Glycogenolysis and Purinergic Signaling View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Leif Hertz , Junnan Xu , Liang Peng

ABSTRACT

Both ATP and glutamate are on one hand essential metabolites in brain and on the other serve a signaling function as transmitters. However, there is the major difference that the flux in the pathway producing transmitter glutamate is comparable to the rate of glucose metabolism in brain, whereas that producing transmitter ATP is orders of magnitude smaller than the metabolic turnover between ATP and ADP. Moreover, de novo glutamate production occurs exclusively in astrocytes, whereas transmitter ATP is produced both in neurons and astrocytes. This chapter deals only with ATP and exclusively with its formation and release in astrocytes, and it focuses on potential associations with glycogenolysis, which is known to be indispensable for the synthesis of glutamate. Glycogenolysis is dependent upon an increase in free intracellular Ca(2+) concentration (Ca(2+)]i). It can be further stimulated by cAMP, but in contrast to widespread beliefs, cAMP can on its own not induce glycogenolysis. Astrocytes generate ATP from accumulated adenosine, and this process does not seem to require glycogenolysis. A minor amount of the generated ATP is utilized as a transmitter, and its synthesis requires the presence of the mainly intracellular nucleoside transporter ENT3. Many transmitters as well as extracellular K(+) concentrations high enough to open the voltage-sensitive L-channels for Ca(2+) cause a release of transmitter ATP from astrocytes. Adenosine and ATP induce release of ATP by action at several different purinergic receptors. The release evoked by transmitters or elevated K(+) concentrations is abolished by DAB, an inhibitor of glycogenolysis. More... »

PAGES

31-54

References to SciGraph publications

  • 2002-02. Up-Regulation of 5-HT2B Receptor Density and Receptor-Mediated Glycogenolysis in Mouse Astrocytes by Long-Term Fluoxetine Administration in NEUROCHEMICAL RESEARCH
  • 2013-03. Requirement of Glycogenolysis for Uptake of Increased Extracellular K+ in Astrocytes: Potential Implications for K+ Homeostasis and Glycogen Usage in Brain in NEUROCHEMICAL RESEARCH
  • 2012-09. The touching story of purinergic signaling in epithelial and endothelial cells in PURINERGIC SIGNALLING
  • 2006-11. Roles of P2 receptors in glial cells: focus on astrocytes in PURINERGIC SIGNALLING
  • 2014-04. Basic Mechanism Leading to Stimulation of Glycogenolysis by Isoproterenol, EGF, Elevated Extracellular K+ Concentrations, or GABA in NEUROCHEMICAL RESEARCH
  • 2012-02. 5-HT2B receptors are required for serotonin-selective antidepressant actions in MOLECULAR PSYCHIATRY
  • 2012-11. Cell Type-Specific Gene Expression and Editing Responses to Chronic Fluoxetine Treatment in the In Vivo Mouse Brain and Their Relevance for Stress-Induced Anhedonia in NEUROCHEMICAL RESEARCH
  • 2009-06. Purinoceptors on Neuroglia in MOLECULAR NEUROBIOLOGY
  • 2006-03. Adenosine receptors as therapeutic targets in NATURE REVIEWS DRUG DISCOVERY
  • 2012-05. Effects of Adrenergic Agents on Intracellular Ca2+ Homeostasis and Metabolism of Glucose in Astrocytes with an Emphasis on Pyruvate Carboxylation, Oxidative Decarboxylation and Recycling: Implications for Glutamate Neurotransmission and Excitotoxicity in NEUROTOXICITY RESEARCH
  • 1975. Glycogen and its Related Enzymes of Metabolism in the Central Nervous System in NONE
  • 2014. Glutamate Metabolism in the Brain Focusing on Astrocytes in GLUTAMATE AND ATP AT THE INTERFACE OF METABOLISM AND SIGNALING IN THE BRAIN
  • 1989-08. Inhibition of adenosine deaminase activity reveals an intense active transport of adenosine into neurons in primary cultures in NEUROCHEMICAL RESEARCH
  • 2014. Purinergic and Glutamatergic Receptors on Astroglia in GLUTAMATE AND ATP AT THE INTERFACE OF METABOLISM AND SIGNALING IN THE BRAIN
  • 1993. Calcium Channel Signaling in Astrocytes in CALCIUM ANTAGONISTS
  • 2013-11. Expression of Nucleoside Transporter in Freshly Isolated Neurons and Astrocytes from Mouse Brain in NEUROCHEMICAL RESEARCH
  • 2012-11. Exocytosis in Astrocytes: Transmitter Release and Membrane Signal Regulation in NEUROCHEMICAL RESEARCH
  • 2013-06. Astrocyte-derived ATP modulates depressive-like behaviors in NATURE MEDICINE
  • 1986-11. Similarities of adenosine uptake systems in astrocytes and neurons in primary cultures in NEUROCHEMICAL RESEARCH
  • 2012-11. Chronic Treatment with Anti-bipolar Drugs Causes Intracellular Alkalinization in Astrocytes, Altering Their Functions in NEUROCHEMICAL RESEARCH
  • 2008-12. Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation in PSYCHOPHARMACOLOGY
  • Book

    TITLE

    Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain

    ISBN

    978-3-319-08893-8
    978-3-319-08894-5

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-319-08894-5_3

    DOI

    http://dx.doi.org/10.1007/978-3-319-08894-5_3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037051876

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25236723


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "China Medical University", 
              "id": "https://www.grid.ac/institutes/grid.412449.e", 
              "name": [
                "Laboratory of Brain Metabolic Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang, P. R. China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hertz", 
            "givenName": "Leif", 
            "id": "sg:person.01055536710.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055536710.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "China Medical University", 
              "id": "https://www.grid.ac/institutes/grid.412449.e", 
              "name": [
                "Laboratory of Brain Metabolic Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang, P. R. China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xu", 
            "givenName": "Junnan", 
            "id": "sg:person.0737000262.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737000262.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "China Medical University", 
              "id": "https://www.grid.ac/institutes/grid.412449.e", 
              "name": [
                "Laboratory of Brain Metabolic Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang, P. R. China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peng", 
            "givenName": "Liang", 
            "id": "sg:person.01027240611.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027240611.51"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1988.tb04868.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000269737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(90)90592-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001227851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(90)90592-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001227851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-012-0938-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001544717", 
              "https://doi.org/10.1007/s11064-012-0938-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-4165(78)90233-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001770683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-4165(78)90233-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001770683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002947389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002947389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1990.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003117862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1990.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003117862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fncom.2013.00114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003641668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1982.tb07903.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004040521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.22623", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004374001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1226740", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005158080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(91)91538-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005695575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(91)91538-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005695575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(92)90329-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005885599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(92)90329-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005885599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-319-08894-5_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006169844", 
              "https://doi.org/10.1007/978-3-319-08894-5_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.1985.tb17385.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008297739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1120997109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009569603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.21138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009725067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-3940(95)11410-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010504675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11302-006-9016-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011183400", 
              "https://doi.org/10.1007/s11302-006-9016-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-94-011-1725-8_29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011268283", 
              "https://doi.org/10.1007/978-94-011-1725-8_29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5698/1535-7511-13.1.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012020458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5698/1535-7511-13.1.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012020458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-012-0837-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012348059", 
              "https://doi.org/10.1007/s11064-012-0837-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-012-0837-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012348059", 
              "https://doi.org/10.1007/s11064-012-0837-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-8993(98)00657-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012763718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0306-4522(97)00653-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012857460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2006.06.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013458556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.490240218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015369045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-4827(03)00090-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017332002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-4827(03)00090-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017332002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/nbm.1772", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017719072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/08923979509019752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017866964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2014.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018052485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.21307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018520343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2003.09.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019382593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000181159.83588.4b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019702853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000181159.83588.4b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019702853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019976141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-009-8063-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020028759", 
              "https://doi.org/10.1007/s12035-009-8063-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-009-8063-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020028759", 
              "https://doi.org/10.1007/s12035-009-8063-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-86875-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020338208", 
              "https://doi.org/10.1007/978-3-642-86875-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-86875-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020338208", 
              "https://doi.org/10.1007/978-3-642-86875-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1054/ceca.2001.0232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020804448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-319-08894-5_4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022146975", 
              "https://doi.org/10.1007/978-3-319-08894-5_4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1958.tb12383.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022497199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/an20110061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023947323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-008-1306-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024106232", 
              "https://doi.org/10.1007/s00213-008-1306-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-008-1306-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024106232", 
              "https://doi.org/10.1007/s00213-008-1306-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1139/y96-012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024822313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/an20130040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025178004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2013.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025252192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(88)81032-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026314365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.22395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026656416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00965770", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027050852", 
              "https://doi.org/10.1007/bf00965770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.1141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027984012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2012.08.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028003130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2012.08.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028003130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.02.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028061932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.02.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028061932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11302-012-9316-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028253065", 
              "https://doi.org/10.1007/s11302-012-9316-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mri.2011.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028666276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-2999(02)01299-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028774504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00964954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029685281", 
              "https://doi.org/10.1007/bf00964954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031479062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2012.200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031598838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2012.200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031598838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031934837", 
              "https://doi.org/10.1038/nm.3162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1073858411418524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032027170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1073858411418524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032027170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032630446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032630446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2004.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033695374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.16.7432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033741344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00202.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034064056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.bjp.0703182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034965464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2011.159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036341860", 
              "https://doi.org/10.1038/mp.2011.159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2010.06995.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036975099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2010.06995.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036975099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1014862808126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037817878", 
              "https://doi.org/10.1023/a:1014862808126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-0186(91)90113-r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038190057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-0186(91)90113-r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038190057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1979.tb05236.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039524340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-014-1244-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039590011", 
              "https://doi.org/10.1007/s11064-014-1244-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnint.2013.00020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040195554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.270.25.15175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041006818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1759091414543439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043568645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1759091414543439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043568645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12640-011-9296-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043694283", 
              "https://doi.org/10.1007/s12640-011-9296-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044863123", 
              "https://doi.org/10.1038/nrd1983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044863123", 
              "https://doi.org/10.1038/nrd1983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0361-9230(97)00345-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045168205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-013-1146-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045311247", 
              "https://doi.org/10.1007/s11064-013-1146-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.npbr.2013.09.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045880308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.21067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046126084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-012-0773-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047053803", 
              "https://doi.org/10.1007/s11064-012-0773-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuint.2013.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047083740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.43.3.506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048426100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.1.316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049058488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-4889(93)90077-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049217434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-4889(93)90077-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049217434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-3806(84)90032-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049709176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-3806(84)90032-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049709176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2183/pjab.87.486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051328555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-012-0814-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051362180", 
              "https://doi.org/10.1007/s11064-012-0814-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11064-012-0814-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051362180", 
              "https://doi.org/10.1007/s11064-012-0814-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1789.2010.01172.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051369216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fendo.2013.00059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052665567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1740925x12000117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054941846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200212000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060185036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200212000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060185036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200212000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060185036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo-85-4-711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064273816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1503/jpn.100094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067426596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1503/jpn.100094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067426596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156802611795347582", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069194082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/brushia", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070917739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.12-12-04923.1992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075658519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075702411", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076561883", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076910949", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079445823", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.06-09-02558.1986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079509379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.08-06-01922.1988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079716429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.jbchem.a129769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080283245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082746472", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082789398", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.18-21-08794.1998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083335760"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014", 
        "datePublishedReg": "2014-01-01", 
        "description": "Both ATP and glutamate are on one hand essential metabolites in brain and on the other serve a signaling function as transmitters. However, there is the major difference that the flux in the pathway producing transmitter glutamate is comparable to the rate of glucose metabolism in brain, whereas that producing transmitter ATP is orders of magnitude smaller than the metabolic turnover between ATP and ADP. Moreover, de novo glutamate production occurs exclusively in astrocytes, whereas transmitter ATP is produced both in neurons and astrocytes. This chapter deals only with ATP and exclusively with its formation and release in astrocytes, and it focuses on potential associations with glycogenolysis, which is known to be indispensable for the synthesis of glutamate. Glycogenolysis is dependent upon an increase in free intracellular Ca(2+) concentration (Ca(2+)]i). It can be further stimulated by cAMP, but in contrast to widespread beliefs, cAMP can on its own not induce glycogenolysis. Astrocytes generate ATP from accumulated adenosine, and this process does not seem to require glycogenolysis. A minor amount of the generated ATP is utilized as a transmitter, and its synthesis requires the presence of the mainly intracellular nucleoside transporter ENT3. Many transmitters as well as extracellular K(+) concentrations high enough to open the voltage-sensitive L-channels for Ca(2+) cause a release of transmitter ATP from astrocytes. Adenosine and ATP induce release of ATP by action at several different purinergic receptors. The release evoked by transmitters or elevated K(+) concentrations is abolished by DAB, an inhibitor of glycogenolysis. ", 
        "editor": [
          {
            "familyName": "Parpura", 
            "givenName": "Vladimir", 
            "type": "Person"
          }, 
          {
            "familyName": "Schousboe", 
            "givenName": "Arne", 
            "type": "Person"
          }, 
          {
            "familyName": "Verkhratsky", 
            "givenName": "Alexei", 
            "type": "Person"
          }
        ], 
        "genre": "chapter", 
        "id": "sg:pub.10.1007/978-3-319-08894-5_3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": {
          "isbn": [
            "978-3-319-08893-8", 
            "978-3-319-08894-5"
          ], 
          "name": "Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain", 
          "type": "Book"
        }, 
        "name": "Glycogenolysis and Purinergic Signaling", 
        "pagination": "31-54", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/978-3-319-08894-5_3"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b0806709fa5d0a561798bb37977faa37bd98e42f39a6267341a81b48f5a56a13"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037051876"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25236723"
            ]
          }
        ], 
        "publisher": {
          "location": "Cham", 
          "name": "Springer International Publishing", 
          "type": "Organisation"
        }, 
        "sameAs": [
          "https://doi.org/10.1007/978-3-319-08894-5_3", 
          "https://app.dimensions.ai/details/publication/pub.1037051876"
        ], 
        "sdDataset": "chapters", 
        "sdDatePublished": "2019-04-15T23:14", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000420.jsonl", 
        "type": "Chapter", 
        "url": "http://link.springer.com/10.1007/978-3-319-08894-5_3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-08894-5_3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-08894-5_3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-08894-5_3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-319-08894-5_3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    420 TRIPLES      23 PREDICATES      132 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/978-3-319-08894-5_3 schema:about anzsrc-for:11
    2 anzsrc-for:1109
    3 schema:author N99a67e2cef7745af9914a0f71dfd42ec
    4 schema:citation sg:pub.10.1007/978-3-319-08894-5_2
    5 sg:pub.10.1007/978-3-319-08894-5_4
    6 sg:pub.10.1007/978-3-642-86875-7
    7 sg:pub.10.1007/978-94-011-1725-8_29
    8 sg:pub.10.1007/bf00964954
    9 sg:pub.10.1007/bf00965770
    10 sg:pub.10.1007/s00213-008-1306-5
    11 sg:pub.10.1007/s11064-012-0773-6
    12 sg:pub.10.1007/s11064-012-0814-1
    13 sg:pub.10.1007/s11064-012-0837-7
    14 sg:pub.10.1007/s11064-012-0938-3
    15 sg:pub.10.1007/s11064-013-1146-5
    16 sg:pub.10.1007/s11064-014-1244-z
    17 sg:pub.10.1007/s11302-006-9016-0
    18 sg:pub.10.1007/s11302-012-9316-5
    19 sg:pub.10.1007/s12035-009-8063-2
    20 sg:pub.10.1007/s12640-011-9296-1
    21 sg:pub.10.1023/a:1014862808126
    22 sg:pub.10.1038/mp.2011.159
    23 sg:pub.10.1038/nm.3162
    24 sg:pub.10.1038/nrd1983
    25 https://app.dimensions.ai/details/publication/pub.1075702411
    26 https://app.dimensions.ai/details/publication/pub.1076561883
    27 https://app.dimensions.ai/details/publication/pub.1076910949
    28 https://app.dimensions.ai/details/publication/pub.1079445823
    29 https://app.dimensions.ai/details/publication/pub.1082746472
    30 https://app.dimensions.ai/details/publication/pub.1082789398
    31 https://doi.org/10.1002/glia.20216
    32 https://doi.org/10.1002/glia.20377
    33 https://doi.org/10.1002/glia.20649
    34 https://doi.org/10.1002/glia.21067
    35 https://doi.org/10.1002/glia.21138
    36 https://doi.org/10.1002/glia.22395
    37 https://doi.org/10.1002/glia.22623
    38 https://doi.org/10.1002/jnr.1141
    39 https://doi.org/10.1002/jnr.21307
    40 https://doi.org/10.1002/jnr.490240218
    41 https://doi.org/10.1002/nbm.1772
    42 https://doi.org/10.1016/0006-8993(90)90592-y
    43 https://doi.org/10.1016/0006-8993(91)91538-c
    44 https://doi.org/10.1016/0165-3806(84)90032-4
    45 https://doi.org/10.1016/0167-4889(93)90077-3
    46 https://doi.org/10.1016/0197-0186(91)90113-r
    47 https://doi.org/10.1016/0304-3940(95)11410-x
    48 https://doi.org/10.1016/0304-4165(78)90233-7
    49 https://doi.org/10.1016/0306-4522(92)90329-z
    50 https://doi.org/10.1016/j.brainres.2003.09.044
    51 https://doi.org/10.1016/j.ceca.2013.08.002
    52 https://doi.org/10.1016/j.ceca.2014.01.002
    53 https://doi.org/10.1016/j.cell.2011.02.018
    54 https://doi.org/10.1016/j.mri.2011.04.013
    55 https://doi.org/10.1016/j.neuint.2013.08.004
    56 https://doi.org/10.1016/j.neuron.2012.08.032
    57 https://doi.org/10.1016/j.neuroscience.2006.06.016
    58 https://doi.org/10.1016/j.npbr.2013.09.004
    59 https://doi.org/10.1016/j.tins.2004.10.008
    60 https://doi.org/10.1016/s0006-291x(88)81032-5
    61 https://doi.org/10.1016/s0006-8993(98)00657-x
    62 https://doi.org/10.1016/s0014-2999(02)01299-2
    63 https://doi.org/10.1016/s0014-4827(03)00090-9
    64 https://doi.org/10.1016/s0306-4522(97)00653-2
    65 https://doi.org/10.1016/s0361-9230(97)00345-6
    66 https://doi.org/10.1017/s1740925x12000117
    67 https://doi.org/10.1038/jcbfm.1990.14
    68 https://doi.org/10.1038/jcbfm.2012.200
    69 https://doi.org/10.1038/sj.bjp.0703182
    70 https://doi.org/10.1038/sj.jcbfm.9600343
    71 https://doi.org/10.1042/an20110061
    72 https://doi.org/10.1042/an20130040
    73 https://doi.org/10.1054/ceca.2001.0232
    74 https://doi.org/10.1073/pnas.1120997109
    75 https://doi.org/10.1073/pnas.89.16.7432
    76 https://doi.org/10.1073/pnas.95.1.316
    77 https://doi.org/10.1074/jbc.270.25.15175
    78 https://doi.org/10.1083/jcb.43.3.506
    79 https://doi.org/10.1093/oxfordjournals.jbchem.a129769
    80 https://doi.org/10.1097/00004647-200212000-00009
    81 https://doi.org/10.1111/j.1440-1789.2010.01172.x
    82 https://doi.org/10.1111/j.1471-4159.1958.tb12383.x
    83 https://doi.org/10.1111/j.1471-4159.1979.tb05236.x
    84 https://doi.org/10.1111/j.1471-4159.1982.tb07903.x
    85 https://doi.org/10.1111/j.1471-4159.1988.tb04868.x
    86 https://doi.org/10.1111/j.1471-4159.2010.06995.x
    87 https://doi.org/10.1111/j.1476-5381.1985.tb17385.x
    88 https://doi.org/10.1126/science.1226740
    89 https://doi.org/10.1139/y96-012
    90 https://doi.org/10.1152/ajpcell.00202.2002
    91 https://doi.org/10.1161/01.res.0000181159.83588.4b
    92 https://doi.org/10.1177/1073858411418524
    93 https://doi.org/10.1177/1759091414543439
    94 https://doi.org/10.1210/endo-85-4-711
    95 https://doi.org/10.1503/jpn.100094
    96 https://doi.org/10.1523/jneurosci.06-09-02558.1986
    97 https://doi.org/10.1523/jneurosci.08-06-01922.1988
    98 https://doi.org/10.1523/jneurosci.12-12-04923.1992
    99 https://doi.org/10.1523/jneurosci.18-21-08794.1998
    100 https://doi.org/10.2174/156802611795347582
    101 https://doi.org/10.2183/pjab.87.486
    102 https://doi.org/10.2741/brushia
    103 https://doi.org/10.3109/08923979509019752
    104 https://doi.org/10.3389/fendo.2013.00059
    105 https://doi.org/10.3389/fncom.2013.00114
    106 https://doi.org/10.3389/fnint.2013.00020
    107 https://doi.org/10.5698/1535-7511-13.1.35
    108 schema:datePublished 2014
    109 schema:datePublishedReg 2014-01-01
    110 schema:description Both ATP and glutamate are on one hand essential metabolites in brain and on the other serve a signaling function as transmitters. However, there is the major difference that the flux in the pathway producing transmitter glutamate is comparable to the rate of glucose metabolism in brain, whereas that producing transmitter ATP is orders of magnitude smaller than the metabolic turnover between ATP and ADP. Moreover, de novo glutamate production occurs exclusively in astrocytes, whereas transmitter ATP is produced both in neurons and astrocytes. This chapter deals only with ATP and exclusively with its formation and release in astrocytes, and it focuses on potential associations with glycogenolysis, which is known to be indispensable for the synthesis of glutamate. Glycogenolysis is dependent upon an increase in free intracellular Ca(2+) concentration (Ca(2+)]i). It can be further stimulated by cAMP, but in contrast to widespread beliefs, cAMP can on its own not induce glycogenolysis. Astrocytes generate ATP from accumulated adenosine, and this process does not seem to require glycogenolysis. A minor amount of the generated ATP is utilized as a transmitter, and its synthesis requires the presence of the mainly intracellular nucleoside transporter ENT3. Many transmitters as well as extracellular K(+) concentrations high enough to open the voltage-sensitive L-channels for Ca(2+) cause a release of transmitter ATP from astrocytes. Adenosine and ATP induce release of ATP by action at several different purinergic receptors. The release evoked by transmitters or elevated K(+) concentrations is abolished by DAB, an inhibitor of glycogenolysis.
    111 schema:editor N2a571229000749538d53bca558f44e01
    112 schema:genre chapter
    113 schema:inLanguage en
    114 schema:isAccessibleForFree false
    115 schema:isPartOf Nf6b514b62e584cd99fd12708801db354
    116 schema:name Glycogenolysis and Purinergic Signaling
    117 schema:pagination 31-54
    118 schema:productId N55366c67ff0043d284dab20c64849b9b
    119 Na27d6c30aa4843bc9be060e17e83bdce
    120 Ne7faf8ce77884e3caf7a00e88e884126
    121 Nf0c3b09deeb243f2ae2be8acd7835218
    122 schema:publisher Nea8a523a77ba4a13addec79b37aa5745
    123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037051876
    124 https://doi.org/10.1007/978-3-319-08894-5_3
    125 schema:sdDatePublished 2019-04-15T23:14
    126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    127 schema:sdPublisher Ne6f79c4f60044fb9a109589ffeb7cee7
    128 schema:url http://link.springer.com/10.1007/978-3-319-08894-5_3
    129 sgo:license sg:explorer/license/
    130 sgo:sdDataset chapters
    131 rdf:type schema:Chapter
    132 N0b6a35cc6e9841578976bcdd888b6070 rdf:first sg:person.01027240611.51
    133 rdf:rest rdf:nil
    134 N25323e89224d4e7e94fcfd36ac77dc6c schema:familyName Parpura
    135 schema:givenName Vladimir
    136 rdf:type schema:Person
    137 N2a571229000749538d53bca558f44e01 rdf:first N25323e89224d4e7e94fcfd36ac77dc6c
    138 rdf:rest N3f7f6a02ade046909b6142e734fafc3e
    139 N3f7f6a02ade046909b6142e734fafc3e rdf:first Nfc37ba9a0b254bfbb1eff59ba2d01884
    140 rdf:rest N4c074524ec414f9cb6cc12972e38a5da
    141 N4c074524ec414f9cb6cc12972e38a5da rdf:first Na601f6c0c2cc4679acca961796a4740f
    142 rdf:rest rdf:nil
    143 N55366c67ff0043d284dab20c64849b9b schema:name pubmed_id
    144 schema:value 25236723
    145 rdf:type schema:PropertyValue
    146 N833e7ec6f002473daf2162b9183eff52 rdf:first sg:person.0737000262.55
    147 rdf:rest N0b6a35cc6e9841578976bcdd888b6070
    148 N99a67e2cef7745af9914a0f71dfd42ec rdf:first sg:person.01055536710.81
    149 rdf:rest N833e7ec6f002473daf2162b9183eff52
    150 Na27d6c30aa4843bc9be060e17e83bdce schema:name dimensions_id
    151 schema:value pub.1037051876
    152 rdf:type schema:PropertyValue
    153 Na601f6c0c2cc4679acca961796a4740f schema:familyName Verkhratsky
    154 schema:givenName Alexei
    155 rdf:type schema:Person
    156 Ne6f79c4f60044fb9a109589ffeb7cee7 schema:name Springer Nature - SN SciGraph project
    157 rdf:type schema:Organization
    158 Ne7faf8ce77884e3caf7a00e88e884126 schema:name doi
    159 schema:value 10.1007/978-3-319-08894-5_3
    160 rdf:type schema:PropertyValue
    161 Nea8a523a77ba4a13addec79b37aa5745 schema:location Cham
    162 schema:name Springer International Publishing
    163 rdf:type schema:Organisation
    164 Nf0c3b09deeb243f2ae2be8acd7835218 schema:name readcube_id
    165 schema:value b0806709fa5d0a561798bb37977faa37bd98e42f39a6267341a81b48f5a56a13
    166 rdf:type schema:PropertyValue
    167 Nf6b514b62e584cd99fd12708801db354 schema:isbn 978-3-319-08893-8
    168 978-3-319-08894-5
    169 schema:name Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain
    170 rdf:type schema:Book
    171 Nfc37ba9a0b254bfbb1eff59ba2d01884 schema:familyName Schousboe
    172 schema:givenName Arne
    173 rdf:type schema:Person
    174 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    175 schema:name Medical and Health Sciences
    176 rdf:type schema:DefinedTerm
    177 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    178 schema:name Neurosciences
    179 rdf:type schema:DefinedTerm
    180 sg:person.01027240611.51 schema:affiliation https://www.grid.ac/institutes/grid.412449.e
    181 schema:familyName Peng
    182 schema:givenName Liang
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027240611.51
    184 rdf:type schema:Person
    185 sg:person.01055536710.81 schema:affiliation https://www.grid.ac/institutes/grid.412449.e
    186 schema:familyName Hertz
    187 schema:givenName Leif
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055536710.81
    189 rdf:type schema:Person
    190 sg:person.0737000262.55 schema:affiliation https://www.grid.ac/institutes/grid.412449.e
    191 schema:familyName Xu
    192 schema:givenName Junnan
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737000262.55
    194 rdf:type schema:Person
    195 sg:pub.10.1007/978-3-319-08894-5_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006169844
    196 https://doi.org/10.1007/978-3-319-08894-5_2
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1007/978-3-319-08894-5_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022146975
    199 https://doi.org/10.1007/978-3-319-08894-5_4
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1007/978-3-642-86875-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020338208
    202 https://doi.org/10.1007/978-3-642-86875-7
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1007/978-94-011-1725-8_29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011268283
    205 https://doi.org/10.1007/978-94-011-1725-8_29
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1007/bf00964954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029685281
    208 https://doi.org/10.1007/bf00964954
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1007/bf00965770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027050852
    211 https://doi.org/10.1007/bf00965770
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1007/s00213-008-1306-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024106232
    214 https://doi.org/10.1007/s00213-008-1306-5
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1007/s11064-012-0773-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047053803
    217 https://doi.org/10.1007/s11064-012-0773-6
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1007/s11064-012-0814-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051362180
    220 https://doi.org/10.1007/s11064-012-0814-1
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1007/s11064-012-0837-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012348059
    223 https://doi.org/10.1007/s11064-012-0837-7
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1007/s11064-012-0938-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001544717
    226 https://doi.org/10.1007/s11064-012-0938-3
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1007/s11064-013-1146-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045311247
    229 https://doi.org/10.1007/s11064-013-1146-5
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1007/s11064-014-1244-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1039590011
    232 https://doi.org/10.1007/s11064-014-1244-z
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1007/s11302-006-9016-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011183400
    235 https://doi.org/10.1007/s11302-006-9016-0
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1007/s11302-012-9316-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028253065
    238 https://doi.org/10.1007/s11302-012-9316-5
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1007/s12035-009-8063-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020028759
    241 https://doi.org/10.1007/s12035-009-8063-2
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1007/s12640-011-9296-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043694283
    244 https://doi.org/10.1007/s12640-011-9296-1
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1023/a:1014862808126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037817878
    247 https://doi.org/10.1023/a:1014862808126
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/mp.2011.159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036341860
    250 https://doi.org/10.1038/mp.2011.159
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/nm.3162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031934837
    253 https://doi.org/10.1038/nm.3162
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nrd1983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044863123
    256 https://doi.org/10.1038/nrd1983
    257 rdf:type schema:CreativeWork
    258 https://app.dimensions.ai/details/publication/pub.1075702411 schema:CreativeWork
    259 https://app.dimensions.ai/details/publication/pub.1076561883 schema:CreativeWork
    260 https://app.dimensions.ai/details/publication/pub.1076910949 schema:CreativeWork
    261 https://app.dimensions.ai/details/publication/pub.1079445823 schema:CreativeWork
    262 https://app.dimensions.ai/details/publication/pub.1082746472 schema:CreativeWork
    263 https://app.dimensions.ai/details/publication/pub.1082789398 schema:CreativeWork
    264 https://doi.org/10.1002/glia.20216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002947389
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1002/glia.20377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031479062
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1002/glia.20649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019976141
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1002/glia.21067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046126084
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1002/glia.21138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009725067
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1002/glia.22395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026656416
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1002/glia.22623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004374001
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1002/jnr.1141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027984012
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1002/jnr.21307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018520343
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1002/jnr.490240218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015369045
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1002/nbm.1772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017719072
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/0006-8993(90)90592-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1001227851
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/0006-8993(91)91538-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1005695575
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/0165-3806(84)90032-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049709176
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/0167-4889(93)90077-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049217434
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/0197-0186(91)90113-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1038190057
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/0304-3940(95)11410-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010504675
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/0304-4165(78)90233-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001770683
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/0306-4522(92)90329-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1005885599
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.brainres.2003.09.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019382593
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/j.ceca.2013.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025252192
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/j.ceca.2014.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018052485
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/j.cell.2011.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028061932
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/j.mri.2011.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028666276
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/j.neuint.2013.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047083740
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.neuron.2012.08.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028003130
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.neuroscience.2006.06.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013458556
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/j.npbr.2013.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045880308
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/j.tins.2004.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033695374
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/s0006-291x(88)81032-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026314365
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/s0006-8993(98)00657-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012763718
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/s0014-2999(02)01299-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028774504
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1016/s0014-4827(03)00090-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017332002
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1016/s0306-4522(97)00653-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012857460
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/s0361-9230(97)00345-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045168205
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1017/s1740925x12000117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054941846
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1038/jcbfm.1990.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003117862
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1038/jcbfm.2012.200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031598838
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1038/sj.bjp.0703182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034965464
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1038/sj.jcbfm.9600343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032630446
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1042/an20110061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023947323
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1042/an20130040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025178004
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1054/ceca.2001.0232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020804448
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1073/pnas.1120997109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009569603
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1073/pnas.89.16.7432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033741344
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1073/pnas.95.1.316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049058488
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1074/jbc.270.25.15175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041006818
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1083/jcb.43.3.506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048426100
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1093/oxfordjournals.jbchem.a129769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080283245
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1097/00004647-200212000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060185036
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1111/j.1440-1789.2010.01172.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051369216
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1111/j.1471-4159.1958.tb12383.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022497199
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1111/j.1471-4159.1979.tb05236.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039524340
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1111/j.1471-4159.1982.tb07903.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004040521
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1111/j.1471-4159.1988.tb04868.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000269737
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1111/j.1471-4159.2010.06995.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036975099
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1111/j.1476-5381.1985.tb17385.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008297739
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1126/science.1226740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005158080
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1139/y96-012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024822313
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1152/ajpcell.00202.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034064056
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1161/01.res.0000181159.83588.4b schema:sameAs https://app.dimensions.ai/details/publication/pub.1019702853
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1177/1073858411418524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032027170
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1177/1759091414543439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043568645
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1210/endo-85-4-711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064273816
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1503/jpn.100094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067426596
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1523/jneurosci.06-09-02558.1986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079509379
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1523/jneurosci.08-06-01922.1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079716429
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1523/jneurosci.12-12-04923.1992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075658519
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1523/jneurosci.18-21-08794.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083335760
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.2174/156802611795347582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069194082
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.2183/pjab.87.486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051328555
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.2741/brushia schema:sameAs https://app.dimensions.ai/details/publication/pub.1070917739
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.3109/08923979509019752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017866964
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.3389/fendo.2013.00059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052665567
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.3389/fncom.2013.00114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003641668
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.3389/fnint.2013.00020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040195554
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.5698/1535-7511-13.1.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012020458
    417 rdf:type schema:CreativeWork
    418 https://www.grid.ac/institutes/grid.412449.e schema:alternateName China Medical University
    419 schema:name Laboratory of Brain Metabolic Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang, P. R. China
    420 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...