Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1 View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Muhammad Akhtar , J. Neville Wright

ABSTRACT

Cytochrome P450 (P450 or CYP) enzymes in their resting state contain the heme-iron in a high-spin FeIII state. Binding of a substrate to a P450 enzyme allows transfer of the first electron, producing a Fe(II) species that reacts with oxygen to generate a low-spin iron superoxide intermediate (FeIII-O-O•) ready to accept the second electron to produce an iron peroxy anion intermediate (a, FeIII-O-O-). In classical monooxygenation reactions, the peroxy anion upon protonation fragments to form the reactive Compound I intermediate (Por•+FeIV=O), or its ferryl radical resonance form (FeIV-O•). However, when the substrate projects a carbonyl functionality, of the type b, at the active site as is the case for reactions catalyzed by CYP17A1, CYP19A1 and CYP51A1, the peroxy anion (FeIII-O-O-) is trapped, yielding a tetrahedral intermediate (c) that fragments to an acyl-carbon cleavage product (d plus an acid). Analogous acyl-carbon cleavage reactions are also catalyzed by certain hepatic P450s and CYP125A1 from Mycobacterium tuberculosis. A further improvisation on the theme is provided by aldehyde deformylases that convert long-chain aliphatic aldehydes to hydrocarbons. CYP17A1 is involved in the biosynthesis of corticoids as well as androgens. The flux toward these two classes of hormones seems to be regulated by cytochrome b 5, at the level of the acyl-carbon cleavage reaction. It is this regulation of CYP17A1 that provides a safety mechanism, ensuring that during corticoid biosynthesis, which requires 17α-hydroxylation by CYP17A1, androgen formation is avoided (Fig. 4.1). More... »

PAGES

107-130

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-16009-2_4

DOI

http://dx.doi.org/10.1007/978-3-319-16009-2_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012767662

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26002733


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenal Cortex Hormones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Androgens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aromatase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacterial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catalytic Domain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Iron", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mycobacterium tuberculosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Steroid 17-alpha-Hydroxylase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sterol 14-Demethylase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Superoxides", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Southampton", 
          "id": "https://www.grid.ac/institutes/grid.5491.9", 
          "name": [
            "School of Biological Sciences, University of the Punjab, New Campus, 54590, Lahore, Pakistan", 
            "Centre for Biological Sciences, University of Southampton, SO17 1BJ, Southampton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akhtar", 
        "givenName": "Muhammad", 
        "id": "sg:person.015572356512.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015572356512.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southampton", 
          "id": "https://www.grid.ac/institutes/grid.5491.9", 
          "name": [
            "Centre for Biological Sciences, University of Southampton, SO17 1BJ, Southampton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wright", 
        "givenName": "J. Neville", 
        "id": "sg:person.0775743326.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775743326.79"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1039/p19880002043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000541705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1140075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000743176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1140075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000743176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2265.2000.01144.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002104132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.1994.tb02469.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002817061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja906192b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003017259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja906192b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003017259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1097-201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003217230", 
          "https://doi.org/10.1038/ng1097-201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0960-0760(94)90082-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003332282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.8.2999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004926877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.21.12445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005564472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/np9910800527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006025418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m113.468926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008466761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja405047b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009301907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c39750000185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010460433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsbmb.2010.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011567518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.390047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012504840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3080901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012722630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3080901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012722630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1973.tb47610.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013498196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/0-387-27447-2_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015350911", 
          "https://doi.org/10.1007/0-387-27447-2_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1690449b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015970714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1690449b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015970714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2010569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018174011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2010569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018174011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/p19940000263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018589180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3320293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018639597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3320293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018639597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/202083b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018908384", 
          "https://doi.org/10.1038/202083b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.20.8963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022835897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1090318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023014018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1090318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023014018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m505261200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024078234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m501732200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024147100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0045-2068(77)90046-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025123707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.1995.1173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025407493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c39760000854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025818941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201300760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029579054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1210131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030343010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1210131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030343010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c39810000129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032003149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/3-540-46592-8_2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035609743", 
          "https://doi.org/10.1007/3-540-46592-8_2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/3-540-46592-8_2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035609743", 
          "https://doi.org/10.1007/3-540-46592-8_2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1969.tb00582.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036270132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1187936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036523636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/0-387-27447-2_1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037089212", 
          "https://doi.org/10.1007/0-387-27447-2_1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(61)90140-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037417023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039837934", 
          "https://doi.org/10.1038/nature07614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.103.026732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039891565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/203182b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040429177", 
          "https://doi.org/10.1038/203182b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1507/endocrj.45.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040632337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.abb.2012.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042500929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsbmb.2004.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042584118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2795(76)90340-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045025835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(85)91190-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045426853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c39940001501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045902625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3210857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046506112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3210857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046506112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0960-0760(92)90295-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046632473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.steroids.2010.11.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048660658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/40.7.1607640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050827365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/40.7.1607640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050827365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1250625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051071258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1250625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051071258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c39910000157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051938884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00043a015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055158513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00180a039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055164104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi0508744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055200601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi0508744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055200601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi051623y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055201033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi051623y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055201033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi300017p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055204871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00335a090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055724406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00848a046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055752657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja01015a074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055761385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja044716w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055836338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja044716w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055836338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja211499q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055851686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3420309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056714170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.150.3692.19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062486827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.831259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062654600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8342039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062654751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.143.4.8718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064284769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.76.5.8496319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064318120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.78.1.8288710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064318516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.84.9.6105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064322960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075736289", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075891276", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076555158", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080159204", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080320341", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081787292", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082235068", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082789142", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015", 
    "datePublishedReg": "2015-01-01", 
    "description": "Cytochrome P450 (P450 or CYP) enzymes in their resting state contain the heme-iron in a high-spin FeIII state. Binding of a substrate to a P450 enzyme allows transfer of the first electron, producing a Fe(II) species that reacts with oxygen to generate a low-spin iron superoxide intermediate (FeIII-O-O\u2022) ready to accept the second electron to produce an iron peroxy anion intermediate (a, FeIII-O-O-). In classical monooxygenation reactions, the peroxy anion upon protonation fragments to form the reactive Compound I intermediate (Por\u2022+FeIV=O), or its ferryl radical resonance form (FeIV-O\u2022). However, when the substrate projects a carbonyl functionality, of the type b, at the active site as is the case for reactions catalyzed by CYP17A1, CYP19A1 and CYP51A1, the peroxy anion (FeIII-O-O-) is trapped, yielding a tetrahedral intermediate (c) that fragments to an acyl-carbon cleavage product (d plus an acid). Analogous acyl-carbon cleavage reactions are also catalyzed by certain hepatic P450s and CYP125A1 from Mycobacterium tuberculosis. A further improvisation on the theme is provided by aldehyde deformylases that convert long-chain aliphatic aldehydes to hydrocarbons. CYP17A1 is involved in the biosynthesis of corticoids as well as androgens. The flux toward these two classes of hormones seems to be regulated by cytochrome b 5, at the level of the acyl-carbon cleavage reaction. It is this regulation of CYP17A1 that provides a safety mechanism, ensuring that during corticoid biosynthesis, which requires 17\u03b1-hydroxylation by CYP17A1, androgen formation is avoided (Fig. 4.1).", 
    "editor": [
      {
        "familyName": "Hrycay", 
        "givenName": "Eugene G.", 
        "type": "Person"
      }, 
      {
        "familyName": "Bandiera", 
        "givenName": "Stelvio M.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-319-16009-2_4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-319-16008-5", 
        "978-3-319-16009-2"
      ], 
      "name": "Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450", 
      "type": "Book"
    }, 
    "name": "Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1", 
    "pagination": "107-130", 
    "productId": [
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26002733"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012767662"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-319-16009-2_4"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3cd2ce4e5c15667744fc5ec07486c2697c188e66209b20405c823aa3ab8fa237"
        ]
      }
    ], 
    "publisher": {
      "location": "Cham", 
      "name": "Springer International Publishing", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-319-16009-2_4", 
      "https://app.dimensions.ai/details/publication/pub.1012767662"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T08:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000364_0000000364/records_72850_00000000.jsonl", 
    "type": "Chapter", 
    "url": "https://link.springer.com/10.1007%2F978-3-319-16009-2_4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-16009-2_4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-16009-2_4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-16009-2_4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-16009-2_4'


 

This table displays all metadata directly associated to this object as RDF triples.

366 TRIPLES      23 PREDICATES      119 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-319-16009-2_4 schema:about N0db84bb213414667917a1cb7dbe22271
2 N1a26387bc56e45a2a4809ae6de137ebc
3 N20e6bf1f8afd4c5aa94cb25de9155376
4 N5ead847b605d4aa39af61f905ec053ab
5 N6f7440f71d114ebcb3b32b6b533e2209
6 N85c77c4b5f3a40579b259120cb6d32fd
7 N8935362f4d3a46b1a5ef8064e03e3735
8 N906821d7795342ecbb1d3d0fc1bf9892
9 N989bd77452f74212a26ad77d6b52ef4d
10 Nbf2b50845ace4df789925aebaed88b49
11 Ne2a99b39c2a64157bf6f35ab7126d9cb
12 Nf91a3843bec54cf48ba8f0fb57626e4f
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author N7c7efc04633b4048975d1f0c219c7557
16 schema:citation sg:pub.10.1007/0-387-27447-2_1
17 sg:pub.10.1007/0-387-27447-2_5
18 sg:pub.10.1007/3-540-46592-8_2
19 sg:pub.10.1038/202083b0
20 sg:pub.10.1038/203182b0
21 sg:pub.10.1038/nature07614
22 sg:pub.10.1038/ng1097-201
23 https://app.dimensions.ai/details/publication/pub.1075736289
24 https://app.dimensions.ai/details/publication/pub.1075891276
25 https://app.dimensions.ai/details/publication/pub.1076555158
26 https://app.dimensions.ai/details/publication/pub.1080159204
27 https://app.dimensions.ai/details/publication/pub.1080320341
28 https://app.dimensions.ai/details/publication/pub.1081787292
29 https://app.dimensions.ai/details/publication/pub.1082235068
30 https://app.dimensions.ai/details/publication/pub.1082789142
31 https://doi.org/10.1002/anie.201300760
32 https://doi.org/10.1006/abbi.1995.1173
33 https://doi.org/10.1016/0005-2795(76)90340-8
34 https://doi.org/10.1016/0006-291x(61)90140-1
35 https://doi.org/10.1016/0006-291x(85)91190-8
36 https://doi.org/10.1016/0045-2068(77)90046-3
37 https://doi.org/10.1016/0960-0760(92)90295-t
38 https://doi.org/10.1016/0960-0760(94)90082-5
39 https://doi.org/10.1016/j.abb.2012.01.003
40 https://doi.org/10.1016/j.jsbmb.2004.07.005
41 https://doi.org/10.1016/j.jsbmb.2010.11.003
42 https://doi.org/10.1016/j.steroids.2010.11.011
43 https://doi.org/10.1021/bi00043a015
44 https://doi.org/10.1021/bi00180a039
45 https://doi.org/10.1021/bi0508744
46 https://doi.org/10.1021/bi051623y
47 https://doi.org/10.1021/bi300017p
48 https://doi.org/10.1021/ja00335a090
49 https://doi.org/10.1021/ja00848a046
50 https://doi.org/10.1021/ja01015a074
51 https://doi.org/10.1021/ja044716w
52 https://doi.org/10.1021/ja211499q
53 https://doi.org/10.1021/ja405047b
54 https://doi.org/10.1021/ja906192b
55 https://doi.org/10.1039/c39750000185
56 https://doi.org/10.1039/c39760000854
57 https://doi.org/10.1039/c39810000129
58 https://doi.org/10.1039/c39910000157
59 https://doi.org/10.1039/c39940001501
60 https://doi.org/10.1039/np9910800527
61 https://doi.org/10.1039/p19880002043
62 https://doi.org/10.1039/p19940000263
63 https://doi.org/10.1042/0264-6021:3420309
64 https://doi.org/10.1042/bj1090318
65 https://doi.org/10.1042/bj1140075
66 https://doi.org/10.1042/bj1210131
67 https://doi.org/10.1042/bj1250625
68 https://doi.org/10.1042/bj1690449b
69 https://doi.org/10.1042/bj2010569
70 https://doi.org/10.1042/bj3080901
71 https://doi.org/10.1042/bj3210857
72 https://doi.org/10.1042/bj3320293
73 https://doi.org/10.1046/j.1365-2265.2000.01144.x
74 https://doi.org/10.1073/pnas.87.8.2999
75 https://doi.org/10.1073/pnas.88.20.8963
76 https://doi.org/10.1074/jbc.271.21.12445
77 https://doi.org/10.1074/jbc.m112.390047
78 https://doi.org/10.1074/jbc.m113.468926
79 https://doi.org/10.1074/jbc.m501732200
80 https://doi.org/10.1074/jbc.m505261200
81 https://doi.org/10.1095/biolreprod.103.026732
82 https://doi.org/10.1111/j.1365-2265.1994.tb02469.x
83 https://doi.org/10.1111/j.1432-1033.1969.tb00582.x
84 https://doi.org/10.1111/j.1749-6632.1973.tb47610.x
85 https://doi.org/10.1126/science.1187936
86 https://doi.org/10.1126/science.150.3692.19
87 https://doi.org/10.1126/science.831259
88 https://doi.org/10.1126/science.8342039
89 https://doi.org/10.1177/40.7.1607640
90 https://doi.org/10.1210/endo.143.4.8718
91 https://doi.org/10.1210/jcem.76.5.8496319
92 https://doi.org/10.1210/jcem.78.1.8288710
93 https://doi.org/10.1210/jcem.84.9.6105
94 https://doi.org/10.1507/endocrj.45.89
95 schema:datePublished 2015
96 schema:datePublishedReg 2015-01-01
97 schema:description Cytochrome P450 (P450 or CYP) enzymes in their resting state contain the heme-iron in a high-spin FeIII state. Binding of a substrate to a P450 enzyme allows transfer of the first electron, producing a Fe(II) species that reacts with oxygen to generate a low-spin iron superoxide intermediate (FeIII-O-O•) ready to accept the second electron to produce an iron peroxy anion intermediate (a, FeIII-O-O-). In classical monooxygenation reactions, the peroxy anion upon protonation fragments to form the reactive Compound I intermediate (Por•+FeIV=O), or its ferryl radical resonance form (FeIV-O•). However, when the substrate projects a carbonyl functionality, of the type b, at the active site as is the case for reactions catalyzed by CYP17A1, CYP19A1 and CYP51A1, the peroxy anion (FeIII-O-O-) is trapped, yielding a tetrahedral intermediate (c) that fragments to an acyl-carbon cleavage product (d plus an acid). Analogous acyl-carbon cleavage reactions are also catalyzed by certain hepatic P450s and CYP125A1 from Mycobacterium tuberculosis. A further improvisation on the theme is provided by aldehyde deformylases that convert long-chain aliphatic aldehydes to hydrocarbons. CYP17A1 is involved in the biosynthesis of corticoids as well as androgens. The flux toward these two classes of hormones seems to be regulated by cytochrome b 5, at the level of the acyl-carbon cleavage reaction. It is this regulation of CYP17A1 that provides a safety mechanism, ensuring that during corticoid biosynthesis, which requires 17α-hydroxylation by CYP17A1, androgen formation is avoided (Fig. 4.1).
98 schema:editor Ne3d2b01987ec4217a7ea65a57e31d512
99 schema:genre chapter
100 schema:inLanguage en
101 schema:isAccessibleForFree false
102 schema:isPartOf N2dbb6d8e7197467791cb8bddf76e5160
103 schema:name Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1
104 schema:pagination 107-130
105 schema:productId N2cc7abe4bee74499be197e5ccb9ffdea
106 N8ea6e72f1b89439382006bddc09e675c
107 Na9905b24ddcb4704b8b067ebbe02679f
108 Nbe6e7d2a6e9947c299b60c040e90b1ce
109 schema:publisher N2110755edd414075b9859da6b71b941a
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012767662
111 https://doi.org/10.1007/978-3-319-16009-2_4
112 schema:sdDatePublished 2019-04-16T08:31
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher N861507f01a4b4fea9ea95ed477f39823
115 schema:url https://link.springer.com/10.1007%2F978-3-319-16009-2_4
116 sgo:license sg:explorer/license/
117 sgo:sdDataset chapters
118 rdf:type schema:Chapter
119 N0db84bb213414667917a1cb7dbe22271 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Humans
121 rdf:type schema:DefinedTerm
122 N1a26387bc56e45a2a4809ae6de137ebc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Androgens
124 rdf:type schema:DefinedTerm
125 N20e6bf1f8afd4c5aa94cb25de9155376 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Iron
127 rdf:type schema:DefinedTerm
128 N2110755edd414075b9859da6b71b941a schema:location Cham
129 schema:name Springer International Publishing
130 rdf:type schema:Organisation
131 N2a31b1c6721546c899f6fc55df0b5fbe schema:familyName Hrycay
132 schema:givenName Eugene G.
133 rdf:type schema:Person
134 N2cc7abe4bee74499be197e5ccb9ffdea schema:name doi
135 schema:value 10.1007/978-3-319-16009-2_4
136 rdf:type schema:PropertyValue
137 N2dbb6d8e7197467791cb8bddf76e5160 schema:isbn 978-3-319-16008-5
138 978-3-319-16009-2
139 schema:name Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450
140 rdf:type schema:Book
141 N5ead847b605d4aa39af61f905ec053ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Animals
143 rdf:type schema:DefinedTerm
144 N6f7440f71d114ebcb3b32b6b533e2209 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Catalytic Domain
146 rdf:type schema:DefinedTerm
147 N7c7efc04633b4048975d1f0c219c7557 rdf:first sg:person.015572356512.49
148 rdf:rest Ndde92c8fe7db4740af3f5cb3d3ce98d9
149 N85c77c4b5f3a40579b259120cb6d32fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Adrenal Cortex Hormones
151 rdf:type schema:DefinedTerm
152 N861507f01a4b4fea9ea95ed477f39823 schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 N8935362f4d3a46b1a5ef8064e03e3735 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Aromatase
156 rdf:type schema:DefinedTerm
157 N8ea6e72f1b89439382006bddc09e675c schema:name pubmed_id
158 schema:value 26002733
159 rdf:type schema:PropertyValue
160 N906821d7795342ecbb1d3d0fc1bf9892 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Sterol 14-Demethylase
162 rdf:type schema:DefinedTerm
163 N989bd77452f74212a26ad77d6b52ef4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Steroid 17-alpha-Hydroxylase
165 rdf:type schema:DefinedTerm
166 Na88847e91c884b33bb52dbe9294a0e47 schema:familyName Bandiera
167 schema:givenName Stelvio M.
168 rdf:type schema:Person
169 Na9905b24ddcb4704b8b067ebbe02679f schema:name readcube_id
170 schema:value 3cd2ce4e5c15667744fc5ec07486c2697c188e66209b20405c823aa3ab8fa237
171 rdf:type schema:PropertyValue
172 Nbe6e7d2a6e9947c299b60c040e90b1ce schema:name dimensions_id
173 schema:value pub.1012767662
174 rdf:type schema:PropertyValue
175 Nbf2b50845ace4df789925aebaed88b49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Superoxides
177 rdf:type schema:DefinedTerm
178 Nda70f4fd272a4be0bbd0968e4ccc508f rdf:first Na88847e91c884b33bb52dbe9294a0e47
179 rdf:rest rdf:nil
180 Ndde92c8fe7db4740af3f5cb3d3ce98d9 rdf:first sg:person.0775743326.79
181 rdf:rest rdf:nil
182 Ne2a99b39c2a64157bf6f35ab7126d9cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Mycobacterium tuberculosis
184 rdf:type schema:DefinedTerm
185 Ne3d2b01987ec4217a7ea65a57e31d512 rdf:first N2a31b1c6721546c899f6fc55df0b5fbe
186 rdf:rest Nda70f4fd272a4be0bbd0968e4ccc508f
187 Nf91a3843bec54cf48ba8f0fb57626e4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Bacterial Proteins
189 rdf:type schema:DefinedTerm
190 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
191 schema:name Biological Sciences
192 rdf:type schema:DefinedTerm
193 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
194 schema:name Biochemistry and Cell Biology
195 rdf:type schema:DefinedTerm
196 sg:person.015572356512.49 schema:affiliation https://www.grid.ac/institutes/grid.5491.9
197 schema:familyName Akhtar
198 schema:givenName Muhammad
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015572356512.49
200 rdf:type schema:Person
201 sg:person.0775743326.79 schema:affiliation https://www.grid.ac/institutes/grid.5491.9
202 schema:familyName Wright
203 schema:givenName J. Neville
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775743326.79
205 rdf:type schema:Person
206 sg:pub.10.1007/0-387-27447-2_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037089212
207 https://doi.org/10.1007/0-387-27447-2_1
208 rdf:type schema:CreativeWork
209 sg:pub.10.1007/0-387-27447-2_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015350911
210 https://doi.org/10.1007/0-387-27447-2_5
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/3-540-46592-8_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035609743
213 https://doi.org/10.1007/3-540-46592-8_2
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/202083b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018908384
216 https://doi.org/10.1038/202083b0
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/203182b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040429177
219 https://doi.org/10.1038/203182b0
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/nature07614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039837934
222 https://doi.org/10.1038/nature07614
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/ng1097-201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003217230
225 https://doi.org/10.1038/ng1097-201
226 rdf:type schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1075736289 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1075891276 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1076555158 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1080159204 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1080320341 schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1081787292 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1082235068 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1082789142 schema:CreativeWork
235 https://doi.org/10.1002/anie.201300760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029579054
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1006/abbi.1995.1173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025407493
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/0005-2795(76)90340-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045025835
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/0006-291x(61)90140-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037417023
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/0006-291x(85)91190-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045426853
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/0045-2068(77)90046-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025123707
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/0960-0760(92)90295-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1046632473
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0960-0760(94)90082-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003332282
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.abb.2012.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042500929
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.jsbmb.2004.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042584118
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.jsbmb.2010.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011567518
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.steroids.2010.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048660658
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1021/bi00043a015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055158513
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1021/bi00180a039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055164104
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1021/bi0508744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055200601
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1021/bi051623y schema:sameAs https://app.dimensions.ai/details/publication/pub.1055201033
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1021/bi300017p schema:sameAs https://app.dimensions.ai/details/publication/pub.1055204871
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1021/ja00335a090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055724406
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1021/ja00848a046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055752657
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1021/ja01015a074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055761385
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1021/ja044716w schema:sameAs https://app.dimensions.ai/details/publication/pub.1055836338
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1021/ja211499q schema:sameAs https://app.dimensions.ai/details/publication/pub.1055851686
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1021/ja405047b schema:sameAs https://app.dimensions.ai/details/publication/pub.1009301907
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1021/ja906192b schema:sameAs https://app.dimensions.ai/details/publication/pub.1003017259
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1039/c39750000185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010460433
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1039/c39760000854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025818941
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1039/c39810000129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032003149
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1039/c39910000157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051938884
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1039/c39940001501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045902625
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1039/np9910800527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006025418
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1039/p19880002043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000541705
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1039/p19940000263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018589180
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1042/0264-6021:3420309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056714170
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1042/bj1090318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023014018
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1042/bj1140075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000743176
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1042/bj1210131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030343010
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1042/bj1250625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051071258
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1042/bj1690449b schema:sameAs https://app.dimensions.ai/details/publication/pub.1015970714
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1042/bj2010569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018174011
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1042/bj3080901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012722630
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1042/bj3210857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046506112
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1042/bj3320293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018639597
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1046/j.1365-2265.2000.01144.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002104132
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1073/pnas.87.8.2999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004926877
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1073/pnas.88.20.8963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022835897
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1074/jbc.271.21.12445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005564472
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1074/jbc.m112.390047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012504840
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1074/jbc.m113.468926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008466761
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1074/jbc.m501732200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024147100
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1074/jbc.m505261200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024078234
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1095/biolreprod.103.026732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039891565
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1111/j.1365-2265.1994.tb02469.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002817061
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1111/j.1432-1033.1969.tb00582.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036270132
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1111/j.1749-6632.1973.tb47610.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013498196
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1126/science.1187936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036523636
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1126/science.150.3692.19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062486827
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1126/science.831259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062654600
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1126/science.8342039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062654751
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1177/40.7.1607640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050827365
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1210/endo.143.4.8718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064284769
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1210/jcem.76.5.8496319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064318120
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1210/jcem.78.1.8288710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064318516
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1210/jcem.84.9.6105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064322960
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1507/endocrj.45.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040632337
362 rdf:type schema:CreativeWork
363 https://www.grid.ac/institutes/grid.5491.9 schema:alternateName University of Southampton
364 schema:name Centre for Biological Sciences, University of Southampton, SO17 1BJ, Southampton, UK
365 School of Biological Sciences, University of the Punjab, New Campus, 54590, Lahore, Pakistan
366 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...