Blood Pressure Genomics View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Georg B. Ehret

ABSTRACT

Blood pressure genetics has been instrumental in understanding the pathways that regulate blood pressure and induce hypertension. Two types of approaches have been used with great success: First, studies of hypertensive families in which monogenic blood pressure elevation can be explained by mutations in one of a dozen genes identified so far. Unfortunately, the relevance of these rare familial variants is limited when predicting primary hypertension in the general population. Second, association meta-analyses based on genome-wide genotyping using large sample sizes that have so far yielded about around 60 common genetic variants predicting blood pressure with a small, but reproducible, impact on blood pressure in the general population. This chapter summarizes the current findings based on genome-wide association studies and outlines the conclusions that can be drawn when considering the variants identified in aggregate and gives an outlook of the challenges ahead. More... »

PAGES

685-694

Book

TITLE

Pathophysiology and Pharmacotherapy of Cardiovascular Disease

ISBN

978-3-319-15960-7
978-3-319-15961-4

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-15961-4_32

DOI

http://dx.doi.org/10.1007/978-3-319-15961-4_32

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043722451


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