
          "type": "Organisation"
        }, 
        "sameAs": [
          "https://doi.org/10.1007/978-3-319-18705-1_1", 
          "https://app.dimensions.ai/details/publication/pub.1042000199"
        ], 
        "sdDataset": "chapters", 
        "sdDatePublished": "2019-04-15T22:52", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000237.jsonl", 
        "type": "Chapter", 
        "url": "http://link.springer.com/10.1007/978-3-319-18705-1_1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-18705-1_1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-18705-1_1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-18705-1_1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-18705-1_1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    943 TRIPLES      23 PREDICATES      285 URIs      20 LITERALS      8 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/978-3-319-18705-1_1 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N98390951c30a4c9391a7a2dfd2cfa3e3
    4 schema:citation sg:pub.10.1007/978-3-0348-7781-7_7
    5 sg:pub.10.1007/978-3-540-34891-7_14
    6 sg:pub.10.1007/978-3-540-34891-7_16
    7 sg:pub.10.1007/978-3-540-34891-7_6
    8 sg:pub.10.1007/978-94-007-0265-3_1
    9 sg:pub.10.1007/978-94-007-0265-3_20
    10 sg:pub.10.1007/978-94-007-0265-3_26
    11 sg:pub.10.1007/978-94-007-0265-3_8
    12 sg:pub.10.1007/bf00581552
    13 sg:pub.10.1007/s00424-003-1221-x
    14 sg:pub.10.1007/s00424-005-1437-z
    15 sg:pub.10.1007/s00424-005-1467-6
    16 sg:pub.10.1007/s00424-009-0703-x
    17 sg:pub.10.1007/s00424-012-1158-z
    18 sg:pub.10.1007/s00424-012-1204-x
    19 sg:pub.10.1007/s00424-013-1292-2
    20 sg:pub.10.1007/s00424-013-1392-z
    21 sg:pub.10.1007/s00726-010-0712-2
    22 sg:pub.10.1007/s12551-009-0020-9
    23 sg:pub.10.1038/18906
    24 sg:pub.10.1038/224285a0
    25 sg:pub.10.1038/35036318
    26 sg:pub.10.1038/35077544
    27 sg:pub.10.1038/35079092
    28 sg:pub.10.1038/35079100
    29 sg:pub.10.1038/367179a0
    30 sg:pub.10.1038/39807
    31 sg:pub.10.1038/423822a
    32 sg:pub.10.1038/79095
    33 sg:pub.10.1038/nature00882
    34 sg:pub.10.1038/nature00894
    35 sg:pub.10.1038/nature01733
    36 sg:pub.10.1038/nature02196
    37 sg:pub.10.1038/nature02282
    38 sg:pub.10.1038/nature02732
    39 sg:pub.10.1038/nature04248
    40 sg:pub.10.1038/nature05910
    41 sg:pub.10.1038/nature08943
    42 sg:pub.10.1038/nature10715
    43 sg:pub.10.1038/nature12822
    44 sg:pub.10.1038/nature12823
    45 sg:pub.10.1038/nature719
    46 sg:pub.10.1038/ncb1801
    47 sg:pub.10.1038/nchembio821
    48 sg:pub.10.1038/nchembio862
    49 sg:pub.10.1038/ncomms3501
    50 sg:pub.10.1038/ng1076
    51 sg:pub.10.1038/ng889
    52 sg:pub.10.1038/ng901
    53 sg:pub.10.1038/nn.2169
    54 sg:pub.10.1038/nn.2552
    55 sg:pub.10.1038/nn0508-528
    56 sg:pub.10.1038/nn0602-852
    57 sg:pub.10.1038/nn1451
    58 sg:pub.10.1038/nn1665
    59 sg:pub.10.1038/nn1692
    60 sg:pub.10.1038/nn1843
    61 sg:pub.10.1038/nn2056
    62 sg:pub.10.1038/nrm1403
    63 sg:pub.10.1186/1471-2148-14-3
    64 sg:pub.10.1186/1744-8069-5-3
    65 sg:pub.10.1186/1744-8069-5-62
    66 sg:pub.10.1186/gb-2011-12-3-218
    67 https://doi.org/10.1016/0014-5793(95)01038-g
    68 https://doi.org/10.1016/0896-6273(89)90069-x
    69 https://doi.org/10.1016/0896-6273(92)90085-r
    70 https://doi.org/10.1016/0896-6273(92)90086-s
    71 https://doi.org/10.1016/j.bbamcr.2009.04.014
    72 https://doi.org/10.1016/j.bbrc.2005.05.123
    73 https://doi.org/10.1016/j.bbrc.2010.03.027
    74 https://doi.org/10.1016/j.bpj.2009.11.007
    75 https://doi.org/10.1016/j.bpj.2013.03.055
    76 https://doi.org/10.1016/j.ceca.2006.10.003
    77 https://doi.org/10.1016/j.ceca.2007.03.005
    78 https://doi.org/10.1016/j.ceca.2007.04.004
    79 https://doi.org/10.1016/j.cell.2006.02.023
    80 https://doi.org/10.1016/j.cub.2005.04.018
    81 https://doi.org/10.1016/j.febslet.2004.04.080
    82 https://doi.org/10.1016/j.neuron.2004.08.038
    83 https://doi.org/10.1016/j.neuron.2006.03.042
    84 https://doi.org/10.1016/j.neuron.2006.06.023
    85 https://doi.org/10.1016/j.neuron.2007.02.024
    86 https://doi.org/10.1016/j.neuron.2007.04.017
    87 https://doi.org/10.1016/j.neuron.2007.05.027
    88 https://doi.org/10.1016/j.neuron.2008.04.012
    89 https://doi.org/10.1016/j.neuron.2011.02.051
    90 https://doi.org/10.1016/j.neuron.2012.12.016
    91 https://doi.org/10.1016/j.pain.2005.07.016
    92 https://doi.org/10.1016/j.semcdb.2006.11.002
    93 https://doi.org/10.1016/j.str.2013.11.008
    94 https://doi.org/10.1016/s0002-9297(07)62941-3
    95 https://doi.org/10.1016/s0006-3495(03)74719-5
    96 https://doi.org/10.1016/s0006-3495(60)86871-3
    97 https://doi.org/10.1016/s0014-5793(00)02212-2
    98 https://doi.org/10.1016/s0079-6123(08)62027-0
    99 https://doi.org/10.1016/s0092-8674(00)00143-4
    100 https://doi.org/10.1016/s0092-8674(02)00637-2
    101 https://doi.org/10.1016/s0092-8674(02)00652-9
    102 https://doi.org/10.1016/s0092-8674(02)00670-0
    103 https://doi.org/10.1016/s0092-8674(02)00719-5
    104 https://doi.org/10.1016/s0092-8674(03)00158-2
    105 https://doi.org/10.1016/s0143-4160(03)00044-7
    106 https://doi.org/10.1016/s0143-4160(03)00057-5
    107 https://doi.org/10.1016/s0165-6147(00)01832-0
    108 https://doi.org/10.1016/s0896-6273(00)80564-4
    109 https://doi.org/10.1016/s0896-6273(00)81135-6
    110 https://doi.org/10.1016/s0896-6273(04)00150-3
    111 https://doi.org/10.1016/s0959-4388(03)00101-6
    112 https://doi.org/10.1016/s0960-9822(03)00431-7
    113 https://doi.org/10.1016/s0966-842x(97)01080-9
    114 https://doi.org/10.1016/s0968-0004(98)01279-1
    115 https://doi.org/10.1016/s1097-2765(02)00448-3
    116 https://doi.org/10.1016/s1532-0456(01)00267-8
    117 https://doi.org/10.1038/sj.bjp.0705467
    118 https://doi.org/10.1038/sj.bjp.0705924
    119 https://doi.org/10.1038/sj.bjp.0706040
    120 https://doi.org/10.1038/sj.emboj.7600795
    121 https://doi.org/10.1038/sj.emboj.7601083
    122 https://doi.org/10.1039/b801481g
    123 https://doi.org/10.1042/bj20060166
    124 https://doi.org/10.1042/bj20101256
    125 https://doi.org/10.1042/bj3110041
    126 https://doi.org/10.1046/j.1365-2958.1998.01049.x
    127 https://doi.org/10.1073/pnas.0406773101
    128 https://doi.org/10.1073/pnas.0703420104
    129 https://doi.org/10.1073/pnas.0808487106
    130 https://doi.org/10.1073/pnas.1000357107
    131 https://doi.org/10.1073/pnas.100129497
    132 https://doi.org/10.1073/pnas.102596199
    133 https://doi.org/10.1073/pnas.1105196108
    134 https://doi.org/10.1073/pnas.1114124108
    135 https://doi.org/10.1073/pnas.1115387108
    136 https://doi.org/10.1073/pnas.1337252100
    137 https://doi.org/10.1073/pnas.141036198
    138 https://doi.org/10.1073/pnas.92.21.9652
    139 https://doi.org/10.1073/pnas.93.26.15435
    140 https://doi.org/10.1073/pnas.97.11.6155
    141 https://doi.org/10.1074/jbc.m002391200
    142 https://doi.org/10.1074/jbc.m006184200
    143 https://doi.org/10.1074/jbc.m109.052548
    144 https://doi.org/10.1074/jbc.m110.106153
    145 https://doi.org/10.1074/jbc.m110.145466
    146 https://doi.org/10.1074/jbc.m110.192526
    147 https://doi.org/10.1074/jbc.m111.223941
    148 https://doi.org/10.1074/jbc.m111.270256
    149 https://doi.org/10.1074/jbc.m111.272823
    150 https://doi.org/10.1074/jbc.m111.273581
    151 https://doi.org/10.1074/jbc.m111.312645
    152 https://doi.org/10.1074/jbc.m112.341859
    153 https://doi.org/10.1074/jbc.m112.362194
    154 https://doi.org/10.1074/jbc.m200062200
    155 https://doi.org/10.1074/jbc.m204828200
    156 https://doi.org/10.1074/jbc.m207882200
    157 https://doi.org/10.1074/jbc.m208277200
    158 https://doi.org/10.1074/jbc.m210810200
    159 https://doi.org/10.1074/jbc.m300945200
    160 https://doi.org/10.1074/jbc.m302590200
    161 https://doi.org/10.1074/jbc.m303251200
    162 https://doi.org/10.1074/jbc.m305127200
    163 https://doi.org/10.1074/jbc.m306705200
    164 https://doi.org/10.1074/jbc.m402966200
    165 https://doi.org/10.1074/jbc.m404164200
    166 https://doi.org/10.1074/jbc.m406260200
    167 https://doi.org/10.1074/jbc.m500596200
    168 https://doi.org/10.1074/jbc.m501686200
    169 https://doi.org/10.1074/jbc.m504745200
    170 https://doi.org/10.1074/jbc.m508210200
    171 https://doi.org/10.1074/jbc.m510422200
    172 https://doi.org/10.1074/jbc.m600807200
    173 https://doi.org/10.1074/jbc.m607227200
    174 https://doi.org/10.1074/jbc.m607591200
    175 https://doi.org/10.1074/jbc.m607756200
    176 https://doi.org/10.1074/jbc.m607849200
    177 https://doi.org/10.1074/jbc.m702577200
    178 https://doi.org/10.1074/jbc.m706535200
    179 https://doi.org/10.1074/jbc.m707205200
    180 https://doi.org/10.1083/jcb.200111004
    181 https://doi.org/10.1085/jgp.111.2.313
    182 https://doi.org/10.1085/jgp.20028605
    183 https://doi.org/10.1085/jgp.20028740
    184 https://doi.org/10.1085/jgp.20028752
    185 https://doi.org/10.1085/jgp.200308906
    186 https://doi.org/10.1085/jgp.200409236
    187 https://doi.org/10.1085/jgp.200810109
    188 https://doi.org/10.1085/jgp.200810153
    189 https://doi.org/10.1085/jgp.201010498
    190 https://doi.org/10.1085/jgp.201210810
    191 https://doi.org/10.1085/jgp.201311024
    192 https://doi.org/10.1093/emboj/19.11.2483
    193 https://doi.org/10.1093/hmg/9.17.2471
    194 https://doi.org/10.1097/00001756-200506210-00023
    195 https://doi.org/10.1111/j.1460-9568.2009.06702.x
    196 https://doi.org/10.1111/j.1460-9568.2009.06901.x
    197 https://doi.org/10.1111/j.1469-7793.2001.t01-1-00697.x
    198 https://doi.org/10.1113/jphysiol.2002.016352
    199 https://doi.org/10.1113/jphysiol.2004.065391
    200 https://doi.org/10.1113/jphysiol.2004.070839
    201 https://doi.org/10.1113/jphysiol.2004.081059
    202 https://doi.org/10.1113/jphysiol.2005.088377
    203 https://doi.org/10.1113/jphysiol.2005.097998
    204 https://doi.org/10.1113/jphysiol.2006.123059
    205 https://doi.org/10.1113/jphysiol.2007.144287
    206 https://doi.org/10.1113/jphysiol.2008.161257
    207 https://doi.org/10.1113/jphysiol.2008.165738
    208 https://doi.org/10.1113/jphysiol.2010.191999
    209 https://doi.org/10.1113/jphysiol.2010.200717
    210 https://doi.org/10.1113/jphysiol.2012.242842
    211 https://doi.org/10.1124/mol.107.040899
    212 https://doi.org/10.1124/pr.55.4.9
    213 https://doi.org/10.1126/science.1058519
    214 https://doi.org/10.1126/science.1062473
    215 https://doi.org/10.1126/science.1073140
    216 https://doi.org/10.1126/science.1083646
    217 https://doi.org/10.1126/science.1084370
    218 https://doi.org/10.1126/science.1098845
    219 https://doi.org/10.1126/science.1108609
    220 https://doi.org/10.1126/science.287.5461.2229
    221 https://doi.org/10.1126/stke.2722005re3
    222 https://doi.org/10.1128/jb.173.3.1120-1124.1991
    223 https://doi.org/10.1146/annurev.biochem.75.103004.142819
    224 https://doi.org/10.1146/annurev.neuro.29.051605.112958
    225 https://doi.org/10.1146/annurev.physiol.68.040204.100431
    226 https://doi.org/10.1146/annurev.physiol.68.040204.101406
    227 https://doi.org/10.1152/ajpcell.00351.2010
    228 https://doi.org/10.1152/ajpcell.00489.2009
    229 https://doi.org/10.1152/physiolgenomics.00322.2005
    230 https://doi.org/10.1152/physiolgenomics.2001.4.3.165
    231 https://doi.org/10.1155/2008/602870
    232 https://doi.org/10.1161/01.res.0000097263.10220.0c
    233 https://doi.org/10.1371/journal.pgen.1002041
    234 https://doi.org/10.1371/journal.pone.0010580
    235 https://doi.org/10.1371/journal.pone.0026218
    236 https://doi.org/10.1371/journal.pone.0031448
    237 https://doi.org/10.1371/journal.pone.0048437
    238 https://doi.org/10.1371/journal.pone.0059593
    239 https://doi.org/10.1523/jneurosci.0202-04.2004
    240 https://doi.org/10.1523/jneurosci.0237-05.2005
    241 https://doi.org/10.1523/jneurosci.0504-08.2008
    242 https://doi.org/10.1523/jneurosci.0890-04.2004
    243 https://doi.org/10.1523/jneurosci.0934-04.2004
    244 https://doi.org/10.1523/jneurosci.1384-09.2011
    245 https://doi.org/10.1523/jneurosci.1645-04.2004
    246 https://doi.org/10.1523/jneurosci.1696-08.2008
    247 https://doi.org/10.1523/jneurosci.1956-07.2007
    248 https://doi.org/10.1523/jneurosci.2108-10.2010
    249 https://doi.org/10.1523/jneurosci.23-04-01340.2003
    250 https://doi.org/10.1523/jneurosci.2324-07.2007
    251 https://doi.org/10.1523/jneurosci.2574-05.2005
    252 https://doi.org/10.1523/jneurosci.2580-10.2010
    253 https://doi.org/10.1523/jneurosci.2740-08.2008
    254 https://doi.org/10.1523/jneurosci.3189-10.2010
    255 https://doi.org/10.1523/jneurosci.3632-04.2005
    256 https://doi.org/10.1523/jneurosci.3752-06.2006
    257 https://doi.org/10.1523/jneurosci.4451-04.2005
    258 https://doi.org/10.1523/jneurosci.4778-08.2009
    259 https://doi.org/10.1523/jneurosci.4903-13.2014
    260 https://doi.org/10.1523/jneurosci.5080-05.2006
    261 https://doi.org/10.2174/138920111793937952
    262 schema:datePublished 2015
    263 schema:datePublishedReg 2015-01-01
    264 schema:description Temperature is one of the physical variables that cells and biological organisms constantly monitor to achieve homeostasis and maintain chemical reactions at a suitable speed for the living environment to which they are adapted. In order to monitor and maintain temperature on a constant basis, thermosensitive molecules were selected during evolution. One of the most remarkable sets of molecules acting as sensors is constituted by thermosensitive transient receptor potential channels (thermoTRP channels). TRP channels are a superfamily of non-selective tetrameric cation channels closely related to the classic superfamily of voltage-gated channels, having a set of distinctive sequence elements in common, while acting as polymodal receptors. This latter ability is what makes them suitable for integrating many kinds of signals in different cells, ranging from chemical to physical stimulation (i.e.: temperature-, mechano- and chemo-sensitivity). These channels act as allosteric proteins modifying sensitivity to one stimulus in the presence of another, and thus allowing the integration of many different signaling processes that are critical for sensing the extracellular and intracellular environment and for maintaining homeostasis. This ability has made them vital for life support. Several subfamilies of TRP channels have been described. From these subfamilies, some types of channels have been distinguished as being temperature-sensitive, such as TRPV1–4, TRPM 2–5/8, TRPA1 and TRPC5. In this chapter, thermosensitivity will be defined. Then, we will describe the thermosensitive molecules identified so far, focusing our analysis on ion channels, particularly on thermosensitive TRP channels involved in sensory transduction. Their gating and permeation properties and gating modifiers shall be at the center of the discussion so as to place them in the context of ion channels and life evolution.
    265 schema:editor N1667b9f9fc89430c8cde9c844a0262b0
    266 schema:genre chapter
    267 schema:inLanguage en
    268 schema:isAccessibleForFree false
    269 schema:isPartOf N3e51061bb7d44931aea7535106212b42
    270 schema:name Biophysical and Molecular Features of Thermosensitive TRP Channels Involved in Sensory Transduction
    271 schema:pagination 1-39
    272 schema:productId N3f1a044c436b44d48a692af502e23596
    273 Nbb28f63a4e434571af41a60656e222e4
    274 Ne6b2cfe247314d96ac7a9dc2326789bc
    275 schema:publisher N73ebd8914fc14d41bd269b903a770f81
    276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042000199
    277 https://doi.org/10.1007/978-3-319-18705-1_1
    278 schema:sdDatePublished 2019-04-15T22:52
    279 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    280 schema:sdPublisher Nf4de05f39f574dfe8b5d217ed3bb2693
    281 schema:url http://link.springer.com/10.1007/978-3-319-18705-1_1
    282 sgo:license sg:explorer/license/
    283 sgo:sdDataset chapters
    284 rdf:type schema:Chapter
    285 N0036a3135dd04fedb296c1fe11251d7a schema:familyName Bacigalupo
    286 schema:givenName Juan
    287 rdf:type schema:Person
    288 N14caa7d7a1af4a06b52e9c687ada0cf6 rdf:first N0036a3135dd04fedb296c1fe11251d7a
    289 rdf:rest rdf:nil
    290 N1667b9f9fc89430c8cde9c844a0262b0 rdf:first N9a4853cdf5084db6b85cc67e60847fef
    291 rdf:rest N14caa7d7a1af4a06b52e9c687ada0cf6
    292 N1a57178c7ced48e9ba3496b2dfe9a690 schema:name Facultad de Ciencias, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaiso
    293 rdf:type schema:Organization
    294 N1fabe2a4a739442d8a2dbfb12fc50ffd rdf:first sg:person.016655564201.66
    295 rdf:rest N77fa747d54ff40b1a209d28a3cb3d6b9
    296 N3966776f7aac45048c1dea2f44c8509d schema:name Facultad de Ciencias, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaiso
    297 rdf:type schema:Organization
    298 N3e51061bb7d44931aea7535106212b42 schema:isbn 978-3-319-18704-4
    299 978-3-319-18705-1
    300 schema:name TRP Channels in Sensory Transduction
    301 rdf:type schema:Book
    302 N3f1a044c436b44d48a692af502e23596 schema:name doi
    303 schema:value 10.1007/978-3-319-18705-1_1
    304 rdf:type schema:PropertyValue
    305 N73ebd8914fc14d41bd269b903a770f81 schema:location Cham
    306 schema:name Springer International Publishing
    307 rdf:type schema:Organisation
    308 N77fa747d54ff40b1a209d28a3cb3d6b9 rdf:first sg:person.01324545661.99
    309 rdf:rest N8a2e972bd8664c6684a97bfe1e66f84c
    310 N8a2e972bd8664c6684a97bfe1e66f84c rdf:first sg:person.0703447630.48
    311 rdf:rest rdf:nil
    312 N98390951c30a4c9391a7a2dfd2cfa3e3 rdf:first sg:person.01142577753.59
    313 rdf:rest Nf9647f66028e4da8adcb1de762c14f95
    314 N9a4853cdf5084db6b85cc67e60847fef schema:familyName Madrid
    315 schema:givenName Rodolfo
    316 rdf:type schema:Person
    317 N9e4cba49d6ab4e7d84f65480aec153c2 schema:name Facultad de Ciencias, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaiso
    318 rdf:type schema:Organization
    319 Nbb28f63a4e434571af41a60656e222e4 schema:name dimensions_id
    320 schema:value pub.1042000199
    321 rdf:type schema:PropertyValue
    322 Ne6b2cfe247314d96ac7a9dc2326789bc schema:name readcube_id
    323 schema:value c811b1a28dca28a327b1c3649a78febbd397680f2e8a86efde73c271a4cf2938
    324 rdf:type schema:PropertyValue
    325 Nec4f8ab9a7c94bc695c07b968c073d8b schema:name Facultad de Ciencias, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaiso
    326 rdf:type schema:Organization
    327 Nf4de05f39f574dfe8b5d217ed3bb2693 schema:name Springer Nature - SN SciGraph project
    328 rdf:type schema:Organization
    329 Nf9647f66028e4da8adcb1de762c14f95 rdf:first sg:person.01064740766.41
    330 rdf:rest N1fabe2a4a739442d8a2dbfb12fc50ffd
    331 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    332 schema:name Biological Sciences
    333 rdf:type schema:DefinedTerm
    334 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    335 schema:name Biochemistry and Cell Biology
    336 rdf:type schema:DefinedTerm
    337 sg:person.01064740766.41 schema:affiliation N1a57178c7ced48e9ba3496b2dfe9a690
    338 schema:familyName Raddatz
    339 schema:givenName Natalia
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064740766.41
    341 rdf:type schema:Person
    342 sg:person.01142577753.59 schema:affiliation https://www.grid.ac/institutes/grid.11630.35
    343 schema:familyName Ferreira
    344 schema:givenName Gonzalo
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142577753.59
    346 rdf:type schema:Person
    347 sg:person.01324545661.99 schema:affiliation N9e4cba49d6ab4e7d84f65480aec153c2
    348 schema:familyName González
    349 schema:givenName Carlos
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324545661.99
    351 rdf:type schema:Person
    352 sg:person.016655564201.66 schema:affiliation Nec4f8ab9a7c94bc695c07b968c073d8b
    353 schema:familyName Lorenzo
    354 schema:givenName Yenisleidy
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016655564201.66
    356 rdf:type schema:Person
    357 sg:person.0703447630.48 schema:affiliation N3966776f7aac45048c1dea2f44c8509d
    358 schema:familyName Latorre
    359 schema:givenName Ramón
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703447630.48
    361 rdf:type schema:Person
    362 sg:pub.10.1007/978-3-0348-7781-7_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026477366
    363 https://doi.org/10.1007/978-3-0348-7781-7_7
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1007/978-3-540-34891-7_14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047141107
    366 https://doi.org/10.1007/978-3-540-34891-7_14
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1007/978-3-540-34891-7_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046448435
    369 https://doi.org/10.1007/978-3-540-34891-7_16
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1007/978-3-540-34891-7_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025998826
    372 https://doi.org/10.1007/978-3-540-34891-7_6
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1007/978-94-007-0265-3_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032934438
    375 https://doi.org/10.1007/978-94-007-0265-3_1
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1007/978-94-007-0265-3_20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053024369
    378 https://doi.org/10.1007/978-94-007-0265-3_20
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1007/978-94-007-0265-3_26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035671967
    381 https://doi.org/10.1007/978-94-007-0265-3_26
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1007/978-94-007-0265-3_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022535430
    384 https://doi.org/10.1007/978-94-007-0265-3_8
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1007/bf00581552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045833579
    387 https://doi.org/10.1007/bf00581552
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1007/s00424-003-1221-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046798381
    390 https://doi.org/10.1007/s00424-003-1221-x
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1007/s00424-005-1437-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1028470114
    393 https://doi.org/10.1007/s00424-005-1437-z
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1007/s00424-005-1467-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032292347
    396 https://doi.org/10.1007/s00424-005-1467-6
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1007/s00424-009-0703-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008603661
    399 https://doi.org/10.1007/s00424-009-0703-x
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1007/s00424-012-1158-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1047693657
    402 https://doi.org/10.1007/s00424-012-1158-z
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1007/s00424-012-1204-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030127469
    405 https://doi.org/10.1007/s00424-012-1204-x
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1007/s00424-013-1292-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022323552
    408 https://doi.org/10.1007/s00424-013-1292-2
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1007/s00424-013-1392-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1042205277
    411 https://doi.org/10.1007/s00424-013-1392-z
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1007/s00726-010-0712-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035075241
    414 https://doi.org/10.1007/s00726-010-0712-2
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1007/s12551-009-0020-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028710147
    417 https://doi.org/10.1007/s12551-009-0020-9
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1038/18906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046797649
    420 https://doi.org/10.1038/18906
    421 rdf:type schema:CreativeWork
    422 sg:pub.10.1038/224285a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034038812
    423 https://doi.org/10.1038/224285a0
    424 rdf:type schema:CreativeWork
    425 sg:pub.10.1038/35036318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029741434
    426 https://doi.org/10.1038/35036318
    427 rdf:type schema:CreativeWork
    428 sg:pub.10.1038/35077544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024001280
    429 https://doi.org/10.1038/35077544
    430 rdf:type schema:CreativeWork
    431 sg:pub.10.1038/35079092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046105258
    432 https://doi.org/10.1038/35079092
    433 rdf:type schema:CreativeWork
    434 sg:pub.10.1038/35079100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005359703
    435 https://doi.org/10.1038/35079100
    436 rdf:type schema:CreativeWork
    437 sg:pub.10.1038/367179a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007191771
    438 https://doi.org/10.1038/367179a0
    439 rdf:type schema:CreativeWork
    440 sg:pub.10.1038/39807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005468710
    441 https://doi.org/10.1038/39807
    442 rdf:type schema:CreativeWork
    443 sg:pub.10.1038/423822a schema:sameAs https://app.dimensions.ai/details/publication/pub.1047717110
    444 https://doi.org/10.1038/423822a
    445 rdf:type schema:CreativeWork
    446 sg:pub.10.1038/79095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050313039
    447 https://doi.org/10.1038/79095
    448 rdf:type schema:CreativeWork
    449 sg:pub.10.1038/nature00882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014675898
    450 https://doi.org/10.1038/nature00882
    451 rdf:type schema:CreativeWork
    452 sg:pub.10.1038/nature00894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006281558
    453 https://doi.org/10.1038/nature00894
    454 rdf:type schema:CreativeWork
    455 sg:pub.10.1038/nature01733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025006672
    456 https://doi.org/10.1038/nature01733
    457 rdf:type schema:CreativeWork
    458 sg:pub.10.1038/nature02196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009114829
    459 https://doi.org/10.1038/nature02196
    460 rdf:type schema:CreativeWork
    461 sg:pub.10.1038/nature02282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037386936
    462 https://doi.org/10.1038/nature02282
    463 rdf:type schema:CreativeWork
    464 sg:pub.10.1038/nature02732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034791748
    465 https://doi.org/10.1038/nature02732
    466 rdf:type schema:CreativeWork
    467 sg:pub.10.1038/nature04248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002522697
    468 https://doi.org/10.1038/nature04248
    469 rdf:type schema:CreativeWork
    470 sg:pub.10.1038/nature05910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035284521
    471 https://doi.org/10.1038/nature05910
    472 rdf:type schema:CreativeWork
    473 sg:pub.10.1038/nature08943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002291889
    474 https://doi.org/10.1038/nature08943
    475 rdf:type schema:CreativeWork
    476 sg:pub.10.1038/nature10715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042434383
    477 https://doi.org/10.1038/nature10715
    478 rdf:type schema:CreativeWork
    479 sg:pub.10.1038/nature12822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042852549
    480 https://doi.org/10.1038/nature12822
    481 rdf:type schema:CreativeWork
    482 sg:pub.10.1038/nature12823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036688363
    483 https://doi.org/10.1038/nature12823
    484 rdf:type schema:CreativeWork
    485 sg:pub.10.1038/nature719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044215674
    486 https://doi.org/10.1038/nature719
    487 rdf:type schema:CreativeWork
    488 sg:pub.10.1038/ncb1801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013396858
    489 https://doi.org/10.1038/ncb1801
    490 rdf:type schema:CreativeWork
    491 sg:pub.10.1038/nchembio821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036537818
    492 https://doi.org/10.1038/nchembio821
    493 rdf:type schema:CreativeWork
    494 sg:pub.10.1038/nchembio862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049348245
    495 https://doi.org/10.1038/nchembio862
    496 rdf:type schema:CreativeWork
    497 sg:pub.10.1038/ncomms3501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001583254
    498 https://doi.org/10.1038/ncomms3501
    499 rdf:type schema:CreativeWork
    500 sg:pub.10.1038/ng1076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037681936
    501 https://doi.org/10.1038/ng1076
    502 rdf:type schema:CreativeWork
    503 sg:pub.10.1038/ng889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045735975
    504 https://doi.org/10.1038/ng889
    505 rdf:type schema:CreativeWork
    506 sg:pub.10.1038/ng901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026327319
    507 https://doi.org/10.1038/ng901
    508 rdf:type schema:CreativeWork
    509 sg:pub.10.1038/nn.2169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031246864
    510 https://doi.org/10.1038/nn.2169
    511 rdf:type schema:CreativeWork
    512 sg:pub.10.1038/nn.2552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038705790
    513 https://doi.org/10.1038/nn.2552
    514 rdf:type schema:CreativeWork
    515 sg:pub.10.1038/nn0508-528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039994048
    516 https://doi.org/10.1038/nn0508-528
    517 rdf:type schema:CreativeWork
    518 sg:pub.10.1038/nn0602-852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007761325
    519 https://doi.org/10.1038/nn0602-852
    520 rdf:type schema:CreativeWork
    521 sg:pub.10.1038/nn1451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017065104
    522 https://doi.org/10.1038/nn1451
    523 rdf:type schema:CreativeWork
    524 sg:pub.10.1038/nn1665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021696391
    525 https://doi.org/10.1038/nn1665
    526 rdf:type schema:CreativeWork
    527 sg:pub.10.1038/nn1692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053745509
    528 https://doi.org/10.1038/nn1692
    529 rdf:type schema:CreativeWork
    530 sg:pub.10.1038/nn1843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015824551
    531 https://doi.org/10.1038/nn1843
    532 rdf:type schema:CreativeWork
    533 sg:pub.10.1038/nn2056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038530879
    534 https://doi.org/10.1038/nn2056
    535 rdf:type schema:CreativeWork
    536 sg:pub.10.1038/nrm1403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041144702
    537 https://doi.org/10.1038/nrm1403
    538 rdf:type schema:CreativeWork
    539 sg:pub.10.1186/1471-2148-14-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049065341
    540 https://doi.org/10.1186/1471-2148-14-3
    541 rdf:type schema:CreativeWork
    542 sg:pub.10.1186/1744-8069-5-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027378111
    543 https://doi.org/10.1186/1744-8069-5-3
    544 rdf:type schema:CreativeWork
    545 sg:pub.10.1186/1744-8069-5-62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000880172
    546 https://doi.org/10.1186/1744-8069-5-62
    547 rdf:type schema:CreativeWork
    548 sg:pub.10.1186/gb-2011-12-3-218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022480513
    549 https://doi.org/10.1186/gb-2011-12-3-218
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1016/0014-5793(95)01038-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1020268832
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1016/0896-6273(89)90069-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044047291
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1016/0896-6273(92)90085-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1021732029
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1016/0896-6273(92)90086-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1037980025
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1016/j.bbamcr.2009.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026827332
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1016/j.bbrc.2005.05.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049768025
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1016/j.bbrc.2010.03.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043415713
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1016/j.bpj.2009.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022338073
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1016/j.bpj.2013.03.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046524129
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1016/j.ceca.2006.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016610693
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1016/j.ceca.2007.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008861173
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1016/j.ceca.2007.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009696714
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1016/j.cell.2006.02.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020428657
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1016/j.cub.2005.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019323662
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1016/j.febslet.2004.04.080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046841714
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1016/j.neuron.2004.08.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033974839
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1016/j.neuron.2006.03.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017268716
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1016/j.neuron.2006.06.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052897568
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1016/j.neuron.2007.02.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005365990
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1016/j.neuron.2007.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034088876
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1016/j.neuron.2007.05.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002812795
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1016/j.neuron.2008.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027176861
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1016/j.neuron.2011.02.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031363619
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1016/j.neuron.2012.12.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037970485
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1016/j.pain.2005.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042075466
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1016/j.semcdb.2006.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021782388
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1016/j.str.2013.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022658462
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1016/s0002-9297(07)62941-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018772203
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.1016/s0006-3495(03)74719-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043296479
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.1016/s0006-3495(60)86871-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001041121
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.1016/s0014-5793(00)02212-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049494555
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.1016/s0079-6123(08)62027-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052954486
    614 rdf:type schema:CreativeWork
    615 https://doi.org/10.1016/s0092-8674(00)00143-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006605513
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.1016/s0092-8674(02)00637-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027077586
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.1016/s0092-8674(02)00652-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044720269
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.1016/s0092-8674(02)00670-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004300715
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.1016/s0092-8674(02)00719-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010221844
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.1016/s0092-8674(03)00158-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041856635
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.1016/s0143-4160(03)00044-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041985220
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.1016/s0143-4160(03)00057-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051463292
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.1016/s0165-6147(00)01832-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036477605
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.1016/s0896-6273(00)80564-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001338216
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.1016/s0896-6273(00)81135-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030883899
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.1016/s0896-6273(04)00150-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022676499
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.1016/s0959-4388(03)00101-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030409285
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.1016/s0960-9822(03)00431-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018517565
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.1016/s0966-842x(97)01080-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005876391
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.1016/s0968-0004(98)01279-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034177061
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.1016/s1097-2765(02)00448-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035078099
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.1016/s1532-0456(01)00267-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038854589
    650 rdf:type schema:CreativeWork
    651 https://doi.org/10.1038/sj.bjp.0705467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011657597
    652 rdf:type schema:CreativeWork
    653 https://doi.org/10.1038/sj.bjp.0705924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029463845
    654 rdf:type schema:CreativeWork
    655 https://doi.org/10.1038/sj.bjp.0706040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031733825
    656 rdf:type schema:CreativeWork
    657 https://doi.org/10.1038/sj.emboj.7600795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009014356
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.1038/sj.emboj.7601083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027094175
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.1039/b801481g schema:sameAs https://app.dimensions.ai/details/publication/pub.1051041679
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.1042/bj20060166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026872459
    664 rdf:type schema:CreativeWork
    665 https://doi.org/10.1042/bj20101256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021156351
    666 rdf:type schema:CreativeWork
    667 https://doi.org/10.1042/bj3110041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052581536
    668 rdf:type schema:CreativeWork
    669 https://doi.org/10.1046/j.1365-2958.1998.01049.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048360114
    670 rdf:type schema:CreativeWork
    671 https://doi.org/10.1073/pnas.0406773101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045618855
    672 rdf:type schema:CreativeWork
    673 https://doi.org/10.1073/pnas.0703420104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047364115
    674 rdf:type schema:CreativeWork
    675 https://doi.org/10.1073/pnas.0808487106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037274847
    676 rdf:type schema:CreativeWork
    677 https://doi.org/10.1073/pnas.1000357107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004944890
    678 rdf:type schema:CreativeWork
    679 https://doi.org/10.1073/pnas.100129497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010566669
    680 rdf:type schema:CreativeWork
    681 https://doi.org/10.1073/pnas.102596199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026445650
    682 rdf:type schema:CreativeWork
    683 https://doi.org/10.1073/pnas.1105196108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025179525
    684 rdf:type schema:CreativeWork
    685 https://doi.org/10.1073/pnas.1114124108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003107649
    686 rdf:type schema:CreativeWork
    687 https://doi.org/10.1073/pnas.1115387108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005569380
    688 rdf:type schema:CreativeWork
    689 https://doi.org/10.1073/pnas.1337252100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033351968
    690 rdf:type schema:CreativeWork
    691 https://doi.org/10.1073/pnas.141036198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004129775
    692 rdf:type schema:CreativeWork
    693 https://doi.org/10.1073/pnas.92.21.9652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005090185
    694 rdf:type schema:CreativeWork
    695 https://doi.org/10.1073/pnas.93.26.15435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030264553
    696 rdf:type schema:CreativeWork
    697 https://doi.org/10.1073/pnas.97.11.6155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040203850
    698 rdf:type schema:CreativeWork
    699 https://doi.org/10.1074/jbc.m002391200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043125566
    700 rdf:type schema:CreativeWork
    701 https://doi.org/10.1074/jbc.m006184200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011173603
    702 rdf:type schema:CreativeWork
    703 https://doi.org/10.1074/jbc.m109.052548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013279978
    704 rdf:type schema:CreativeWork
    705 https://doi.org/10.1074/jbc.m110.106153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030853318
    706 rdf:type schema:CreativeWork
    707 https://doi.org/10.1074/jbc.m110.145466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009231656
    708 rdf:type schema:CreativeWork
    709 https://doi.org/10.1074/jbc.m110.192526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003704583
    710 rdf:type schema:CreativeWork
    711 https://doi.org/10.1074/jbc.m111.223941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034997233
    712 rdf:type schema:CreativeWork
    713 https://doi.org/10.1074/jbc.m111.270256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003012502
    714 rdf:type schema:CreativeWork
    715 https://doi.org/10.1074/jbc.m111.272823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013257881
    716 rdf:type schema:CreativeWork
    717 https://doi.org/10.1074/jbc.m111.273581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046787029
    718 rdf:type schema:CreativeWork
    719 https://doi.org/10.1074/jbc.m111.312645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009646141
    720 rdf:type schema:CreativeWork
    721 https://doi.org/10.1074/jbc.m112.341859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000386570
    722 rdf:type schema:CreativeWork
    723 https://doi.org/10.1074/jbc.m112.362194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053423952
    724 rdf:type schema:CreativeWork
    725 https://doi.org/10.1074/jbc.m200062200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044404936
    726 rdf:type schema:CreativeWork
    727 https://doi.org/10.1074/jbc.m204828200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017698402
    728 rdf:type schema:CreativeWork
    729 https://doi.org/10.1074/jbc.m207882200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046729788
    730 rdf:type schema:CreativeWork
    731 https://doi.org/10.1074/jbc.m208277200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038594305
    732 rdf:type schema:CreativeWork
    733 https://doi.org/10.1074/jbc.m210810200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032933590
    734 rdf:type schema:CreativeWork
    735 https://doi.org/10.1074/jbc.m300945200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002508022
    736 rdf:type schema:CreativeWork
    737 https://doi.org/10.1074/jbc.m302590200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033892944
    738 rdf:type schema:CreativeWork
    739 https://doi.org/10.1074/jbc.m303251200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010963625
    740 rdf:type schema:CreativeWork
    741 https://doi.org/10.1074/jbc.m305127200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041383315
    742 rdf:type schema:CreativeWork
    743 https://doi.org/10.1074/jbc.m306705200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044879521
    744 rdf:type schema:CreativeWork
    745 https://doi.org/10.1074/jbc.m402966200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001727625
    746 rdf:type schema:CreativeWork
    747 https://doi.org/10.1074/jbc.m404164200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011726365
    748 rdf:type schema:CreativeWork
    749 https://doi.org/10.1074/jbc.m406260200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016387999
    750 rdf:type schema:CreativeWork
    751 https://doi.org/10.1074/jbc.m500596200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023176442
    752 rdf:type schema:CreativeWork
    753 https://doi.org/10.1074/jbc.m501686200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030568900
    754 rdf:type schema:CreativeWork
    755 https://doi.org/10.1074/jbc.m504745200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007863668
    756 rdf:type schema:CreativeWork
    757 https://doi.org/10.1074/jbc.m508210200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053452541
    758 rdf:type schema:CreativeWork
    759 https://doi.org/10.1074/jbc.m510422200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006216894
    760 rdf:type schema:CreativeWork
    761 https://doi.org/10.1074/jbc.m600807200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009492519
    762 rdf:type schema:CreativeWork
    763 https://doi.org/10.1074/jbc.m607227200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039788534
    764 rdf:type schema:CreativeWork
    765 https://doi.org/10.1074/jbc.m607591200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034996447
    766 rdf:type schema:CreativeWork
    767 https://doi.org/10.1074/jbc.m607756200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017974650
    768 rdf:type schema:CreativeWork
    769 https://doi.org/10.1074/jbc.m607849200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002873906
    770 rdf:type schema:CreativeWork
    771 https://doi.org/10.1074/jbc.m702577200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041242812
    772 rdf:type schema:CreativeWork
    773 https://doi.org/10.1074/jbc.m706535200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025887588
    774 rdf:type schema:CreativeWork
    775 https://doi.org/10.1074/jbc.m707205200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013941501
    776 rdf:type schema:CreativeWork
    777 https://doi.org/10.1083/jcb.200111004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008266374
    778 rdf:type schema:CreativeWork
    779 https://doi.org/10.1085/jgp.111.2.313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041282282
    780 rdf:type schema:CreativeWork
    781 https://doi.org/10.1085/jgp.20028605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021385339
    782 rdf:type schema:CreativeWork
    783 https://doi.org/10.1085/jgp.20028740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022104573
    784 rdf:type schema:CreativeWork
    785 https://doi.org/10.1085/jgp.20028752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003502394
    786 rdf:type schema:CreativeWork
    787 https://doi.org/10.1085/jgp.200308906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024188771
    788 rdf:type schema:CreativeWork
    789 https://doi.org/10.1085/jgp.200409236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021917311
    790 rdf:type schema:CreativeWork
    791 https://doi.org/10.1085/jgp.200810109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009905950
    792 rdf:type schema:CreativeWork
    793 https://doi.org/10.1085/jgp.200810153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038946905
    794 rdf:type schema:CreativeWork
    795 https://doi.org/10.1085/jgp.201010498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002940492
    796 rdf:type schema:CreativeWork
    797 https://doi.org/10.1085/jgp.201210810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027514784
    798 rdf:type schema:CreativeWork
    799 https://doi.org/10.1085/jgp.201311024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034901972
    800 rdf:type schema:CreativeWork
    801 https://doi.org/10.1093/emboj/19.11.2483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024002152
    802 rdf:type schema:CreativeWork
    803 https://doi.org/10.1093/hmg/9.17.2471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029421993
    804 rdf:type schema:CreativeWork
    805 https://doi.org/10.1097/00001756-200506210-00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048941847
    806 rdf:type schema:CreativeWork
    807 https://doi.org/10.1111/j.1460-9568.2009.06702.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034031929
    808 rdf:type schema:CreativeWork
    809 https://doi.org/10.1111/j.1460-9568.2009.06901.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053637455
    810 rdf:type schema:CreativeWork
    811 https://doi.org/10.1111/j.1469-7793.2001.t01-1-00697.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009446179
    812 rdf:type schema:CreativeWork
    813 https://doi.org/10.1113/jphysiol.2002.016352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005129773
    814 rdf:type schema:CreativeWork
    815 https://doi.org/10.1113/jphysiol.2004.065391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034948262
    816 rdf:type schema:CreativeWork
    817 https://doi.org/10.1113/jphysiol.2004.070839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028654832
    818 rdf:type schema:CreativeWork
    819 https://doi.org/10.1113/jphysiol.2004.081059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003963913
    820 rdf:type schema:CreativeWork
    821 https://doi.org/10.1113/jphysiol.2005.088377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044843517
    822 rdf:type schema:CreativeWork
    823 https://doi.org/10.1113/jphysiol.2005.097998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010735471
    824 rdf:type schema:CreativeWork
    825 https://doi.org/10.1113/jphysiol.2006.123059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041605996
    826 rdf:type schema:CreativeWork
    827 https://doi.org/10.1113/jphysiol.2007.144287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027762954
    828 rdf:type schema:CreativeWork
    829 https://doi.org/10.1113/jphysiol.2008.161257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028466419
    830 rdf:type schema:CreativeWork
    831 https://doi.org/10.1113/jphysiol.2008.165738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031755200
    832 rdf:type schema:CreativeWork
    833 https://doi.org/10.1113/jphysiol.2010.191999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001435943
    834 rdf:type schema:CreativeWork
    835 https://doi.org/10.1113/jphysiol.2010.200717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028576080
    836 rdf:type schema:CreativeWork
    837 https://doi.org/10.1113/jphysiol.2012.242842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031005706
    838 rdf:type schema:CreativeWork
    839 https://doi.org/10.1124/mol.107.040899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052896891
    840 rdf:type schema:CreativeWork
    841 https://doi.org/10.1124/pr.55.4.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048347718
    842 rdf:type schema:CreativeWork
    843 https://doi.org/10.1126/science.1058519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062444425
    844 rdf:type schema:CreativeWork
    845 https://doi.org/10.1126/science.1062473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050449731
    846 rdf:type schema:CreativeWork
    847 https://doi.org/10.1126/science.1073140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446663
    848 rdf:type schema:CreativeWork
    849 https://doi.org/10.1126/science.1083646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448038
    850 rdf:type schema:CreativeWork
    851 https://doi.org/10.1126/science.1084370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041129516
    852 rdf:type schema:CreativeWork
    853 https://doi.org/10.1126/science.1098845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449700
    854 rdf:type schema:CreativeWork
    855 https://doi.org/10.1126/science.1108609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062451506
    856 rdf:type schema:CreativeWork
    857 https://doi.org/10.1126/science.287.5461.2229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062568865
    858 rdf:type schema:CreativeWork
    859 https://doi.org/10.1126/stke.2722005re3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062692561
    860 rdf:type schema:CreativeWork
    861 https://doi.org/10.1128/jb.173.3.1120-1124.1991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062720130
    862 rdf:type schema:CreativeWork
    863 https://doi.org/10.1146/annurev.biochem.75.103004.142819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033906151
    864 rdf:type schema:CreativeWork
    865 https://doi.org/10.1146/annurev.neuro.29.051605.112958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004133517
    866 rdf:type schema:CreativeWork
    867 https://doi.org/10.1146/annurev.physiol.68.040204.100431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032055653
    868 rdf:type schema:CreativeWork
    869 https://doi.org/10.1146/annurev.physiol.68.040204.101406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014971350
    870 rdf:type schema:CreativeWork
    871 https://doi.org/10.1152/ajpcell.00351.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003821757
    872 rdf:type schema:CreativeWork
    873 https://doi.org/10.1152/ajpcell.00489.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030958428
    874 rdf:type schema:CreativeWork
    875 https://doi.org/10.1152/physiolgenomics.00322.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037397883
    876 rdf:type schema:CreativeWork
    877 https://doi.org/10.1152/physiolgenomics.2001.4.3.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074751852
    878 rdf:type schema:CreativeWork
    879 https://doi.org/10.1155/2008/602870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026679844
    880 rdf:type schema:CreativeWork
    881 https://doi.org/10.1161/01.res.0000097263.10220.0c schema:sameAs https://app.dimensions.ai/details/publication/pub.1018965511
    882 rdf:type schema:CreativeWork
    883 https://doi.org/10.1371/journal.pgen.1002041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001066920
    884 rdf:type schema:CreativeWork
    885 https://doi.org/10.1371/journal.pone.0010580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033896693
    886 rdf:type schema:CreativeWork
    887 https://doi.org/10.1371/journal.pone.0026218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010977471
    888 rdf:type schema:CreativeWork
    889 https://doi.org/10.1371/journal.pone.0031448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021846931
    890 rdf:type schema:CreativeWork
    891 https://doi.org/10.1371/journal.pone.0048437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051218193
    892 rdf:type schema:CreativeWork
    893 https://doi.org/10.1371/journal.pone.0059593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045627130
    894 rdf:type schema:CreativeWork
    895 https://doi.org/10.1523/jneurosci.0202-04.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051623289
    896 rdf:type schema:CreativeWork
    897 https://doi.org/10.1523/jneurosci.0237-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025949320
    898 rdf:type schema:CreativeWork
    899 https://doi.org/10.1523/jneurosci.0504-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033730493
    900 rdf:type schema:CreativeWork
    901 https://doi.org/10.1523/jneurosci.0890-04.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050192797
    902 rdf:type schema:CreativeWork
    903 https://doi.org/10.1523/jneurosci.0934-04.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024662825
    904 rdf:type schema:CreativeWork
    905 https://doi.org/10.1523/jneurosci.1384-09.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035863227
    906 rdf:type schema:CreativeWork
    907 https://doi.org/10.1523/jneurosci.1645-04.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023184705
    908 rdf:type schema:CreativeWork
    909 https://doi.org/10.1523/jneurosci.1696-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015366988
    910 rdf:type schema:CreativeWork
    911 https://doi.org/10.1523/jneurosci.1956-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045634452
    912 rdf:type schema:CreativeWork
    913 https://doi.org/10.1523/jneurosci.2108-10.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041581270
    914 rdf:type schema:CreativeWork
    915 https://doi.org/10.1523/jneurosci.23-04-01340.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075241252
    916 rdf:type schema:CreativeWork
    917 https://doi.org/10.1523/jneurosci.2324-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040708801
    918 rdf:type schema:CreativeWork
    919 https://doi.org/10.1523/jneurosci.2574-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015427564
    920 rdf:type schema:CreativeWork
    921 https://doi.org/10.1523/jneurosci.2580-10.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000695908
    922 rdf:type schema:CreativeWork
    923 https://doi.org/10.1523/jneurosci.2740-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015952106
    924 rdf:type schema:CreativeWork
    925 https://doi.org/10.1523/jneurosci.3189-10.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014415472
    926 rdf:type schema:CreativeWork
    927 https://doi.org/10.1523/jneurosci.3632-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000513766
    928 rdf:type schema:CreativeWork
    929 https://doi.org/10.1523/jneurosci.3752-06.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049432785
    930 rdf:type schema:CreativeWork
    931 https://doi.org/10.1523/jneurosci.4451-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002673187
    932 rdf:type schema:CreativeWork
    933 https://doi.org/10.1523/jneurosci.4778-08.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008206364
    934 rdf:type schema:CreativeWork
    935 https://doi.org/10.1523/jneurosci.4903-13.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031337274
    936 rdf:type schema:CreativeWork
    937 https://doi.org/10.1523/jneurosci.5080-05.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022808300
    938 rdf:type schema:CreativeWork
    939 https://doi.org/10.2174/138920111793937952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069177773
    940 rdf:type schema:CreativeWork
    941 https://www.grid.ac/institutes/grid.11630.35 schema:alternateName University of the Republic
    942 schema:name Departamento de Biofísica, Facultad de Medicina, Universidad de La República
    943 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...