Mutational Similarities Across Cancers: Implications for Research, Diagnostics, and Personalized Therapy Design View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Frederick Klauschen , Albrecht Stenzinger , Daniel Heim

ABSTRACT

Oncology and cancer research are based on the principle that cancers are regarded as organ- and tissue-specific diseases. One of the central aspects of histopathological tumor diagnostics is to determine the tumor’s anatomic origin and other morphological features that are the basis for selecting the appropriate therapy. Similarly, research programs are usually also focused on particular cancer entities. However, mutational tumor profiling performed with next-generation-sequencing techniques has made it possible to analyze whether this anatomical tumor classification is valid also on the genetic level. Here, we review recent evidence that substantial similarities exist among tumors across classical anatomic cancer entities on the mutational level. We furthermore discuss the implications of these complex mutational profiles and similarity patterns across cancers for diagnostics, research, and clinical study design and explain why the comprehensive genomic data should be complemented by functional proteomic analyses. More... »

PAGES

57-65

Book

TITLE

Next Generation Sequencing in Cancer Research, Volume 2

ISBN

978-3-319-15810-5
978-3-319-15811-2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-15811-2_4

DOI

http://dx.doi.org/10.1007/978-3-319-15811-2_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001071520


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