Parkinson’s Disease in Intensive Care Unit View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014-04-10

AUTHORS

Lionel Velly , Delphine Boumaza , Nicolas Bruder

ABSTRACT

Parkinson’s disease is the second most frequent neurodegenerative disease and it is due to the degeneration of pigmented cells in the dopaminergic system of the substancia nigria. The cardinal symptoms are bradykinesia, extrapyramidal rigidity, tremor, posture and gait disorders. Patients are often admitted in ICU with a pre-established diagnosis. The major risks are related to the respiratory impairment, with aspiration pneumonia, first cause of death in these patients, and dysautonomia. Treatment includes L-Dopa combined with peripheral inhibitor of Dopa-decarboxylase, dopamine agonists, and surgical treatment for advanced-stage disease. An interruption in L-Dopa or administration of dopamine antagonists can have dramatic consequences on muscular rigidity or cause neuroleptic malignant syndrome-like. The main aim in ICU is not to stop L-Dopa treatment. Drug interactions between Parkinson’s medication and anaesthetics agents or drugs used in ICU are numerous and need to be known by physicians for an appropriate management of these patients in ICU. More... »

PAGES

125-138

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-319-04576-4_12

DOI

http://dx.doi.org/10.1007/978-3-319-04576-4_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002274123


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