Synthetic High-Density Lipoprotein-Like Nanoparticles as Cancer Therapy View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2015

AUTHORS

Kaylin M. McMahon , Linda Foit , Nicholas L. Angeloni , Francis J. Giles , Leo I. Gordon , C. Shad Thaxton

ABSTRACT

High-density lipoproteins (HDL) are diverse natural nanoparticles that carry cholesterol and are best known for the role that they play in cardiovascular disease. However, due to their unique targeting capabilities, diverse molecular cargo, and natural functions beyond cholesterol transport, it is becoming increasingly appreciated that HDLs are critical to cancer development and progression. Accordingly, this chapter highlights ongoing research focused on the connections between HDL and cancer in order to design new drugs and targeted drug delivery vehicles. Research is focused on synthesizing biomimetic HDL-like nanoparticles (NP) that can be loaded with diverse therapeutic cargo (e.g., chemotherapies, nucleic acids, proteins) and specifically targeted to cancer cells. Beyond drug delivery, new data is emerging that HDL-like NPs may be therapeutically active in certain tumor types, for example, B cell lymphoma. Overall, HDL-like NPs are becoming increasingly appreciated as targeted, biocompatible, and efficient therapies for cancer, and may soon become indispensable agents in the cancer therapeutic armamentarium. More... »

PAGES

129-150

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  • Book

    TITLE

    Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer

    ISBN

    978-3-319-16554-7
    978-3-319-16555-4

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-16555-4_6

    DOI

    http://dx.doi.org/10.1007/978-3-319-16555-4_6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049992538

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25895867


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