Cholinergic responses in human neocortical neurones View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

J V Halliwell

ABSTRACT

Neurones in deeper layers of slices of temporal or frontal human neocortex maintained in vitro were impaled with microelectrodes and responses to cholinergic agonists were studied under current and voltage clamp conditions. A range of membrane currents were identifiable: inactivating and persistent Na(+)-conductances, inactivating and persistent Ca2(+)-conductances, two types of inward currents activated by hyperpolarization (IQ and If.i.r.) and voltage and Ca2(+)-activated K(+)-conductances, which were distinguished on the grounds of their characteristic voltage or pharmacological specificity. The cholinergic agonists muscarine or carbachol were applied in the medium superfusing the slices. Two major effects were observed: consistently, the time and voltage-dependent noninactivating K(+)-conductance IM was suppressed and, when Ca2(+)-influx was permitted (in the absence of Ca2(+)-channel blockers), a Ca2(+)-activated K(+)-conductance was transiently or persistently potentiated. Consistent with a suppression of IM, muscarine excited human neocortical neurones only when applied during a period of membrane depolarization to a potential at which IM would be expected to exert a braking effect on excitability. Applied at a potential negative to the M-current activation range, muscarine had no excitatory or even an inhibitory effect on the cell. Collectively, these results demonstrate that in the human, IM can be a target for cholinergic regulation and, in addition, complex effects of ACh on other conductances could modulate cell firing patterns. More... »

PAGES

138-149

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-0348-9138-7_14

DOI

http://dx.doi.org/10.1007/978-3-0348-9138-7_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025965546

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2533088


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acetylcholine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Action Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carbachol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evoked Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscarine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Muscarinic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synapses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetrodotoxin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Pharmacology, University College, London, England."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Halliwell", 
        "givenName": "J V", 
        "id": "sg:person.01107054157.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107054157.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1113/jphysiol.1971.sp009467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003348426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(83)90166-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005613649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(83)90166-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005613649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(81)90682-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011336499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(81)90682-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011336499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(87)90724-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012132244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(87)90724-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012132244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1987.sp016569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014243738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1983.sp014624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014278664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/315498a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022647404", 
          "https://doi.org/10.1038/315498a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1986.sp015993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026418356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/319402a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028347627", 
          "https://doi.org/10.1038/319402a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/319402a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028347627", 
          "https://doi.org/10.1038/319402a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1987.sp016865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028914455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.9.3022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030871728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/283673a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033131130", 
          "https://doi.org/10.1038/283673a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/319405a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034677177", 
          "https://doi.org/10.1038/319405a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/319405a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034677177", 
          "https://doi.org/10.1038/319405a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(86)90198-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035011807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(86)90198-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035011807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1983.sp014747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035023535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(86)91118-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035954906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(86)91118-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035954906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1986.sp016112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036267838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(76)90366-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039397325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(76)90366-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039397325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(86)90381-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044040404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(86)90381-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044040404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1984.sp015285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046705146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(82)90954-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047200704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(82)90954-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047200704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1983.sp014526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047784131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1988.sp017301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050987281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2456612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062538419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1986.55.6.1268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078817276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1985.53.1.153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079059191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1988.59.2.424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079699115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1988.59.2.450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079699117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.07-03-00733.1987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079821179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1987.57.5.1555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079835771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1982.48.6.1302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081666638"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1989", 
    "datePublishedReg": "1989-01-01", 
    "description": "Neurones in deeper layers of slices of temporal or frontal human neocortex maintained in vitro were impaled with microelectrodes and responses to cholinergic agonists were studied under current and voltage clamp conditions. A range of membrane currents were identifiable: inactivating and persistent Na(+)-conductances, inactivating and persistent Ca2(+)-conductances, two types of inward currents activated by hyperpolarization (IQ and If.i.r.) and voltage and Ca2(+)-activated K(+)-conductances, which were distinguished on the grounds of their characteristic voltage or pharmacological specificity. The cholinergic agonists muscarine or carbachol were applied in the medium superfusing the slices. Two major effects were observed: consistently, the time and voltage-dependent noninactivating K(+)-conductance IM was suppressed and, when Ca2(+)-influx was permitted (in the absence of Ca2(+)-channel blockers), a Ca2(+)-activated K(+)-conductance was transiently or persistently potentiated. Consistent with a suppression of IM, muscarine excited human neocortical neurones only when applied during a period of membrane depolarization to a potential at which IM would be expected to exert a braking effect on excitability. Applied at a potential negative to the M-current activation range, muscarine had no excitatory or even an inhibitory effect on the cell. Collectively, these results demonstrate that in the human, IM can be a target for cholinergic regulation and, in addition, complex effects of ACh on other conductances could modulate cell firing patterns.", 
    "editor": [
      {
        "familyName": "Frotscher", 
        "givenName": "Michael", 
        "type": "Person"
      }, 
      {
        "familyName": "Misgeld", 
        "givenName": "Ulrich", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-0348-9138-7_14", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-0348-9922-2", 
        "978-3-0348-9138-7"
      ], 
      "name": "Central Cholinergic Synaptic Transmission", 
      "type": "Book"
    }, 
    "name": "Cholinergic responses in human neocortical neurones", 
    "pagination": "138-149", 
    "productId": [
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2533088"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025965546"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-0348-9138-7_14"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7bb3245c221fc2660971787f59aa809aff925a14633db2672833c8915bb92a76"
        ]
      }
    ], 
    "publisher": {
      "location": "Basel", 
      "name": "Birkh\u00e4user Basel", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-0348-9138-7_14", 
      "https://app.dimensions.ai/details/publication/pub.1025965546"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T09:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117087_00000001.jsonl", 
    "type": "Chapter", 
    "url": "https://link.springer.com/10.1007%2F978-3-0348-9138-7_14"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-0348-9138-7_14'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-0348-9138-7_14'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-0348-9138-7_14'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-0348-9138-7_14'


 

This table displays all metadata directly associated to this object as RDF triples.

227 TRIPLES      23 PREDICATES      73 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-0348-9138-7_14 schema:about N3cc7d5d9de91441b807066bd0216287d
2 N45b31a2246a941bfb52de0514d21684f
3 N5b4c382d25594c12ba1a4267873102b4
4 N5d9b1bbdac8f494eb1f9b2b216941781
5 N635d90574d72460fbcaf1611c253ce4d
6 N6409dfa97bf44203951eea365cb2fb4f
7 N89003606ec3d4f93a57517332b72dbf2
8 Nac9cb064a5ca442b87980ddfa5200e44
9 Nbb807ee7ee6549869bf7b60e85573480
10 Nd9a0938ffe0543719fba8ee69ef035c9
11 Ndf71a836801c4225b00cc242b33373f6
12 Ne156aa9271444874976f07d8becd626c
13 Ne1e39a71f7d14d62b5c20d7e4a81717d
14 Ne7ddf56d119c4bf6a7e1d8ff7e5a655d
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author N8acbe4cbffe244a6ae910a4c312070ac
18 schema:citation sg:pub.10.1038/283673a0
19 sg:pub.10.1038/315498a0
20 sg:pub.10.1038/319402a0
21 sg:pub.10.1038/319405a0
22 https://doi.org/10.1016/0006-8993(76)90366-8
23 https://doi.org/10.1016/0006-8993(81)90682-x
24 https://doi.org/10.1016/0006-8993(82)90954-4
25 https://doi.org/10.1016/0006-8993(86)91118-2
26 https://doi.org/10.1016/0304-3940(83)90166-0
27 https://doi.org/10.1016/0304-3940(86)90198-9
28 https://doi.org/10.1016/0304-3940(86)90381-2
29 https://doi.org/10.1016/0304-3940(87)90724-5
30 https://doi.org/10.1073/pnas.83.9.3022
31 https://doi.org/10.1113/jphysiol.1971.sp009467
32 https://doi.org/10.1113/jphysiol.1983.sp014526
33 https://doi.org/10.1113/jphysiol.1983.sp014624
34 https://doi.org/10.1113/jphysiol.1983.sp014747
35 https://doi.org/10.1113/jphysiol.1984.sp015285
36 https://doi.org/10.1113/jphysiol.1986.sp015993
37 https://doi.org/10.1113/jphysiol.1986.sp016112
38 https://doi.org/10.1113/jphysiol.1987.sp016569
39 https://doi.org/10.1113/jphysiol.1987.sp016865
40 https://doi.org/10.1113/jphysiol.1988.sp017301
41 https://doi.org/10.1126/science.2456612
42 https://doi.org/10.1152/jn.1982.48.6.1302
43 https://doi.org/10.1152/jn.1985.53.1.153
44 https://doi.org/10.1152/jn.1986.55.6.1268
45 https://doi.org/10.1152/jn.1987.57.5.1555
46 https://doi.org/10.1152/jn.1988.59.2.424
47 https://doi.org/10.1152/jn.1988.59.2.450
48 https://doi.org/10.1523/jneurosci.07-03-00733.1987
49 schema:datePublished 1989
50 schema:datePublishedReg 1989-01-01
51 schema:description Neurones in deeper layers of slices of temporal or frontal human neocortex maintained in vitro were impaled with microelectrodes and responses to cholinergic agonists were studied under current and voltage clamp conditions. A range of membrane currents were identifiable: inactivating and persistent Na(+)-conductances, inactivating and persistent Ca2(+)-conductances, two types of inward currents activated by hyperpolarization (IQ and If.i.r.) and voltage and Ca2(+)-activated K(+)-conductances, which were distinguished on the grounds of their characteristic voltage or pharmacological specificity. The cholinergic agonists muscarine or carbachol were applied in the medium superfusing the slices. Two major effects were observed: consistently, the time and voltage-dependent noninactivating K(+)-conductance IM was suppressed and, when Ca2(+)-influx was permitted (in the absence of Ca2(+)-channel blockers), a Ca2(+)-activated K(+)-conductance was transiently or persistently potentiated. Consistent with a suppression of IM, muscarine excited human neocortical neurones only when applied during a period of membrane depolarization to a potential at which IM would be expected to exert a braking effect on excitability. Applied at a potential negative to the M-current activation range, muscarine had no excitatory or even an inhibitory effect on the cell. Collectively, these results demonstrate that in the human, IM can be a target for cholinergic regulation and, in addition, complex effects of ACh on other conductances could modulate cell firing patterns.
52 schema:editor Ne98a8cd5d65a44b1a59adf040535045c
53 schema:genre chapter
54 schema:inLanguage en
55 schema:isAccessibleForFree false
56 schema:isPartOf N93027118d2ba447fa22f19b5348c263c
57 schema:name Cholinergic responses in human neocortical neurones
58 schema:pagination 138-149
59 schema:productId N2d580230d8c3477b889d927869f5d446
60 N6ad0db0528de4f9a858793f549f74dda
61 Naf178603a0e9465b9e32015a0485123f
62 Ne0f4cae337eb4942af73d908dfcd256b
63 schema:publisher N0ec16c954c9844229239affa0fba73af
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025965546
65 https://doi.org/10.1007/978-3-0348-9138-7_14
66 schema:sdDatePublished 2019-04-16T09:25
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N108c12e7adba4c89b0f7e916bb9575a0
69 schema:url https://link.springer.com/10.1007%2F978-3-0348-9138-7_14
70 sgo:license sg:explorer/license/
71 sgo:sdDataset chapters
72 rdf:type schema:Chapter
73 N0ec16c954c9844229239affa0fba73af schema:location Basel
74 schema:name Birkhäuser Basel
75 rdf:type schema:Organisation
76 N108c12e7adba4c89b0f7e916bb9575a0 schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N2d580230d8c3477b889d927869f5d446 schema:name dimensions_id
79 schema:value pub.1025965546
80 rdf:type schema:PropertyValue
81 N3cc7d5d9de91441b807066bd0216287d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Neurons
83 rdf:type schema:DefinedTerm
84 N45b31a2246a941bfb52de0514d21684f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Evoked Potentials
86 rdf:type schema:DefinedTerm
87 N5b4c382d25594c12ba1a4267873102b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Synapses
89 rdf:type schema:DefinedTerm
90 N5d9b1bbdac8f494eb1f9b2b216941781 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Receptors, Muscarinic
92 rdf:type schema:DefinedTerm
93 N635d90574d72460fbcaf1611c253ce4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Cations
95 rdf:type schema:DefinedTerm
96 N6409dfa97bf44203951eea365cb2fb4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Carbachol
98 rdf:type schema:DefinedTerm
99 N6ad0db0528de4f9a858793f549f74dda schema:name pubmed_id
100 schema:value 2533088
101 rdf:type schema:PropertyValue
102 N89003606ec3d4f93a57517332b72dbf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Acetylcholine
104 rdf:type schema:DefinedTerm
105 N8acbe4cbffe244a6ae910a4c312070ac rdf:first sg:person.01107054157.00
106 rdf:rest rdf:nil
107 N93027118d2ba447fa22f19b5348c263c schema:isbn 978-3-0348-9138-7
108 978-3-0348-9922-2
109 schema:name Central Cholinergic Synaptic Transmission
110 rdf:type schema:Book
111 Nabbc2ccbb45447eda3430adf9d94399e schema:familyName Misgeld
112 schema:givenName Ulrich
113 rdf:type schema:Person
114 Nac9cb064a5ca442b87980ddfa5200e44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cerebral Cortex
116 rdf:type schema:DefinedTerm
117 Naf178603a0e9465b9e32015a0485123f schema:name doi
118 schema:value 10.1007/978-3-0348-9138-7_14
119 rdf:type schema:PropertyValue
120 Nbb807ee7ee6549869bf7b60e85573480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Action Potentials
122 rdf:type schema:DefinedTerm
123 Nd323c7f25d2b4117a6805be62f7365eb rdf:first Nabbc2ccbb45447eda3430adf9d94399e
124 rdf:rest rdf:nil
125 Nd9a0938ffe0543719fba8ee69ef035c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 Ndee84b27d9df46658207c639fcd62176 schema:familyName Frotscher
129 schema:givenName Michael
130 rdf:type schema:Person
131 Ndf71a836801c4225b00cc242b33373f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name In Vitro Techniques
133 rdf:type schema:DefinedTerm
134 Ne0f4cae337eb4942af73d908dfcd256b schema:name readcube_id
135 schema:value 7bb3245c221fc2660971787f59aa809aff925a14633db2672833c8915bb92a76
136 rdf:type schema:PropertyValue
137 Ne156aa9271444874976f07d8becd626c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Tetrodotoxin
139 rdf:type schema:DefinedTerm
140 Ne1e39a71f7d14d62b5c20d7e4a81717d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Brain Neoplasms
142 rdf:type schema:DefinedTerm
143 Ne7ddf56d119c4bf6a7e1d8ff7e5a655d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Muscarine
145 rdf:type schema:DefinedTerm
146 Ne98a8cd5d65a44b1a59adf040535045c rdf:first Ndee84b27d9df46658207c639fcd62176
147 rdf:rest Nd323c7f25d2b4117a6805be62f7365eb
148 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
149 schema:name Biological Sciences
150 rdf:type schema:DefinedTerm
151 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
152 schema:name Biochemistry and Cell Biology
153 rdf:type schema:DefinedTerm
154 sg:person.01107054157.00 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
155 schema:familyName Halliwell
156 schema:givenName J V
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107054157.00
158 rdf:type schema:Person
159 sg:pub.10.1038/283673a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033131130
160 https://doi.org/10.1038/283673a0
161 rdf:type schema:CreativeWork
162 sg:pub.10.1038/315498a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022647404
163 https://doi.org/10.1038/315498a0
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/319402a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028347627
166 https://doi.org/10.1038/319402a0
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/319405a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034677177
169 https://doi.org/10.1038/319405a0
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/0006-8993(76)90366-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039397325
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/0006-8993(81)90682-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011336499
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/0006-8993(82)90954-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047200704
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/0006-8993(86)91118-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035954906
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/0304-3940(83)90166-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005613649
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/0304-3940(86)90198-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035011807
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/0304-3940(86)90381-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044040404
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/0304-3940(87)90724-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012132244
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1073/pnas.83.9.3022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030871728
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1113/jphysiol.1971.sp009467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003348426
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1113/jphysiol.1983.sp014526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047784131
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1113/jphysiol.1983.sp014624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014278664
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1113/jphysiol.1983.sp014747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035023535
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1113/jphysiol.1984.sp015285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046705146
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1113/jphysiol.1986.sp015993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026418356
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1113/jphysiol.1986.sp016112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036267838
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1113/jphysiol.1987.sp016569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014243738
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1113/jphysiol.1987.sp016865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028914455
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1113/jphysiol.1988.sp017301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050987281
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1126/science.2456612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062538419
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1152/jn.1982.48.6.1302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081666638
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1152/jn.1985.53.1.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079059191
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1152/jn.1986.55.6.1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078817276
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1152/jn.1987.57.5.1555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079835771
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1152/jn.1988.59.2.424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079699115
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1152/jn.1988.59.2.450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079699117
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1523/jneurosci.07-03-00733.1987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079821179
224 rdf:type schema:CreativeWork
225 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
226 schema:name Department of Pharmacology, University College, London, England.
227 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...