Chymotrypsin Probe for Real-Time Visualization of Pancreatic Leak View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Suguru Yamashita , Takeaki Ishizawa , Masayo Sakabe , Mako Kamiya , Yasuteru Urano , Norihiro Kokudo

ABSTRACT

Pancreatic fistula remains the most serious complication after digestive surgery. This is mainly because there are no techniques to identify pancreatic leak from the pancreatic stump during surgery. Nor have there been any techniques for rapid evaluation of protease activity in leaking fluid during surgery that can cause severe tissue damage. We have designed and developed a novel fluorescence probe (glutaryl phenylalanine hydroxymethyl rhodamine green) that is activated by chymotrypsin. The use of this novel probe is expected to result in a reduced incidence of pancreatic fistula and operative mortality after digestive surgery. More... »

PAGES

333-339

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-15678-1_36

DOI

http://dx.doi.org/10.1007/978-3-319-15678-1_36

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014696255


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