Physiological Aspects of GAD-GABA System in the Pancreatic Islet View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1996

AUTHORS

Hiroshi Taniguchi , Junichi Katoh , Motoyoshi Sakaue , Yasuhiro Okada

ABSTRACT

In the pancreatic islet, which is non-neuronal, γ-aminobutyric acid (GABA) and its synthesizing enzyme, L-glutamate decarboxylase (GAD), are so high in concentration and activity respectively as in the brain, where GABA functions as an inhibitory neurotransmitter. This GABA may exert an inhibitory action on the secretion of somatostatin and glucagon possibly via GABAergic peri-insular neurons. Besides, the GAD-GABA system appears to be involved in insulin synthesis in the islet. More... »

PAGES

7-12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-0348-8990-2_2

DOI

http://dx.doi.org/10.1007/978-3-0348-8990-2_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044103375


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