Animal Models of Metastasis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Dawn R Cochrane , Dong Lin , Graham Dellaire , Elizabeth C Halvorsen , Jason N Berman , Yuzhou Wang , David G Huntsman , Kevin L Bennewith

ABSTRACT

Tumour metastasis is a complex and dynamic process that is estimated to be associated with over 90% of cancer-related deaths. The various stages of the metastatic cascade are made up of interactions between metastatic tumour cells, the solid tumour microenvironment, host normal cells, and host tissue. While our understanding of tumour cell migration and invasion has been greatly improved using a variety of in vitro cell culture systems, the inherent complexity of the entire metastatic process is best studied using animal models. There are several in vivo models that are amenable to studying tumour metastasis, and this Chapter will focus on some of the more notable animal models that are commonly used in the metastasis field. We will first consider the zebrafish as a burgeoning model for tumour cell migration and invasion that is particularly well-suited for intravital imaging of labeled tumour cells to study mechanisms underlying metastatic tumour cell dissemination. We then discuss selected genetically engineered mouse models of metastatic cancer, which are powerful tools to elucidate the oncogenic potential of genes of interest. Murine tumour xenografts are also considered as the traditional “gold standard” models for metastasis research. We have included descriptions of strategies to artificially seed murine tissues with tumour cells to study the proliferation and survival of these cells in host tissues, and we provide an overview of quantitative methods to study the development of spontaneous metastases from solid tumour xenografts. We conclude with the use of patient-derived xenografts (PDXs), which are becoming increasingly common tools to validate experimental findings established in other model systems in an effort to enhance the clinical applicability of in vivo data. More... »

PAGES

95-123

Book

TITLE

Genomic Instability and Cancer Metastasis

ISBN

978-3-319-12135-2
978-3-319-12136-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-12136-9_5

DOI

http://dx.doi.org/10.1007/978-3-319-12136-9_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012718129


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cochrane", 
        "givenName": "Dawn R", 
        "id": "sg:person.0712361347.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712361347.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Experimental Therapeutics, British Columbia Cancer Agency, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Dong", 
        "id": "sg:person.01313665023.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313665023.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dalhousie University", 
          "id": "https://www.grid.ac/institutes/grid.55602.34", 
          "name": [
            "Department of Pathology, Dalhousie University, Halifax, NS, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dellaire", 
        "givenName": "Graham", 
        "id": "sg:person.01222472242.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222472242.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Integrative Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Halvorsen", 
        "givenName": "Elizabeth C", 
        "id": "sg:person.01075661764.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075661764.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dalhousie University", 
          "id": "https://www.grid.ac/institutes/grid.55602.34", 
          "name": [
            "Department of Pathology, Dalhousie University, Halifax, NS, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berman", 
        "givenName": "Jason N", 
        "id": "sg:person.0700742406.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700742406.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Experimental Therapeutics, British Columbia Cancer Agency, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yuzhou", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huntsman", 
        "givenName": "David G", 
        "id": "sg:person.015140454124.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015140454124.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Integrative Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bennewith", 
        "givenName": "Kevin L", 
        "id": "sg:person.01330564552.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330564552.16"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-2396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000035999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000573294", 
          "https://doi.org/10.1038/sj.onc.1203273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000573294", 
          "https://doi.org/10.1038/sj.onc.1203273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.22740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000999188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.10198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001689397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001795574", 
          "https://doi.org/10.1038/nature04186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001795574", 
          "https://doi.org/10.1038/nature04186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001795574", 
          "https://doi.org/10.1038/nature04186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001795574", 
          "https://doi.org/10.1038/nature04186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00215-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002407236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-12-3274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003141699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/9.16.2443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003243866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0305-7372(84)90050-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004352910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-0041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005345973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dmm.006395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005407979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005705586", 
          "https://doi.org/10.1038/nature12111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-2871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005793690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005931214", 
          "https://doi.org/10.1038/nrc3001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-4411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006231681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-01-0179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006932314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-9-128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006956748", 
          "https://doi.org/10.1186/1471-2407-9-128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-11-0109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006967405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.8.3439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007093997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007108469", 
          "https://doi.org/10.1038/ni1007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007108469", 
          "https://doi.org/10.1038/ni1007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007166971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.22.10578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007554858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008356436", 
          "https://doi.org/10.1038/35065016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008356436", 
          "https://doi.org/10.1038/35065016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-13-453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009200142", 
          "https://doi.org/10.1186/1471-2407-13-453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-384892-5.00018-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010422100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-13-2921-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010439231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.2002.0711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010607289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010946448", 
          "https://doi.org/10.1038/nature08021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010946448", 
          "https://doi.org/10.1038/nature08021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-4210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010981927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/1008-682x.125394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011291908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011569196", 
          "https://doi.org/10.1038/nrg2101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011569196", 
          "https://doi.org/10.1038/nrg2101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-4049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011683694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470669891.ch8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011958694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.018937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012074364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.4013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013038909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2012.61", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013064241", 
          "https://doi.org/10.1038/nrclinonc.2012.61"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/895238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013981282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014019844", 
          "https://doi.org/10.1038/sj.gt.3301335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014019844", 
          "https://doi.org/10.1038/sj.gt.3301335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr3095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014060180", 
          "https://doi.org/10.1186/bcr3095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014952575", 
          "https://doi.org/10.1038/nrc1911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014952575", 
          "https://doi.org/10.1038/nrc1911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000162947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015226912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0024950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015367538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-11-0261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015448876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016338837", 
          "https://doi.org/10.1186/bcr614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-0803.2006.00028.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016887016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2010.150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017065936", 
          "https://doi.org/10.1038/nprot.2010.150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-10-0376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017819019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1051603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018686807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2004.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018993051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1022618909921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019134793", 
          "https://doi.org/10.1023/a:1022618909921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-3524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020118168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0145-305x(03)00103-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020329004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0145-305x(03)00103-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020329004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020800104", 
          "https://doi.org/10.1038/nm1469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020800104", 
          "https://doi.org/10.1038/nm1469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-10-246488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020806670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021328631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021328631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.193.6.727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021607618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-3982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022115785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2010.031401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022291190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/8743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022713663", 
          "https://doi.org/10.1038/8743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/8743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022713663", 
          "https://doi.org/10.1038/8743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(77)90154-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022804771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr3573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023067585", 
          "https://doi.org/10.1186/bcr3573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023480717", 
          "https://doi.org/10.1038/nature09677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023709287", 
          "https://doi.org/10.1038/sj.onc.1204929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023709287", 
          "https://doi.org/10.1038/sj.onc.1204929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0031281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024293717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024726520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djn481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025109745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0295-149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025343841", 
          "https://doi.org/10.1038/nm0295-149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-5727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026234602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001099900040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026910351", 
          "https://doi.org/10.1007/s001099900040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910520118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027358586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2009.171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027751247", 
          "https://doi.org/10.1038/nprot.2009.171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2009.171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027751247", 
          "https://doi.org/10.1038/nprot.2009.171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-0372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028196580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-11-0233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029103877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-10-314120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029194758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0045(20000601)43:4<263::aid-pros5>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029462270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2004.09.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029497009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.36.9678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030053960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1476-5586(03)80058-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030137434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-3465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030185361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030207920", 
          "https://doi.org/10.1038/nature03799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030207920", 
          "https://doi.org/10.1038/nature03799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030207920", 
          "https://doi.org/10.1038/nature03799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030207920", 
          "https://doi.org/10.1038/nature03799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2013.92", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030892012", 
          "https://doi.org/10.1038/labinvest.2013.92"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-3047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032293222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-14-s10-s5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032558990", 
          "https://doi.org/10.1186/1471-2105-14-s10-s5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-2878", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032689696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nima.2010.11.092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034177581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.1296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034652278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034799474", 
          "https://doi.org/10.1038/bjc.1998.674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034799474", 
          "https://doi.org/10.1038/bjc.1998.674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2010.12.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034888434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2010.12.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034888434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035314762", 
          "https://doi.org/10.1038/sj.onc.1208229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035314762", 
          "https://doi.org/10.1038/sj.onc.1208229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-05-024075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036859857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0065957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037713790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2008.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037757546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2008.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037757546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-0252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038591844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.069443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038707674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)63568-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039352615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2003.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039619466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19831215)52:12<2185::aid-cncr2820521202>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039624859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2003.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041619937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(02)00212-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041691507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-1740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041754986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-1206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042540001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042664529", 
          "https://doi.org/10.1038/nrc1098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042664529", 
          "https://doi.org/10.1038/nrc1098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.24.14417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042742928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.12.5645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042760191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0909228106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042805375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0025103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043684884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044243050", 
          "https://doi.org/10.1038/nm.2454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-1052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044396619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1150224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044864905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045353672", 
          "https://doi.org/10.1038/sj.gt.3300951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045353672", 
          "https://doi.org/10.1038/sj.gt.3300951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10456-006-9040-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045375934", 
          "https://doi.org/10.1007/s10456-006-9040-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10456-006-9040-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045375934", 
          "https://doi.org/10.1007/s10456-006-9040-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0042739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045432383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00194-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045699739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00194-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045699739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2013.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045770883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.21199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045854185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.21199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045854185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-5237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046124060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-12-4081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046982757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.20471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047831618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.20471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047831618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0061801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049413812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pathol.3.121806.154244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049473792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-6396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050018199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200410000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051630285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200410000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051630285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2011.08661.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051966477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-3782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052233154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0074-7696(08)60088-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053173143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053367909", 
          "https://doi.org/10.1038/labinvest.3700335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053367909", 
          "https://doi.org/10.1038/labinvest.3700335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053367909", 
          "https://doi.org/10.1038/labinvest.3700335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.10.21.17921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072296227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.5.16.2864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.5.16.3018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.9.5.10853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072301377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074957467", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075270429", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3978/j.issn.2072-1439.2011.06.07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078510548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079204684", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082952820", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082958827", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083134771", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347765", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/1-59259-100-0:113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1088548938", 
          "https://doi.org/10.1385/1-59259-100-0:113"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015", 
    "datePublishedReg": "2015-01-01", 
    "description": "Tumour metastasis is a complex and dynamic process that is estimated to be associated with over 90% of cancer-related deaths. The various stages of the metastatic cascade are made up of interactions between metastatic tumour cells, the solid tumour microenvironment, host normal cells, and host tissue. While our understanding of tumour cell migration and invasion has been greatly improved using a variety of in vitro cell culture systems, the inherent complexity of the entire metastatic process is best studied using animal models. There are several in vivo models that are amenable to studying tumour metastasis, and this Chapter will focus on some of the more notable animal models that are commonly used in the metastasis field. We will first consider the zebrafish as a burgeoning model for tumour cell migration and invasion that is particularly well-suited for intravital imaging of labeled tumour cells to study mechanisms underlying metastatic tumour cell dissemination. We then discuss selected genetically engineered mouse models of metastatic cancer, which are powerful tools to elucidate the oncogenic potential of genes of interest. Murine tumour xenografts are also considered as the traditional \u201cgold standard\u201d models for metastasis research. We have included descriptions of strategies to artificially seed murine tissues with tumour cells to study the proliferation and survival of these cells in host tissues, and we provide an overview of quantitative methods to study the development of spontaneous metastases from solid tumour xenografts. We conclude with the use of patient-derived xenografts (PDXs), which are becoming increasingly common tools to validate experimental findings established in other model systems in an effort to enhance the clinical applicability of in vivo data.", 
    "editor": [
      {
        "familyName": "Maxwell", 
        "givenName": "Chris", 
        "type": "Person"
      }, 
      {
        "familyName": "Roskelley", 
        "givenName": "Cal", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-319-12136-9_5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-319-12135-2", 
        "978-3-319-12136-9"
      ], 
      "name": "Genomic Instability and Cancer Metastasis", 
      "type": "Book"
    }, 
    "name": "Animal Models of Metastasis", 
    "pagination": "95-123", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-319-12136-9_5"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3c9636bbdae3269fadaa2ca94d2740efa72484406d993b0a483aac475c9457c0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012718129"
        ]
      }
    ], 
    "publisher": {
      "location": "Cham", 
      "name": "Springer International Publishing", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-319-12136-9_5", 
      "https://app.dimensions.ai/details/publication/pub.1012718129"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T00:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000021.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-3-319-12136-9_5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-12136-9_5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-12136-9_5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-12136-9_5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-12136-9_5'


 

This table displays all metadata directly associated to this object as RDF triples.

569 TRIPLES      23 PREDICATES      166 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-319-12136-9_5 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N48b81e7757fd431eb0b03e9b18d9c083
4 schema:citation sg:pub.10.1007/s001099900040
5 sg:pub.10.1007/s10456-006-9040-2
6 sg:pub.10.1023/a:1022618909921
7 sg:pub.10.1038/35065016
8 sg:pub.10.1038/8743
9 sg:pub.10.1038/bjc.1998.674
10 sg:pub.10.1038/labinvest.2013.92
11 sg:pub.10.1038/labinvest.3700335
12 sg:pub.10.1038/nature03799
13 sg:pub.10.1038/nature04186
14 sg:pub.10.1038/nature08021
15 sg:pub.10.1038/nature09677
16 sg:pub.10.1038/nature12111
17 sg:pub.10.1038/ni1007
18 sg:pub.10.1038/nm.2454
19 sg:pub.10.1038/nm0295-149
20 sg:pub.10.1038/nm1469
21 sg:pub.10.1038/nprot.2009.171
22 sg:pub.10.1038/nprot.2010.150
23 sg:pub.10.1038/nrc1098
24 sg:pub.10.1038/nrc1911
25 sg:pub.10.1038/nrc3001
26 sg:pub.10.1038/nrclinonc.2012.61
27 sg:pub.10.1038/nrg2101
28 sg:pub.10.1038/sj.gt.3300951
29 sg:pub.10.1038/sj.gt.3301335
30 sg:pub.10.1038/sj.onc.1203273
31 sg:pub.10.1038/sj.onc.1204929
32 sg:pub.10.1038/sj.onc.1208229
33 sg:pub.10.1186/1471-2105-14-s10-s5
34 sg:pub.10.1186/1471-2407-13-453
35 sg:pub.10.1186/1471-2407-9-128
36 sg:pub.10.1186/bcr3095
37 sg:pub.10.1186/bcr3573
38 sg:pub.10.1186/bcr614
39 sg:pub.10.1385/1-59259-100-0:113
40 https://app.dimensions.ai/details/publication/pub.1074957467
41 https://app.dimensions.ai/details/publication/pub.1075270429
42 https://app.dimensions.ai/details/publication/pub.1079204684
43 https://app.dimensions.ai/details/publication/pub.1082952820
44 https://app.dimensions.ai/details/publication/pub.1082958827
45 https://app.dimensions.ai/details/publication/pub.1083134771
46 https://app.dimensions.ai/details/publication/pub.1083347765
47 https://doi.org/10.1002/1097-0045(20000601)43:4<263::aid-pros5>3.0.co;2-i
48 https://doi.org/10.1002/1097-0142(19831215)52:12<2185::aid-cncr2820521202>3.0.co;2-p
49 https://doi.org/10.1002/9780470669891.ch8
50 https://doi.org/10.1002/dvdy.20471
51 https://doi.org/10.1002/ijc.2910520118
52 https://doi.org/10.1002/path.1936
53 https://doi.org/10.1002/path.4013
54 https://doi.org/10.1002/pros.10198
55 https://doi.org/10.1002/pros.21199
56 https://doi.org/10.1002/pros.22740
57 https://doi.org/10.1006/dbio.2002.0711
58 https://doi.org/10.1016/0012-1606(77)90154-3
59 https://doi.org/10.1016/0305-7372(84)90050-1
60 https://doi.org/10.1016/b978-0-12-384892-5.00018-9
61 https://doi.org/10.1016/j.canlet.2013.10.010
62 https://doi.org/10.1016/j.ccr.2004.07.008
63 https://doi.org/10.1016/j.ccr.2008.11.012
64 https://doi.org/10.1016/j.cell.2006.11.001
65 https://doi.org/10.1016/j.ejca.2003.10.011
66 https://doi.org/10.1016/j.ejca.2010.12.019
67 https://doi.org/10.1016/j.humpath.2003.11.001
68 https://doi.org/10.1016/j.nima.2010.11.092
69 https://doi.org/10.1016/j.ygyno.2004.09.025
70 https://doi.org/10.1016/s0002-9440(10)63568-7
71 https://doi.org/10.1016/s0074-7696(08)60088-1
72 https://doi.org/10.1016/s0145-305x(03)00103-4
73 https://doi.org/10.1016/s1476-5586(03)80058-1
74 https://doi.org/10.1016/s1535-6108(02)00212-x
75 https://doi.org/10.1016/s1535-6108(03)00194-6
76 https://doi.org/10.1016/s1535-6108(03)00215-0
77 https://doi.org/10.1073/pnas.0909228106
78 https://doi.org/10.1073/pnas.89.12.5645
79 https://doi.org/10.1073/pnas.89.22.10578
80 https://doi.org/10.1073/pnas.92.8.3439
81 https://doi.org/10.1073/pnas.95.24.14417
82 https://doi.org/10.1074/jbc.m109.018937
83 https://doi.org/10.1084/jem.193.6.727
84 https://doi.org/10.1093/hmg/9.16.2443
85 https://doi.org/10.1093/jnci/djn481
86 https://doi.org/10.1097/00006676-200410000-00004
87 https://doi.org/10.1101/gad.1051603
88 https://doi.org/10.1111/j.1365-2141.2011.08661.x
89 https://doi.org/10.1111/j.1747-0803.2006.00028.x
90 https://doi.org/10.1126/science.1150224
91 https://doi.org/10.1146/annurev.pathol.3.121806.154244
92 https://doi.org/10.1155/2011/895238
93 https://doi.org/10.1158/0008-5472.can-03-3465
94 https://doi.org/10.1158/0008-5472.can-03-3524
95 https://doi.org/10.1158/0008-5472.can-05-4411
96 https://doi.org/10.1158/0008-5472.can-06-2396
97 https://doi.org/10.1158/0008-5472.can-06-3782
98 https://doi.org/10.1158/0008-5472.can-07-5237
99 https://doi.org/10.1158/0008-5472.can-07-5727
100 https://doi.org/10.1158/0008-5472.can-07-6396
101 https://doi.org/10.1158/0008-5472.can-08-0041
102 https://doi.org/10.1158/0008-5472.can-08-2871
103 https://doi.org/10.1158/0008-5472.can-08-4210
104 https://doi.org/10.1158/0008-5472.can-10-3982
105 https://doi.org/10.1158/0008-5472.can-10-4049
106 https://doi.org/10.1158/0008-5472.can-11-1052
107 https://doi.org/10.1158/0008-5472.can-12-3274
108 https://doi.org/10.1158/0008-5472.can-12-4081
109 https://doi.org/10.1158/0008-5472.can-13-2921-t
110 https://doi.org/10.1158/1078-0432.ccr-06-0252
111 https://doi.org/10.1158/1078-0432.ccr-08-0138
112 https://doi.org/10.1158/1078-0432.ccr-09-2878
113 https://doi.org/10.1158/1078-0432.ccr-10-1206
114 https://doi.org/10.1158/1078-0432.ccr-12-0372
115 https://doi.org/10.1158/1078-0432.ccr-12-1740
116 https://doi.org/10.1158/1078-0432.ccr-13-3047
117 https://doi.org/10.1158/1535-7163.mct-10-0376
118 https://doi.org/10.1158/1535-7163.mct-11-0233
119 https://doi.org/10.1158/2159-8290.cd-11-0109
120 https://doi.org/10.1158/2159-8290.cd-11-0261
121 https://doi.org/10.1159/000162947
122 https://doi.org/10.1182/blood-2005-01-0179
123 https://doi.org/10.1182/blood-2006-05-024075
124 https://doi.org/10.1182/blood-2009-10-246488
125 https://doi.org/10.1182/blood-2010-10-314120
126 https://doi.org/10.1200/jco.2011.36.9678
127 https://doi.org/10.1242/dmm.006395
128 https://doi.org/10.1242/jcs.069443
129 https://doi.org/10.1371/journal.pone.0024950
130 https://doi.org/10.1371/journal.pone.0025103
131 https://doi.org/10.1371/journal.pone.0031281
132 https://doi.org/10.1371/journal.pone.0042739
133 https://doi.org/10.1371/journal.pone.0061801
134 https://doi.org/10.1371/journal.pone.0065957
135 https://doi.org/10.18632/oncotarget.1296
136 https://doi.org/10.3324/haematol.2010.031401
137 https://doi.org/10.3978/j.issn.2072-1439.2011.06.07
138 https://doi.org/10.4103/1008-682x.125394
139 https://doi.org/10.4161/cc.10.21.17921
140 https://doi.org/10.4161/cc.5.16.2864
141 https://doi.org/10.4161/cc.5.16.3018
142 https://doi.org/10.4161/cc.9.5.10853
143 schema:datePublished 2015
144 schema:datePublishedReg 2015-01-01
145 schema:description Tumour metastasis is a complex and dynamic process that is estimated to be associated with over 90% of cancer-related deaths. The various stages of the metastatic cascade are made up of interactions between metastatic tumour cells, the solid tumour microenvironment, host normal cells, and host tissue. While our understanding of tumour cell migration and invasion has been greatly improved using a variety of in vitro cell culture systems, the inherent complexity of the entire metastatic process is best studied using animal models. There are several in vivo models that are amenable to studying tumour metastasis, and this Chapter will focus on some of the more notable animal models that are commonly used in the metastasis field. We will first consider the zebrafish as a burgeoning model for tumour cell migration and invasion that is particularly well-suited for intravital imaging of labeled tumour cells to study mechanisms underlying metastatic tumour cell dissemination. We then discuss selected genetically engineered mouse models of metastatic cancer, which are powerful tools to elucidate the oncogenic potential of genes of interest. Murine tumour xenografts are also considered as the traditional “gold standard” models for metastasis research. We have included descriptions of strategies to artificially seed murine tissues with tumour cells to study the proliferation and survival of these cells in host tissues, and we provide an overview of quantitative methods to study the development of spontaneous metastases from solid tumour xenografts. We conclude with the use of patient-derived xenografts (PDXs), which are becoming increasingly common tools to validate experimental findings established in other model systems in an effort to enhance the clinical applicability of in vivo data.
146 schema:editor N642649c86c0649c4a252e07f386de9bc
147 schema:genre chapter
148 schema:inLanguage en
149 schema:isAccessibleForFree false
150 schema:isPartOf Na5f6c0d7aca44e84b340e3ca3412605c
151 schema:name Animal Models of Metastasis
152 schema:pagination 95-123
153 schema:productId N39431a4e4fc946d8a5ae9a9dcde7caca
154 N784ffe9cb20b4cb8b8df4bf6b393a90a
155 Na8401e86ad334366950635cd2b937589
156 schema:publisher Nfc0b722925bf48d287a06719a443df61
157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012718129
158 https://doi.org/10.1007/978-3-319-12136-9_5
159 schema:sdDatePublished 2019-04-16T00:34
160 schema:sdLicense https://scigraph.springernature.com/explorer/license/
161 schema:sdPublisher Nde5af3eb3a3045b4b3eecdd867959022
162 schema:url http://link.springer.com/10.1007/978-3-319-12136-9_5
163 sgo:license sg:explorer/license/
164 sgo:sdDataset chapters
165 rdf:type schema:Chapter
166 N39431a4e4fc946d8a5ae9a9dcde7caca schema:name readcube_id
167 schema:value 3c9636bbdae3269fadaa2ca94d2740efa72484406d993b0a483aac475c9457c0
168 rdf:type schema:PropertyValue
169 N47c7461e1a1845aa87a0213f37132255 rdf:first sg:person.01313665023.48
170 rdf:rest Ne17b12ac7e6f4b2e84d934928db1a0bc
171 N47e67c019a2a456a8553c6c306ea7035 rdf:first sg:person.01075661764.11
172 rdf:rest N9d09f4d6c43548da84734f7691bd39ac
173 N48b81e7757fd431eb0b03e9b18d9c083 rdf:first sg:person.0712361347.98
174 rdf:rest N47c7461e1a1845aa87a0213f37132255
175 N642649c86c0649c4a252e07f386de9bc rdf:first N68f95b4aaa924d2cbbda43934d75c298
176 rdf:rest N71b8a9362bba458b94dc56ae37fe516f
177 N68f95b4aaa924d2cbbda43934d75c298 schema:familyName Maxwell
178 schema:givenName Chris
179 rdf:type schema:Person
180 N71b8a9362bba458b94dc56ae37fe516f rdf:first Nb936eb0bb7cb4dfbae72cf742c8d7665
181 rdf:rest rdf:nil
182 N784ffe9cb20b4cb8b8df4bf6b393a90a schema:name doi
183 schema:value 10.1007/978-3-319-12136-9_5
184 rdf:type schema:PropertyValue
185 N8b5b2ab2f5a9453b8d3b5fe89d689551 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
186 schema:familyName Wang
187 schema:givenName Yuzhou
188 rdf:type schema:Person
189 N9d09f4d6c43548da84734f7691bd39ac rdf:first sg:person.0700742406.95
190 rdf:rest Nfacc8f5d08c54b8892b1cc98a5b957c5
191 Na5f6c0d7aca44e84b340e3ca3412605c schema:isbn 978-3-319-12135-2
192 978-3-319-12136-9
193 schema:name Genomic Instability and Cancer Metastasis
194 rdf:type schema:Book
195 Na8401e86ad334366950635cd2b937589 schema:name dimensions_id
196 schema:value pub.1012718129
197 rdf:type schema:PropertyValue
198 Nb936eb0bb7cb4dfbae72cf742c8d7665 schema:familyName Roskelley
199 schema:givenName Cal
200 rdf:type schema:Person
201 Nb98be6ec23404376ab7b1b6377f9a3ef rdf:first sg:person.015140454124.62
202 rdf:rest Nf0230889d4154c0eade7cc4c2f40e3be
203 Nde5af3eb3a3045b4b3eecdd867959022 schema:name Springer Nature - SN SciGraph project
204 rdf:type schema:Organization
205 Ne17b12ac7e6f4b2e84d934928db1a0bc rdf:first sg:person.01222472242.12
206 rdf:rest N47e67c019a2a456a8553c6c306ea7035
207 Nf0230889d4154c0eade7cc4c2f40e3be rdf:first sg:person.01330564552.16
208 rdf:rest rdf:nil
209 Nfacc8f5d08c54b8892b1cc98a5b957c5 rdf:first N8b5b2ab2f5a9453b8d3b5fe89d689551
210 rdf:rest Nb98be6ec23404376ab7b1b6377f9a3ef
211 Nfc0b722925bf48d287a06719a443df61 schema:location Cham
212 schema:name Springer International Publishing
213 rdf:type schema:Organisation
214 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
215 schema:name Medical and Health Sciences
216 rdf:type schema:DefinedTerm
217 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
218 schema:name Oncology and Carcinogenesis
219 rdf:type schema:DefinedTerm
220 sg:person.01075661764.11 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
221 schema:familyName Halvorsen
222 schema:givenName Elizabeth C
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075661764.11
224 rdf:type schema:Person
225 sg:person.01222472242.12 schema:affiliation https://www.grid.ac/institutes/grid.55602.34
226 schema:familyName Dellaire
227 schema:givenName Graham
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222472242.12
229 rdf:type schema:Person
230 sg:person.01313665023.48 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
231 schema:familyName Lin
232 schema:givenName Dong
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313665023.48
234 rdf:type schema:Person
235 sg:person.01330564552.16 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
236 schema:familyName Bennewith
237 schema:givenName Kevin L
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330564552.16
239 rdf:type schema:Person
240 sg:person.015140454124.62 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
241 schema:familyName Huntsman
242 schema:givenName David G
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015140454124.62
244 rdf:type schema:Person
245 sg:person.0700742406.95 schema:affiliation https://www.grid.ac/institutes/grid.55602.34
246 schema:familyName Berman
247 schema:givenName Jason N
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700742406.95
249 rdf:type schema:Person
250 sg:person.0712361347.98 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
251 schema:familyName Cochrane
252 schema:givenName Dawn R
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712361347.98
254 rdf:type schema:Person
255 sg:pub.10.1007/s001099900040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026910351
256 https://doi.org/10.1007/s001099900040
257 rdf:type schema:CreativeWork
258 sg:pub.10.1007/s10456-006-9040-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045375934
259 https://doi.org/10.1007/s10456-006-9040-2
260 rdf:type schema:CreativeWork
261 sg:pub.10.1023/a:1022618909921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019134793
262 https://doi.org/10.1023/a:1022618909921
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/35065016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008356436
265 https://doi.org/10.1038/35065016
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/8743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022713663
268 https://doi.org/10.1038/8743
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/bjc.1998.674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034799474
271 https://doi.org/10.1038/bjc.1998.674
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/labinvest.2013.92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030892012
274 https://doi.org/10.1038/labinvest.2013.92
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/labinvest.3700335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053367909
277 https://doi.org/10.1038/labinvest.3700335
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/nature03799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030207920
280 https://doi.org/10.1038/nature03799
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nature04186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001795574
283 https://doi.org/10.1038/nature04186
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nature08021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010946448
286 https://doi.org/10.1038/nature08021
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nature09677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023480717
289 https://doi.org/10.1038/nature09677
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nature12111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005705586
292 https://doi.org/10.1038/nature12111
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/ni1007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007108469
295 https://doi.org/10.1038/ni1007
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/nm.2454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044243050
298 https://doi.org/10.1038/nm.2454
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/nm0295-149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025343841
301 https://doi.org/10.1038/nm0295-149
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/nm1469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020800104
304 https://doi.org/10.1038/nm1469
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/nprot.2009.171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027751247
307 https://doi.org/10.1038/nprot.2009.171
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/nprot.2010.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017065936
310 https://doi.org/10.1038/nprot.2010.150
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/nrc1098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042664529
313 https://doi.org/10.1038/nrc1098
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/nrc1911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014952575
316 https://doi.org/10.1038/nrc1911
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/nrc3001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005931214
319 https://doi.org/10.1038/nrc3001
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/nrclinonc.2012.61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013064241
322 https://doi.org/10.1038/nrclinonc.2012.61
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/nrg2101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011569196
325 https://doi.org/10.1038/nrg2101
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/sj.gt.3300951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045353672
328 https://doi.org/10.1038/sj.gt.3300951
329 rdf:type schema:CreativeWork
330 sg:pub.10.1038/sj.gt.3301335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014019844
331 https://doi.org/10.1038/sj.gt.3301335
332 rdf:type schema:CreativeWork
333 sg:pub.10.1038/sj.onc.1203273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000573294
334 https://doi.org/10.1038/sj.onc.1203273
335 rdf:type schema:CreativeWork
336 sg:pub.10.1038/sj.onc.1204929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023709287
337 https://doi.org/10.1038/sj.onc.1204929
338 rdf:type schema:CreativeWork
339 sg:pub.10.1038/sj.onc.1208229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035314762
340 https://doi.org/10.1038/sj.onc.1208229
341 rdf:type schema:CreativeWork
342 sg:pub.10.1186/1471-2105-14-s10-s5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032558990
343 https://doi.org/10.1186/1471-2105-14-s10-s5
344 rdf:type schema:CreativeWork
345 sg:pub.10.1186/1471-2407-13-453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009200142
346 https://doi.org/10.1186/1471-2407-13-453
347 rdf:type schema:CreativeWork
348 sg:pub.10.1186/1471-2407-9-128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006956748
349 https://doi.org/10.1186/1471-2407-9-128
350 rdf:type schema:CreativeWork
351 sg:pub.10.1186/bcr3095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014060180
352 https://doi.org/10.1186/bcr3095
353 rdf:type schema:CreativeWork
354 sg:pub.10.1186/bcr3573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023067585
355 https://doi.org/10.1186/bcr3573
356 rdf:type schema:CreativeWork
357 sg:pub.10.1186/bcr614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016338837
358 https://doi.org/10.1186/bcr614
359 rdf:type schema:CreativeWork
360 sg:pub.10.1385/1-59259-100-0:113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1088548938
361 https://doi.org/10.1385/1-59259-100-0:113
362 rdf:type schema:CreativeWork
363 https://app.dimensions.ai/details/publication/pub.1074957467 schema:CreativeWork
364 https://app.dimensions.ai/details/publication/pub.1075270429 schema:CreativeWork
365 https://app.dimensions.ai/details/publication/pub.1079204684 schema:CreativeWork
366 https://app.dimensions.ai/details/publication/pub.1082952820 schema:CreativeWork
367 https://app.dimensions.ai/details/publication/pub.1082958827 schema:CreativeWork
368 https://app.dimensions.ai/details/publication/pub.1083134771 schema:CreativeWork
369 https://app.dimensions.ai/details/publication/pub.1083347765 schema:CreativeWork
370 https://doi.org/10.1002/1097-0045(20000601)43:4<263::aid-pros5>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1029462270
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1002/1097-0142(19831215)52:12<2185::aid-cncr2820521202>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1039624859
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1002/9780470669891.ch8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011958694
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1002/dvdy.20471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047831618
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1002/ijc.2910520118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027358586
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1002/path.1936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021328631
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1002/path.4013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013038909
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1002/pros.10198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001689397
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1002/pros.21199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045854185
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1002/pros.22740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000999188
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1006/dbio.2002.0711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010607289
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1016/0012-1606(77)90154-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022804771
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1016/0305-7372(84)90050-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004352910
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1016/b978-0-12-384892-5.00018-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010422100
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1016/j.canlet.2013.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045770883
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1016/j.ccr.2004.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018993051
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1016/j.ccr.2008.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037757546
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1016/j.cell.2006.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024726520
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1016/j.ejca.2003.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041619937
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1016/j.ejca.2010.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034888434
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1016/j.humpath.2003.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039619466
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1016/j.nima.2010.11.092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034177581
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1016/j.ygyno.2004.09.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029497009
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1016/s0002-9440(10)63568-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039352615
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1016/s0074-7696(08)60088-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053173143
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1016/s0145-305x(03)00103-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020329004
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1016/s1476-5586(03)80058-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030137434
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1016/s1535-6108(02)00212-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041691507
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1016/s1535-6108(03)00194-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045699739
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1016/s1535-6108(03)00215-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002407236
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1073/pnas.0909228106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042805375
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1073/pnas.89.12.5645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042760191
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1073/pnas.89.22.10578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007554858
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1073/pnas.92.8.3439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007093997
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1073/pnas.95.24.14417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042742928
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1074/jbc.m109.018937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012074364
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1084/jem.193.6.727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021607618
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1093/hmg/9.16.2443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003243866
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1093/jnci/djn481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025109745
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1097/00006676-200410000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051630285
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1101/gad.1051603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018686807
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1111/j.1365-2141.2011.08661.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051966477
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1111/j.1747-0803.2006.00028.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016887016
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1126/science.1150224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044864905
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1146/annurev.pathol.3.121806.154244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049473792
459 rdf:type schema:CreativeWork
460 https://doi.org/10.1155/2011/895238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013981282
461 rdf:type schema:CreativeWork
462 https://doi.org/10.1158/0008-5472.can-03-3465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030185361
463 rdf:type schema:CreativeWork
464 https://doi.org/10.1158/0008-5472.can-03-3524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020118168
465 rdf:type schema:CreativeWork
466 https://doi.org/10.1158/0008-5472.can-05-4411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006231681
467 rdf:type schema:CreativeWork
468 https://doi.org/10.1158/0008-5472.can-06-2396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000035999
469 rdf:type schema:CreativeWork
470 https://doi.org/10.1158/0008-5472.can-06-3782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052233154
471 rdf:type schema:CreativeWork
472 https://doi.org/10.1158/0008-5472.can-07-5237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046124060
473 rdf:type schema:CreativeWork
474 https://doi.org/10.1158/0008-5472.can-07-5727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026234602
475 rdf:type schema:CreativeWork
476 https://doi.org/10.1158/0008-5472.can-07-6396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050018199
477 rdf:type schema:CreativeWork
478 https://doi.org/10.1158/0008-5472.can-08-0041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005345973
479 rdf:type schema:CreativeWork
480 https://doi.org/10.1158/0008-5472.can-08-2871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005793690
481 rdf:type schema:CreativeWork
482 https://doi.org/10.1158/0008-5472.can-08-4210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010981927
483 rdf:type schema:CreativeWork
484 https://doi.org/10.1158/0008-5472.can-10-3982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022115785
485 rdf:type schema:CreativeWork
486 https://doi.org/10.1158/0008-5472.can-10-4049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011683694
487 rdf:type schema:CreativeWork
488 https://doi.org/10.1158/0008-5472.can-11-1052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044396619
489 rdf:type schema:CreativeWork
490 https://doi.org/10.1158/0008-5472.can-12-3274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003141699
491 rdf:type schema:CreativeWork
492 https://doi.org/10.1158/0008-5472.can-12-4081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046982757
493 rdf:type schema:CreativeWork
494 https://doi.org/10.1158/0008-5472.can-13-2921-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1010439231
495 rdf:type schema:CreativeWork
496 https://doi.org/10.1158/1078-0432.ccr-06-0252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038591844
497 rdf:type schema:CreativeWork
498 https://doi.org/10.1158/1078-0432.ccr-08-0138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007166971
499 rdf:type schema:CreativeWork
500 https://doi.org/10.1158/1078-0432.ccr-09-2878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032689696
501 rdf:type schema:CreativeWork
502 https://doi.org/10.1158/1078-0432.ccr-10-1206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042540001
503 rdf:type schema:CreativeWork
504 https://doi.org/10.1158/1078-0432.ccr-12-0372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028196580
505 rdf:type schema:CreativeWork
506 https://doi.org/10.1158/1078-0432.ccr-12-1740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041754986
507 rdf:type schema:CreativeWork
508 https://doi.org/10.1158/1078-0432.ccr-13-3047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032293222
509 rdf:type schema:CreativeWork
510 https://doi.org/10.1158/1535-7163.mct-10-0376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017819019
511 rdf:type schema:CreativeWork
512 https://doi.org/10.1158/1535-7163.mct-11-0233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029103877
513 rdf:type schema:CreativeWork
514 https://doi.org/10.1158/2159-8290.cd-11-0109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006967405
515 rdf:type schema:CreativeWork
516 https://doi.org/10.1158/2159-8290.cd-11-0261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015448876
517 rdf:type schema:CreativeWork
518 https://doi.org/10.1159/000162947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015226912
519 rdf:type schema:CreativeWork
520 https://doi.org/10.1182/blood-2005-01-0179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006932314
521 rdf:type schema:CreativeWork
522 https://doi.org/10.1182/blood-2006-05-024075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036859857
523 rdf:type schema:CreativeWork
524 https://doi.org/10.1182/blood-2009-10-246488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020806670
525 rdf:type schema:CreativeWork
526 https://doi.org/10.1182/blood-2010-10-314120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029194758
527 rdf:type schema:CreativeWork
528 https://doi.org/10.1200/jco.2011.36.9678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030053960
529 rdf:type schema:CreativeWork
530 https://doi.org/10.1242/dmm.006395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005407979
531 rdf:type schema:CreativeWork
532 https://doi.org/10.1242/jcs.069443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038707674
533 rdf:type schema:CreativeWork
534 https://doi.org/10.1371/journal.pone.0024950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015367538
535 rdf:type schema:CreativeWork
536 https://doi.org/10.1371/journal.pone.0025103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043684884
537 rdf:type schema:CreativeWork
538 https://doi.org/10.1371/journal.pone.0031281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024293717
539 rdf:type schema:CreativeWork
540 https://doi.org/10.1371/journal.pone.0042739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045432383
541 rdf:type schema:CreativeWork
542 https://doi.org/10.1371/journal.pone.0061801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049413812
543 rdf:type schema:CreativeWork
544 https://doi.org/10.1371/journal.pone.0065957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037713790
545 rdf:type schema:CreativeWork
546 https://doi.org/10.18632/oncotarget.1296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034652278
547 rdf:type schema:CreativeWork
548 https://doi.org/10.3324/haematol.2010.031401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022291190
549 rdf:type schema:CreativeWork
550 https://doi.org/10.3978/j.issn.2072-1439.2011.06.07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078510548
551 rdf:type schema:CreativeWork
552 https://doi.org/10.4103/1008-682x.125394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011291908
553 rdf:type schema:CreativeWork
554 https://doi.org/10.4161/cc.10.21.17921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072296227
555 rdf:type schema:CreativeWork
556 https://doi.org/10.4161/cc.5.16.2864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298556
557 rdf:type schema:CreativeWork
558 https://doi.org/10.4161/cc.5.16.3018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298564
559 rdf:type schema:CreativeWork
560 https://doi.org/10.4161/cc.9.5.10853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072301377
561 rdf:type schema:CreativeWork
562 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
563 schema:name Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, BC, Canada
564 Experimental Therapeutics, British Columbia Cancer Agency, Vancouver, BC, Canada
565 Integrative Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada
566 rdf:type schema:Organization
567 https://www.grid.ac/institutes/grid.55602.34 schema:alternateName Dalhousie University
568 schema:name Department of Pathology, Dalhousie University, Halifax, NS, Canada
569 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...