Integrating Tissue Microenvironment with Scaffold Design to Promote Immune-Mediated Regeneration View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Kaitlyn Sadtler , Franck Housseau , Drew Pardoll , Jennifer H. Elisseeff

ABSTRACT

The role of tissue and immune microenvironments has played a large role in fields such as tumor immunology. Recently, there has been interest in the role of the immune microenvironment in tissue engineering, more specifically how that environment can influence regeneration. Immune cells secrete a diverse repertoire of signaling molecules that can influence other immune cells as well as surrounding parenchyma. In regenerating tissues, these signaling molecules become very important in tissue growth and differentiation. In vitro studies include the role of a scaffold in macrophage polarization, a critical determinant in regenerative success. In vivo innate and adaptive immune responses to varying scaffolds give us insights into the correct scaffold to choose for the goal tissue to be regenerated. By combining the optimum regenerative immune environment with the innate polarization tendencies of scaffolds, we will be better able to cater specific scaffolds to their applications and improve clinical outcomes. More... »

PAGES

35-51

References to SciGraph publications

Book

TITLE

Biomaterials in Regenerative Medicine and the Immune System

ISBN

978-3-319-18044-1
978-3-319-18045-8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-18045-8_3

DOI

http://dx.doi.org/10.1007/978-3-319-18045-8_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010329344


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