Imaging of Complications in Atherosclerosis: Thrombosis and Platelet Aggregation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014-10-01

AUTHORS

Satoshi Nishimura

ABSTRACT

The thrombotic cellular mechanisms associated with cardiovascular events remain unclear, largely because of an inability to visualize thrombus formation in vivo. In this chapter, bio-imaging approach is introduced, mainly using in vivo imaging technique based on single-photon and multiphoton microscopy. Recent progress in optics enabled us to identify single-platelet behavior in the developing thrombus in living animals. In the physiological and pathological conditions, complex cellular interplay takes place, and bio-imaging can directly elucidate cross talks among multiple cell types. We visualized that rapidly developing thrombi composed of discoid platelets were triggered by reactive oxygen species photochemically induced by laser irradiation, and developed thrombi occluded blood vessels. Inflammatory cytokine and adhesion molecules dynamically control these processes. Intravital imaging can be a powerful tool to analyze thrombus formation and evaluate the therapeutic strategies against thrombotic diseases. More... »

PAGES

171-184

Book

TITLE

Cardiovascular Imaging

ISBN

978-3-319-09267-6
978-3-319-09268-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-09268-3_8

DOI

http://dx.doi.org/10.1007/978-3-319-09268-3_8

DIMENSIONS

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